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Volumn 44, Issue 9, 2016, Pages 2591-2610

Multiscale Modeling in the Clinic: Drug Design and Development

Author keywords

Drug delivery; Mathematical; Multiscale modeling; Pharmacology; Simulation

Indexed keywords

COMPUTER AIDED DESIGN; DISEASE CONTROL; DRUG DELIVERY; STEM CELLS;

EID: 84959282928     PISSN: 00906964     EISSN: 15739686     Source Type: Journal    
DOI: 10.1007/s10439-016-1563-0     Document Type: Article
Times cited : (53)

References (138)
  • 2
    • 84894206648 scopus 로고    scopus 로고
    • Multiscale factorization method for simulating mesoscopic systems with atomic precision
    • COI: 1:CAS:528:DC%2BC2cXlslCksw%3D%3D, PID: 24803852
    • Abi Mansour, A., and P. J. Ortoleva. Multiscale factorization method for simulating mesoscopic systems with atomic precision. J. Chem. Theory Comput. 10:518–523, 2014. doi:10.1021/ct400615a.
    • (2014) J. Chem. Theory Comput. , vol.10 , pp. 518-523
    • Abi Mansour, A.1    Ortoleva, P.J.2
  • 3
    • 77952477710 scopus 로고    scopus 로고
    • Development of a three dimensional multiscale computational model of the human epidermis
    • PID: 20076760
    • Adra, S., T. Sun, S. MacNeil, M. Holcombe, and R. Smallwood. Development of a three dimensional multiscale computational model of the human epidermis. PLoS ONE 5:e8511, 2010. doi:10.1371/journal.pone.0008511.
    • (2010) PLoS ONE , vol.5
    • Adra, S.1    Sun, T.2    MacNeil, S.3    Holcombe, M.4    Smallwood, R.5
  • 4
    • 0035491584 scopus 로고    scopus 로고
    • Agent-based computer simulation and SIRS: Building a bridge between basic science and clinical trials
    • COI: 1:STN:280:DC%2BD3MrjtlSitQ%3D%3D, PID: 11580108
    • An, G. Agent-based computer simulation and SIRS: Building a bridge between basic science and clinical trials. Shock 16:266–273, 2001. doi:10.1097/00024382-200116040-00006.
    • (2001) Shock , vol.16 , pp. 266-273
    • An, G.1
  • 5
    • 4744344132 scopus 로고    scopus 로고
    • In silico experiments of existing and hypothetical cytokine-directed clinical trials using agent-based modeling
    • COI: 1:CAS:528:DC%2BD2cXosVSltr8%3D, PID: 15483414
    • An, G. In silico experiments of existing and hypothetical cytokine-directed clinical trials using agent-based modeling. Crit. Care Med. 32:2050–2060, 2004.
    • (2004) Crit. Care Med. , vol.32 , pp. 2050-2060
    • An, G.1
  • 6
    • 79953894415 scopus 로고    scopus 로고
    • In silico augmentation of the drug development pipeline: examples from the study of acute inflammation
    • COI: 1:CAS:528:DC%2BC3MXktl2jsLw%3D, PID: 21552346
    • An, G., J. Bartels, and Y. Vodovotz. In silico augmentation of the drug development pipeline: examples from the study of acute inflammation. Drug Dev. Res. 72:187–200, 2011. doi:10.1002/ddr.20415.
    • (2011) Drug Dev. Res. , vol.72 , pp. 187-200
    • An, G.1    Bartels, J.2    Vodovotz, Y.3
  • 7
    • 84868336424 scopus 로고    scopus 로고
    • Addressing the translational dilemma: dynamic knowledge representation of inflammation using agent-based modeling
    • PID: 23140123
    • An, G., and S. Christley. Addressing the translational dilemma: dynamic knowledge representation of inflammation using agent-based modeling. Crit. Rev. Biomed. Eng. 40:323–340, 2012.
    • (2012) Crit. Rev. Biomed. Eng. , vol.40 , pp. 323-340
    • An, G.1    Christley, S.2
  • 8
    • 84949557648 scopus 로고    scopus 로고
    • Introduction of a framework for dynamic knowledge representation of the control structure of transplant immunology: employing the power of abstraction with a Solid Organ Transplant Agent-based Model (SOTABM)
    • An, G. Introduction of a framework for dynamic knowledge representation of the control structure of transplant immunology: employing the power of abstraction with a Solid Organ Transplant Agent-based Model (SOTABM). Front. Immunol. 6, 2015. doi:10.3389/fimmu.2015.00561.
    • (2015) Front. Immunol , pp. 6
    • An, G.1
  • 9
    • 0032535999 scopus 로고    scopus 로고
    • Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model
    • COI: 1:CAS:528:DyaK1cXmtl2juw%3D%3D, PID: 9430587
    • Arap, W., R. Pasqualini, and E. Ruoslahti. Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Science 279:377–380, 1998.
    • (1998) Science , vol.279 , pp. 377-380
    • Arap, W.1    Pasqualini, R.2    Ruoslahti, E.3
  • 10
    • 78751676012 scopus 로고    scopus 로고
    • Development of CHARMM polarizable force field for nucleic acid bases based on the classical drude oscillator model
    • PID: 21166469
    • Baker, C. M., V. M. Anisimov, and A. D. MacKerell. Development of CHARMM polarizable force field for nucleic acid bases based on the classical drude oscillator model. J. Phys. Chem. B 115:580–596, 2010. doi:10.1021/jp1092338.
    • (2010) J. Phys. Chem. B , vol.115 , pp. 580-596
    • Baker, C.M.1    Anisimov, V.M.2    MacKerell, A.D.3
  • 11
    • 0020388877 scopus 로고
    • Estimating population-kinetics
    • COI: 1:STN:280:DyaL3s%2Flt1arsA%3D%3D
    • Beal, S. L., and L. B. Sheiner. Estimating population-kinetics. Crc. Crit. Rev. Biomed. Eng. 8:195–222, 1982.
    • (1982) Crc. Crit. Rev. Biomed. Eng. , vol.8 , pp. 195-222
    • Beal, S.L.1    Sheiner, L.B.2
  • 12
    • 58149175662 scopus 로고    scopus 로고
    • Multiscale modelling of drug-induced effects on cardiac electrophysiological activity
    • COI: 1:CAS:528:DC%2BD1MXhsFSntA%3D%3D, PID: 19061955
    • Brennan, T., M. Fink, and B. Rodriguez. Multiscale modelling of drug-induced effects on cardiac electrophysiological activity. Eur. J. Pharm. Sci. 36:62–77, 2009. doi:10.1016/j.ejps.2008.09.013.
    • (2009) Eur. J. Pharm. Sci. , vol.36 , pp. 62-77
    • Brennan, T.1    Fink, M.2    Rodriguez, B.3
  • 13
    • 84878734095 scopus 로고    scopus 로고
    • Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology
    • COI: 1:CAS:528:DC%2BC3sXhtFGktr7O, PID: 23690584
    • Britton, O. J., et al. Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology. Proc. Natl. Acad. Sci. USA 110:E2098–E2105, 2013. doi:10.1073/pnas.1304382110.
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. E2098-E2105
    • Britton, O.J.1
  • 14
    • 84863012821 scopus 로고    scopus 로고
    • Systems biology and systems chemistry: new directions for drug discovery
    • COI: 1:CAS:528:DC%2BC38Xhs1Ggs78%3D, PID: 22284351
    • Brown, J. B., and Y. Okuno. Systems biology and systems chemistry: new directions for drug discovery. Chem. Biol. 19:23–28, 2012. doi:10.1016/j.chembiol.2011.12.012.
    • (2012) Chem. Biol. , vol.19 , pp. 23-28
    • Brown, J.B.1    Okuno, Y.2
  • 15
    • 79952468781 scopus 로고    scopus 로고
    • ® over four years as defined by Total IgG and competitive Luminex immunoassay
    • COI: 1:CAS:528:DC%2BC3MXns1Chsbk%3D
    • ® over four years as defined by Total IgG and competitive Luminex immunoassay. Hum. Vaccines 7:230–238, 2011. doi:10.4161/hv.7.2.13948.
    • (2011) Hum. Vaccines , vol.7 , pp. 230-238
    • Brown, D.R.1
  • 16
    • 84886669732 scopus 로고    scopus 로고
    • Identification of a possible secondary picrotoxin-binding site on the GABAA receptor
    • COI: 1:CAS:528:DC%2BC3sXhsVaru7bP, PID: 24028067
    • Carpenter, T. S., E. Y. Lau, and F. C. Lightstone. Identification of a possible secondary picrotoxin-binding site on the GABAA receptor. Chem. Res. Toxicol. 26:1444–1454, 2013. doi:10.1021/tx400167b.
    • (2013) Chem. Res. Toxicol. , vol.26 , pp. 1444-1454
    • Carpenter, T.S.1    Lau, E.Y.2    Lightstone, F.C.3
  • 17
    • 33645533255 scopus 로고    scopus 로고
    • Role of target geometry in phagocytosis
    • COI: 1:CAS:528:DC%2BD28XjsVGls70%3D, PID: 16549762
    • Champion, J. A., and S. Mitragotri. Role of target geometry in phagocytosis. Proc. Natl. Acad. Sci. USA 103:4930–4934, 2006.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 4930-4934
    • Champion, J.A.1    Mitragotri, S.2
  • 18
    • 84863655863 scopus 로고    scopus 로고
    • Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner
    • COI: 1:CAS:528:DC%2BC38XltFOgsLo%3D, PID: 22484912
    • Chauhan, V. P., et al. Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner. Nat. Nanotechnol. 7:383–388, 2012. doi:10.1038/nnano.2012.45.
