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Volumn 5, Issue 4, 2013, Pages 461-480

Agent-based modeling: A systematic assessment of use cases and requirements for enhancing pharmaceutical research and development productivity

Author keywords

[No Author keywords available]

Indexed keywords

AGENT BASED MODELING AND SIMULATION; CLINICAL RESEARCH; COMPUTER MODEL; DECISION MAKING; DRUG INDUSTRY; INFORMATION TECHNOLOGY; KNOWLEDGE; MODEL; PHARMACEUTICS; PREDICTION; PRODUCTIVITY; REVIEW; SIMULATION; UNCERTAINTY;

EID: 84879287149     PISSN: 19395094     EISSN: 1939005X     Source Type: Journal    
DOI: 10.1002/wsbm.1222     Document Type: Review
Times cited : (35)

References (172)
  • 3
    • 0037076356 scopus 로고    scopus 로고
    • Agent-based modeling: a revolution?
    • doi:10.1073/pnas.072081299.
    • Bankes SC. Agent-based modeling: a revolution? Proc Natl Acad Sci USA 2002, 99:7199-7200. doi:10.1073/pnas.072081299.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 7199-7200
    • Bankes, S.C.1
  • 4
    • 0037076425 scopus 로고    scopus 로고
    • Agent-based modeling: methods and techniques for simulating human systems
    • doi:10.1073/pnas.082080899
    • Bonabeau E. Agent-based modeling: methods and techniques for simulating human systems. Proc Natl Acad Sci USA 2002, 99(suppl 3):7280-7287. doi:10.1073/pnas.082080899.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.SUPPL 3 , pp. 7280-7287
    • Bonabeau, E.1
  • 6
    • 49149145193 scopus 로고
    • Cannibalism and size dispersal in young-of-the-year largemouth bass: experiment and model
    • DeAngelis DL, Cox DK, Coutant CC. Cannibalism and size dispersal in young-of-the-year largemouth bass: experiment and model. Ecol Model 1979, 8:133-148.
    • (1979) Ecol Model , vol.8 , pp. 133-148
    • DeAngelis, D.L.1    Cox, D.K.2    Coutant, C.C.3
  • 7
    • 30344446670 scopus 로고    scopus 로고
    • Individual-based modeling of ecological and evolutionary processes
    • doi:10.1146/annurev.ecolsys.36.102003.152644.
    • DeAngelis DL, Mooij WM. Individual-based modeling of ecological and evolutionary processes. Annu Rev Ecol Evol Syst 2005, 36:147-168. doi:10.1146/annurev.ecolsys.36.102003.152644.
    • (2005) Annu Rev Ecol Evol Syst , vol.36 , pp. 147-168
    • DeAngelis, D.L.1    Mooij, W.M.2
  • 9
    • 0033557660 scopus 로고    scopus 로고
    • Ten years of individual-based modelling in ecology: what have we learned and what could we learn in the future?
    • doi:10.1016/S0304-3800(98)00188-4.
    • Grimm V. Ten years of individual-based modelling in ecology: what have we learned and what could we learn in the future? Ecol Model 1999, 115:129-148. doi:10.1016/S0304-3800(98)00188-4.
    • (1999) Ecol Model , vol.115 , pp. 129-148
    • Grimm, V.1
  • 10
    • 0028181670 scopus 로고
    • The rise of the individual-based model in ecology
    • doi:10.1016/ 0169-5347(94)90225-9.
    • Judson OP. The rise of the individual-based model in ecology. Trends Ecol Evol 1994, 9:9-14. doi:10.1016/ 0169-5347(94)90225-9.
    • (1994) Trends Ecol Evol , vol.9 , pp. 9-14
    • Judson, O.P.1
  • 11
    • 0037076306 scopus 로고    scopus 로고
    • Software agents and the route to the information economy
    • doi:10.1073/pnas.082080499
    • Kephart JO. Software agents and the route to the information economy. Proc Natl Acad Sci USA 2002, 99(suppl 3):7207-7213. doi:10.1073/pnas.082080499.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.SUPPL 3 , pp. 7207-7213
    • Kephart, J.O.1
  • 12
    • 0037076423 scopus 로고    scopus 로고
    • Short-memory traders and their impact on group learning in financial markets
    • doi:10.1073/pnas.072079699
    • LeBaron B. Short-memory traders and their impact on group learning in financial markets. Proc Natl Acad Sci USA 2002, 99(suppl 3):7201-7206. doi:10.1073/pnas.072079699.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.SUPPL 3 , pp. 7201-7206
    • LeBaron, B.1
  • 14
    • 0007834833 scopus 로고    scopus 로고
    • Predicting fish population dynamics: compensation and the importance of site-specific considerations
    • doi:10.1016/S1462-9011(00)00054-X
    • Rose KA, Cowan JH. Predicting fish population dynamics: compensation and the importance of site-specific considerations. Environ Sci Policy 2000, 3(suppl 1):433-443. doi:10.1016/S1462-9011(00)00054-X.
