Mapping the interaction site for a β-scorpion toxin in the pore module of domain III of voltage-gated Na+ channels

Journal of Biological Chemistry

Volumn 287, Issue 36, 2012, Pages 30719-30728

  Zhang, Joel Z ^a   Yarov Yarovoy, Vladimir ^a,c   Scheuer, Todd ^a   Karbat, Izhar ^b   Cohen, Lior ^b   Gordon, Dalia ^b   Gurevitz, Michael ^b   Catterall, William A ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b TEL AVIV UNIVERSITY   (Israel)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTION POTENTIALS; AMINO ACID RESIDUES; BIDIRECTIONAL EFFECTS; BINDING AFFINITIES; CHANNEL GATING; EXCITABLE CELLS; EXTRACELLULAR LOOPS; INTERACTION SITE; MOLECULAR INSIGHTS; NEGATIVE INTERACTION; RECEPTOR SITES; RESTING STATE; ROSETTA; SITE DIRECTED MUTAGENESIS; THREE-DIMENSIONAL MODEL; TOXIN-CHANNEL INTERACTIONS; TRAPPING MECHANISMS; VOLTAGE CLAMP; VOLTAGE SENSOR;

AMINO ACIDS; BINDING ENERGY; ELECTROPHYSIOLOGY; ENZYME ACTIVITY; METABOLITES; SENSORS; SODIUM; THREE DIMENSIONAL;

TOXIC MATERIALS;

ALPHA SCORPION TOXIN; BETA SCORPION TOXIN; SCORPION VENOM; SODIUM CHANNEL NAV1.2; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CENTRUROIDES SUFFUSUS SUFFUSUS; CHANNEL GATING; COMPLEX FORMATION; CONTROLLED STUDY; PRIORITY JOURNAL; SCORPION; SITE DIRECTED MUTAGENESIS; VOLTAGE CLAMP;

AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; ION CHANNEL GATING; MUTATION, MISSENSE; NAV1.2 VOLTAGE-GATED SODIUM CHANNEL; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RATS; SCORPION VENOMS;

CENTRUROIDES SUFFUSUS SUFFUSUS; SCORPIONES;

EID: 84865733660     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.370742     Document Type: Article

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