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Volumn 1, Issue 1, 2012, Pages

Has the time come for predictive computer modeling in CNS drug discovery and development?

Author keywords

[No Author keywords available]

Indexed keywords

ARIPIPRAZOLE; BIFEPRUNOX; CENTRAL NERVOUS SYSTEM AGENTS; DIMEBON;

EID: 84875456220     PISSN: None     EISSN: 21638306     Source Type: Journal    
DOI: 10.1038/psp.2012.17     Document Type: Review
Times cited : (18)

References (10)
  • 1
    • 4344645978 scopus 로고    scopus 로고
    • Can the pharmaceutical industry reduce attrition rates?
    • Kola, I. & Landis, J. Can the pharmaceutical industry reduce attrition rates?. Nat. Rev. Drug Discov. 3, 711-715 (2004
    • (2004) Nat. Rev. Drug Discov , vol.3 , pp. 711-715
    • Kola, I.1    Landis, J.2
  • 2
    • 79955601786 scopus 로고    scopus 로고
    • Trial watch: Phase II failures: 2008-2010
    • Arrowsmith, J. Trial watch: Phase II failures: 2008-2010. Nat. Rev. Drug Discov. 10, 328- 329 (2011
    • (2011) Nat. Rev. Drug Discov , vol.10 , pp. 328-329
    • Arrowsmith, J.1
  • 3
    • 70350338847 scopus 로고    scopus 로고
    • Of mice and men: Bridging the translational disconnect in CNS drug discovery
    • Geerts, H. Of mice and men: Bridging the translational disconnect in CNS drug discovery. CNS Drugs 23, 915-926 (2009
    • (2009) CNS Drugs , vol.23 , pp. 915-926
    • Geerts, H.1
  • 4
    • 35649001607 scopus 로고
    • A quantitative description of membrane current and its application to conduction and excitation in nerve
    • (Lond.)
    • Hodgkin, A.L. & Huxley, A.F. A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. (Lond.) 117, 500-544 (1952
    • (1952) J. Physiol , vol.117 , pp. 500-544
    • Hodgkin, A.L.1    Huxley, A.F.2
  • 5
    • 77954887669 scopus 로고    scopus 로고
    • Improving productivity with model-based drug development: An enterprise perspective
    • Grasela, T.H. & Slusser, R. Improving productivity with model-based drug development: An enterprise perspective. Clin. Pharmacol. Ther. 88, 263-268 (2010
    • (2010) Clin. Pharmacol. Ther , vol.88 , pp. 263-268
    • Grasela, T.H.1    Slusser, R.2
  • 6
    • 84862896528 scopus 로고    scopus 로고
    • A Quantitative systems pharmacology computer model for schizophrenia efficacy and extrapyramidal side effects
    • Spiros, A., Roberts, P., & Geerts, H. A Quantitative systems pharmacology computer model for schizophrenia efficacy and extrapyramidal side effects. Drug Dev. Res. 73, 1098-1109 (2012
    • (2012) Drug Dev. Res , vol.73 , pp. 1098-1109
    • Spiros, A.1    Roberts, P.2    Geerts, H.3
  • 7
    • 79961165805 scopus 로고    scopus 로고
    • Not all partial dopamine D(2) receptor agonists are the same in treating schizophrenia. Exploring the effects of bifeprunox and aripiprazole using a computer model of a primate striatal dopaminergic synapse
    • Spiros, A., Carr, R. & Geerts, H. Not all partial dopamine D(2) receptor agonists are the same in treating schizophrenia. Exploring the effects of bifeprunox and aripiprazole using a computer model of a primate striatal dopaminergic synapse. Neuropsychiatr. Dis. Treat. 6, 589-603 (2010
    • (2010) Neuropsychiatr. Dis. Treat , vol.6 , pp. 589-603
    • Spiros, A.1    Carr, R.2    Geerts, H.3
  • 8
    • 84881217762 scopus 로고    scopus 로고
    • Failure analysis of dimebon using mechanistic disease modeling: Lessons for clinical development of new AD therapies
    • Geerts H., Roberts, P., & Spiros, A. Failure analysis of dimebon using mechanistic disease modeling: lessons for clinical development of new AD therapies. Alzheimer's & Dementia 8 (suppl.311), P1-307 (2012
    • (2012) Alzheimer's & Dementia , vol.8 , Issue.SUPPL. 311
    • Geerts, H.1    Roberts, P.2    Spiros, A.3
  • 9
    • 80053135628 scopus 로고    scopus 로고
    • Integrated multiscale modeling of the nervous system: Predicting changes in hippocampal network activity by a positive AMPA receptor modulator
    • Bouteiller, J.M. et al. Integrated multiscale modeling of the nervous system: Predicting changes in hippocampal network activity by a positive AMPA receptor modulator. IEEE Trans. Biomed. Eng. 58, 3008-3011 (2011
    • (2011) IEEE Trans. Biomed. Eng , vol.58 , pp. 3008-3011
    • Bouteiller, J.M.1
  • 10
    • 25844469581 scopus 로고    scopus 로고
    • Translational research in central nervous system drug discovery
    • Hurko, O. & Ryan, J.L. Translational research in central nervous system drug discovery. NeuroRx 2, 671-682 (2005
    • (2005) NeuroRx , vol.2 , pp. 671-682
    • Hurko, O.1    Ryan, J.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.