Antihypertensive effects and mechanisms of chlorogenic acids

Hypertension Research

Volumn 35, Issue 4, 2012, Pages 370-374

  Zhao, Youyou ^a   Wang, Junkuan ^a   Ballevre, Olivier ^a   Luo, Hongliang ^a   Zhang, Weiguo ^a  

^a NESTLÉ RESEARCH CENTER   (Switzerland)

Author keywords

arterial blood pressure and hypertension; chlorogenic acid; coffee derivatives and metabolites; nitric oxide synthase; reactive oxygen species

Indexed keywords

1,2,4 BENZENETRIOL; ANTIHYPERTENSIVE AGENT; CAFFEIC ACID; CAFFEINE; CHLOROGENIC ACID; FERULIC ACID; GREEN COFFEE BEAN EXTRACT; NITRIC OXIDE; PLACEBO; PLANT EXTRACT; QUINIC ACID; UNCLASSIFIED DRUG;

ANTIHYPERTENSIVE ACTIVITY; ANTIHYPERTENSIVE THERAPY; ARTERIAL PRESSURE; BLOOD PRESSURE REGULATION; CARDIOVASCULAR RISK; COFFEE; DIASTOLIC BLOOD PRESSURE; DIETARY INTAKE; DRUG MECHANISM; HUMAN; HYPERTENSION; LIFESTYLE MODIFICATION; NONHUMAN; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; REVIEW; SYSTOLIC BLOOD PRESSURE;

ANIMALS; ANTIHYPERTENSIVE AGENTS; ANTIOXIDANTS; BLOOD PRESSURE; CHLOROGENIC ACID; HUMANS; HYPERTENSION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 84859590248     PISSN: 09169636     EISSN: 13484214     Source Type: Journal    
DOI: 10.1038/hr.2011.195     Document Type: Review

References (64)

