Coffee and metabolic impairment: An updated review of epidemiological studies

NFS Journal

Volumn 3, Issue , 2016, Pages 1-7

  Buscemi, Silvio ^a   Marventano, Stefano ^b   Antoci, Mariagrazia ^b   Cagnetti, Antonella ^b   Castorina, Gabriele ^b   Galvano, Fabio ^c   Marranzano, Marina ^b   Mistretta, Antonio ^b  

^a UNIVERSITY OF PALERMO   (Italy)

^b UNIVERSITY OF CATANIA   (Italy)

^c UNIVERSITY OF CATANIA   (Italy)

Author keywords

Caffeine; Coffee; Diabetes; Metabolic disorders

Indexed keywords

EID: 84959348138     PISSN: None     EISSN: 23523646     Source Type: Journal    
DOI: 10.1016/j.nfs.2016.02.001     Document Type: Review

References (115)

1. G.B.D.Mortality, C.Causes of death Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study. Lancet 2013, 385(2015):117-171.
2. Danaei G., Finucane M.M., Lu Y., Singh G.M., Cowan M.J., Paciorek C.J., Lin J.K., Farzadfar F., Khang Y.H., Stevens G.A., Rao M., Ali M.K., Riley L.M., Robinson C.A., Ezzati M. National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. Lancet 2011, 378:31-40. G. Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating.
3. Hedner T., Kjeldsen S.E., Narkiewicz K. State of global health-hypertension burden and control. Blood Press. 2012, 21(Suppl. 1):1-2.
4. Grosso G., Mistretta A., Frigiola A., Gruttadauria S., Biondi A., Basile F., Vitaglione P., D'Orazio N., Galvano F. Mediterranean diet and cardiovascular risk factors: a systematic review. Crit. Rev. Food Sci. Nutr. 2014, 54:593-610.
5. Buscemi S., Sprini D., Grosso G., Galvano F., Nicolucci A., Lucisano G., Massenti F.M., Amodio E., Rini G.B. Impact of lifestyle on metabolic syndrome in apparently healthy people. Eat. Weight Disord. 2014, 19:225-232.
6. Siervo M., Lara J., Chowdhury S., Ashor A., Oggioni C., Mathers J.C. Effects of the dietary approach to stop hypertension (DASH) diet on cardiovascular risk factors: a systematic review and meta-analysis. Br. J. Nutr. 2014, 1-15.
7. A comprehensive meta-analysis on evidence of mediterranean diet and cardiovascular disease: are individual components equal?
8. Grosso G., Pajak A., Mistretta A., Marventano S., Raciti T., Buscemi S., Drago F., Scalfi L., Galvano F. Protective role of the Mediterranean diet on several cardiovascular risk factors: evidence from Sicily, Southern Italy. Nutr. Metab. Cardiovasc. Dis. 2014, 24:370-377.
9. Grosso G., Stepaniak U., Micek A., Topor-Madry R., Stefler D., Szafraniec K., Bobak M., Pajak A. A Mediterranean-type diet is associated with better metabolic profile in urban Polish adults: results from the HAPIEE Study. Metabolism 2015, 64:738-746.
10. Higdon J.V., Frei B. Coffee and health: a review of recent human research. Crit. Rev. Food Sci. Nutr. 2006, 46:101-123.
11. O'Keefe J.H., Bhatti S.K., Patil H.R., DiNicolantonio J.J., Lucan S.C., Lavie C.J. Effects of habitual coffee consumption on cardiometabolic disease, cardiovascular health, and all-cause mortality. J. Am. Coll. Cardiol. 2013, 62:1043-1051.
12. Liu J., Sui X., Lavie C.J., Hebert j.R., Earnest C.P., Zhang J., Blair S.N. Association of coffee consumption with all-cause and cardiovascular disease mortality. Mayo Clin. Proc. 2013, 88:1066-1074.
13. van Dam R.M. Coffee and type 2 diabetes: from beans to beta-cells. Nutr. Metab. Cardiovasc. Dis. 2006, 16:69-77.
14. Ding M., Bhupathiraju S.N., Chen M., van Dam R.M., Hu F.B. Caffeinated and decaffeinated coffee consumption and risk of type 2 diabetes: a systematic review and a dose-response meta-analysis. Diabetes Care 2014, 37:569-586.