    • (2012) Nat. Nanotechnol. , vol.7 , pp. 383-388
    • Chauhan, V.P.1
  • 19
    • 85030027209 scopus 로고    scopus 로고
    • Computational studies of the intestinal host-microbiota interactome
    • Christley, S., C. Cockrell, and G. An. Computational studies of the intestinal host-microbiota interactome. Computation 3:2079–3197, 2015. doi:10.3390/computation3010002.
    • (2015) Computation , vol.3 , pp. 2079-3197
    • Christley, S.1    Cockrell, C.2    An, G.3
  • 20
    • 33846247128 scopus 로고    scopus 로고
    • Pharmacogenetics and anti-arrhythmic drug therapy: a theoretical investigation
    • COI: 1:CAS:528:DC%2BD2sXisFGjtbg%3D, PID: 16997895
    • Clancy, C. E., Z. I. Zhu, and Y. Rudy. Pharmacogenetics and anti-arrhythmic drug therapy: a theoretical investigation. Am. J. Physiol. Heart Circ. Physiol. 292:H66–H75, 2007. doi:10.1152/ajpheart.00312.2006.
    • (2007) Am. J. Physiol. Heart Circ. Physiol. , vol.292 , pp. H66-H75
    • Clancy, C.E.1    Zhu, Z.I.2    Rudy, Y.3
  • 21
    • 84933036808 scopus 로고    scopus 로고
    • Molecular mechanism matters: Benefits of mechanistic computational models for drug development
    • COI: 1:CAS:528:DC%2BC2MXhtFSjsbjM, PID: 26093283
    • Clegg, L. E., and F. Mac Gabhann. Molecular mechanism matters: Benefits of mechanistic computational models for drug development. Pharmacol. Res. 99:149–154, 2015. doi:10.1016/j.phrs.2015.06.002.
    • (2015) Pharmacol. Res. , vol.99 , pp. 149-154
    • Clegg, L.E.1    Mac Gabhann, F.2
  • 22
    • 4043056616 scopus 로고    scopus 로고
    • In silico design of clinical trials: a method coming of age
    • PID: 15483415
    • Clermont, G., et al. In silico design of clinical trials: a method coming of age. Crit. Care Med. 32:2061–2070, 2004.
    • (2004) Crit. Care Med. , vol.32 , pp. 2061-2070
    • Clermont, G.1
  • 23
    • 84936742707 scopus 로고    scopus 로고
    • Modeling and simulation approaches for cardiovascular function and their role in safety assessment
    • COI: 1:STN:280:DC%2BC28%2FotVOntw%3D%3D
    • Collins, T. A., et al. Modeling and simulation approaches for cardiovascular function and their role in safety assessment. CPT Pharmacomet. Syst. Pharmacol. 4:e00018, 2015. doi:10.1002/psp4.18.
    • (2015) CPT Pharmacomet. Syst. Pharmacol. , vol.4
    • Collins, T.A.1
  • 24
    • 4344670936 scopus 로고    scopus 로고
    • Bow ties, metabolism and disease
    • COI: 1:CAS:528:DC%2BD2cXntFCjt7s%3D, PID: 15331224
    • Csete, M., and J. Doyle. Bow ties, metabolism and disease. Trends Biotechnol. 22:446–450, 2004. doi:10.1016/j.tibtech.2004.07.007.
    • (2004) Trends Biotechnol. , vol.22 , pp. 446-450
    • Csete, M.1    Doyle, J.2
  • 25
    • 58149094776 scopus 로고    scopus 로고
    • RosettaLigand docking with full ligand and receptor flexibility
    • COI: 1:CAS:528:DC%2BD1MXkt1WhsQ%3D%3D, PID: 19041878
    • Davis, I. W., and D. Baker. RosettaLigand docking with full ligand and receptor flexibility. J. Mol. Biol. 385:381–392, 2009. doi:10.1016/j.jmb.2008.11.010.
    • (2009) J. Mol. Biol. , vol.385 , pp. 381-392
    • Davis, I.W.1    Baker, D.2
  • 26
    • 51049090204 scopus 로고    scopus 로고
    • Nanoparticle therapeutics: an emerging treatment modality for cancer
    • COI: 1:CAS:528:DC%2BD1cXhtVGgtL%2FJ, PID: 18758474
    • Davis, M. E., Z. Chen, and D. M. Shin. Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat. Rev. Drug. Discov. 7:771–782, 2008.
    • (2008) Nat. Rev. Drug. Discov. , vol.7 , pp. 771-782
    • Davis, M.E.1    Chen, Z.2    Shin, D.M.3
  • 27
    • 33746092084 scopus 로고    scopus 로고
    • The adhesive strength of non-spherical particles mediated by specific interactions
    • COI: 1:CAS:528:DC%2BD28Xnt1Kktb0%3D, PID: 16797691
    • Decuzzi, P., and M. Ferrari. The adhesive strength of non-spherical particles mediated by specific interactions. Biomaterials 27:5307–5314, 2006. doi:10.1016/j.biomaterials.2006.05.024.
    • (2006) Biomaterials , vol.27 , pp. 5307-5314
    • Decuzzi, P.1    Ferrari, M.2
  • 28
    • 17144417434 scopus 로고    scopus 로고
    • A theoretical model for the margination of particles within blood vessels
    • COI: 1:STN:280:DC%2BD2M7jvFentw%3D%3D, PID: 15771271
    • Decuzzi, P., S. Lee, B. Bhushan, and M. Ferrari. A theoretical model for the margination of particles within blood vessels. Ann. Biomed. Eng. 33:179–190, 2005. doi:10.1007/s10439-005-8976-5.
    • (2005) Ann. Biomed. Eng. , vol.33 , pp. 179-190
    • Decuzzi, P.1    Lee, S.2    Bhushan, B.3    Ferrari, M.4
  • 29
    • 3242715145 scopus 로고    scopus 로고
    • Adhesion of microfabricated particles on vascular endothelium: a parametric analysis
    • PID: 15255210
    • Decuzzi, P., S. Lee, M. Decuzzi, and M. Ferrari. Adhesion of microfabricated particles on vascular endothelium: a parametric analysis. Ann. Biomed. Eng. 32:793–802, 2004.
    • (2004) Ann. Biomed. Eng. , vol.32 , pp. 793-802
    • Decuzzi, P.1    Lee, S.2    Decuzzi, M.3    Ferrari, M.4
  • 31
    • 77953710988 scopus 로고    scopus 로고
    • Molecular and structural characterization of the L1 virus-like particles that are used as vaccine antigens in Cervarix™, the AS04-adjuvanted HPV-16 and -18 cervical cancer vaccine
    • COI: 1:CAS:528:DC%2BC3cXhsFaktbzL
    • Deschuyteneer, M., et al. Molecular and structural characterization of the L1 virus-like particles that are used as vaccine antigens in Cervarix™, the AS04-adjuvanted HPV-16 and -18 cervical cancer vaccine. Hum. Vaccines 6:407–419, 2010.
    • (2010) Hum. Vaccines , vol.6 , pp. 407-419
    • Deschuyteneer, M.1
  • 32
    • 84871907134 scopus 로고    scopus 로고
    • High-throughput screening of drug-binding dynamics to HERG improves early drug safety assessment
    • PID: 23103500
    • Di Veroli, G. Y., M. R. Davies, H. Zhang, N. Abi-Gerges, and M. R. Boyett. High-throughput screening of drug-binding dynamics to HERG improves early drug safety assessment. Am. J. Physiol. Heart Circ. Physiol. 304:H104–H117, 2013. doi:10.1152/ajpheart.00511.2012.
    • (2013) Am. J. Physiol. Heart Circ. Physiol. , vol.304 , pp. H104-H117
    • Di Veroli, G.Y.1    Davies, M.R.2    Zhang, H.3    Abi-Gerges, N.4    Boyett, M.R.5
  • 33
    • 27844574799 scopus 로고    scopus 로고
    • Motifs, control, and stability
    • PID: 16277557
    • Doyle, J., and M. Csete. Motifs, control, and stability. PLoS Biol. 3:e392, 2005. doi:10.1371/journal.pbio.0030392.
    • (2005) PLoS Biol. , vol.3
    • Doyle, J.1    Csete, M.2
  • 34
    • 80053153518 scopus 로고    scopus 로고
    • Architecture, constraints, and behavior
    • COI: 1:CAS:528:DC%2BC3MXht1CisbzJ, PID: 21788505
    • Doyle, J. C., and M. Csete. Architecture, constraints, and behavior. Proc. Natl. Acad. Sci. USA 108(Suppl 3):15624–15630, 2011. doi:10.1073/pnas.1103557108.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 15624-15630
    • Doyle, J.C.1    Csete, M.2
  • 35
    • 82155186863 scopus 로고    scopus 로고
    • Interaction of specialized cardiac conduction system with antiarrhythmic drugs: a simulation study
    • Dux-Santoy, L., R. Sebastian, J. Felix-Rodriguez, J. M. Ferrero, and J. Saiz. Interaction of specialized cardiac conduction system with antiarrhythmic drugs: a simulation study. IEEE Trans. Bio-med. Eng. 58:3475–3478, 2011. doi:10.1109/TBME.2011.2165213.
    • (2011) IEEE Trans. Bio-med. Eng. , vol.58 , pp. 3475-3478
    • Dux-Santoy, L.1    Sebastian, R.2    Felix-Rodriguez, J.3    Ferrero, J.M.4    Saiz, J.5
  • 36
    • 79953054576 scopus 로고    scopus 로고
    • The EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect
    • COI: 1:CAS:528:DC%2BC3MXktF2jur8%3D, PID: 20441782
    • Fang, J., H. Nakamura, and H. Maeda. The EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. Adv. Drug Deliv. Rev. 63:136–151, 2011.
