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Volumn 31, Issue 3, 2011, Pages 944-953

Multipotent adult progenitor cells prevent macrophage-mediated axonal dieback and promote regrowth after spinal cord injury

Author keywords

[No Author keywords available]

Indexed keywords

GELATINASE B; PROTEOGLYCAN;

EID: 78751507491     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3566-10.2011     Document Type: Article
Times cited : (125)

References (56)
  • 1
    • 70349159499 scopus 로고    scopus 로고
    • Multipotent mesenchymal stromal cells attenuate chronic inflammation and injury-induced sensitivity to mechanical stimuli in experimental spinal cord injury
    • Abrams MB, Dominguez C, Pernold K, Reger R, Wiesenfeld-Hallin Z, Olson L, Prockop D (2009) Multipotent mesenchymal stromal cells attenuate chronic inflammation and injury-induced sensitivity to mechanical stimuli in experimental spinal cord injury. Restor Neurol Neurosci 27:307-321.
    • (2009) Restor Neurol Neurosci , vol.27 , pp. 307-321
    • Abrams, M.B.1    Dominguez, C.2    Pernold, K.3    Reger, R.4    Wiesenfeld-Hallin, Z.5    Olson, L.6    Prockop, D.7
  • 2
    • 69449094846 scopus 로고    scopus 로고
    • Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury
    • Alto LT, Havton LA, Conner JM, Hollis Ii ER, Blesch A, Tuszynski MH (2009) Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury. Nat Neurosci 12:1106-1113.
    • (2009) Nat Neurosci , vol.12 , pp. 1106-1113
    • Alto, L.T.1    Havton, L.A.2    Conner, J.M.3    Hollis Ii, E.R.4    Blesch, A.5    Tuszynski, M.H.6
  • 5
    • 34848854789 scopus 로고    scopus 로고
    • Skin-derived precursors generate myelinating Schwann cells that promote remyelination and functional recovery after contusion spinal cord injury
    • Biernaskie J, Sparling JS, Liu J, Shannon CP, Plemel JR, Xie Y, Miller FD, Tetzlaff W (2007) Skin-derived precursors generate myelinating Schwann cells that promote remyelination and functional recovery after contusion spinal cord injury. J Neurosci 27:9545-9559.
    • (2007) J Neurosci , vol.27 , pp. 9545-9559
    • Biernaskie, J.1    Sparling, J.S.2    Liu, J.3    Shannon, C.P.4    Plemel, J.R.5    Xie, Y.6    Miller, F.D.7    Tetzlaff, W.8
  • 6
    • 33845768784 scopus 로고    scopus 로고
    • Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms
    • Block ML, Zecca L, Hong JS (2007) Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 8:57-69.
    • (2007) Nat Rev Neurosci , vol.8 , pp. 57-69
    • Block, M.L.1    Zecca, L.2    Hong, J.S.3
  • 7
    • 65849333907 scopus 로고    scopus 로고
    • Adult stem cell therapies for neurological disorders: Benefits beyond neuronal replacement?
    • Boucherie C, Hermans E (2009) Adult stem cell therapies for neurological disorders: benefits beyond neuronal replacement? J Neurosci Res 87:1509-1521.
    • (2009) J Neurosci Res , vol.87 , pp. 1509-1521
    • Boucherie, C.1    Hermans, E.2
  • 8
    • 68849086666 scopus 로고    scopus 로고
    • Overcoming macrophagemediated axonal dieback following CNS injury
    • Busch SA, Horn KP, Silver DJ, Silver J (2009) Overcoming macrophagemediated axonal dieback following CNS injury. J Neurosci 29:9967-9976.
    • (2009) J Neurosci , vol.29 , pp. 9967-9976
    • Busch, S.A.1    Horn, K.P.2    Silver, D.J.3    Silver, J.4
  • 9
    • 74849106116 scopus 로고    scopus 로고
    • Adult NG2+ cells are permissive to neurite outgrowth and stabilize sensory axons during macrophage-induced axonal dieback after spinal cord injury
    • Busch SA, Horn KP, Cuascut FX, Hawthorne AL, Bai L, Miller RH, Silver J (2010) Adult NG2+ cells are permissive to neurite outgrowth and stabilize sensory axons during macrophage-induced axonal dieback after spinal cord injury. J Neurosci 30:255-265.