15. Jiang X., Zhang D., Jiang W. Coffee and caffeine intake and incidence of type 2 diabetes mellitus: a meta-analysis of prospective studies. Eur. J. Nutr. 2014, 53:25-38.
16. Muley A., Muley P., Shah M. Coffee to reduce risk of type 2 diabetes? A systematic review. Curr. Diabetes Rev. 2012, 8:162-168.
17. Doo T., Morimoto Y., Steinbrecher A., Kolonel L.N., Maskarinec G. Coffee intake and risk of type 2 diabetes: the multiethnic cohort. Public Health Nutr. 2013, 1-9.
18. Floegel A., Pischon T., Bergmann M.M., Teucher B., Kaaks R., Boeing H. Coffee consumption and risk of chronic disease in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany study. Am. J. Clin. Nutr. 2012, 95:901-908.
19. Bhupathiraju S.N., Pan A., Malik V.S., Manson J.E., Willett W.C., van Dam R.M., Hu F.B. Caffeinated and caffeine-free beverages and risk of type 2 diabetes. Am. J. Clin. Nutr. 2013, 97:155-166.
20. Kato M., Noda M., Inoue M., Kadowaki T., Tsugane S., Group J.S. Psychological factors, coffee and risk of diabetes mellitus among middle-aged Japanese: a population-based prospective study in the JPHC study cohort. Endocr. J. 2009, 56:459-468.
21. Oba S., Nagata C., Nakamura K., Fujii K., Kawachi T., Takatsuka N., Shimizu H. Consumption of coffee, green tea, oolong tea, black tea, chocolate snacks and the caffeine content in relation to risk of diabetes in Japanese men and women. Br. J. Nutr. 2010, 103:453-459.
22. Zhang Y., Lee E.T., Cowan L.D., Fabsitz R.R., Howard B.V. Coffee consumption and the incidence of type 2 diabetes in men and women with normal glucose tolerance: the Strong Heart Study. Nutr. Metab. Cardiovasc. Dis. 2011, 21:418-423.
23. Hiramatsu T., Tajima O., Uezono K., Tabata S., Abe H., Ohnaka K., Kono S. Coffee consumption, serum gamma-glutamyltransferase, and glucose tolerance status in middle-aged Japanese men. Clin. Chem. Lab. Med. 2013, 51:1233-1239.
24. Pham N.M., Nanri A., Kochi T., Kuwahara K., Tsuruoka H., Kurotani K., Akter S., Kabe I., Sato M., Hayabuchi H., Mizoue T. Coffee and green tea consumption is associated with insulin resistance in Japanese adults. Metabolism 2013, 400-408.
25. Lecoultre V., Carrel G., Egli L., Binnert C., Boss A., Macmillan E.L., Kreis R., Boesch C., Darimont C., Tappy L. Coffee consumption attenuates short-term fructose-induced liver insulin resistance in healthy men. Am. J. Clin. Nutr. 2014, 99:268-275.
26. Rebello S.A., Chen C.H., Naidoo N., Xu W., Lee J., Chia K.S., Tai E.S., van Dam R.M. Coffee and tea consumption in relation to inflammation and basal glucose metabolism in a multi-ethnic Asian population: a cross-sectional study. Nutr. J. 2011, 10:61.
27. Loopstra-Masters R.C., Liese A.D., Haffner S.M., Wagenknecht L.E., Hanley A.J. Associations between the intake of caffeinated and decaffeinated coffee and measures of insulin sensitivity and beta cell function. Diabetologia 2011, 54:320-328.
28. Whitehead N., White H. Systematic review of randomised controlled trials of the effects of caffeine or caffeinated drinks on blood glucose concentrations and insulin sensitivity in people with diabetes mellitus. J. Hum. Nutr. Diet. 2013, 26:111-125.
29. Ohnaka K., Ikeda M., Maki T., Okada T., Shimazoe T., Adachi M., Nomura M., Takayanagi R., Kono S. Effects of 16-week consumption of caffeinated and decaffeinated instant coffee on glucose metabolism in a randomized controlled trial. J. Nutr. Metab. 2012, 2012:207426.
30. Rakvaag E., Dragsted L.O. Acute effects of light and dark roasted coffee on glucose tolerance: a randomized, controlled crossover trial in healthy volunteers. Eur. J. Nutr. 2015.
