Macrophages decide between regeneration and fibrosis in muscle

Trends in Endocrinology and Metabolism

Volumn 26, Issue 9, 2015, Pages 449-450

  Muñoz Cánoves, Pura ^a,b   Serrano, Antonio L ^a  

^a UNIVERSITAT POMPEU FABRA   (Spain)

^b INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

Fibro adipogenic progenitors; Fibrosis; Macrophages; Nilotinib; Regeneration

Indexed keywords

CHEMOKINE RECEPTOR CCR2; INTERLEUKIN 10; MITOGEN ACTIVATED PROTEIN KINASE P38; NEUTRALIZING ANTIBODY; NILOTINIB; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR;

APOPTOSIS; CELL INFILTRATION; CELL SURVIVAL; CHRONIC MYELOID LEUKEMIA; DUCHENNE MUSCULAR DYSTROPHY; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; MACROPHAGE; MUSCLE INJURY; MUSCLE REGENERATION; MYOFIBROSIS; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY; STEM CELL; ANIMAL; FIBROSIS; HUMAN; MUSCLE; PATHOLOGY; REGENERATION;

ANIMALS; FIBROSIS; HUMANS; MACROPHAGES; MUSCLES; REGENERATION;

EID: 84940447241     PISSN: 10432760     EISSN: 18793061     Source Type: Journal    
DOI: 10.1016/j.tem.2015.07.005     Document Type: Short Survey

References (10)

1. Mann C.J., et al. Aberrant repair and fibrosis development in skeletal muscle. Skelet. Muscle 2011, 1:21.
2. Mounier R., et al. Blood vessels and the satellite cell niche. Curr. Top. Dev. Biol. 2011, 96:121-138.
3. Joe A.W., et al. Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis. Nat. Cell Biol. 2010, 12:153-163.
4. Uezumi A., et al. Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle. Nat. Cell Biol. 2010, 12:143-152.
5. Uezumi A., et al. Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle. J. Cell Sci. 2011, 124:3654-3664.
6. Arnold L., et al. Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis. J. Exp. Med. 2007, 204:1057-1069.
7. Perdiguero E., et al. p38/MKP-1-regulated AKT coordinates macrophage transitions and resolution of inflammation during tissue repair. J. Cell Biol. 2011, 195:307-322.
8. Wehling-Henricks M., et al. Arginine metabolism by macrophages promotes cardiac and muscle fibrosis in mdx muscular dystrophy. PLoS ONE 2010, 5:e10763.
9. Zordan P., et al. Macrophages commit postnatal endothelium-derived progenitors to angiogenesis and restrict endothelial to mesenchymal transition during muscle regeneration. Cell Death Dis. 2014, 5:e1031.
10. Lemos D.R., et al. Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors. Nat. Med. 2015, 21:786-794.