    • (2010) J Neurosci , vol.30 , pp. 255-265
    • Busch, S.A.1    Horn, K.P.2    Cuascut, F.X.3    Hawthorne, A.L.4    Bai, L.5    Miller, R.H.6    Silver, J.7
  • 10
    • 33746424373 scopus 로고    scopus 로고
    • Mesenchymal stem cells as trophic mediators
    • Caplan AI, Dennis JE (2006) Mesenchymal stem cells as trophic mediators. J Cell Biochem 98:1076-1084.
    • (2006) J Cell Biochem , vol.98 , pp. 1076-1084
    • Caplan, A.I.1    Dennis, J.E.2
  • 11
    • 0034096943 scopus 로고    scopus 로고
    • Th2 cell membrane factors in association with IL-4 enhance matrix metalloproteinase-1 (MMP-1) while decreasing MMP-9 production by granulocyte-macrophage colony-stimulating factor-differentiated human monocytes
    • Chizzolini C, Rezzonico R, De Luca C, Burger D, Dayer JM (2000) Th2 cell membrane factors in association with IL-4 enhance matrix metalloproteinase-1 (MMP-1) while decreasing MMP-9 production by granulocyte-macrophage colony-stimulating factor-differentiated human monocytes. J Immunol 164:5952-5960.
    • (2000) J Immunol , vol.164 , pp. 5952-5960
    • Chizzolini, C.1    Rezzonico, R.2    De Luca, C.3    Burger, D.4    Dayer, J.M.5
  • 12
    • 0019856865 scopus 로고
    • Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats
    • David S, Aguayo AJ (1981) Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats. Science 214:931-933.
    • (1981) Science , vol.214 , pp. 931-933
    • David, S.1    Aguayo, A.J.2
  • 13
    • 42149092238 scopus 로고    scopus 로고
    • Current status of experimental cell replacement approaches to spinal cord injury
    • Eftekharpour E, Karimi-Abdolrezaee S, Fehlings MG (2008) Current status of experimental cell replacement approaches to spinal cord injury. Neurosurg Focus 24:E19.
    • (2008) Neurosurg Focus , vol.24
    • Eftekharpour, E.1    Karimi-Abdolrezaee, S.2    Fehlings, M.G.3
  • 14
    • 0029801579 scopus 로고    scopus 로고
    • Oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells derived from adult rat spinal cord: In vitro characteristics and response to PDGF, bFGF and NT-3
    • Engel U, Wolswijk G (1996) Oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells derived from adult rat spinal cord: in vitro characteristics and response to PDGF, bFGF and NT-3. Glia 16:16-26.
    • (1996) Glia , vol.16 , pp. 16-26
    • Engel, U.1    Wolswijk, G.2
  • 15
    • 33646576505 scopus 로고    scopus 로고
    • Functional considerations of stem cell transplantation therapy for spinal cord repair
    • DOI 10.1089/neu.2006.23.479
    • Enzmann GU, Benton RL, Talbott JF, Cao Q, Whittemore SR (2006) Functional considerations of stem cell transplantation therapy for spinal cord repair. J Neurotrauma 23:479-495. (Pubitemid 43726323)
    • (2006) Journal of Neurotrauma , vol.23 , Issue.3-4 , pp. 479-485
    • Enzmann, G.U.1    Benton, R.L.2    Talbott, J.F.3    Cao, Q.4    Whittemore, S.R.5
  • 17
    • 0033216123 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of glial scarring and progressive cavitation: In vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma
    • Fitch MT, Doller C, Combs CK, Landreth GE, Silver J (1999) Cellular and molecular mechanisms of glial scarring and progressive cavitation: in vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma. J Neurosci 19:8182-8198.
