Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation

Biochemical Pharmacology

Volumn 85, Issue 9, 2013, Pages 1341-1351

  Ong, Khang Wei ^a   Hsu, Annie ^a   Tan, Benny Kwong Huat ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

AMPK; Chlorogenic acid; db db Mice; Fatty acids; Gluconegenesis; Glucose uptake; GLUT 4; HepG2 hepatocytes

Indexed keywords

CHLOROGENIC ACID; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLUCOSE TRANSPORTER 4; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; METFORMIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; BODY WEIGHT; CELL MEMBRANE; CELL STRAIN HEPG2; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; FATTY ACID SYNTHESIS; FLUID INTAKE; FOOD INTAKE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INSULIN SENSITIVITY; LIPID METABOLISM; MOUSE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SKELETAL MUSCLE;

ACETYL-COA CARBOXYLASE; ADENYLATE KINASE; ANIMALS; CELL MEMBRANE; CHLOROGENIC ACID; DOWN-REGULATION; ENZYME ACTIVATION; FATTY ACIDS; GLUCONEOGENESIS; GLUCOSE; GLUCOSE TOLERANCE TEST; GLUCOSE TRANSPORTER TYPE 4; GLUCOSE-6-PHOSPHATASE; HEP G2 CELLS; HUMANS; HYPOGLYCEMIC AGENTS; HYPOLIPIDEMIC AGENTS; INSULIN RESISTANCE; LIPID METABOLISM; LIVER; MICE; MICE, INBRED C57BL; MUSCLE, SKELETAL; PHOSPHORYLATION; PROTEIN TRANSPORT;

EID: 84875703218     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.02.008     Document Type: Article

References (40)

