Mathematical modeling of liver injury and dysfunction after acetaminophen overdose: Early discrimination between survival and death

Hepatology

Volumn 56, Issue 2, 2012, Pages 727-734

  Remien, Christopher H ^a   Adler, Frederick R ^a   Waddoups, Lindsey ^a   Box, Terry D ^a   Sussman, Norman L ^b  

^a UNIVERSITY OF UTAH   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CREATININE; PARACETAMOL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CREATININE BLOOD LEVEL; DEATH; DRUG OVERDOSE; HUMAN; INTERNATIONAL NORMALIZED RATIO; LIVER DYSFUNCTION; LIVER INJURY; MAJOR CLINICAL STUDY; MATHEMATICAL MODEL; PREDICTIVE VALUE; PRIORITY JOURNAL; PROGNOSIS; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; SURVIVAL; UNITED STATES;

ACETAMINOPHEN; ALANINE TRANSAMINASE; ANALGESICS, NON-NARCOTIC; ASPARTATE AMINOTRANSFERASES; CREATININE; DRUG-INDUCED LIVER INJURY; HEPATOCYTES; HUMANS; INTERNATIONAL NORMALIZED RATIO; MODELS, BIOLOGICAL; MODELS, STATISTICAL; OVERDOSE; PREDICTIVE VALUE OF TESTS; SENSITIVITY AND SPECIFICITY;

EID: 84864345143     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.25656     Document Type: Article

References (47)

