Computational model for nanocarrier binding to endothelium validated using in vivo, in vitro, and atomic force microscopy experiments

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 38, 2010, Pages 16530-16535

  Liu, Jin ^a   Weller, Gregory E R ^b   Zern, Blaine ^b,c   Ayyaswamy, Portonovo S ^a   Eckmann, David M ^a,b   Muzykantov, Vladimir R ^b,c   Radhakrishnan, Ravi ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Absolute binding free energy; Antibody surface coverage; Monte Carlo; Multivalent interactions; Targeted drug delivery

Indexed keywords

ANTIBODY; CELL ANTIBODY; INTRACELLULAR ADHESION MOLECULE 1; INTRACELLULAR ADHESION MOLECULE 1 ANTIBODY; NANOCARRIER; UNCLASSIFIED DRUG; DRUG CARRIER; INTERCELLULAR ADHESION MOLECULE 1; NANOSPHERE;

ANIMAL CELL; ARTICLE; ATOMIC FORCE MICROSCOPY; CELL SURFACE; ENDOTHELIUM; FEMALE; HISTOGRAM; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR BACTERIUM; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BIOLOGICAL MODEL; BIOPHYSICS; C57BL MOUSE; DRUG DELIVERY SYSTEM; ENDOTHELIUM CELL; GLYCOCALYX; IMMUNOLOGY; LUNG; METABOLISM; MONTE CARLO METHOD; THERMODYNAMICS; VALIDATION STUDY; VASCULARIZATION;

MUS;

ANIMALS; ANTIBODIES; BIOPHYSICAL PHENOMENA; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; ENDOTHELIAL CELLS; FEMALE; GLYCOCALYX; IN VITRO TECHNIQUES; INTERCELLULAR ADHESION MOLECULE-1; LUNG; MICE; MICE, INBRED C57BL; MICROSCOPY, ATOMIC FORCE; MODELS, BIOLOGICAL; MONTE CARLO METHOD; NANOSPHERES; THERMODYNAMICS;

EID: 78049238597     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1006611107     Document Type: Article

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