1. H. Ben-Ami, P. Nagachandran, A. Mendelson, and Y. Edoute Drug-induced hypoglycemic coma in 102 diabetic patients Arch Intern Med 159 1999 281 284
2. H. Yki-Järvinen Thiazolidinediones N Engl J Med 351 2004 1106 1118
3. A.M. Lincoff, K. Wolski, S.J. Nicholls, and S.E. Nissen Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis of randomized trials J Am Med Assoc 298 2007 1180 1188
4. C. Manach, A. Scalbert, C. Morand, C. Rémésy, and L. Jiménez Polyphenols: food sources and bioavailability Am J Clin Nutr 79 2004 727 747
5. W.Y. Lin, F. Xaiver Pi-Sunyer, C.C. Chen, L.E. Davidson, C.S. Liu, and T.C. Li Coffee consumption is inversely associated with type 2 diabetes in Chinese Eur J Clin Invest 41 2011 659 666
6. R.M. Van Dam Coffee consumption and risk of type 2 diabetes, cardiovascular diseases, and cancer Appl Physiol Nutr Metab 33 2008 1269 1283
7. M.F. McCarty A chlorogenic acid-induced increase in GLP-1 production may mediate the impact of heavy coffee consumption on diabetes risk Med Hypotheses 64 2005 848 853
8. B.K. Bassoli, P. Cassolla, G.R. Borba-Murad, J. Constantin, C.L. Salgueiro-Pagadigorria, and R.B. Bazotte Chlorogenic acid reduces the plasma glucose peak in the oral glucose tolerance test: effects on hepatic glucose release and glycaemia Cell Biochem Funct 26 2008 320 328
9. A.E. Van Dijk, M.R. Olthof, J.C. Meeuse, E. Seebus, R.J. Heine, and R.M. Van Dam Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance Diab Care 32 2009 1023 1025
10. P.K. Prabhakar, and M. Doble Synergistic effect of phytochemicals in combination with hypoglycemic drugs on glucose uptake in myotubes Phytomedicine 16 2009 1119 1126
11. A.J. Alonso-Castro, A.C. Miranda-Torres, M.M. González- Chávez, and L.A. Salazar-Olivo Cecropia obtusifolia Bertol and its active compound, chlorogenic acid, stimulate 2-NBDglucose uptake in both insulin-sensitive and insulin-resistant 3T3 adipocytes J Ethnopharmacol 120 2008 458 464
12. K.W. Ong, A. Hsu, and B.K.H. Tan Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: a contributor to the beneficial effects of coffee on diabetes PLoS ONE 7 2012 Article number: e32718
13. H. Shimoda, E. Seki, and M. Aitani Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice BMC Complement Altern Med 6 2006 Article number: 9
14. K.A. McAuley, S.M. Williams, J.I. Mann, R.J. Walker, N.J. Lewis-Barned, and L.A. Temple Diagnosing insulin resistance in the general population Diab Care 24 2001 460 464
15. S.N. Anderson, B.L. Cool, L. Kifle, W. Chiou, D.A. Egan, and L.W. Barrett Microarrayed compound screening (μARCS) to identify activators and inhibitors of AMP-activated protein kinase J Biomol Screen 9 2004 112 121
16. B. Cool, B. Zinker, W. Chiou, L. Kifle, N. Cao, and M. Perham Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome Cell Metab 3 2006 403 416
17. E.S. Baginski, P.P. Foa, and B. Zak Methods of Enzymatic Analysis 1974 Academic Press Inc New York
18. A. Guma, J.R. Zierath, H. Wallberg-Henriksson, and A. Klip Insulin induces translocation of GLUT-4 glucose transporters in human skeletal muscle Am J Physiol Endocrinol Metab 268 1995 613 622
19. S.A. Hawley, D.A. Pan, K.J. Mustard, L. Ross, J. Bain, and A.M. Edelman Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase Cell Metab 2 2005 9 19
20. H. Hemmerle, H.J. Burger, P. Below, G. Schubert, R. Rippel, and P.W. Schindler Chlorogenic acid and synthetic chlorogenic acid derivatives: novel inhibitors of hepatic glucose-6-phosphate translocase J Med Chem 40 1997 137 145
21. M.A. Charles, A. Fontbonne, N. Thibult, J.M. Warnet, G.E. Rosselin, and E. Eschwege Risk factors for NIDDM in white population: Paris prospective study Diabetes 40 1991 796 799
22. F. Greer, R. Hudson, R. Ross, and T. Graham Caffeine ingestion decreases glucose disposal during a hyperinsulinemic-euglycemic clamp in sedentary humans Diabetes 50 2001 2349 2354
23. J.D. Lane, C.E. Barkauskas, R.S. Surwit, and M.N. Feinglos Caffeine impairs glucose metabolism in type 2 diabetes Diab Care 27 2004 2047 2048
24. H.J. Petrie, S.E. Chown, L.M. Belfie, A.M. Duncan, D.H. McLaren, and J.A. Conquer Caffeine ingestion increases the insulin response to an oral-glucose-tolerance test in obese men before and after weight loss Am J Clin Nutr 80 2004 22 28
25. A. Tagliabue, D. Terracina, H. Cena, G. Turconi, E. Lanzola, and C. Montomoli Coffee induced thermogenesis and skin temperature Int J Obes 18 1994 537 541
26. D. Bracco, J.M. Ferrarra, M.J. Arnaud, E. Jequier, and Y. Schutz Effects of caffeine on energy metabolism, heart rate, and methylxanthine metabolism in lean and obese women Am J Physiol Endocrinol Metab 269 1995 E671 E678
27. D.L. Costill, G.P. Dalsky, and W.J. Fink Effects of caffeine ingestion on metabolism and exercise performance Med Sci Sports Exerc 10 1978 155 158
28. K.L. Donnelly, C.I. Smith, S.J. Schwarzenberg, J. Jessurun, M.D. Boldt, and E.J. Parks Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease J Clin Invest 115 2005 1343 1351
29. P. Kovacs, and M. Stumvoll Fatty acids and insulin resistance in muscle and liver Best Pract Res: Clin Endocrinol Metab 19 2005 625 635
30. M. Roden, M. Krssak, H. Stingl, S. Gruber, A. Hofer, and C. Fürnsinn Rapid impairment of skeletal muscle glucose transport/phosphorylation by free fatty acids in humans Diabetes 48 1999 358 364
31. M. Roden, H. Stingl, V. Chandramouli, W.C. Schumann, A. Hofer, and B.R. Landau Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans Diabetes 49 2000 701 707
32. E. Thom The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people J Int Med Res 35 2007 900 908
33. G.R. Steinberg, and S. Beck Jørgensen The AMP-activated protein kinase: role in regulation of skeletal muscle metabolism and insulin sensitivity Mini-Rev Med Chem 7 2007 521 528
34. A.L. Carey, and B.A. Kingwell Novel pharmacological approaches to combat obesity and insulin resistance: targeting skeletal muscle with 'exercise mimetics' Diabetologia 52 2009 2015 2026
35. P.A. Lochhead, I.P. Salt, K.S. Walker, D.G. Hardie, and C. Sutherland 5-Aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6- phosphatase Diabetes 49 2000 896 903
36. B. Viollet, B. Guigas, J. Leclerc, S. Hébrard, L. Lantier, and R. Mounier AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives Acta Physiol 196 2009 81 98
37. K. Hotta, T. Funahashi, Y. Arita, M. Takahashi, M. Matsuda, and Y. Okamoto Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients Arterioscler Thromb Vasc Biol 20 2000 1595 1599
38. A.H. Berg, T.P. Combs, X. Du, M. Brownlee, and P.E. Scherer The adipocyte-secreted protein Acrp30 enhances hepatic insulin action Nat Med 7 2001 947 953
39. J. Fruebis, T.S. Tsao, S. Javorschi, D. Ebbets-Reed, M.R.S. Erickson, and F.T. Yen Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice Proc Natl Acad Sci U S A 98 2001 2005 2010
40. 2+ and AMPK/SIRT1 Nature 464 2010 1313 1319