    • (2000) Environ Sci Policy , vol.3 , Issue.SUPPL 1 , pp. 433-443
    • Rose, K.A.1    Cowan, J.H.2
  • 16
    • 79951738971 scopus 로고    scopus 로고
    • An agent-based model of income inequalities in diet in the context of residential segregation
    • doi:10.1016/j.amepre.2010.10.033
    • Auchincloss AH, Riolo RL, Brown DG, Cook J, Diez Roux AV. An agent-based model of income inequalities in diet in the context of residential segregation. Am J Prev Med 2011, 40:303-311. doi:10.1016/j.amepre.2010.10.033.
    • (2011) Am J Prev Med , vol.40 , pp. 303-311
    • Auchincloss, A.H.1    Riolo, R.L.2    Brown, D.G.3    Cook, J.4    Diez Roux, A.V.5
  • 18
    • 3042695979 scopus 로고    scopus 로고
    • Multi-agent simulations and ecosystem management: a review
    • doi:10.1016/j.ecolmodel.2004.01.011.
    • Bousquet F, Le Page C. Multi-agent simulations and ecosystem management: a review. Ecol Model 2004, 176:313-332. doi:10.1016/j.ecolmodel.2004.01.011.
    • (2004) Ecol Model , vol.176 , pp. 313-332
    • Bousquet, F.1    Le Page, C.2
  • 19
    • 38349192323 scopus 로고    scopus 로고
    • Symmetric competition causes population oscillations in an individual-based model of forest dynamics
    • doi:10.1016/j.ecolmodel.2007.10.002.
    • Caplat P, Anand M, Bauch C. Symmetric competition causes population oscillations in an individual-based model of forest dynamics. Ecol Model 2008, 211:491-500. doi:10.1016/j.ecolmodel.2007.10.002.
    • (2008) Ecol Model , vol.211 , pp. 491-500
    • Caplat, P.1    Anand, M.2    Bauch, C.3
  • 20
    • 33847631664 scopus 로고    scopus 로고
    • Combination of process-oriented and pattern-oriented models of land-use change in a mountain area of Vietnam
    • doi:10.1016/j.ecolmodel.2006.11.011.
    • Castella J-C, Verburg PH. Combination of process-oriented and pattern-oriented models of land-use change in a mountain area of Vietnam. Ecol Model 2007, 202:410-420. doi:10.1016/j.ecolmodel.2006.11.011.
    • (2007) Ecol Model , vol.202 , pp. 410-420
    • Castella, J.-C.1    Verburg, P.H.2
  • 21
    • 45049084332 scopus 로고    scopus 로고
    • An individual-based model to describe a bullhead population dynamics including temperature variations
    • doi:10.1016/j.ecolmodel.2008.04.005.
    • Charles S, Subtil F, Kielbassa J, Pont D. An individual-based model to describe a bullhead population dynamics including temperature variations. Ecol Model 2008, 215:377-392. doi:10.1016/j.ecolmodel.2008.04.005.
    • (2008) Ecol Model , vol.215 , pp. 377-392
    • Charles, S.1    Subtil, F.2    Kielbassa, J.3    Pont, D.4
  • 22
    • 34447620153 scopus 로고    scopus 로고
    • Modeling fish population movements: from an individual-based representation to an advection-diffusion equation
    • doi:10.1016/j.jtbi.2007.04.012.
    • Faugeras B, Maury O. Modeling fish population movements: from an individual-based representation to an advection-diffusion equation. J Theor Biol 2007, 247:837-848. doi:10.1016/j.jtbi.2007.04.012.
    • (2007) J Theor Biol , vol.247 , pp. 837-848
    • Faugeras, B.1    Maury, O.2
  • 23
    • 25144450815 scopus 로고    scopus 로고
    • Uses of agent-based modeling in innovation/new product development research
    • doi:10.1111/ j.1540-5885.2005.00136.x.