31. Gavrieli A., Fragopoulou E., Mantzoros C.S., Yannakoulia M. Gender and body mass index modify the effect of increasing amounts of caffeinated coffee on postprandial glucose and insulin concentrations; a randomized, controlled, clinical trial. Metabolism 2013, 62:1099-1106.
32. Moisey L.L., Kacker S., Bickerton A.C., Robinson L.E., Graham T.E. Caffeinated coffee consumption impairs blood glucose homeostasis in response to high and low glycemic index meals in healthy men. Am. J. Clin. Nutr. 2008, 87:1254-1261.
33. Greenberg J.A., Owen D.R., Geliebter A. Decaffeinated coffee and glucose metabolism in young men. Diabetes Care 2010, 33:278-280.
34. Beaudoin M.S., Robinson L.E., Graham T.E. An oral lipid challenge and acute intake of caffeinated coffee additively decrease glucose tolerance in healthy men. J. Nutr. 2011, 141:574-581.
35. Moisey L.L., Robinson L.E., Graham T.E. Consumption of caffeinated coffee and a high carbohydrate meal affects postprandial metabolism of a subsequent oral glucose tolerance test in young, healthy males. Br. J. Nutr. 2010, 103:833-841.
36. Krebs J.D., Parry-Strong A., Weatherall M., Carroll R.W., Downie M. A cross-over study of the acute effects of espresso coffee on glucose tolerance and insulin sensitivity in people with type 2 diabetes mellitus. Metabolism 2012, 61:1231-1237.
37. Wedick N.M., Brennan A.M., Sun Q., Hu F.B., Mantzoros C.S., van Dam R.M. Effects of caffeinated and decaffeinated coffee on biological risk factors for type 2 diabetes: a randomized controlled trial. Nutr. J. 2011, 10:93.
38. Kempf K., Herder C., Erlund I., Kolb H., Martin S., Carstensen M., Koenig W., Sundvall J., Bidel S., Kuha S., Tuomilehto J. Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial. Am. J. Clin. Nutr. 2010, 91:950-957.
39. Zhang Z., Hu G., Caballero B., Appel L., Chen L. Habitual coffee consumption and risk of hypertension: a systematic review and meta-analysis of prospective observational studies. Am. J. Clin. Nutr. 2011, 93:1212-1219.
40. Steffen M., Kuhle C., Hensrud D., Erwin P.J., Murad M.H. The effect of coffee consumption on blood pressure and the development of hypertension: a systematic review and meta-analysis. J. Hypertens. 2012, 30:2245-2254.
41. Mesas A.E., Leon-Munoz L.M., Rodriguez-Artalejo F., Lopez-Garcia E. The effect of coffee on blood pressure and cardiovascular disease in hypertensive individuals: a systematic review and meta-analysis. Am. J. Clin. Nutr. 2011, 94:1113-1126.
42. Noordzij M., Uiterwaal C.S., Arends L.R., Kok F.J., Grobbee D.E., Geleijnse J.M. Blood pressure response to chronic intake of coffee and caffeine: a meta-analysis of randomized controlled trials. J. Hypertens. 2005, 23:921-928.
43. Grosso G., Stepaniak U., Micek A., Topor-Madry R., Pikhart H., Szafraniec K., Pajak A. Association of daily coffee and tea consumption and metabolic syndrome: results from the Polish arm of the HAPIEE Study. Eur. J. Nutr. 2014, (ahead of Print).
44. S.U.Grosso G., Polak M., Micek A., Topor-Madry R., Stefler D., Szafraniec K., Pajak A. Coffee consumption and risk of hypertension in the Polish arm of the HAPIEE cohort study. Eur. J. Clin. Nutr. 2015, [(ahead of print)].
45. Thelle D.S., Arnesen E., Forde O.H. The Tromso Heart Study. Does coffee raise serum cholesterol?. N. Engl. J. Med. 1983, 308:1454-1457.
46. Aro A., Pietinen P., Uusitalo U., Tuomilehto J. Coffee and tea consumption, dietary fat intake and serum cholesterol concentration of Finnish men and women. J. Intern. Med. 1989, 226:127-132.
47. Pietinen P., Geboers J., Kesteloot H. Coffee consumption and serum cholesterol: an epidemiological study in Belgium. Int. J. Epidemiol. 1988, 17:98-104.