1. Stalmach A, Steiling H, Williamson G, Crozier A. Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy. Arch Biochem Biophys 2010; 501: 98-105.
2. Clifford M. Chlorogenic acids and other cinnamates - nature, occurrence and dietary burden. J Sci Food Agric 1999; 79: 362-372. (Pubitemid 29150578)
3. Olthof MR, Hollman PC, Katan MB. Chlorogenic acid and caffeic acid are absorbed in humans. J Nutr 2001; 131: 66-71. (Pubitemid 32060624)
4. Salazar-Martinez E, Willett WC, Ascherio A, Manson JE, Leitzmann MF, Stampfer MJ, Hu FB. Coffee consumption and risk for type 2 diabetes mellitus. Ann Intern Med 2004; 140: 1-8.
5. van Dam RM, Hu FB. Coffee consumption and risk of type 2 diabetes: a systematic review. JAMA 2005; 294: 97-104. (Pubitemid 41002844)
6. Thom E. The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people. J Int Med Res 2007; 35: 900-908. (Pubitemid 350238424)
7. Lindsay J, Laurin D, Verreault R, Hebert R, Helliwell B, Hill GB, McDowell I. Risk factors for Alzheimer's disease: a prospective analysis from the Canadian Study of Health and Aging. Am J Epidemiol 2002; 156: 445-453. (Pubitemid 34976983)
8. Eskelinen MH, Kivipelto M. Caffeine as a protective factor in dementia and Alzheimer¢s disease. J Alzheimers Dis 2010; 20(Suppl 1): S167-S174.
9. Larsson SC, Virtamo J, Wolk A. Coffee consumption and risk of stroke in women. Stroke 2011; 42: 908-912.
10. Lopez-Garcia E, Rodriguez-Artalejo F, Rexrode KM, Logroscino G, Hu FB, van Dam RM. Coffee consumption and risk of stroke in women. Circulation 2009; 119: 1116-1123.
11. Cho AS, Jeon SM, Kim MJ, Yeo J, Seo KI, Choi MS, Lee MK. Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice. Food Chem Toxicol 2011; 48: 937-943.
12. Actis-Goretta L, Ottaviani JI, Fraga CG. Inhibition of angiotensin converting enzyme activity by flavanol-rich foods. J Agric Food Chem 2006; 54: 229-234. (Pubitemid 43119944)
13. Rodriguez de Sotillo DV, Hadley M, Sotillo JE. Insulin receptor exon 11+/- is expressed in Zucker (fa/fa) rats, and chlorogenic acid modifies their plasma insulin and liver protein and DNA. J Nutr Biochem 2006; 17: 63-71. (Pubitemid 41774408)
14. Suzuki A, Kagawa D, Fujii A, Ochiai R, Tokimitsu I, Saito I. Short- and long-term effects of ferulic acid on blood pressure in spontaneously hypertensive rats. Am J Hypertens 2002; 15: 351-357. (Pubitemid 34408976)
15. Kozuma K, Tsuchiya S, Kohori J, Hase T, Tokimitsu I. Antihypertensive effect of green coffee bean extract on mildly hypertensive subjects. Hypertens Res 2005; 28: 711-718. (Pubitemid 41723529)
16. Suzuki A, Fujii A, Yamamoto N, Yamamoto M, Ohminami H, Kameyama A, Shibuya Y, Nishizawa Y, Tokimitsu I, Saito I. Improvement of hypertension and vascular dysfunction by hydroxyhydroquinone-free coffee in a genetic model of hypertension. FEBS Lett 2006; 580: 2317-2322.
17. Ochiai R, Jokura H, Suzuki A, Tokimitsu I, Ohishi M, Komai N, Rakugi H, Ogihara T. Green coffee bean extract improves human vasoreactivity. Hypertens Res 2004; 27: 731-737. (Pubitemid 40045512)
18. Suzuki A, Kagawa D, Ochiai R, Tokimitsu I, Saito I. Green coffee bean extract and its metabolites have a hypotensive effect in spontaneously hypertensive rats. Hypertens Res 2002; 25: 99-107. (Pubitemid 34196302)
19. Suzuki A, Yamamoto N, Jokura H, Yamamoto M, Fujii A, Tokimitsu I, Saito I. Chlorogenic acid attenuates hypertension and improves endothelial function in spontaneously hypertensive rats. J Hypertens 2006; 24: 1065-1073. (Pubitemid 43772314)
20. Suzuki A, Fujii A, Jokura H, Tokimitsu I, Hase T, Saito I. Hydroxyhydroquinone interferes with the chlorogenic acid-induced restoration of endothelial function in spontaneously hypertensive rats. Am J Hypertens 2008; 21: 23-27.
21. Watanabe T, Arai Y, Mitsui Y, Kusaura T, Okawa W, Kajihara Y, Saito I. The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension. Clin Exp Hypertens 2006; 28: 439-449. (Pubitemid 44034669)
22. Zhang Z, Hu G, Caballero B, Appel L, Chen L. Habitual coffee consumption and risk of hypertension: a systematic review and meta-analysis of prospective observational studies. Am J Clin Nutr 2011; 93: 1212-1219.
23. Corti R, Binggeli C, Sudano I, Spieker L, Hanseler E, Ruschitzka F, Chaplin WF, Luscher TF, Noll G. Coffee acutely increases sympathetic nerve activity and blood pressure independently of caffeine content: role of habitual versus nonhabitual drinking. Circulation 2002; 106: 2935-2940. (Pubitemid 35424745)