    • Garcia R. Uses of agent-based modeling in innovation/new product development research. J Prod Innovat Manage 2005, 22:380-398. doi:10.1111/ j.1540-5885.2005.00136.x.
    • (2005) J Prod Innovat Manage , vol.22 , pp. 380-398
    • Garcia, R.1
  • 24
    • 79951800277 scopus 로고    scopus 로고
    • From the special issue editors: agent-based modeling of innovation diffusion
    • doi:10.1111/j.1540-5885.2011.00788.x.
    • Garcia R, Jager W. From the special issue editors: agent-based modeling of innovation diffusion. J Prod Innovat Manage 2011, 28:148-151. doi:10.1111/j.1540-5885.2011.00788.x.
    • (2011) J Prod Innovat Manage , vol.28 , pp. 148-151
    • Garcia, R.1    Jager, W.2
  • 26
    • 79953024051 scopus 로고    scopus 로고
    • Trade-off between road avoidance and attraction by roadside salt pools in moose: An agent-based model to assess measures for reducing moose-vehicle collisions
    • doi:10.1016/j.ecolmodel.2011.01.022.
    • Grosman PD, Jaeger JAG, Biron PM, Dussault C, Oullet J-P. Trade-off between road avoidance and attraction by roadside salt pools in moose: An agent-based model to assess measures for reducing moose-vehicle collisions. Ecol Model 2011, 222:1423-1435. doi:10.1016/j.ecolmodel.2011.01.022.
    • (2011) Ecol Model , vol.222 , pp. 1423-1435
    • Grosman, P.D.1    Jaeger, J.A.G.2    Biron, P.M.3    Dussault, C.4    Oullet, J.-P.5
  • 28
    • 21544472391 scopus 로고    scopus 로고
    • Simulating ancient societies
    • 84. doi:10.1038/scientificamerican0705-76
    • Kohler TA, Gumerman GJ, Reynolds RG. Simulating ancient societies. Sci Am 2005, 293:76-82, 84. doi:10.1038/scientificamerican0705-76.
    • (2005) Sci Am , vol.293 , pp. 76-82
    • Kohler, T.A.1    Gumerman, G.J.2    Reynolds, R.G.3
  • 29
    • 35248874731 scopus 로고    scopus 로고
    • A multi-agent based framework for the simulation of human and social behaviors during emergency evacuations
    • doi:10.1186/1471-2105-6-228.
    • Pan X, Han CS, Dauber K, Law KH. A multi-agent based framework for the simulation of human and social behaviors during emergency evacuations. AI Soc 2007, 22:113-132. doi:10.1186/1471-2105-6-228.
    • (2007) AI Soc , vol.22 , pp. 113-132
    • Pan, X.1    Han, C.S.2    Dauber, K.3    Law, K.H.4
  • 30
    • 64149117527 scopus 로고    scopus 로고
    • Simulation of the vegetation structure and function in a Malaysian tropical rain forest using the individual-based dynamic vegetation model SEIB-DGVM
    • doi:10.1016/j.foreco.2009.03.002.
    • Sato H. Simulation of the vegetation structure and function in a Malaysian tropical rain forest using the individual-based dynamic vegetation model SEIB-DGVM. Forest Ecol Manage 2009, 257:2277-2286. doi:10.1016/j.foreco.2009.03.002.
    • (2009) Forest Ecol Manage , vol.257 , pp. 2277-2286
    • Sato, H.1
  • 31
    • 77956637116 scopus 로고    scopus 로고
    • Agent-based modeling of animal movement: a review
    • doi:10.1111/j.1749-8198.2010.00337.x.
    • Tang W, Bennett DA. Agent-based modeling of animal movement: a review. Geography Compass 2010, 4:682-700. doi:10.1111/j.1749-8198.2010.00337.x.
    • (2010) Geography Compass , vol.4 , pp. 682-700
    • Tang, W.1    Bennett, D.A.2
  • 32
    • 80052565478 scopus 로고    scopus 로고
    • Agent-based modeling in marketing: Guidelines for rigor
    • doi:10.1016/j.ijresmar.2011.04.002.
    • Rand R, Rust RT. Agent-based modeling in marketing: Guidelines for rigor. Int J Res Market 2011, 28:181-193. doi:10.1016/j.ijresmar.2011.04.002.