    • (2011) Adv. Drug Deliv. Rev. , vol.63 , pp. 136-151
    • Fang, J.1    Nakamura, H.2    Maeda, H.3
  • 37
    • 70449513046 scopus 로고    scopus 로고
    • A systems biology framework for modeling metabolic enzyme inhibition of Mycobacterium tuberculosis
    • PID: 19754970
    • Fang, X., A. Wallqvist, and J. Reifman. A systems biology framework for modeling metabolic enzyme inhibition of Mycobacterium tuberculosis. BMC Syst. Biol. 3:92, 2009. doi:10.1186/1752-0509-3-92.
    • (2009) BMC Syst. Biol. , vol.3 , pp. 92
    • Fang, X.1    Wallqvist, A.2    Reifman, J.3
  • 38
    • 80051708188 scopus 로고    scopus 로고
    • Modeling synergistic drug inhibition of Mycobacterium tuberculosis growth in murine macrophages
    • COI: 1:CAS:528:DC%2BC3MXhtVSmtL%2FJ, PID: 21713281
    • Fang, X., A. Wallqvist, and J. Reifman. Modeling synergistic drug inhibition of Mycobacterium tuberculosis growth in murine macrophages. Mol. BioSyst. 7:2622–2636, 2011. doi:10.1039/c1mb05106g.
    • (2011) Mol. BioSyst. , vol.7 , pp. 2622-2636
    • Fang, X.1    Wallqvist, A.2    Reifman, J.3
  • 39
    • 84956584796 scopus 로고    scopus 로고
    • Pharmacokinetics of anti-VEGF agent aflibercept in cancer predicted by data driven, molecular-detailed model
    • COI: 1:CAS:528:DC%2BC2MXhs1egs7rM
    • Finley, S. D., P. Angelikopoulos, P. Koumoutsakos, and A. S. Popel. Pharmacokinetics of anti-VEGF agent aflibercept in cancer predicted by data driven, molecular-detailed model. CPT Pharmacomet. Syst. Pharmacol. 4(11):641–649, 2015.
    • (2015) CPT Pharmacomet. Syst. Pharmacol. , vol.4 , Issue.11 , pp. 641-649
    • Finley, S.D.1    Angelikopoulos, P.2    Koumoutsakos, P.3    Popel, A.S.4
  • 40
    • 84922909177 scopus 로고    scopus 로고
    • Computational systems biology approaches to anti-angiogenic cancer therapeutics
    • COI: 1:CAS:528:DC%2BC2cXhslansrnO, PID: 25286370
    • Finley, S. D., L. H. Chu, and A. S. Popel. Computational systems biology approaches to anti-angiogenic cancer therapeutics. Drug Discov. Today 20:187–197, 2015. doi:10.1016/j.drudis.2014.09.026.
    • (2015) Drug Discov. Today , vol.20 , pp. 187-197
    • Finley, S.D.1    Chu, L.H.2    Popel, A.S.3
  • 41
    • 41949099291 scopus 로고    scopus 로고
    • Immersed-boundary-type models of intravascular platelet aggregation
    • Fogelson, A. L., and R. D. Guy. Immersed-boundary-type models of intravascular platelet aggregation. Comput. Method Appl. M 197:2087–2104, 2008. doi:10.1016/j.cma.2007.06.030.
    • (2008) Comput. Method Appl. M , vol.197 , pp. 2087-2104
    • Fogelson, A.L.1    Guy, R.D.2
  • 42
    • 0034705040 scopus 로고    scopus 로고
    • Preventing ventricular fibrillation by flattening cardiac restitution
    • COI: 1:CAS:528:DC%2BD3cXjvFartrs%3D, PID: 10811880
    • Garfinkel, A., et al. Preventing ventricular fibrillation by flattening cardiac restitution. Proc. Natl. Acad. Sci. USA 97:6061–6066, 2000. doi:10.1073/pnas.090492697.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 6061-6066
    • Garfinkel, A.1
  • 43
    • 84875456220 scopus 로고    scopus 로고
    • Has the time come for predictive computer modeling in CNS drug discovery and development?
    • COI: 1:STN:280:DC%2BC3sjptFKhsA%3D%3D
    • Geerts, H., A. Spiros, P. Roberts, and R. Carr. Has the time come for predictive computer modeling in CNS drug discovery and development? CPT Pharmacomet. Syst. Pharmacol. 1:e16, 2012. doi:10.1038/psp.2012.17.
    • (2012) CPT Pharmacomet. Syst. Pharmacol. , vol.1
    • Geerts, H.1    Spiros, A.2    Roberts, P.3    Carr, R.4
  • 44
    • 34248402413 scopus 로고    scopus 로고
    • Shape effects of filaments versus spherical particles in flow and drug delivery
    • COI: 1:CAS:528:DC%2BD1cXktVGgsbs%3D, PID: 18654271
    • Geng, Y., et al. Shape effects of filaments versus spherical particles in flow and drug delivery. Nat. Nanotechnol. 2:249–255, 2007.
    • (2007) Nat. Nanotechnol. , vol.2 , pp. 249-255
    • Geng, Y.1
  • 45
    • 84947488588 scopus 로고    scopus 로고
    • Broad spectrum assessment of the epitope fluctuation—immunogenicity hypothesis
    • PID: 26187254
    • Grosch, J., J. Yang, A. Shen, Y. V. Sereda, and P. Ortoleva. Broad spectrum assessment of the epitope fluctuation—immunogenicity hypothesis. Vaccine 2015. doi:10.1016/j.vaccine.2015.06.111.
    • (2015) Vaccine
    • Grosch, J.1    Yang, J.2    Shen, A.3    Sereda, Y.V.4    Ortoleva, P.5
  • 46
    • 69749115146 scopus 로고    scopus 로고
    • The role of multiscale computational approaches for rational design of conventional and nanoparticle oral drug delivery systems
    • COI: 1:CAS:528:DC%2BD2sXhtlektbrE
    • Haddish-Berhane, N., J. L. Rickus, and K. Haghighi. The role of multiscale computational approaches for rational design of conventional and nanoparticle oral drug delivery systems. Int. J. Nanomed. 2:315, 2007.
    • (2007) Int. J. Nanomed. , vol.2 , pp. 315
    • Haddish-Berhane, N.1    Rickus, J.L.2    Haghighi, K.3
  • 48
    • 50849096670 scopus 로고    scopus 로고
    • Quantifying nanoparticle adhesion mediated by specific molecular interactions
    • COI: 1:CAS:528:DC%2BD1cXosFKltr0%3D, PID: 18630976
    • Haun, J. B., and D. A. Hammer. Quantifying nanoparticle adhesion mediated by specific molecular interactions. Langmuir 24:8821–8832, 2008.
    • (2008) Langmuir , vol.24 , pp. 8821-8832
    • Haun, J.B.1    Hammer, D.A.2
  • 49
    • 4944266313 scopus 로고    scopus 로고
    • High interstitial fluid pressure [mdash] an obstacle in cancer therapy
    • COI: 1:CAS:528:DC%2BD2cXos1ymu7s%3D, PID: 15510161
    • Heldin, C.-H., K. Rubin, K. Pietras, and A. Ostman. High interstitial fluid pressure [mdash] an obstacle in cancer therapy. Nat. Rev. Cancer 4:806–813, 2004.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 806-813
    • Heldin, C.-H.1    Rubin, K.2    Pietras, K.3    Ostman, A.4
  • 51
    • 84874847729 scopus 로고    scopus 로고
    • In silico vascular modeling for personalized nanoparticle delivery
    • COI: 1:CAS:528:DC%2BC3sXjslKhs7Y%3D, PID: 23199308
    • Hossain, S. S., et al. In silico vascular modeling for personalized nanoparticle delivery. Nanomedicine 8:343–357, 2013.
    • (2013) Nanomedicine , vol.8 , pp. 343-357
    • Hossain, S.S.1
  • 52
    • 84879287149 scopus 로고    scopus 로고
    • Agent-based modeling: a systematic assessment of use cases and requirements for enhancing pharmaceutical research and development productivity
    • PID: 23737142
    • Hunt, C. A., R. C. Kennedy, S. H. Kim, and G. E. Ropella. Agent-based modeling: a systematic assessment of use cases and requirements for enhancing pharmaceutical research and development productivity. Wiley Interdiscip Rev Syst Biol Med 5:461–480, 2013. doi:10.1002/wsbm.1222.
    • (2013) Wiley Interdiscip Rev Syst Biol Med , vol.5 , pp. 461-480
    • Hunt, C.A.1    Kennedy, R.C.2    Kim, S.H.3    Ropella, G.E.4
  • 53
    • 84918513220 scopus 로고    scopus 로고
    • Numerical simulation of red blood cell distributions in three-dimensional microvascular bifurcations
    • PID: 25446286
    • Hyakutake, T., and S. Nagai. Numerical simulation of red blood cell distributions in three-dimensional microvascular bifurcations. Microvasc. Res. 97:115–123, 2015. doi:10.1016/j.mvr.2014.10.001.
    • (2015) Microvasc. Res. , vol.97 , pp. 115-123
    • Hyakutake, T.1    Nagai, S.2
  • 54
    • 0028470454 scopus 로고
    • Barriers to drug delivery in solid tumors
    • Jain, R. K. Barriers to drug delivery in solid tumors. Sci. Am. 58–65:e29528, 1994.