24. Noordzij M, Uiterwaal CS, Arends LR, Kok FJ, Grobbee DE, Geleijnse JM. Blood pressure response to chronic intake of coffee and caffeine: a meta-analysis of randomized controlled trials. J Hypertens 2005; 23: 921-928. (Pubitemid 40637906)
25. Rosmarin PC, Applegate WB, Somes GW. Coffee consumption and blood pressure: a randomized, crossover clinical trial. J Gen Intern Med 1990; 5: 211-213. (Pubitemid 20175492)
26. Echeverri D, Montes FR, Cabrera M, Galan A, Prieto A. Caffeine's Vascular Mechanisms of Action. Int J Vasc Med 2010; 2010: 834-844.
27. van Dusseldorp M, Smits P, Thien T, Katan MB. Effect of decaffeinated versus regular coffee on blood pressure. A 12-week, double-blind trial. Hypertension 1989; 14: 563-569. (Pubitemid 19270523)
28. Ammon HP, Bieck PR, Mandalaz D, Verspohl EJ. Adaptation of blood pressure to continuous heavy coffee drinking in young volunteers. A double-blind crossover study. Br J Clin Pharm 1983; 15: 701-706. (Pubitemid 13099726)
29. Farag NH, Vincent AS, Sung BH, Whitsett TL, Wilson MF, Lovallo WR. Caffeine tolerance is incomplete: persistent blood pressure responses in the ambulatory setting. Am J Hypertens 2005; 18: 714-719. (Pubitemid 40692441)
30. Lovallo WR, Wilson MF, Vincent AS, Sung BH, McKey BS, Whitsett TL. Blood pressure response to caffeine shows incomplete tolerance after short-term regular consumption. Hypertension 2004; 43: 760-765. (Pubitemid 38405583)
31. Ochiai R, Chikama A, Kataoka K, Tokimitsu I, Maekawa Y, Ohishi M, Rakugi H, Mikami H. Effects of hydroxyhydroquinone-reduced coffee on vasoreactivity and blood pressure. Hypertens Res 2009; 32: 969-974.
32. Yamaguchi T, Chikama A, Mori K, Watanabe T, Shioya Y, Katsuragi Y, Tokimitsu I. Hydroxyhydroquinone-free coffee: a double-blind, randomized controlled dose-response study of blood pressure. Nutr Metab Cardiovasc Dis 2008; 18: 408-414. (Pubitemid 351899106)
33. Halliwell B, Long LH, Yee TP, Lim S, Kelly R. Establishing biomarkers of oxidative stress: the measurement of hydrogen peroxide in human urine. Curr Med Chem 2004; 11: 1085-1092. (Pubitemid 38585054)
34. Hiramoto K, Li X, Makimoto M, Kato T, Kikugawa K. Identification of hydroxyhydroquinone in coffee as a generator of reactive oxygen species that break DNA single strands. Mutat Res 1998; 419: 43-51. (Pubitemid 28512971)
35. Suzuki A, Yamamoto M, Jokura H, Fujii A, Tokimitsu I, Hase T, Saito I. Ferulic acid restores endothelium-dependent vasodilation in aortas of spontaneously hypertensive rats. Am J Hypertens 2007; 20: 508-513. (Pubitemid 46678706)
36. Azuma K, Ippoushi K, Nakayama M, Ito H, Higashio H, Terao J. Absorption of chlorogenic acid and caffeic acid in rats after oral administration. J Agric Food Chem 2000; 48: 5496-5500.
37. Lafay S, Gil-Izquierdo A, Manach C, Morand C, Besson C, Scalbert A. Chlorogenic acid is absorbed in its intact form in the stomach of rats. J Nutr 2006; 136: 1192-1197.
38. Renouf M, Guy PA, Marmet C, Fraering AL, Longet K, Moulin J, Enslen M, Barron D, Dionisi F, Cavin C, Williamson G, Steiling H. Measurement of caffeic and ferulic acid equivalents in plasma after coffee consumption: small intestine and colon are key sites for coffee metabolism. Mol Nutr Food Res 2010; 54: 760-766.
39. Stalmach A, Mullen W, Barron D, Uchida K, Yokota T, Cavin C, Steiling H, Williamson G, Crozier A. Metabolite profiling of hydroxycinnamate derivatives in plasma and urine after the ingestion of coffee by humans: identification of biomarkers of coffee consumption. Drug Metab Dispos 2009; 37: 1749-1758.
40. Monteiro M, Farah A, Perrone D, Trugo LC, Donangelo C. Chlorogenic acid compounds from coffee are differentially absorbed and metabolized in humans. J Nutr 2007; 137: 2196-2201. (Pubitemid 47529576)
41. Ardiansyah, Ohsaki Y, Shirakawa H, Koseki T, Komai M. Novel effects of a single administration of ferulic acid on the regulation of blood pressure and the hepatic lipid metabolic profile in stroke-prone spontaneously hypertensive rats. J Agric Food Chem 2008; 56: 2825-2830. (Pubitemid 351685231)
42. Banday AA, Muhammad AB, Fazili FR, Lokhandwala M. Mechanisms of oxidative stress-induced increase in salt sensitivity and development of hypertension in Sprague- Dawley rats. Hypertension 2007; 49: 664-671.
43. Paravicini TM, Touyz RM. NADPH oxidases, reactive oxygen species, and hypertension: clinical implications and therapeutic possibilities. Diabetes Care 2008; 31 (Suppl 2): S170-S180.