    • (2011) Int J Res Market , vol.28 , pp. 181-193
    • Rand, R.1    Rust, R.T.2
  • 33
    • 77956300313 scopus 로고    scopus 로고
    • Tutorial on agent-based modelling and simulation
    • doi:10.1057/jos.2010.3.
    • Macal CM, North MJ. Tutorial on agent-based modelling and simulation. J Simul 2010, 4:151-162. doi:10.1057/jos.2010.3.
    • (2010) J Simul , vol.4 , pp. 151-162
    • Macal, C.M.1    North, M.J.2
  • 34
    • 0035491584 scopus 로고    scopus 로고
    • Agent-based computer simulation and sirs: building a bridge between basic science and clinical trials
    • An G. Agent-based computer simulation and sirs: building a bridge between basic science and clinical trials. Shock 2001, 16:266-273.
    • (2001) Shock , vol.16 , pp. 266-273
    • An, G.1
  • 35
    • 23744434889 scopus 로고    scopus 로고
    • Agent-based modeling of the context dependency in T cell recognition
    • doi:10.1016/j.jtbi.2005.03.019.
    • Casal A, Sumen C, Reddy TE, Alber MS, Lee PP. Agent-based modeling of the context dependency in T cell recognition. J Theor Biol 2005, 236:376-391. doi:10.1016/j.jtbi.2005.03.019.
    • (2005) J Theor Biol , vol.236 , pp. 376-391
    • Casal, A.1    Sumen, C.2    Reddy, T.E.3    Alber, M.S.4    Lee, P.P.5
  • 36
    • 0032436318 scopus 로고    scopus 로고
    • Bacsim, a simulator for individual-based modelling of bacterial colony growth
    • doi:10.1099/00221287-144-12-3275.
    • Kreft JU, Booth G, Wimpenny JWT. Bacsim, a simulator for individual-based modelling of bacterial colony growth. Microbiology 1998, 144:3275-3287. doi:10.1099/00221287-144-12-3275.
    • (1998) Microbiology , vol.144 , pp. 3275-3287
    • Kreft, J.U.1    Booth, G.2    Wimpenny, J.W.T.3
  • 37
    • 0036428799 scopus 로고    scopus 로고
    • Emerging patterns in tumor systems: simulating the dynamics of multicellular clusters with an agent-based spatial agglomeration model
    • doi:10.1006/jtbi.2002.3131.
    • Mansury Y, Kimura M, Lobo J, Deisboeck TS. Emerging patterns in tumor systems: simulating the dynamics of multicellular clusters with an agent-based spatial agglomeration model. J Theor Biol 2002, 219:343-370. doi:10.1006/jtbi.2002.3131.
    • (2002) J Theor Biol , vol.219 , pp. 343-370
    • Mansury, Y.1    Kimura, M.2    Lobo, J.3    Deisboeck, T.S.4
  • 38
    • 6344281115 scopus 로고    scopus 로고
    • Identifying control mechanisms of granuloma formation during M. tuberculosis infection using an agent-based model
    • doi:10.1016/j.jtbi.2004.06.031.
    • Segovia-Juarez JL, Ganguli S, Kirschner D. Identifying control mechanisms of granuloma formation during M. tuberculosis infection using an agent-based model. J Theor Biol 2004, 231:357-376. doi:10.1016/j.jtbi.2004.06.031.
    • (2004) J Theor Biol , vol.231 , pp. 357-376
    • Segovia-Juarez, J.L.1    Ganguli, S.2    Kirschner, D.3
  • 39
    • 34548342938 scopus 로고    scopus 로고
    • Combining experiments with multi-cell agent-based modeling to study biological tissue patterning
    • doi:10.1093/bib/bbm024.
    • Thorne BC, Bailey AM, Peirce SM. Combining experiments with multi-cell agent-based modeling to study biological tissue patterning. Brief Bioinform 2007, 8:245-257. doi:10.1093/bib/bbm024.
    • (2007) Brief Bioinform , vol.8 , pp. 245-257
    • Thorne, B.C.1    Bailey, A.M.2    Peirce, S.M.3
  • 41
    • 84881524954 scopus 로고    scopus 로고
    • Population structuring of multi-copy, antigen-encoding genes in Plasmodium falciparum
    • doi:10.7554/ eLife.00093.
    • Artzy-Randrup Y, Rorick MM, Day K, Chen D, Dobson AP, Pascual M. Population structuring of multi-copy, antigen-encoding genes in Plasmodium falciparum eLife 2012, 1:e00093. doi:10.7554/ eLife.00093.