    • (1994) Sci. Am. , vol.58-65
    • Jain, R.K.1
  • 55
    • 81955165176 scopus 로고    scopus 로고
    • A molecular dynamics study of loop fluctuation in human papillomavirus type 16 virus-like particles: a possible indicator of immunogenicity
    • COI: 1:CAS:528:DC%2BC3MXhsFGjtrbO, PID: 22027487
    • Joshi, H., S. Cheluvaraja, E. Somogyi, D. R. Brown, and P. J. Ortoleva. A molecular dynamics study of loop fluctuation in human papillomavirus type 16 virus-like particles: a possible indicator of immunogenicity. Vaccine 29:9423–9430, 2011. doi:10.1016/j.vaccine.2011.10.039.
    • (2011) Vaccine , vol.29 , pp. 9423-9430
    • Joshi, H.1    Cheluvaraja, S.2    Somogyi, E.3    Brown, D.R.4    Ortoleva, P.J.5
  • 56
    • 84875828298 scopus 로고    scopus 로고
    • Cancer therapeutics-opportunities, challenges and advances in drug delivery
    • Kakde, D., D. Jain, V. Shrivastava, R. Kakde, and A. Patil. Cancer therapeutics-opportunities, challenges and advances in drug delivery. J. Appl. Pharm. Sci. 1(9):1–10, 2011.
    • (2011) J. Appl. Pharm. Sci. , vol.1 , Issue.9 , pp. 1-10
    • Kakde, D.1    Jain, D.2    Shrivastava, V.3    Kakde, R.4    Patil, A.5
  • 57
    • 84891067126 scopus 로고    scopus 로고
    • Current advances in mathematical modeling of anti-cancer drug penetration into tumor tissues
    • Kim, M., R. J. Gillies, and K. A. Rejniak. Current advances in mathematical modeling of anti-cancer drug penetration into tumor tissues. Front. Oncol. 3:120, 2013.
    • (2013) Front. Oncol. , vol.3 , pp. 120
    • Kim, M.1    Gillies, R.J.2    Rejniak, K.A.3
  • 58
    • 0035909961 scopus 로고    scopus 로고
    • Multiparticle adhesive dynamics: hydrodynamic recruitment of rolling leukocytes
    • COI: 1:CAS:528:DC%2BD38XptlOq, PID: 11752440
    • King, M. R., and D. A. Hammer. Multiparticle adhesive dynamics: hydrodynamic recruitment of rolling leukocytes. Proc. Natl. Acad. Sci. USA 98:14919–14924, 2001. doi:10.1073/pnas.261272498.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 14919-14924
    • King, M.R.1    Hammer, D.A.2
  • 59
    • 0035838770 scopus 로고    scopus 로고
    • Hydrodynamic collisions suppress fluctuations in the rolling velocity of adhesive blood cells
    • COI: 1:CAS:528:DC%2BD3MXktF2nt78%3D
    • King, M. R., S. D. Rodgers, and D. A. Hammer. Hydrodynamic collisions suppress fluctuations in the rolling velocity of adhesive blood cells. Langmuir 17:4139–4143, 2001. doi:10.1021/La010234b.
    • (2001) Langmuir , vol.17 , pp. 4139-4143
    • King, M.R.1    Rodgers, S.D.2    Hammer, D.A.3
  • 60
    • 4043154901 scopus 로고    scopus 로고
    • The dynamics of acute inflammation
    • COI: 1:CAS:528:DC%2BD2cXmsVCrtbY%3D, PID: 15321710
    • Kumar, R., G. Clermont, Y. Vodovotz, and C. C. Chow. The dynamics of acute inflammation. J. Theor. Biol. 230:145–155, 2004. doi:10.1016/j.jtbi.2004.04.044.
    • (2004) J. Theor. Biol. , vol.230 , pp. 145-155
    • Kumar, R.1    Clermont, G.2    Vodovotz, Y.3    Chow, C.C.4
  • 61
    • 34250749661 scopus 로고    scopus 로고
    • Model-based drug development
    • COI: 1:CAS:528:DC%2BD2sXotVGjurc%3D, PID: 17522597
    • Lalonde, R. L., et al. Model-based drug development. Clin. Pharmacol. Ther. 82:21–32, 2007. doi:10.1038/sj.clpt.6100235.
    • (2007) Clin. Pharmacol. Ther. , vol.82 , pp. 21-32
    • Lalonde, R.L.1
  • 62
    • 41549142134 scopus 로고    scopus 로고
    • CFD study on the magnetic fluid delivering in the vessel in high-gradient magnetic field
    • COI: 1:CAS:528:DC%2BD1cXkt1yjt74%3D
    • Li, X. L., K. L. Yao, and Z. L. Liu. CFD study on the magnetic fluid delivering in the vessel in high-gradient magnetic field. J. Magn. Magn. Mater. 320:1753–1758, 2008. doi:10.1016/j.jmmm.2008.01.041.
    • (2008) J. Magn. Magn. Mater. , vol.320 , pp. 1753-1758
    • Li, X.L.1    Yao, K.L.2    Liu, Z.L.3
  • 63
    • 80053532720 scopus 로고    scopus 로고
    • Multiscale modeling of functionalized nanocarriers in targeted drug delivery
    • COI: 1:CAS:528:DC%2BC3MXhtlOnu7fK, PID: 22116782
    • Liu, J., R. Bradley, D. M. Eckmann, P. S. Ayyaswamy, and R. Radhakrishnan. Multiscale modeling of functionalized nanocarriers in targeted drug delivery. Curr. Nanosci. 7:727, 2011.
    • (2011) Curr. Nanosci. , vol.7 , pp. 727
    • Liu, J.1    Bradley, R.2    Eckmann, D.M.3    Ayyaswamy, P.S.4    Radhakrishnan, R.5
  • 64
    • 78049238597 scopus 로고    scopus 로고
    • Computational model for nanocarrier binding to endothelium validated using in vivo, in vitro, and atomic force microscopy experiments
    • COI: 1:CAS:528:DC%2BC3cXht1Wrtr7J, PID: 20823256
    • Liu, J., et al. Computational model for nanocarrier binding to endothelium validated using in vivo, in vitro, and atomic force microscopy experiments. Proc. Natl. Acad. Sci. 107:16530–16535, 2010. doi:10.1073/pnas.1006611107.
    • (2010) Proc. Natl. Acad. Sci. , vol.107 , pp. 16530-16535
    • Liu, J.1
  • 65
    • 33646421976 scopus 로고    scopus 로고
    • Prophylactic human papillomavirus vaccines
    • COI: 1:CAS:528:DC%2BD28XksVWgu78%3D, PID: 16670757
    • Lowy, D. R., and J. T. Schiller. Prophylactic human papillomavirus vaccines. J. Clin. Invest. 116:1167–1173, 2006. doi:10.1172/JCI28607.
    • (2006) J. Clin. Invest. , vol.116 , pp. 1167-1173
    • Lowy, D.R.1    Schiller, J.T.2
  • 66
    • 84902464181 scopus 로고    scopus 로고
    • Model-based meta-analysis for quantifying Paclitaxel dose response in cancer patients
    • COI: 1:STN:280:DC%2BC2cjltVyitQ%3D%3D
    • Lu, D., et al. Model-based meta-analysis for quantifying Paclitaxel dose response in cancer patients. CPT Pharmacomet. Syst. Pharmacol. 3:e115, 2014. doi:10.1038/psp.2014.14.
    • (2014) CPT Pharmacomet. Syst. Pharmacol. , vol.3
    • Lu, D.1
  • 67
    • 65249184500 scopus 로고    scopus 로고
    • Multiphysics flow modeling and in vitro toxicity of iron oxide nanoparticles coated with poly(vinyl alcohol)
    • COI: 1:CAS:528:DC%2BD1MXns1Oksg%3D%3D
    • Mahmoudi, M., et al. Multiphysics flow modeling and in vitro toxicity of iron oxide nanoparticles coated with poly(vinyl alcohol). J. Phys. Chem. C 113:2322–2331, 2009. doi:10.1021/jp809453v.
    • (2009) J. Phys. Chem. C , vol.113 , pp. 2322-2331
    • Mahmoudi, M.1
  • 68
    • 84871644617 scopus 로고    scopus 로고
    • Binding pocket optimization by computational protein design
    • COI: 1:CAS:528:DC%2BC3sXnsVKhsw%3D%3D, PID: 23300688
    • Malisi, C., et al. Binding pocket optimization by computational protein design. PLoS ONE 7:e52505, 2012. doi:10.1371/journal.pone.0052505.
    • (2012) PLoS ONE , vol.7
    • Malisi, C.1
  • 69
    • 68349104348 scopus 로고    scopus 로고
    • Sub-angstrom accuracy in protein loop reconstruction by robotics-inspired conformational sampling
    • COI: 1:CAS:528:DC%2BD1MXpt1Whtbw%3D, PID: 19644455
    • Mandell, D. J., E. A. Coutsias, and T. Kortemme. Sub-angstrom accuracy in protein loop reconstruction by robotics-inspired conformational sampling. Nat. Methods 6:551–552, 2009.
    • (2009) Nat. Methods , vol.6 , pp. 551-552
    • Mandell, D.J.1    Coutsias, E.A.2    Kortemme, T.3
  • 70
    • 84885615964 scopus 로고    scopus 로고
    • A systems chemical biology study of malate synthase and isocitrate lyase inhibition in Mycobacterium tuberculosis during active and NRP growth
    • COI: 1:CAS:528:DC%2BC3sXhvVehtrfE, PID: 24121675
    • May, E. E., A. Leitao, A. Tropsha, and T. I. Oprea. A systems chemical biology study of malate synthase and isocitrate lyase inhibition in Mycobacterium tuberculosis during active and NRP growth. Comput. Biol. Chem. 47:167–180, 2013. doi:10.1016/j.compbiolchem.2013.07.002.