    • (1999) J Neurosci , vol.19 , pp. 8182-8198
    • Fitch, M.T.1    Doller, C.2    Combs, C.K.3    Landreth, G.E.4    Silver, J.5
  • 20
    • 58149347238 scopus 로고    scopus 로고
    • Paracrine mechanisms in adult stem cell signaling and therapy
    • Gnecchi M, Zhang Z, Ni A, Dzau VJ (2008) Paracrine mechanisms in adult stem cell signaling and therapy. Circ Res 103:1204-1219.
    • (2008) Circ Res , vol.103 , pp. 1204-1219
    • Gnecchi, M.1    Zhang, Z.2    Ni, A.3    Dzau, V.J.4
  • 21
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • Gordon S (2003) Alternative activation of macrophages. Nat Rev Immunol 3:23-35.
    • (2003) Nat Rev Immunol , vol.3 , pp. 23-35
    • Gordon, S.1
  • 23
    • 56949089831 scopus 로고    scopus 로고
    • Another barrier to regeneration in the CNS: Activated macrophages induce extensive retraction of dystrophic axons through direct physical interactions
    • Horn KP, Busch SA, Hawthorne AL, van Rooijen N, Silver J (2008) Another barrier to regeneration in the CNS: activated macrophages induce extensive retraction of dystrophic axons through direct physical interactions. J Neurosci 28:9330-9341.
    • (2008) J Neurosci , vol.28 , pp. 9330-9341
    • Horn, K.P.1    Busch, S.A.2    Hawthorne, A.L.3    Van Rooijen, N.4    Silver, J.5
  • 24
    • 33746094328 scopus 로고    scopus 로고
    • Combining an autologous peripheral nervous system "bridge" and matrix modification by chondroitinase allows robust, functional regeneration beyond a hemisection lesion of the adult rat spinal cord
    • Houle JD, Tom VJ, Mayes D, Wagoner G, Phillips N, Silver J (2006) Combining an autologous peripheral nervous system "bridge" and matrix modification by chondroitinase allows robust, functional regeneration beyond a hemisection lesion of the adult rat spinal cord. J Neurosci 26:7405-7415.
    • (2006) J Neurosci , vol.26 , pp. 7405-7415
    • Houle, J.D.1    Tom, V.J.2    Mayes, D.3    Wagoner, G.4    Phillips, N.5    Silver, J.6
  • 26
    • 0036322544 scopus 로고    scopus 로고
    • Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain
    • Jiang Y, Vaessen B, Lenvik T, Blackstad M, Reyes M, Verfaillie CM (2002b) Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain. Exp Hematol 30:896-904.
    • (2002) Exp Hematol , vol.30 , pp. 896-904
    • Jiang, Y.1    Vaessen, B.2    Lenvik, T.3    Blackstad, M.4    Reyes, M.5    Verfaillie, C.M.6
  • 27
    • 0142250844 scopus 로고    scopus 로고
    • Axonal regeneration through regions of chondroitin sulfate proteoglycan deposition after spinal cord injury: A balance of permissiveness and inhibition
    • Jones LL, Sajed D, Tuszynski MH (2003) Axonal regeneration through regions of chondroitin sulfate proteoglycan deposition after spinal cord injury: a balance of permissiveness and inhibition. J Neurosci 23:9276-9288.
    • (2003) J Neurosci , vol.23 , pp. 9276-9288
    • Jones, L.L.1    Sajed, D.2    Tuszynski, M.H.3
  • 28
    • 70350203996 scopus 로고    scopus 로고
    • Combined intrinsic and extrinsic neuronal mechanisms facilitate bridging axonal regeneration one year after spinal cord injury
    • Kadoya K, Tsukada S, Lu P, Coppola G, Geschwind D, Filbin MT, Blesch A, Tuszynski MH (2009) Combined intrinsic and extrinsic neuronal mechanisms facilitate bridging axonal regeneration one year after spinal cord injury. Neuron 64:165-172.