44. Nabha L, Garbern JC, Buller CL, Charpie JR. Vascular oxidative stress precedes high blood pressure in spontaneously hypertensive rats. Clin Exp Hypertens 2005; 27: 71-82. (Pubitemid 40315209)
45. Chung S, Park CW, Shin SJ, Lim JH, Chung HW, Youn DY, Kim HW, Kim BS, Lee JH, Kim GH, Chang YS. Tempol or candesartan prevents high-fat diet-induced hypertension and renal damage in spontaneously hypertensive rats. Nephrol Dial Transplant 2010; 25: 389-399.
46. Ushio-Fukai M, Zafari AM, Fukui T, Ishizaka N, Griendling KK. p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells. J Biol Chem 1996; 271: 23317-23321. (Pubitemid 26314775)
47. Zhao W, Swanson SA, Ye J, Li X, Shelton JM, Zhang W, Thomas GD. Reactive oxygen species impair sympathetic vasoregulation in skeletal muscle in angiotensin II-dependent hypertension. Hypertension 2006; 48: 637-643. (Pubitemid 44848210)
48. Griendling KK, Sorescu D, Ushio-Fukai M. NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res 2000; 86: 494-501. (Pubitemid 30165039)
49. Lambeth JD. NOX enzymes and the biology of reactive oxygen. Nat Rev 2004; 4: 181-189. (Pubitemid 38339084)
50. Augustyniak RA, Thomas GD, Victor RG, Zhang W. Nitric oxide pathway as new drug targets for refractory hypertension. Curr Pharm Design 2005; 11: 3307-3315. (Pubitemid 41300780)
51. Li PG, Xu JW, Ikeda K, Kobayakawa A, Kayano Y, Mitani T, Ikami T, Yamori Y. Caffeic acid inhibits vascular smooth muscle cell proliferation induced by angiotensin II in stroke-prone spontaneously hypertensive rats. Hypertens Res 2005; 28: 369-377. (Pubitemid 40895060)
52. Johnson DK, Schillinger KJ, Kwait DM, Hughes CV, McNamara EJ, Ishmael F, O¢Donnell RW, Chang MM, Hogg MG, Dordick JS, Santhanam L, Ziegler LM, Holland JA. Inhibition of NADPH oxidase activation in endothelial cells by ortho-methoxy-substituted catechols. Endothelium 2002; 9: 191-203.
53. Kanegae MP, da Fonseca LM, Brunetti IL, Silva SO, Ximenes VF. The reactivity of orthomethoxy- substituted catechol radicals with sulfhydryl groups: contribution for the comprehension of the mechanism of inhibition of NADPH oxidase by apocynin. Biochem Pharm 2007; 74: 457-464. (Pubitemid 46963239)
54. Sato Y, Itagaki S, Kurokawa T, Ogura J, Kobayashi M, Hirano T, Sugawara M, Iseki K. In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid. Int J Pharm 2011; 403: 136-138.
55. Kempf K, Herder C, Erlund I, Kolb H, Martin S, Carstensen M, Koenig W, Sundvall J, Bidel S, Kuha S, Tuomilehto J. Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial. Am J Clin Nutr 2010; 91: 950-957.
56. dos Santos MD, Almeida MC, Lopes NP, de Souza GE. Evaluation of the antiinflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid. Biol Pharm Bull 2006; 29: 2236-2240. (Pubitemid 44690948)
57. Zhang GQ, Zhang W. Heart rate, lifespan, and mortality risk. Ageing Res Rev 2009; 8: 52-60.
58. Zhang W, Wang Z. Resetting baroreceptors to a lower arterial pressure level by enalapril avoids baroreflex mediated activation of sympathetic nervous system by nifedipine. Life Sci 2001; 68: 2769-2779. (Pubitemid 32448883)
59. Sultana R, Ravagna A, Mohmmad-Abdul H, Calabrese V, Butterfield DA. Ferulic acid ethyl ester protects neurons against amyloid beta- peptide(1-42)-induced oxidative stress and neurotoxicity: relationship to antioxidant activity. J Neurochem 2005; 92: 749-758. (Pubitemid 40229546)
60. Wenk GL, McGann-Gramling K, Hauss-Wegrzyniak B, Ronchetti D, Maucci R, Rosi S, Gasparini L, Ongini E. Attenuation of chronic neuroinflammation by a nitric oxide-releasing derivative of the antioxidant ferulic acid. J Neurochem 2004; 89: 484-493. (Pubitemid 38495996)
61. Aladag MA, Turkoz Y, Ozcan C, Sahna E, Parlakpinar H, Akpolat N, Cigremis Y. Caffeic acid phenethyl ester (CAPE) attenuates cerebral vasospasm after experimental subarachnoidal haemorrhage by increasing brain nitric oxide levels. Int J Dev Neurosci 2006; 24: 9-14. (Pubitemid 43287941)
62. Augustyniak RA, Victor RG, Morgan DA, Zhang W. L-NAME- and ADMA-induced sympathetic neural activation in conscious rats. Am J Physiol 2006; 290: R726-R732.
63. Thomas GD, Zhang W, Victor RG. Nitric oxide deficiency as a cause of clinical hypertension: promising new drug targets for refractory hypertension. JAMA 2001; 285: 2055-2057. (Pubitemid 32367811)
64. Butt MS, Sultan MT. Coffee and its consumption: benefits and risks. Crit Rev Food Sci Nutr 2011; 51: 363-373.