48. Arnesen E., Forde O.H., Thelle D.S. Coffee and serum cholesterol. Br. Med. J. 1984, 288:1960.
49. Urgert R., Katan M.B. The cholesterol-raising factor from coffee beans. Annu. Rev. Nutr. 1997, 17:305-324.
50. Bak A.A., Grobbee D.E. The effect on serum cholesterol levels of coffee brewed by filtering or boiling. N. Engl. J. Med. 1989, 321:1432-1437.
51. Naidoo N., Chen C., Rebello S.A., Speer K., Tai E.S., Lee J., Buchmann S., Koelling-Speer I., van Dam R.M. Cholesterol-raising diterpenes in types of coffee commonly consumed in Singapore, Indonesia and India and associations with blood lipids: a survey and cross sectional study. Nutr. J. 2011, 10:48.
52. Lopez-Garcia E., van Dam R.M., Willett W.C., Rimm E.B., Manson J.E., Stampfer M.J., Rexrode K.M., Hu F.B. Coffee consumption and coronary heart disease in men and women: a prospective cohort study. Circulation 2006, 113:2045-2053.
53. Grosso G., Marventano S., Galvano F., Pajak A., Mistretta A. Factors associated with metabolic syndrome in a Mediterranean population: role of caffeinated beverages. J. Epidemiol. 2014, 24:327-333.
54. Cai L., Ma D., Zhang Y., Liu Z., Wang P. The effect of coffee consumption on serum lipids: a meta-analysis of randomized controlled trials. Eur. J. Clin. Nutr. 2012, 66:872-877.
55. Zargar A., Auttapibarn C., Hong S.H., Larson T.J., Hayworth K.H., Ito M.K. The effect of acute cafe latte ingestion on fasting serum lipid levels in healthy individuals. J. Clin. Lipidol. 2013, 7:165-168.
56. Murase T., Yokoi Y., Misawa K., Ominami H., Suzuki Y., Shibuya Y., Hase T. Coffee polyphenols modulate whole-body substrate oxidation and suppress postprandial hyperglycaemia, hyperinsulinaemia and hyperlipidaemia. Br. J. Nutr. 2012, 107:1757-1765.
57. Thong F.S., Derave W., Kiens B., Graham T.E., Urso B., Wojtaszewski J.F., Hansen B.F., Richter E.A. Caffeine-induced impairment of insulin action but not insulin signaling in human skeletal muscle is reduced by exercise. Diabetes 2002, 51:583-590.
58. Thong F.S., Graham T.E. Caffeine-induced impairment of glucose tolerance is abolished by beta-adrenergic receptor blockade in humans. J. Appl. Physiol. 1985, 92(2002):2347-2352.
59. Graham T.E., Hibbert E., Sathasivam P. Metabolic and exercise endurance effects of coffee and caffeine ingestion. J. Appl. Physiol. 1998, 85:883-889.
60. Grosso G., Stepaniak U., Topor-Madry R., Szafraniec K., Pajak A. Estimated dietary intake and major food sources of polyphenols in the Polish arm of the HAPIEE Study. Nutrition 2014, 30:1398-1403.
61. 2-induced mitochondrial membrane depolarization and apoptosis in PC-12 cells. Food Funct. 2013, 4:1632-1638.
62. Godos J., Pluchinotta F.R., Marventano S., Buscemi S., Li Volti G., Galvano F., Grosso G. Coffee components and cardiovascular risk: beneficial and detrimental effects. Int. J. Food Sci. Nutr. 2014, 65:925-936.
63. Andrade-Cetto A., Wiedenfeld H. Hypoglycemic effect of Cecropia obtusifolia on streptozotocin diabetic rats. J. Ethnopharmacol. 2001, 78:145-149.
64. Rodriguez de Sotillo D.V., Hadley M. Chlorogenic acid modifies plasma and liver concentrations of: cholesterol, triacylglycerol, and minerals in (fa/fa) Zucker rats. J. Nutr. Biochem. 2002, 13:717-726.
65. Rodriguez de Sotillo D.V., Hadley M., Sotillo J.E. Insulin receptor exon 11+/- is expressed in Zucker (fa/fa) rats, and chlorogenic acid modifies their plasma insulin and liver protein and DNA. J. Nutr. Biochem. 2006, 17:63-71.