    • (2009) Neuron , vol.64 , pp. 165-172
    • Kadoya, K.1    Tsukada, S.2    Lu, P.3    Coppola, G.4    Geschwind, D.5    Filbin, M.T.6    Blesch, A.7    Tuszynski, M.H.8
  • 29
    • 76149105178 scopus 로고    scopus 로고
    • Synergistic effects of transplanted adult neural stem/progenitor cells, chondroitinase, and growth factors promote functional repair and plasticity of the chronically injured spinal cord
    • Karimi-Abdolrezaee S, Eftekharpour E, Wang J, Schut D, Fehlings MG (2010) Synergistic effects of transplanted adult neural stem/progenitor cells, chondroitinase, and growth factors promote functional repair and plasticity of the chronically injured spinal cord. J Neurosci 30:1657-1676.
    • (2010) J Neurosci , vol.30 , pp. 1657-1676
    • Karimi-Abdolrezaee, S.1    Eftekharpour, E.2    Wang, J.3    Schut, D.4    Fehlings, M.G.5
  • 30
    • 18644384444 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury
    • Keirstead HS, Nistor G, Bernal G, Totoiu M, Cloutier F, Sharp K, Steward O (2005) Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury. J Neurosci 25:4694-4705.
    • (2005) J Neurosci , vol.25 , pp. 4694-4705
    • Keirstead, H.S.1    Nistor, G.2    Bernal, G.3    Totoiu, M.4    Cloutier, F.5    Sharp, K.6    Steward, O.7
  • 31
    • 18844436224 scopus 로고    scopus 로고
    • In vivo imaging of axonal degeneration and regeneration in the injured spinal cord
    • Kerschensteiner M, Schwab ME, Lichtman JW, Misgeld T (2005) In vivo imaging of axonal degeneration and regeneration in the injured spinal cord. Nat Med 11:572-577.
    • (2005) Nat Med , vol.11 , pp. 572-577
    • Kerschensteiner, M.1    Schwab, M.E.2    Lichtman, J.W.3    Misgeld, T.4
  • 32
    • 70350558453 scopus 로고    scopus 로고
    • Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord
    • Kigerl KA, Gensel JC, Ankeny DP, Alexander JK, Donnelly DJ, Popovich PG (2009) Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord. J Neurosci 29:13435-13444.
    • (2009) J Neurosci , vol.29 , pp. 13435-13444
    • Kigerl, K.A.1    Gensel, J.C.2    Ankeny, D.P.3    Alexander, J.K.4    Donnelly, D.J.5    Popovich, P.G.6
  • 34
    • 33846653546 scopus 로고    scopus 로고
    • Development of adult pluripotent stem cell therapies for ischemic injury and disease
    • Mays RW, van't Hof W, Ting AE, Perry R, Deans R (2007) Development of adult pluripotent stem cell therapies for ischemic injury and disease. Expert Opin Biol Ther 7:173-184.
    • (2007) Expert Opin Biol Ther , vol.7 , pp. 173-184
    • Mays, R.W.1    Van't Hof, W.2    Ting, A.E.3    Perry, R.4    Deans, R.5
  • 35
    • 0035873062 scopus 로고    scopus 로고
    • Proliferation of NG2-positive cells and altered oligodendrocyte numbers in the contused rat spinal cord
    • McTigue DM, Wei P, Stokes BT (2001) Proliferation of NG2-positive cells and altered oligodendrocyte numbers in the contused rat spinal cord. J Neurosci 21:3392-3400. (Pubitemid 32422804)
    • (2001) Journal of Neuroscience , vol.21 , Issue.10 , pp. 3392-3400
    • McTigue, D.M.1    Wei, P.2    Stokes, B.T.3
  • 36
    • 0033137077 scopus 로고    scopus 로고
    • Regeneration of dorsal column fibers into and beyond the lesion site following adult spinal cord injury
    • Neumann S, Woolf CJ (1999) Regeneration of dorsal column fibers into and beyond the lesion site following adult spinal cord injury. Neuron 23:83-91.