1. Nourjah P, Ahmad SR, Karwoski C, Willy M. Estimates of acetaminophen (Paracetamol)-associated overdoses in the United States. Pharmacoepidemiol Drug Saf 2006; 15: 398-405.
2. Mitchell JR, Jollow DJ, Potter WZ, Davis DC, Gillette JR, Brodie BB. Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. J Pharmacol Exp Ther 1973; 187: 185-194.
3. Bond GR. Acetaminophen protein adducts: a review. Clin Toxicol 2009; 47: 2-7.
4. Mitchell JR, Jollow DJ, Potter WZ, Gillette JR, Brodie BB. Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. J Pharmacol Exp Ther 1973; 187: 211-217.
5. Mitchell JR, Thorgeirsson SS, Potter WZ, Jollow DJ, Keiser H. Acetaminophen-induced hepatic injury: protective role of glutathione in man and rationale for therapy. Clin Parmacol Ther 1974; 16: 676-684.
6. Potter WZ, Davis DC, Mitchell JR, Jollow DJ, Gillette JR, Brodie BB. Acetaminophen-induced hepatic necrosis. III. Cytochrome p-450 mediated covalent binding in vitro. J Pharmacol Exp Ther 1973; 187: 203-210.
7. Jollow DJ, Mitchell JR, Potter WZ, Davis DC, Gillette JR, Brodie BB. Acetaminophen-induced hepatic necrosis II. Role of covalent binding in vivo. J Pharmacol Exp Ther 1973; 187: 195-202.
8. Schmidt LE, Dalhoff K, Poulsen HE. Acute versus chronic alcohol consumption in acetaminophen-induced hepatotoxicity. HEPATOLOGY 2002; 35: 876-882.
9. Smilkstein MJ, Knapp GL, Kulig KW, Rumack BH. Efficacy of oral N-acetylcystein in the treatment of acetaminophen overdose: analysis of the National Multicenter Study (1975 to 1985). N Engl J Med 1988; 319: 1557-1562.
10. Singer AJ, Carracio TR, Mofenson HC. The temporal profile of increased transaminase levels in patients with acetaminophen-induced liver dysfunction. Ann Emerg Med 1995; 25: 49-53.
11. Slattery JT, Wilson JM, Kalhorn TF, Nelson SD. Dose-dependent pharmacokinetics of acetaminophen: evidence of glutathione depletion in humans. Clin Pharmacol Ther 1987; 41: 413-418.
12. Price CP, Alberti KGMM. Biochemical assessment of liver function. In: Wright R, Alberti KGMM, Karran S, Millward-Sadler GH, eds. Liver and Biliary Disease: Pathophysiology, Diagnosis, Management. London: WB Saunders; 1979: 381-416.
13. Harrison PM, O'Grady JG, Keays RT, Alexander GJ, Williams R. Serial prothrombin time as prognostic indicator in paracetamol induced fulminant hepatic failure. Br Med J 1990; 301: 964-966.
14. Sohlenius-Sternbeck AK. Determination of the hepatocellularity number for human, dog, rabbit, rat and mouse livers from protein concentration measurements. Toxicol In Vitro 2006; 20: 1582-1586.
15. Furchtgott LA, Chow CC, Periwal V. A model of liver regeneration. Biophys J 2009; 96: 3926-3935.
16. Donaldson BW, Gopinath R, Wanless IR, Phillips MJ, Cameron R, Roberts EA, et al. The role of transjugular liver biopsy in fulminant liver failure: relation to other prognostic indicators. HEPATOLOGY 1993; 18: 1370-1376.
17. Rumack BH, Matthew H. Acetaminophen poisoning and toxicity. Pediatrics 1975; 55: 871-876.
18. Miner DJ, Kissinger PT. Evidence for the involvement of n-acetyl-p-benzoquinone imine in acetaminophen metabolism. Biochem Pharmacol 1979; 28: 3285-3290.
19. Ookhtens M, Hobdy K, Corvasce MC, Aw TY, Kaplowitz N. Sinusoidal efflux of glutathione in the perfused rat liver. J Clin Invest 1985; 75: 258-265.
20. Lauterburg BH, Adams JD, Mitchell JR. Hepatic glutathione homeostasis in the rat: efflux accounts for glutathione turnover. HEPATOLOGY 1984; 4: 586-590.
21. Aw TY, Ookhtens M, Clement R, Kaplowitz N. Kinetics of glutathione efflux from isolated rat hepatocytes. Am J Physiol Gast Liver 1986; 250: G236-G243.
22. Pehlivanov B, Milchev N, Kroumov G. Factor VII deficiency and its treatment in delivery with recombinant factor VII. Eur J Obst Gynecol Reprod Biol 2004; 116: 237-238.
23. Chun LJ, Tong MJ, Busuttil RW, Hiatt JR. Acetaminophen hepatotoxicity and acute liver failure. J Clin Gastroenterol 2009; 43: 342-349.
24. O'Grady JG, Alexander GJ, Hayllar KM, Williams R. Early indicators of prognosis in fulminant hepatic failure. Gastroenterology 1989; 97: 439-445.
25. Lee WM, Squires RH, Nyberg SL, Doo E, Hoofnagle JH. Acute liver failure: summary of a workshop. HEPATOLOGY 2008; 47: 1401-1415.
26. Sivilotti MLA, Good AM, Yarema MC, Juurlink DN, Johnson DW. A new predictor of toxicity following acetaminophen overdose based on pretreatment exposure. Clin Toxicol 2005; 43: 229-234.
27. Craig DG, Ford AC, Hayes PC, Simpson KJ. Systematic review: prognostic tests of paracetamol-induced acute liver failure. Aliment Pharmacol Ther 2010; 31: 1064-1976.
28. Bailey B, Amre DK, Gaudreault P. Fulminant hepatic failure secondary to acetaminophen poisoning: a systematic review and meta-analysis of prognostic criteria determining the need for liver transplantation. Crit Care Med 2003; 31: 299-305.
29. Renner EL. How to decide when to list a patient with acute liver failure for liver transplantation? Clichy or King's College Criteria, or something else? J Hepatol 2007; 46: 554-557.
30. Schmidt LE, Dalhoff K. Alpha-fetoprotein is a predictor of outcome in acetaminophen-induced liver injury. HEPATOLOGY 2005; 41: 26-31.
31. Mitchell I, Bihari D, Chang R, Wendon J, Williams R. Earlier identification of patients at risk from acetaminophen-induced acute liver failure. Crit Care Med 1998; 26: 279-284.
32. Bernal W, Auzinger G, Sizer E, Wendon J. Early prediction of outcome of acute liver failure using bedside measurement of interleukin-6. HEPATOLOGY 2007; 46(Suppl 1): 617A.
33. Zaman MB, Hoti E, Qasim A, Maguire D, McCormick PA, Hegarty JE, et al. MELD score as a prognostic model for listing acute liver failure patients for liver transplantation. Transplant Proc 2006; 38: 2097-2098.
34. Bechmann LP, Jochum C, Kocabayoglu P, Sowa JP, Kassalik M, Gieseler RK, et al. Cytokeratin 18-based modification of the MELD score improves prediction of spontaneous survival after acute liver injury. J Hepatol 2010; 53: 639-647.
35. Bernal W, Wendon J. More on serum phosphate and prognosis of acute liver failure. HEPATOLOGY 2003; 38: 533-534.
36. Bernal W, Donaldson N, Wyncoll D, Wendon J. Blood lactate as an early predictor of outcome in paracetamol-induced acute liver failure: a cohort study. Lancet 2002; 359: 558-563.
37. Schmidt LE, Larsen FS. Is lactate concentration of major value in determining the prognosis in patients with acute liver failure? Hardly. J Hepatol 2010; 53: 211-212.
38. Rumack BH. Acetaminophen overdose in young children. Am J Dis Child 1984; 138: 428-433.
39. McClain CJ, Kromhout JP, Peterson FJ, Holtzman JL. Potentiation of acetaminophen hepatotoxicity by alcohol. JAMA 1980; 244: 251-253.
40. Lesser PB, Vietti MM, Clark WD. Lethal enhancement of therapeutic doses of acetaminophen by alcohol. Dig Dis Sci 1986; 3: 103-105.
41. Bonkovsky HL, Kane RE, Jones DP, Galinsky RE, Banner B. Acute hepatic and renal toxicity from low doses of acetaminophen in the absence of alcohol abuse of malnutrition: evidence for increased susceptibility to drug toxicity due to cardiopulmonary and renal insufficiency. HEPATOLOGY 1994; 19: 1141-1148.
42. McClements BM, Hyland M, Callender ME, Blair TL. Management of paracetamol poisoning complicated by enzyme induction due to alcohol or drugs. Lancet 1990; 335: 1526.
43. Pirotte JH. Apparent potentiation of hepatotoxicity from small doses of acetaminophen by phenobarbital. Ann Intern Med 1984; 101: 403.
44. Crippin JS. Acetaminophen hepatotoxicity: potentiation by isoniazid. Am J Gastroenterol 1993; 88: 590-592.
45. James LP, Letzig L, Simpson PM, Capparelli E, Roberts DW, Hinson JA, et al. Pharmacokinetics of acetaminophen protein adducts in adults with acetaminophen overdose and acute liver failure. Drug Metab Dispos 2009; 37: 1-6.
46. Gregory B, Larson AM, Reisch J, Lee WM. Acetaminophen dose does not predict outcome in acetaminophen-induced acute liver failure. J Invest Med 2010; 58: 707-710.
47. Larson AM, Polson J, Fontana RJ, Davern TJ, Lalani E, Hynan LS, et al. Acetaminophen-induced acute liver failure: Results of a United States multicenter, prospective study. HEPATOLOGY 2005; 42: 1364-1372.