    • (2013) Comput. Biol. Chem. , vol.47 , pp. 167-180
    • May, E.E.1    Leitao, A.2    Tropsha, A.3    Oprea, T.I.4
  • 71
    • 61849103491 scopus 로고    scopus 로고
    • Understanding virulence mechanisms in M. tuberculosis infection via a circuit-based simulation framework
    • May, E., et al. Understanding virulence mechanisms in M. tuberculosis infection via a circuit-based simulation framework. Conf. Proc. IEEE Eng. Med. Biol. Soc. 4953–4955:2008, 2008. doi:10.1109/IEMBS.2008.4650325.
    • (2008) Conf. Proc. IEEE Eng. Med. Biol. Soc. , vol.4953-4955 , pp. 2008
    • May, E.1
  • 72
    • 33750056673 scopus 로고    scopus 로고
    • ROSETTALIGAND: protein-small molecule docking with full side-chain flexibility
    • COI: 1:CAS:528:DC%2BD28XhtFWqt7nJ, PID: 16972285
    • Meiler, J., and D. Baker. ROSETTALIGAND: protein-small molecule docking with full side-chain flexibility. Proteins 65:538–548, 2006. doi:10.1002/prot.21086.
    • (2006) Proteins , vol.65 , pp. 538-548
    • Meiler, J.1    Baker, D.2
  • 73
    • 34848830242 scopus 로고    scopus 로고
    • Agent-based model of inflammation and wound healing: insights into diabetic foot ulcer pathology and the role of transforming growth factor-beta1
    • PID: 17971013
    • Mi, Q., B. Riviere, G. Clermont, D. L. Steed, and Y. Vodovotz. Agent-based model of inflammation and wound healing: insights into diabetic foot ulcer pathology and the role of transforming growth factor-beta1. Wound Repair Regen. 15:671–682, 2007. doi:10.1111/j.1524-475X.2007.00271.x.
    • (2007) Wound Repair Regen. , vol.15 , pp. 671-682
    • Mi, Q.1    Riviere, B.2    Clermont, G.3    Steed, D.L.4    Vodovotz, Y.5
  • 74
    • 84878238854 scopus 로고    scopus 로고
    • Model-based drug development: a rational approach to efficiently accelerate drug development
    • COI: 1:CAS:528:DC%2BC3sXot1arsbs%3D, PID: 23588322
    • Milligan, P. A., et al. Model-based drug development: a rational approach to efficiently accelerate drug development. Clin. Pharmacol. Ther. 93:502–514, 2013. doi:10.1038/clpt.2013.54.
    • (2013) Clin. Pharmacol. Ther. , vol.93 , pp. 502-514
    • Milligan, P.A.1
  • 75
    • 34447341225 scopus 로고    scopus 로고
    • Transport kinetics of four-coordinate and six-coordinate platinum compounds in the multicell layer tumour model
    • COI: 1:CAS:528:DC%2BD2sXnsFaqsb0%3D, PID: 17579620
    • Modok, S., et al. Transport kinetics of four-coordinate and six-coordinate platinum compounds in the multicell layer tumour model. Br. J. Cancer 97:194–200, 2007. doi:10.1038/sj.bjc.6603854.
    • (2007) Br. J. Cancer , vol.97 , pp. 194-200
    • Modok, S.1
  • 76
    • 80052358982 scopus 로고    scopus 로고
    • A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms
    • Moreno, J. D., et al. A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms. Sci. Trans. Med. 3:98ra83, 2011. doi:10.1126/scitranslmed.3002588.
    • (2011) Sci. Trans. Med. , vol.3 , pp. 98ra83
    • Moreno, J.D.1
  • 77
    • 84884815637 scopus 로고    scopus 로고
    • Ranolazine for congenital and acquired late INa-linked arrhythmias: in silico pharmacological screening
    • COI: 1:CAS:528:DC%2BC3sXhsVens7%2FO, PID: 23897695
    • Moreno, J. D., et al. Ranolazine for congenital and acquired late INa-linked arrhythmias: in silico pharmacological screening. Circ. Res. 113:e50–e61, 2013. doi:10.1161/CIRCRESAHA.113.301971.
    • (2013) Circ. Res. , vol.113 , pp. e50-e61
    • Moreno, J.D.1
  • 78
    • 84865414223 scopus 로고    scopus 로고
    • Model-based meta-analysis: an important tool for making quantitative decisions during drug development
    • COI: 1:CAS:528:DC%2BC38Xht1GisrfN, PID: 22910485
    • Mould, D. R. Model-based meta-analysis: an important tool for making quantitative decisions during drug development. Clin. Pharmacol. Ther. 92:283–286, 2012. doi:10.1038/clpt.2012.122.
    • (2012) Clin. Pharmacol. Ther. , vol.92 , pp. 283-286
    • Mould, D.R.1
  • 79
    • 84862625643 scopus 로고    scopus 로고
    • Models for disease progression: new approaches and uses
    • COI: 1:CAS:528:DC%2BC38XptVGmurw%3D, PID: 22617225
    • Mould, D. R. Models for disease progression: new approaches and uses. Clin. Pharmacol. Ther. 92:125–131, 2012. doi:10.1038/clpt.2012.53.
    • (2012) Clin. Pharmacol. Ther. , vol.92 , pp. 125-131
    • Mould, D.R.1
  • 80
    • 84899862179 scopus 로고    scopus 로고
    • Muller, K., Fedosov, D. A. & Gompper, G. Margination of micro- and nano-particles in blood flow and its effect on drug delivery. 4: supplementary-information
    • Muller, K., Fedosov, D. A. & Gompper, G. Margination of micro- and nano-particles in blood flow and its effect on drug delivery. Sci. Rep. 4: doi:10.1038/srep04871. http://www.nature.com/srep/2014/140502/srep04871/abs/srep04871.html—supplementary-information, 2014.
    • (2014) Sci. Rep.
  • 81
    • 37349125566 scopus 로고    scopus 로고
    • progesterone regulates cardiac repolarization through a nongenomic pathway: an in vitro patch-clamp and computational modeling study
    • COI: 1:CAS:528:DC%2BD2sXhsVWjsr7P, PID: 18056530
    • Nakamura, H., et al. progesterone regulates cardiac repolarization through a nongenomic pathway: an in vitro patch-clamp and computational modeling study. Circulation 116:2913–2922, 2007. doi:10.1161/circulationaha.107.702407.
    • (2007) Circulation , vol.116 , pp. 2913-2922
    • Nakamura, H.1
  • 82
    • 79952159586 scopus 로고    scopus 로고
    • A multiscale simulation system for the prediction of drug-induced cardiotoxicity
    • COI: 1:CAS:528:DC%2BC3MXnvVSmsQ%3D%3D, PID: 21250697
    • Obiol-Pardo, C., J. Gomis-Tena, F. Sanz, J. Saiz, and M. Pastor. A multiscale simulation system for the prediction of drug-induced cardiotoxicity. J. Chem. Inf. Model. 51:483–492, 2011. doi:10.1021/ci100423z.
    • (2011) J. Chem. Inf. Model. , vol.51 , pp. 483-492
    • Obiol-Pardo, C.1    Gomis-Tena, J.2    Sanz, F.3    Saiz, J.4    Pastor, M.5
  • 83
    • 79952118609 scopus 로고    scopus 로고
    • Computational systems chemical biology
    • COI: 1:CAS:528:DC%2BC3cXhtlejsr%2FP, PID: 20838980
    • Oprea, T. I., E. E. May, A. Leitao, and A. Tropsha. Computational systems chemical biology. Methods Mol. Biol. 672:459–488, 2011. doi:10.1007/978-1-60761-839-3_18.
    • (2011) Methods Mol. Biol. , vol.672 , pp. 459-488
    • Oprea, T.I.1    May, E.E.2    Leitao, A.3    Tropsha, A.4
  • 84
    • 34447558299 scopus 로고    scopus 로고
    • Systems chemical biology
    • COI: 1:CAS:528:DC%2BD2sXnvFaqs7Y%3D, PID: 17637771
    • Oprea, T. I., A. Tropsha, J. L. Faulon, and M. D. Rintoul. Systems chemical biology. Nat. Chem. Biol. 3:447–450, 2007. doi:10.1038/nchembio0807-447.
    • (2007) Nat. Chem. Biol. , vol.3 , pp. 447-450
    • Oprea, T.I.1    Tropsha, A.2    Faulon, J.L.3    Rintoul, M.D.4
  • 85
    • 78649356768 scopus 로고    scopus 로고
    • A hybrid approach to multi-scale modelling of cancer
    • COI: 1:STN:280:DC%2BC3cfnt1GjtQ%3D%3D, PID: 20921009
    • Osborne, J. M., et al. A hybrid approach to multi-scale modelling of cancer. Philos. Trans. A Math. Phys. Eng. Sci. 368:5013–5028, 2010.
    • (2010) Philos. Trans. A Math. Phys. Eng. Sci. , vol.368 , pp. 5013-5028
    • Osborne, J.M.1
  • 86
    • 70350221827 scopus 로고    scopus 로고
    • Numerical simulation of blood and interstitial flow through a solid tumor
    • COI: 1:STN:280:DC%2BD1MnitlOnug%3D%3D, PID: 19277663
    • Pozrikidis, C. Numerical simulation of blood and interstitial flow through a solid tumor. J. Math. Biol. 60:75–94, 2010.
    • (2010) J. Math. Biol. , vol.60 , pp. 75-94
    • Pozrikidis, C.1
  • 87
    • 0024321898 scopus 로고
    • Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction. The Cardiac Arrhythmia Suppression Trial (CAST) 321:406–412, 1989
    • Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction. The Cardiac Arrhythmia Suppression Trial (CAST) Investigators. N. Engl. J. Med. 321:406–412, 1989.