66. Shearer J., Farah A., de Paulis T., Bracy D.P., Pencek R.R., Graham T.E., Wasserman D.H. Quinides of roasted coffee enhance insulin action in conscious rats. J. Nutr. 2003, 133:3529-3532.
67. van Dijk A.E., Olthof M.R., Meeuse J.C., Seebus E., Heine R.J., van Dam R.M. Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance. Diabetes Care 2009, 32:1023-1025.
68. Bassoli B.K., Cassolla P., Borba-Murad G.R., Constantin J., Salgueiro-Pagadigorria C.L., Bazotte R.B., da Silva R.S., de Souza H.M. Chlorogenic acid reduces the plasma glucose peak in the oral glucose tolerance test: effects on hepatic glucose release and glycaemia. Cell Biochem. Funct. 2008, 26:320-328.
69. Arion W.J., Canfield W.K., Ramos F.C., Schindler P.W., Burger H.J., Hemmerle H., Schubert G., Below P., Herling A.W. Chlorogenic acid and hydroxynitrobenzaldehyde: new inhibitors of hepatic glucose 6-phosphatase. Arch. Biochem. Biophys. 1997, 339:315-322.
70. Ong K.W., Hsu A., Tan B.K. Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation. Biochem. Pharmacol. 2013, 85:1341-1351.
71. Welsch C.A., Lachance P.A., Wasserman B.P. Dietary phenolic compounds: inhibition of Na+-dependent d-glucose uptake in rat intestinal brush border membrane vesicles. J. Nutr. 1989, 119:1698-1704.
72. Funke I., Melzig M.F. Effect of different phenolic compounds on alpha-amylase activity: screening by microplate-reader based kinetic assay. Pharmazie 2005, 60:796-797.
73. Narita Y., Inouye K. Kinetic analysis and mechanism on the inhibition of chlorogenic acid and its components against porcine pancreas alpha-amylase isozymes I and II. J. Agric. Food Chem. 2009, 57:9218-9225.
74. Ishikawa A., Yamashita H., Hiemori M., Inagaki E., Kimoto M., Okamoto M., Tsuji H., Memon A.N., Mohammadio A., Natori Y. Characterization of inhibitors of postprandial hyperglycemia from the leaves of Nerium indicum. J. Nutr. Sci. Vitaminol. 2007, 53:166-173.
75. Adisakwattana S., Chantarasinlapin P., Thammarat H., Yibchok-Anun S. A series of cinnamic acid derivatives and their inhibitory activity on intestinal alpha-glucosidase. J. Enzyme Inhib. Med. Chem. 2009, 24:1194-1200.
76. Goto A., Song Y., Chen B.H., Manson J.E., Buring J.E., Liu S. Coffee and caffeine consumption in relation to sex hormone-binding globulin and risk of type 2 diabetes in postmenopausal women. Diabetes 2011, 60:269-275.
77. Hamden K., Bengara A., Amri Z., Elfeki A. Experimental diabetes treated with trigonelline: effect on key enzymes related to diabetes and hypertension, beta-cell and liver function. Mol. Cell. Biochem. 2013, 381:85-94.
78. Yoshinari O., Takenake A., Igarashi K. Trigonelline ameliorates oxidative stress in type 2 diabetic Goto-Kakizaki rats. J. Med. Food 2013, 16:34-41.
79. Ding E.L., Song Y., Manson J.E., Hunter D.J., Lee C.C., Rifai N., Buring J.E., Gaziano J.M., Liu S. Sex hormone-binding globulin and risk of type 2 diabetes in women and men. N. Engl. J. Med. 2009, 361:1152-1163.
80. Suzuki A., Fujii A., Jokura H., Tokimitsu I., Hase T., Saito I. Hydroxyhydroquinone interferes with the chlorogenic acid-induced restoration of endothelial function in spontaneously hypertensive rats. Am. J. Hypertens. 2008, 21:23-27.
81. Yukawa G.S., Mune M., Otani H., Tone Y., Liang X.M., Iwahashi H., Sakamoto W. Effects of coffee consumption on oxidative susceptibility of low-density lipoproteins and serum lipid levels in humans. Biochemistry (Mosc) 2004, 69:70-74.