    • (1999) Neuron , vol.23 , pp. 83-91
    • Neumann, S.1    Woolf, C.J.2
  • 37
    • 0036758650 scopus 로고    scopus 로고
    • Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events
    • Noble LJ, Donovan F, Igarashi T, Goussev S, Werb Z (2002) Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events. J Neurosci 22:7526-7535.
    • (2002) J Neurosci , vol.22 , pp. 7526-7535
    • Noble, L.J.1    Donovan, F.2    Igarashi, T.3    Goussev, S.4    Werb, Z.5
  • 38
    • 55749098498 scopus 로고    scopus 로고
    • Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses
    • Ohtaki H, Ylostalo JH, Foraker JE, Robinson AP, Reger RL, Shioda S, Prockop DJ (2008) Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses. Proc Natl Acad Sci U S A 105:14638-14643.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 14638-14643
    • Ohtaki, H.1    Ylostalo, J.H.2    Foraker, J.E.3    Robinson, A.P.4    Reger, R.L.5    Shioda, S.6    Prockop, D.J.7
  • 39
    • 38549154182 scopus 로고    scopus 로고
    • Therapeutic benefits by human mesenchymal stem cells (hMSCs) and Ang-1 gene-modified hMSCs after cerebral ischemia
    • Onda T, Honmou O, Harada K, Houkin K, Hamada H, Kocsis JD (2008) Therapeutic benefits by human mesenchymal stem cells (hMSCs) and Ang-1 gene-modified hMSCs after cerebral ischemia. J Cereb Blood Flow Metab 28:329-340.
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 329-340
    • Onda, T.1    Honmou, O.2    Harada, K.3    Houkin, K.4    Hamada, H.5    Kocsis, J.D.6
  • 41
    • 34648860537 scopus 로고    scopus 로고
    • Bone marrow-derived mesenchymal stromal cells for the repair of central nervous system injury
    • Parr AM, Tator CH, Keating A (2007) Bone marrow-derived mesenchymal stromal cells for the repair of central nervous system injury. Bone Marrow Transplant 40:609-619.
    • (2007) Bone Marrow Transplant , vol.40 , pp. 609-619
    • Parr, A.M.1    Tator, C.H.2    Keating, A.3
  • 43
    • 72449122797 scopus 로고    scopus 로고
    • BDNF-hypersecreting human mesenchymal stem cells promote functional recovery, axonal sprouting, and protection of corticospinal neurons after spinal cord injury
    • Sasaki M, Radtke C, Tan AM, Zhao P, Hamada H, Houkin K, Honmou O, Kocsis JD (2009) BDNF-hypersecreting human mesenchymal stem cells promote functional recovery, axonal sprouting, and protection of corticospinal neurons after spinal cord injury. J Neurosci 29:14932-14941.
    • (2009) J Neurosci , vol.29 , pp. 14932-14941
    • Sasaki, M.1    Radtke, C.2    Tan, A.M.3    Zhao, P.4    Hamada, H.5    Houkin, K.6    Honmou, O.7    Kocsis, J.D.8
  • 44
    • 34848852247 scopus 로고    scopus 로고
    • Retrograde axonal degeneration ("dieback") in the corticospinal tract after transection injury of the rat spinal cord: A confocal microscopy study
    • Seif GI, Nomura H, Tator CH (2007) Retrograde axonal degeneration ("dieback") in the corticospinal tract after transection injury of the rat spinal cord: a confocal microscopy study. J Neurotrauma 24:1513-1528.
    • (2007) J Neurotrauma , vol.24 , pp. 1513-1528
    • Seif, G.I.1    Nomura, H.2    Tator, C.H.3
  • 45
    • 0742288565 scopus 로고    scopus 로고
    • Regeneration beyond the glial scar
    • Silver J, Miller JH (2004) Regeneration beyond the glial scar. Nat Rev Neurosci 5:146-156.