    • (1989) Investigators. N. Engl. J. Med.
  • 88
    • 0032897904 scopus 로고    scopus 로고
    • Cardiac electrical restitution properties and stability of reentrant spiral waves: a simulation study
    • COI: 1:CAS:528:DyaK1MXnt12msw%3D%3D, PID: 9887041
    • Qu, Z., J. N. Weiss, and A. Garfinkel. Cardiac electrical restitution properties and stability of reentrant spiral waves: a simulation study. Am. J. Physiol. 276:H269–H283, 1999.
    • (1999) Am. J. Physiol. , vol.276 , pp. H269-H283
    • Qu, Z.1    Weiss, J.N.2    Garfinkel, A.3
  • 89
    • 47249159421 scopus 로고    scopus 로고
    • Modeling HERG and its interactions with drugs: recent advances in light of current potassium channel simulations
    • COI: 1:CAS:528:DC%2BD1cXlsVSktrg%3D, PID: 18224703
    • Recanatini, M., A. Cavalli, and M. Masetti. Modeling HERG and its interactions with drugs: recent advances in light of current potassium channel simulations. ChemMedChem 3:523–535, 2008. doi:10.1002/cmdc.200700264.
    • (2008) ChemMedChem , vol.3 , pp. 523-535
    • Recanatini, M.1    Cavalli, A.2    Masetti, M.3
  • 90
    • 84864345143 scopus 로고    scopus 로고
    • Mathematical modeling of liver injury and dysfunction after acetaminophen overdose: Early discrimination between survival and death
    • COI: 1:CAS:528:DC%2BC38XhtVylu77O, PID: 22331703
    • Remien, C. H., F. R. Adler, L. Waddoups, T. D. Box, and N. L. Sussman. Mathematical modeling of liver injury and dysfunction after acetaminophen overdose: Early discrimination between survival and death. Hepatology 56:727–734, 2012. doi:10.1002/hep.25656.
    • (2012) Hepatology , vol.56 , pp. 727-734
    • Remien, C.H.1    Adler, F.R.2    Waddoups, L.3    Box, T.D.4    Sussman, N.L.5
  • 91
    • 84946239939 scopus 로고    scopus 로고
    • Physiologically based pharmacokinetic (PBPK) modeling and simulation approaches: a systematic review of published models, applications and model verification
    • PID: 26296709
    • Sager, J. E., J. Yu, I. Ragueneau-Majlessi, and N. Isoherranen. Physiologically based pharmacokinetic (PBPK) modeling and simulation approaches: a systematic review of published models, applications and model verification. Drug Metab. Dispos. 2015. doi:10.1124/dmd.115.065920.
    • (2015) Drug Metab. Dispos.
    • Sager, J.E.1    Yu, J.2    Ragueneau-Majlessi, I.3    Isoherranen, N.4
  • 92
    • 80054994249 scopus 로고    scopus 로고
    • Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: a computational analysis
    • PID: 21699863
    • Sarkar, A. X., and E. A. Sobie. Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: a computational analysis. Heart Rhythm. 8:1749–1755, 2011. doi:10.1016/j.hrthm.2011.05.023.
    • (2011) Heart Rhythm. , vol.8 , pp. 1749-1755
    • Sarkar, A.X.1    Sobie, E.A.2
  • 93
    • 84880733804 scopus 로고    scopus 로고
    • Bench to bedside translation of antibody drug conjugates using a multiscale mechanistic PK/PD model: a case study with brentuximab-vedotin
    • PID: 23151991
    • Shah, D. K., N. Haddish-Berhane, and A. Betts. Bench to bedside translation of antibody drug conjugates using a multiscale mechanistic PK/PD model: a case study with brentuximab-vedotin. J. Pharmacokinet Pharmacodyn. 39:643–659, 2012.
    • (2012) J. Pharmacokinet Pharmacodyn. , vol.39 , pp. 643-659
    • Shah, D.K.1    Haddish-Berhane, N.2    Betts, A.3
  • 94
    • 77955171004 scopus 로고    scopus 로고
    • Multiscale modelling of fluid and drug transport in vascular tumours
    • PID: 20099043
    • Shipley, R. J., and S. J. Chapman. Multiscale modelling of fluid and drug transport in vascular tumours. Bull. Math. Biol. 72:1464–1491, 2010. doi:10.1007/s11538-010-9504-9.
    • (2010) Bull. Math. Biol. , vol.72 , pp. 1464-1491
    • Shipley, R.J.1    Chapman, S.J.2
  • 95
    • 84920837701 scopus 로고    scopus 로고
    • Cancer statistics, 2015
    • PID: 25559415
    • Siegel, R. L., K. D. Miller, and A. Jemal. Cancer statistics, 2015. CA Cancer J. Clin. 65:5–29, 2015. doi:10.3322/caac.21254.
    • (2015) CA Cancer J. Clin. , vol.65 , pp. 5-29
    • Siegel, R.L.1    Miller, K.D.2    Jemal, A.3
  • 96
    • 84864193635 scopus 로고    scopus 로고
    • Space warping order parameters and symmetry: application to multiscale simulation of macromolecular assemblies
    • COI: 1:CAS:528:DC%2BC38XislSks7g%3D, PID: 22356532
    • Singharoy, A., H. Joshi, Y. Miao, and P. J. Ortoleva. Space warping order parameters and symmetry: application to multiscale simulation of macromolecular assemblies. J. Phys. Chem. B 116:8423–8434, 2012. doi:10.1021/jp2119247.
    • (2012) J. Phys. Chem. B , vol.116 , pp. 8423-8434
    • Singharoy, A.1    Joshi, H.2    Miao, Y.3    Ortoleva, P.J.4
  • 97
    • 16344373015 scopus 로고    scopus 로고
    • Protein homology detection by HMM-HMM comparison
    • Soding, J. Protein homology detection by HMM-HMM comparison. Bioinformatics (Oxford, England) 21:951–960, 2005.
    • (2005) Bioinformatics (Oxford, England) , vol.21 , pp. 951-960
    • Soding, J.1
  • 98
    • 84923214110 scopus 로고    scopus 로고
    • Numerical simulation of particle transport and deposition in the pulmonary vasculature
    • PID: 25322073
    • Sohrabi, S., J. Zheng, E. A. Finol, and Y. Liu. Numerical simulation of particle transport and deposition in the pulmonary vasculature. J. Biomech. Eng. 136:121010, 2014.
    • (2014) J. Biomech. Eng. , vol.136 , pp. 121010
    • Sohrabi, S.1    Zheng, J.2    Finol, E.A.3    Liu, Y.4
  • 99
    • 85054271306 scopus 로고    scopus 로고
    • Mathematical modeling of microbial community dynamics: a methodological review
    • Song, H.-S., W. Cannon, A. Beliaev, and A. Konopka. Mathematical modeling of microbial community dynamics: a methodological review. Processes 2:711, 2014.
    • (2014) Processes , vol.2 , pp. 711
    • Song, H.-S.1    Cannon, W.2    Beliaev, A.3    Konopka, A.4
  • 100
    • 84858767373 scopus 로고    scopus 로고
    • Quantitative and systems pharmacology in the post-genomic era: new approaches to discovering drugs and understanding therapeutic mechanisms
    • Sorger, P. K. et al. Quantitative and systems pharmacology in the post-genomic era: new approaches to discovering drugs and understanding therapeutic mechanisms. An NIH White Paper by the QSP Workshop Group. (2011). https://www.nigms.nih.gov/training/documents/systemspharmawpsorger2011.pdf.
    • (2011) An NIH White Paper by the QSP Workshop Group
    • Sorger, P.K.1
  • 101
    • 77954140235 scopus 로고    scopus 로고
    • An advanced discrete state-discrete event multiscale simulation model of the response of a solid tumor to chemotherapy: mimicking a clinical study
    • COI: 1:CAS:528:DC%2BC3cXpvVejtr8%3D, PID: 20515697
    • Stamatakos, G. S., E. A. Kolokotroni, D. D. Dionysiou, E. Georgiadi, and C. Desmedt. An advanced discrete state-discrete event multiscale simulation model of the response of a solid tumor to chemotherapy: mimicking a clinical study. J. Theor. Biol. 266:124–139, 2010. doi:10.1016/j.jtbi.2010.05.019.
    • (2010) J. Theor. Biol. , vol.266 , pp. 124-139
    • Stamatakos, G.S.1    Kolokotroni, E.A.2    Dionysiou, D.D.3    Georgiadi, E.4    Desmedt, C.5
  • 102
    • 84982304072 scopus 로고    scopus 로고
    • Circadian gating of the mammalian cell cycle restriction point: a mathematical analysis. Life Sci
    • Su, J. & Henson, M. A. Circadian gating of the mammalian cell cycle restriction point: a mathematical analysis. Life Sci. Lett. IEEE:1–1, 2015, doi:10.1109/LLS.2015.2449511.
    • (2015) Lett. IEEE , pp. 1
    • Su, J.1    Henson, M.A.2
  • 103
    • 84900339768 scopus 로고    scopus 로고
    • Targeting the biophysical properties of the myeloma initiating cell niches: a pharmaceutical synergism analysis using multi-scale agent-based modeling
    • PID: 24475036
    • Su, J., et al. Targeting the biophysical properties of the myeloma initiating cell niches: a pharmaceutical synergism analysis using multi-scale agent-based modeling. PLoS ONE 9:e85059, 2014.
    • (2014) PLoS ONE , vol.9
    • Su, J.1
  • 104
    • 84866174424 scopus 로고    scopus 로고
    • Cytokine combination therapy prediction for bone remodeling in tissue engineering based on the intracellular signaling pathway
    • COI: 1:CAS:528:DC%2BC38Xht1ahtr7N, PID: 22910219
    • Sun, X., et al. Cytokine combination therapy prediction for bone remodeling in tissue engineering based on the intracellular signaling pathway. Biomaterials 33:8265–8276, 2012.