    • (2012) eLife , vol.1
    • Artzy-Randrup, Y.1    Rorick, M.M.2    Day, K.3    Chen, D.4    Dobson, A.P.5    Pascual, M.6
  • 42
    • 61449164943 scopus 로고    scopus 로고
    • Agent-based model of therapeutic adipose-derived stromal cell trafficking during ischemia predicts ability to roll on P-selectin
    • doi:10.1371/journal.pcbi.1000294.
    • Bailey AM, Lawrence MB, Shang H, Katz AJ, Peirce SM. Agent-based model of therapeutic adipose-derived stromal cell trafficking during ischemia predicts ability to roll on P-selectin. PLoS Comput Biol 2009, 5:e1000294. doi:10.1371/journal.pcbi.1000294.
    • (2009) PLoS Comput Biol , vol.5
    • Bailey, A.M.1    Lawrence, M.B.2    Shang, H.3    Katz, A.J.4    Peirce, S.M.5
  • 43
    • 77149134316 scopus 로고    scopus 로고
    • Agent-based simulation of T-cell activation and proliferation within a lymph node
    • doi:10.1038/icb.2009.78.
    • Bogle G, Dunbar PR. Agent-based simulation of T-cell activation and proliferation within a lymph node. Immunol Cell Biol 2010, 88:172-179. doi:10.1038/icb.2009.78.
    • (2010) Immunol Cell Biol , vol.88 , pp. 172-179
    • Bogle, G.1    Dunbar, P.R.2
  • 44
    • 79953194081 scopus 로고    scopus 로고
    • Multiscale computational modeling reveals a critical role for TNF-α receptor 1 dynamics in tuberculosis granuloma formation
    • doi:10.4049/jimmunol.1003299.
    • Fallahi-Sichani M, El-Kebir M, Marino S, Kirschner DE, Linderman JJ. Multiscale computational modeling reveals a critical role for TNF-α receptor 1 dynamics in tuberculosis granuloma formation. J Immunol 2011, 186:3472-3483. doi:10.4049/jimmunol.1003299.
    • (2011) J Immunol , vol.186 , pp. 3472-3483
    • Fallahi-Sichani, M.1    El-Kebir, M.2    Marino, S.3    Kirschner, D.E.4    Linderman, J.J.5
  • 45
    • 84863860086 scopus 로고    scopus 로고
    • Complexity in a brain-inspired agent-based model
    • doi:10.1016/j.neunet.2012.05.012.
    • Joyce KE, Laurienti PJ, Hayasaka S. Complexity in a brain-inspired agent-based model. Neural Networks 2012, 33:275-290. doi:10.1016/j.neunet.2012.05.012.
    • (2012) Neural Networks , vol.33 , pp. 275-290
    • Joyce, K.E.1    Laurienti, P.J.2    Hayasaka, S.3
  • 46
    • 84868101858 scopus 로고    scopus 로고
    • Modeling protective anti-tumor immunity via preventative cancer vaccines using a hybrid agent-based and delay differential equation approach
    • doi:10.1371/journal.pcbi.1002742.
    • Kim PS, Lee PP. Modeling protective anti-tumor immunity via preventative cancer vaccines using a hybrid agent-based and delay differential equation approach. PLoS Comput Biol 2012, 8:e1002742. doi:10.1371/journal.pcbi.1002742.
    • (2012) PLoS Comput Biol , vol.8
    • Kim, P.S.1    Lee, P.P.2
  • 47
    • 79955815642 scopus 로고    scopus 로고
    • Agent-based simulation of reactions in the crowded and structured intracellular environment: Influence of mobility and location of the reactants
    • doi:10.1186/1752-0509-5-71.
    • Klann MT, Lapin A, Reuss M. Agent-based simulation of reactions in the crowded and structured intracellular environment: Influence of mobility and location of the reactants. BMC Syst Biol 2011, 5:71. doi:10.1186/1752-0509-5-71.
    • (2011) BMC Syst Biol , vol.5 , pp. 71
    • Klann, M.T.1    Lapin, A.2    Reuss, M.3
  • 48
    • 50949091234 scopus 로고    scopus 로고
    • A patient-specific in silico model of inflammation and healing tested in acute vocal fold injury
    • doi:10.1371/journal.pone.0002789.
    • Li NY, Verdolini K, Clermont G, Mi Q, Rubinstein EN, Hebda PA, Vodovotz Y. A patient-specific in silico model of inflammation and healing tested in acute vocal fold injury. PLoS ONE 2008, 3:e2789. doi:10.1371/journal.pone.0002789.