82. Karthikesan K., Pari L., Menon V.P. Antihyperlipidemic effect of chlorogenic acid and tetrahydrocurcumin in rats subjected to diabetogenic agents. Chem. Biol. Interact. 2010, 188:643-650.
83. Mure K., Maeda S., Mukoubayashi C., Mugitani K., Iwane M., Kinoshita F., Mohara O., Takeshita T. Habitual coffee consumption inversely associated with metabolic syndrome-related biomarkers involving adiponectin. Nutrition 2013, 29:982-987.
84. Yamashita K., Yatsuya H., Muramatsu T., Toyoshima H., Murohara T., Tamakoshi K. Association of coffee consumption with serum adiponectin, leptin, inflammation and metabolic markers in Japanese workers: a cross-sectional study. Nutr. Diabetes 2012, 2:e33.
85. Murakami K., Sasaki S., Uenishi K., N.Japan Dietetic Students' study for, G.Biomarkers Serum adiponectin concentration in relation to macronutrient and food intake in young Japanese women. Nutrition 2013, 29:1315-1320.
86. Imatoh T., Tanihara S., Miyazaki M., Momose Y., Uryu Y., Une H. Coffee consumption but not green tea consumption is associated with adiponectin levels in Japanese males. Eur. J. Nutr. 2011, 50:279-284.
87. Ostrowska L., Fiedorczuk J., Adamska E. Effect of diet and other factors on serum adiponectin concentrations in patients with type 2 diabetes. Rocz. Panstw. Zakl. Hig. 2013, 64:61-66.
88. Williams C.J., Fargnoli J.L., Hwang J.J., van Dam R.M., Blackburn G.L., Hu F.B., Mantzoros C.S. Coffee consumption is associated with higher plasma adiponectin concentrations in women with or without type 2 diabetes: a prospective cohort study. Diabetes Care 2008, 31:504-507.
89. de Oliveira C., de Mattos A.B., Silva C.B., Mota J.F., Zemdegs J.C. Nutritional and hormonal modulation of adiponectin and its receptors adipoR1 and adipoR2. Vitam. Horm. 2012, 90:57-94.
90. Vitaglione P., Morisco F., Mazzone G., Amoruso D.C., Ribecco M.T., Romano A., Fogliano V., Caporaso N., D'Argenio G. Coffee reduces liver damage in a rat model of steatohepatitis: the underlying mechanisms and the role of polyphenols and melanoidins. Hepatology 2010, 52:1652-1661.
91. Echeverri D., Montes F.R., Cabrera M., Galan A., Prieto A. Caffeine's vascular mechanisms of action. Int. J. Vasc. Med. 2010, 2010:834060.
92. Robertson D., Wade D., Workman R., Woosley R.L., Oates J.A. Tolerance to the humoral and hemodynamic effects of caffeine in man. J. Clin. Invest. 1981, 67:1111-1117.
93. Ammon H.P., Bieck P.R., Mandalaz D., Verspohl E.J. Adaptation of blood pressure to continuous heavy coffee drinking in young volunteers. A double-blind crossover study. Br. J. Clin. Pharmacol. 1983, 15:701-706.
94. Corti R., Binggeli C., Sudano I., Spieker L., Hanseler E., Ruschitzka F., Chaplin W.F., Luscher T.F., Noll G. Coffee acutely increases sympathetic nerve activity and blood pressure independently of caffeine content: role of habitual versus nonhabitual drinking. Circulation 2002, 106:2935-2940.
95. Zhao Y., Wang J., Ballevre O., Luo H., Zhang W. Antihypertensive effects and mechanisms of chlorogenic acids. Hypertens. Res. 2012, 35:370-374.
96. Suzuki A., Yamamoto M., Jokura H., Fujii A., Tokimitsu I., Hase T., Saito I. Ferulic acid restores endothelium-dependent vasodilation in aortas of spontaneously hypertensive rats. Am. J. Hypertens. 2007, 20:508-513.
97. Yamaguchi T., Chikama A., Mori K., Watanabe T., Shioya Y., Katsuragi Y., Tokimitsu I. Hydroxyhydroquinone-free coffee: a double-blind, randomized controlled dose-response study of blood pressure. Nutr. Metab. Cardiovasc. Dis. 2008, 18:408-414.