    • (2012) Biomaterials , vol.33 , pp. 8265-8276
    • Sun, X.1
  • 105
    • 84895928188 scopus 로고    scopus 로고
    • A polarizable empirical force field for molecular dynamics simulation of liquid hydrocarbons
    • COI: 1:CAS:528:DC%2BC2cXivVCgs74%3D, PID: 26248885
    • Szklarczyk, O. M., S. J. Bachmann, and W. F. van Gunsteren. A polarizable empirical force field for molecular dynamics simulation of liquid hydrocarbons. J. Comput. Chem. 35:789–801, 2014. doi:10.1002/jcc.23551.
    • (2014) J. Comput. Chem. , vol.35 , pp. 789-801
    • Szklarczyk, O.M.1    Bachmann, S.J.2    van Gunsteren, W.F.3
  • 106
    • 84878595723 scopus 로고    scopus 로고
    • The influence of size, shape and vessel geometry on nanoparticle distribution
    • COI: 1:CAS:528:DC%2BC3sXhtFajsr0%3D, PID: 23554583
    • Tan, J., S. Shah, A. Thomas, H. D. Ou-Yang, and Y. Liu. The influence of size, shape and vessel geometry on nanoparticle distribution. Microfluidics Nanofluidics 14:77–87, 2013.
    • (2013) Microfluidics Nanofluidics , vol.14 , pp. 77-87
    • Tan, J.1    Shah, S.2    Thomas, A.3    Ou-Yang, H.D.4    Liu, Y.5
  • 107
    • 84863012606 scopus 로고    scopus 로고
    • Influence of red blood cells on nanoparticle targeted delivery in microcirculation
    • COI: 1:CAS:528:DC%2BC38Xos1SrsA%3D%3D
    • Tan, J., A. Thomas, and Y. Liu. Influence of red blood cells on nanoparticle targeted delivery in microcirculation. Soft. Matter. 8(6):1934–1946, 2012.
    • (2012) Soft. Matter. , vol.8 , Issue.6 , pp. 1934-1946
    • Tan, J.1    Thomas, A.2    Liu, Y.3
  • 108
    • 84878359213 scopus 로고    scopus 로고
    • Coupled particulate and continuum model for nanoparticle targeted delivery
    • PID: 23729869
    • Tan, J., S. Wang, J. Yang, and Y. Liu. Coupled particulate and continuum model for nanoparticle targeted delivery. Comput. Struct. 122:128–134, 2013.
    • (2013) Comput. Struct. , vol.122 , pp. 128-134
    • Tan, J.1    Wang, S.2    Yang, J.3    Liu, Y.4
  • 109
    • 84896769946 scopus 로고    scopus 로고
    • Computational modeling of 3D tumor growth and angiogenesis for chemotherapy evaluation
    • PID: 24404145
    • Tang, L., et al. Computational modeling of 3D tumor growth and angiogenesis for chemotherapy evaluation. PLoS ONE 9:e83962, 2014. doi:10.1371/journal.pone.0083962.
    • (2014) PLoS ONE , vol.9
    • Tang, L.1
  • 110
    • 33748419943 scopus 로고    scopus 로고
    • Alternans and spiral breakup in a human ventricular tissue model
    • PID: 16565318
    • ten Tusscher, K. H. W. J., and A. V. Panfilov. Alternans and spiral breakup in a human ventricular tissue model. Am. J. Physiol. Heart Circ. Physiol. 291:H1088–H1100, 2006.
    • (2006) Am. J. Physiol. Heart Circ. Physiol. , vol.291 , pp. H1088-H1100
    • ten Tusscher, K.H.W.J.1    Panfilov, A.V.2
  • 111
    • 0026050195 scopus 로고
    • A new approach to the classification of antiarrhythmic drugs based on their actions on arrhythmogenic mechanisms. Task Force of the Working Group on Arrhythmias of the European Society of Cardiology
    • The Sicilian gambit. A new approach to the classification of antiarrhythmic drugs based on their actions on arrhythmogenic mechanisms. Task Force of the Working Group on Arrhythmias of the European Society of Cardiology. Circulation 84:1831–1851, 1991.
    • (1991) Circulation , vol.84 , pp. 1831-1851
  • 112
    • 0026045912 scopus 로고
    • A new approach to the classification of antiarrhythmic drugs based on their actions on arrhythmogenic mechanisms. The Task Force of the Working Group on Arrhythmias of the European Society of Cardiology
    • The ‘Sicilian Gambit’. A new approach to the classification of antiarrhythmic drugs based on their actions on arrhythmogenic mechanisms. The Task Force of the Working Group on Arrhythmias of the European Society of Cardiology. Eur. Heart J. 12:1112–1131, 1991.
    • (1991) Eur. Heart J. , vol.12 , pp. 1112-1131
  • 113
    • 84919935391 scopus 로고    scopus 로고
    • Comparison of optimal thermodynamic models of the tricarboxylic acid cycle from heterotrophs, cyanobacteria, and green sulfur bacteria
    • Thomas, D. G., S. Jaramillo-Riveri, D. J. Baxter, and W. R. Cannon. Comparison of optimal thermodynamic models of the tricarboxylic acid cycle from heterotrophs, cyanobacteria, and green sulfur bacteria. J. Phys. Chem. B 2014. doi:10.1021/jp5075913.
    • (2014) J. Phys. Chem. B
    • Thomas, D.G.1    Jaramillo-Riveri, S.2    Baxter, D.J.3    Cannon, W.R.4
  • 114
    • 79953048071 scopus 로고    scopus 로고
    • Tumor delivery of macromolecular drugs based on the EPR effect
    • COI: 1:CAS:528:DC%2BC3MXktF2jur4%3D, PID: 20304019
    • Torchilin, V. Tumor delivery of macromolecular drugs based on the EPR effect. Adv. Drug Deliv. Rev. 63:131–135, 2011.
    • (2011) Adv. Drug Deliv. Rev. , vol.63 , pp. 131-135
    • Torchilin, V.1
  • 115
    • 84874846341 scopus 로고    scopus 로고
    • Applications of pharmacometrics in the clinical development and pharmacotherapy of anti-infectives
    • COI: 1:CAS:528:DC%2BC3sXjslWntbw%3D
    • Trivedi, A., R. E. Lee, and B. Meibohm. Applications of pharmacometrics in the clinical development and pharmacotherapy of anti-infectives. Expert Rev. Clin. Phar. 6:159–170, 2013. doi:10.1586/ECP.13.6.
    • (2013) Expert Rev. Clin. Phar. , vol.6 , pp. 159-170
    • Trivedi, A.1    Lee, R.E.2    Meibohm, B.3
  • 116
    • 84968520470 scopus 로고
    • On the product of semi-groups of operators
    • Trotter, H. F. On the product of semi-groups of operators. Proc. Am. Math. Soc. 10:545–551, 1959. doi:10.1090/S0002-9939-1959-0108732-6.
    • (1959) Proc. Am. Math. Soc. , vol.10 , pp. 545-551
    • Trotter, H.F.1
  • 117
    • 79960904977 scopus 로고    scopus 로고
    • Nanoparticle Brownian motion and hydrodynamic interactions in the presence of flow fields
    • Uma, B., T. N. Swaminathan, R. Radhakrishnan, D. M. Eckmann, and P. S. Ayyaswamy. Nanoparticle Brownian motion and hydrodynamic interactions in the presence of flow fields. Phys Fluids 23:073602, 2011. doi:10.1063/1.3611026.
    • (2011) Phys Fluids , vol.23 , pp. 073602
    • Uma, B.1    Swaminathan, T.N.2    Radhakrishnan, R.3    Eckmann, D.M.4    Ayyaswamy, P.S.5
  • 118
    • 84899911728 scopus 로고    scopus 로고
    • Investigation of the essential role of platelet-tumor cell interactions in metastasis progression using an agent-based model
    • PID: 24725600
    • Uppal, A., S. C. Wightman, S. Ganai, R. R. Weichselbaum, and G. An. Investigation of the essential role of platelet-tumor cell interactions in metastasis progression using an agent-based model. Theor. Biol. Med. Model 11:17, 2014. doi:10.1186/1742-4682-11-17.
    • (2014) Theor. Biol. Med. Model , vol.11 , pp. 17
    • Uppal, A.1    Wightman, S.C.2    Ganai, S.3    Weichselbaum, R.R.4    An, G.5
  • 119
    • 84881200963 scopus 로고    scopus 로고
    • CPT: pharmacometrics and systems pharmacology
    • van der Graaf, P. H. CPT: pharmacometrics and systems pharmacology. CPT Pharmacomet. Syst. Pharmacol 1:e8, 2012. doi:10.1038/psp.2012.8.
    • (2012) CPT Pharmacomet. Syst. Pharmacol , vol.1
    • van der Graaf, P.H.1
  • 120
    • 76249087938 scopus 로고    scopus 로고
    • CHARMM general force field: A force field for drug-like molecules compatible with the CHARMM all-atom additive biological force fields
    • Vanommeslaeghe, K., et al. CHARMM general force field: A force field for drug-like molecules compatible with the CHARMM all-atom additive biological force fields. J. Comput. Chem. 31:671–690, 2009.
    • (2009) J. Comput. Chem. , vol.31 , pp. 671-690
    • Vanommeslaeghe, K.1
  • 121
    • 84900993066 scopus 로고    scopus 로고
    • Whither pharmacometrics?: present state and future choices
    • COI: 1:STN:280:DC%2BC2cjktlOhtQ%3D%3D, PID: 24842634
    • Vicini, P., and B. P. Smith. Whither pharmacometrics?: present state and future choices. Clin. Pharmacol. Ther. 95:567–571, 2014. doi:10.1038/clpt.2014.72.