    • (2004) Nat Rev Neurosci , vol.5 , pp. 146-156
    • Silver, J.1    Miller, J.H.2
  • 46
    • 33845207898 scopus 로고    scopus 로고
    • Review of treatment trials in human spinal cord injury: Issues, difficulties, and recommendations
    • discussion 982-987
    • Tator CH. (2006) Review of treatment trials in human spinal cord injury: issues, difficulties, and recommendations. Neurosurgery 59:957-982, discussion 982-987.
    • Neurosurgery , vol.59 , pp. 957-982
    • Tator, C.H.1
  • 49
    • 3242759236 scopus 로고    scopus 로고
    • Studies on the development and behavior of the dystrophic growth cone, the hallmark of regeneration failure, in an in vitro model of the glial scar and after spinal cord injury
    • Tom VJ, Steinmetz MP, Miller JH, Doller CM, Silver J (2004) Studies on the development and behavior of the dystrophic growth cone, the hallmark of regeneration failure, in an in vitro model of the glial scar and after spinal cord injury. J Neurosci 24:6531-6539.
    • (2004) J Neurosci , vol.24 , pp. 6531-6539
    • Tom, V.J.1    Steinmetz, M.P.2    Miller, J.H.3    Doller, C.M.4    Silver, J.5
  • 50
    • 34548555990 scopus 로고    scopus 로고
    • Direct delivery of syngeneic and allogeneic large-scale expanded multipotent adult progenitor cells improves cardiac function after myocardial infarct
    • Van't Hof W, Mal N, Huang Y, Zhang M, Popovic Z, Forudi F, Deans R, Penn MS (2007) Direct delivery of syngeneic and allogeneic large-scale expanded multipotent adult progenitor cells improves cardiac function after myocardial infarct. Cytotherapy 9:477-487.
    • (2007) Cytotherapy , vol.9 , pp. 477-487
    • Van't Hof, W.1    Mal, N.2    Huang, Y.3    Zhang, M.4    Popovic, Z.5    Forudi, F.6    Deans, R.7    Penn, M.S.8
  • 51
    • 32344443093 scopus 로고    scopus 로고
    • The evolving roles of axonally synthesized proteins in regeneration
    • Willis DE, Twiss JL (2006) The evolving roles of axonally synthesized proteins in regeneration. Curr Opin Neurobiol 16:111-118.
    • (2006) Curr Opin Neurobiol , vol.16 , pp. 111-118
    • Willis, D.E.1    Twiss, J.L.2
  • 53
    • 54949145003 scopus 로고    scopus 로고
    • Intravenous grafts recapitulate the neurorestoration afforded by intracerebrally delivered multipotent adult progenitor cells in neonatal hypoxic-ischemic rats
    • Yasuhara T, Hara K, Maki M, Mays RW, Deans RJ, Hess DC, Carroll JE, Borlongan CV (2008) Intravenous grafts recapitulate the neurorestoration afforded by intracerebrally delivered multipotent adult progenitor cells in neonatal hypoxic-ischemic rats. J Cereb Blood Flow Metab 28:1804-1810.
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 1804-1810
    • Yasuhara, T.1    Hara, K.2    Maki, M.3    Mays, R.W.4    Deans, R.J.5    Hess, D.C.6    Carroll, J.E.7    Borlongan, C.V.8
  • 55
    • 28644435880 scopus 로고    scopus 로고
    • Metalloproteinases: Mediators of pathology and regeneration in the CNS
    • Yong VW (2005) Metalloproteinases: mediators of pathology and regeneration in the CNS. Nat Rev Neurosci 6:931-944.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 931-944
    • Yong, V.W.1
  • 56
    • 0036118625 scopus 로고    scopus 로고
    • Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats
    • Zhao LR, Duan WM, Reyes M, Keene CD, Verfaillie CM, Low WC (2002) Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats. Exp Neurol 174:11-20.
    • (2002) Exp Neurol , vol.174 , pp. 11-20
    • Zhao, L.R.1    Duan, W.M.2    Reyes, M.3    Keene, C.D.4    Verfaillie, C.M.5    Low, W.C.6


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