98. Geleijnse J.M. Habitual coffee consumption and blood pressure: an epidemiological perspective. Vasc. Health Risk Manag. 2008, 4:963-970.
99. Ranheim T., Halvorsen B. Coffee consumption and human health-beneficial or detrimental?-Mechanisms for effects of coffee consumption on different risk factors for cardiovascular disease and type 2 diabetes mellitus. Mol. Nutr. Food Res. 2005, 49:274-284.
100. Krakauer T. The polyphenol chlorogenic acid inhibits staphylococcal exotoxin-induced inflammatory cytokines and chemokines. Immunopharmacol. Immunotoxicol. 2002, 24:113-119.
101. dos Santos M.D., Almeida M.C., Lopes N.P., de Souza G.E. Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid. Biol. Pharm. Bull. 2006, 29:2236-2240.
102. Gomez-Ruiz J.A., Leake D.S., Ames J.M. In vitro antioxidant activity of coffee compounds and their metabolites. J. Agric. Food. Chem. 2007, 55:6962-6969.
103. Muthusamy V.S., Saravanababu C., Ramanathan M., Bharathi Raja R., Sudhagar S., Anand S., Lakshmi B.S. Inhibition of protein tyrosine phosphatase 1B and regulation of insulin signalling markers by caffeoyl derivatives of chicory (Cichorium intybus) salad leaves. Br. J. Nutr. 2010, 104:813-823.
104. Matsuda Y., Kobayashi M., Yamauchi R., Ojika M., Hiramitsu M., Inoue T., Katagiri T., Murai A., Horio F. Coffee and caffeine improve insulin sensitivity and glucose tolerance in C57BL/6J mice fed a high-fat diet. Biosci. Biotechnol. Biochem. 2011, 75:2309-2315.
105. Fukushima Y., Kasuga M., Nakao K., Shimomura I., Matsuzawa Y. Effects of coffee on inflammatory cytokine gene expression in mice fed high-fat diets. J. Agric. Food Chem. 2009, 57:11100-11105.
106. Lopez-Garcia E., van Dam R.M., Qi L., Hu F.B. Coffee consumption and markers of inflammation and endothelial dysfunction in healthy and diabetic women. Am. J. Clin. Nutr. 2006, 84:888-893.
107. Kim S.R., Jung Y.R., Kim D.H., An H.J., Kim M.K., Kim N.D., Chung H.Y. Caffeic acid regulates LPS-induced NF-kappaB activation through NIK/IKK and c-src/ERK signaling pathways in endothelial cells. Arch. Pharm. Res. 2013.
108. Wang S., Yoon Y.C., Sung M.J., Hur H.J., Park J.H. Antiangiogenic properties of cafestol, a coffee diterpene, in human umbilical vein endothelial cells. Biochem. Biophys. Res. Commun. 2012, 421:567-571.
109. Cardenas C., Quesada A.R., Medina M.A. Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene. PLoS One 2011, 6:e23407.
110. Lee K.A., Chae J.I., Shim J.H. Natural diterpenes from coffee, cafestol and kahweol induce apoptosis through regulation of specificity protein 1 expression in human malignant pleural mesothelioma. J. Biomed. Sci. 2012, 19:60.
111. Borrelli R.C., Visconti A., Mennella C., Anese M., Fogliano V. Chemical characterization and antioxidant properties of coffee melanoidins. J. Agric. Food Chem. 2002, 50:6527-6533.
112. Shizuuchi S., Hayase F. Antioxidative activity of the blue pigment formed in a d-xylose-glycine reaction system. Biosci. Biotechnol. Biochem. 2003, 67:54-59.
113. Azam S., Hadi N., Khan N.U., Hadi S.M. Antioxidant and prooxidant properties of caffeine, theobromine and xanthine. Med. Sci. Monit. 2003, 9:BR325-BR330.
114. Paganini-Hill A., Kawas C.H., Corrada M.M. Non-alcoholic beverage and caffeine consumption and mortality: the Leisure World Cohort Study. Prev. Med. 2007, 44:305-310.
115. Andersen L.F., Jacobs D.R., Carlsen M.H., Blomhoff R. Consumption of coffee is associated with reduced risk of death attributed to inflammatory and cardiovascular diseases in the Iowa Women's health study. Am. J. Clin. Nutr. 2006, 83:1039-1046.