    • (2014) Clin. Pharmacol. Ther. , vol.95 , pp. 567-571
    • Vicini, P.1    Smith, B.P.2
  • 122
    • 84876567464 scopus 로고    scopus 로고
    • Systems pharmacology for drug discovery and development: paradigm shift or flash in the pan?
    • COI: 1:STN:280:DC%2BC3srmsFaqtA%3D%3D, PID: 23598453
    • Vicini, P., and P. H. van der Graaf. Systems pharmacology for drug discovery and development: paradigm shift or flash in the pan? Clin. Pharmacol. Ther. 93:379–381, 2013. doi:10.1038/clpt.2013.40.
    • (2013) Clin. Pharmacol. Ther. , vol.93 , pp. 379-381
    • Vicini, P.1    van der Graaf, P.H.2
  • 123
    • 8944234858 scopus 로고    scopus 로고
    • Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. The SWORD Investigators. Survival With Oral d-Sotalol
    • COI: 1:CAS:528:DyaK28Xkslerurg%3D, PID: 8691967
    • Waldo, A. L., et al. Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. The SWORD Investigators. Survival With Oral d-Sotalol. Lancet 348:7–12, 1996.
    • (1996) Lancet , vol.348 , pp. 7-12
    • Waldo, A.L.1
  • 124
    • 34548861782 scopus 로고    scopus 로고
    • Protein-protein docking with backbone flexibility
    • COI: 1:CAS:528:DC%2BD2sXhtFSks7%2FL, PID: 17825317
    • Wang, C., P. Bradley, and D. Baker. Protein-protein docking with backbone flexibility. J. Mol. Biol. 373:503–519, 2007. doi:10.1016/j.jmb.2007.07.050.
    • (2007) J. Mol. Biol. , vol.373 , pp. 503-519
    • Wang, C.1    Bradley, P.2    Baker, D.3
  • 125
    • 84895922732 scopus 로고    scopus 로고
    • Mathematical modeling in cancer drug discovery
    • PID: 23831857
    • Wang, Z., and T. S. Deisboeck. Mathematical modeling in cancer drug discovery. Drug Discov. Today 19:145–150, 2014. doi:10.1016/j.drudis.2013.06.015.
    • (2014) Drug Discov. Today , vol.19 , pp. 145-150
    • Wang, Z.1    Deisboeck, T.S.2
  • 126
    • 0036201247 scopus 로고    scopus 로고
    • Electrical restitution and cardiac fibrillation
    • PID: 11942602
    • Weiss, J. N., et al. Electrical restitution and cardiac fibrillation. J. Cardiovasc. Electrophysiol. 13:292–295, 2002.
    • (2002) J. Cardiovasc. Electrophysiol. , vol.13 , pp. 292-295
    • Weiss, J.N.1
  • 127
    • 84857453874 scopus 로고    scopus 로고
    • If we designed airplanes like we design drugsaEuro broken vertical bar
    • COI: 1:CAS:528:DC%2BC38XhsV2ltrc%3D
    • Woltosz, W. S. If we designed airplanes like we design drugsaEuro broken vertical bar. J. Comput. Aid. Mol. Des. 26:159–163, 2012. doi:10.1007/s10822-011-9490-5.
    • (2012) J. Comput. Aid. Mol. Des. , vol.26 , pp. 159-163
    • Woltosz, W.S.1
  • 128
    • 84896497448 scopus 로고    scopus 로고
    • Arrhythmogenic transient dynamics in cardiac myocytes
    • COI: 1:CAS:528:DC%2BC2cXks1Wgs7o%3D, PID: 24655514
    • Xie, Y., L. T. Izu, D. M. Bers, and D. Sato. Arrhythmogenic transient dynamics in cardiac myocytes. Biophys. J. 106:1391–1397, 2014. doi:10.1016/j.bpj.2013.12.050.
    • (2014) Biophys. J. , vol.106 , pp. 1391-1397
    • Xie, Y.1    Izu, L.T.2    Bers, D.M.3    Sato, D.4
  • 130
    • 76749160779 scopus 로고    scopus 로고
    • Acute effects of sex steroid hormones on susceptibility to cardiac arrhythmias: a simulation study
    • PID: 20126530
    • Yang, P. C., J. Kurokawa, T. Furukawa, and C. E. Clancy. Acute effects of sex steroid hormones on susceptibility to cardiac arrhythmias: a simulation study. PLoS Comput. Biol. 6:e1000658, 2010. doi:10.1371/journal.pcbi.1000658.
    • (2010) PLoS Comput. Biol. , vol.6
    • Yang, P.C.1    Kurokawa, J.2    Furukawa, T.3    Clancy, C.E.4
  • 131
    • 84908457672 scopus 로고    scopus 로고
    • Quasiequivalence of multiscale coevolution and ensemble MD simulations: a demonstration with lactoferrin
    • Yang, J., A. Singharoy, Y. V. Sereda, and P. J. Ortoleva. Quasiequivalence of multiscale coevolution and ensemble MD simulations: a demonstration with lactoferrin. Chem. Phys. Lett. 616–617:154–160, 2014. doi:10.1016/j.cplett.2014.10.020.
    • (2014) Chem. Phys. Lett. , vol.616-617 , pp. 154-160
    • Yang, J.1    Singharoy, A.2    Sereda, Y.V.3    Ortoleva, P.J.4
  • 132
    • 84872373202 scopus 로고    scopus 로고
    • Computational assessment of drug-induced effects on the electrocardiogram: from ion channel to body surface potentials
    • COI: 1:CAS:528:DC%2BC3sXhsFKhsL4%3D, PID: 22946617
    • Zemzemi, N., et al. Computational assessment of drug-induced effects on the electrocardiogram: from ion channel to body surface potentials. Br. J. Pharmacol. 168:718–733, 2013. doi:10.1111/j.1476-5381.2012.02200.x.
    • (2013) Br. J. Pharmacol. , vol.168 , pp. 718-733
    • Zemzemi, N.1
  • 133
    • 78751705345 scopus 로고    scopus 로고
    • Multiscale modeling and simulation of soft adhesion and contact of stem cells
    • PID: 21262496
    • Zeng, X., and S. Li. Multiscale modeling and simulation of soft adhesion and contact of stem cells. J. Mech. Behav. Biomed. Mater. 4:180–189, 2011. doi:10.1016/j.jmbbm.2010.06.002.
    • (2011) J. Mech. Behav. Biomed. Mater. , vol.4 , pp. 180-189
    • Zeng, X.1    Li, S.2
  • 134
    • 80053013648 scopus 로고    scopus 로고
    • Structure-function map of the receptor site for beta-scorpion toxins in domain II of voltage-gated sodium channels
    • COI: 1:CAS:528:DC%2BC3MXhtFOitL%2FJ, PID: 21795675
    • Zhang, J. Z., et al. Structure-function map of the receptor site for beta-scorpion toxins in domain II of voltage-gated sodium channels. J. Biol. Chem. 286:33641–33651, 2011. doi:10.1074/jbc.M111.282509.
    • (2011) J. Biol. Chem. , vol.286 , pp. 33641-33651
    • Zhang, J.Z.1
  • 135
    • 84865733660 scopus 로고    scopus 로고
    • Mapping the interaction site for a beta-scorpion toxin in the pore module of domain III of voltage-gated Na(+) channels
    • COI: 1:CAS:528:DC%2BC38Xht1yqtLrN, PID: 22761417
    • Zhang, J. Z., et al. Mapping the interaction site for a beta-scorpion toxin in the pore module of domain III of voltage-gated Na(+) channels. J. Biol. Chem. 287:30719–30728, 2012. doi:10.1074/jbc.M112.370742.
    • (2012) J. Biol. Chem. , vol.287 , pp. 30719-30728
    • Zhang, J.Z.1
  • 136
    • 84864666223 scopus 로고    scopus 로고
    • Markov models of use-dependence and reverse use-dependence during the mouse cardiac action potential
    • COI: 1:CAS:528:DC%2BC38XhtFOlt73I, PID: 22879935
    • Zhou, Q., G. C. Bett, and R. L. Rasmusson. Markov models of use-dependence and reverse use-dependence during the mouse cardiac action potential. PLoS ONE 7:e42295, 2012. doi:10.1371/journal.pone.0042295.
    • (2012) PLoS ONE , vol.7
    • Zhou, Q.1    Bett, G.C.2    Rasmusson, R.L.3
  • 137
    • 36849092037 scopus 로고    scopus 로고
    • 2+channel mutations and T-wave alternans: a model study
    • COI: 1:CAS:528:DC%2BD2sXhsVOgtbzJ, PID: 17933974
    • 2+channel mutations and T-wave alternans: a model study. Am. J. Physiol. Heart Circ. Physiol. 293:H3480–H3489, 2007. doi:10.1152/ajpheart.00476.2007.
    • (2007) Am. J. Physiol. Heart Circ. Physiol. , vol.293 , pp. H3480-H3489
    • Zhu, Z.I.1    Clancy, C.E.2
  • 138
    • 84953790814 scopus 로고    scopus 로고
    • A computational, tissue-realistic model of pressure ulcer formation in individuals with spinal cord injury
    • PID: 26111346
    • Ziraldo, C., et al. A computational, tissue-realistic model of pressure ulcer formation in individuals with spinal cord injury. PLoS Comput. Biol. 11:e1004309, 2015. doi:10.1371/journal.pcbi.1004309.
    • (2015) PLoS Comput. Biol. , vol.11
    • Ziraldo, C.1


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