Progesterone regulates cardiac repolarization through a nongenomic pathway: An in vitro patch-clamp and computational modeling study

Circulation

Volumn 116, Issue 25, 2007, Pages 2913-2922

  Nakamura, Hiroaki ^a,b   Kurokawa, Junko ^a   Bai, Chang Xi ^a   Asada, Ken ^a   Xu, Jun ^c   Oren, Ronit V ^c   Zhu, Zheng I ^c   Clancy, Colleen E ^c   Isobe, Mitsuaki ^b   Furukawa, Tetsushi ^a,d  

^a Tokyo Scientific Research Institute   (Japan)

^b GRADUATE SCHOOL OF MEDICINE   (Japan)

^c Department of Obstetrics Gynecology   (United States)

^d NONE   (Japan)

Author keywords

Arrhythmia; Computers; Ion channel; Long QT syndrome; Nitric oxide; Progesterone

Indexed keywords

CALCIUM CHANNEL L TYPE; CYCLIC AMP; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHATIDYLINOSITOL 3 KINASE; POTASSIUM CHANNEL KCNQ1; PROGESTERONE; PROTEIN KINASE B;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ARTICLE; CAVEOLA; CONTROLLED STUDY; FEMALE; GUINEA PIG; HEART ARRHYTHMIA; HEART MUSCLE CELL; HEART REPOLARIZATION; HEART RHYTHM; HEART VENTRICLE; HORMONE ACTION; LONG QT SYNDROME; MATHEMATICAL MODEL; MENSTRUAL CYCLE; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; QT INTERVAL; TORSADE DES POINTES; VOLTAGE CLAMP;

ACTION POTENTIALS; ANIMALS; COMPUTATIONAL BIOLOGY; CYCLIC AMP; FEMALE; GUINEA PIGS; LONG QT SYNDROME; MODELS, CARDIOVASCULAR; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; NITRIC OXIDE; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; PROGESTERONE; SEX FACTORS; SIGNAL TRANSDUCTION; TORSADES DE POINTES;

EID: 37349125566     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.107.702407     Document Type: Article

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