    • (2008) PLoS ONE , vol.3
    • Li, N.Y.1    Verdolini, K.2    Clermont, G.3    Mi, Q.4    Rubinstein, E.N.5    Hebda, P.A.6    Vodovotz, Y.7
  • 49
    • 79954611569 scopus 로고    scopus 로고
    • A hybrid multi-compartment model of granuloma formation and T cell priming in Tuberculosis
    • doi:10.1016/j.jtbi.2011.03.022.
    • Marino S, El-Kebir M, Kirschner D. A hybrid multi-compartment model of granuloma formation and T cell priming in Tuberculosis. J Theor Biol 2011, 280:50-62. doi:10.1016/j.jtbi.2011.03.022.
    • (2011) J Theor Biol , vol.280 , pp. 50-62
    • Marino, S.1    El-Kebir, M.2    Kirschner, D.3
  • 51
    • 84871288413 scopus 로고    scopus 로고
    • Modelling emergence of oscillations in communicating bacteria: a structured approach from one to many cells
    • doi:10.1098/rsif.2012.0612.
    • Mina P, di Bernardo M, Savery NJ, Tsaneva-Atanasova K. Modelling emergence of oscillations in communicating bacteria: a structured approach from one to many cells. J R Soc Interface 2013, 10:20120612. doi:10.1098/rsif.2012.0612.
    • (2013) J R Soc Interface , vol.10 , pp. 20120612
    • Mina, P.1    di Bernardo, M.2    Savery, N.J.3    Tsaneva-Atanasova, K.4
  • 52
    • 48649097820 scopus 로고    scopus 로고
    • Introducing spatial information into predictive NF-kappaB modeling-an agent-based approach
    • doi:10.1371/journal.pone.0002367.
    • Pogson M, Holcombe M, Smallwood R, Qwarnstrom E. Introducing spatial information into predictive NF-kappaB modeling-an agent-based approach. PLoS ONE 2008, 3:e2367. doi:10.1371/journal.pone.0002367.
    • (2008) PLoS ONE , vol.3
    • Pogson, M.1    Holcombe, M.2    Smallwood, R.3    Qwarnstrom, E.4
  • 53
    • 78049432163 scopus 로고    scopus 로고
    • Computational modeling of epithelial tissues
    • doi:10.1002/wsbm.18.
    • Smallwood R. Computational modeling of epithelial tissues. Wiley Interdiscip Rev Syst Biol Med, 2009, 1:191-201. doi:10.1002/wsbm.18.
    • (2009) Wiley Interdiscip Rev Syst Biol Med , vol.1 , pp. 191-201
    • Smallwood, R.1
  • 54
    • 84868562330 scopus 로고    scopus 로고
    • Integration of TGF-β- and EGFR-based signaling pathways using an agent-based model of epithelial restitution
    • doi:10.1111/j.1524-475X.2012.00852.x.
    • Stern JR, Christley S, Zaborina O, Alverdy JC, An G. Integration of TGF-β- and EGFR-based signaling pathways using an agent-based model of epithelial restitution. Wound Repair Regen 2012, 20:862-871. doi:10.1111/j.1524-475X.2012.00852.x.
    • (2012) Wound Repair Regen , vol.20 , pp. 862-871
    • Stern, J.R.1    Christley, S.2    Zaborina, O.3    Alverdy, J.C.4    An, G.5
  • 55
    • 79953758249 scopus 로고    scopus 로고
    • Phenotypic transition maps of 3D breast acini obtained by imaging-guided agent-based modeling
    • doi:10.1039/C0IB00092B.
    • Tang J, Enderling H, Becker-Weimann S, Pham C, Polyzos A, Chen CY, Costes SV. Phenotypic transition maps of 3D breast acini obtained by imaging-guided agent-based modeling. Integr Biol 2011, 3:408-421. doi:10.1039/C0IB00092B.
    • (2011) Integr Biol , vol.3 , pp. 408-421
    • Tang, J.1    Enderling, H.2    Becker-Weimann, S.3    Pham, C.4    Polyzos, A.5    Chen, C.Y.6    Costes, S.V.7
  • 56
    • 84866904221 scopus 로고    scopus 로고
    • The mechanistic basis of Myxococcus xanthus rippling behavior and its physiological role during predation
    • doi:10.1371/journal.pcbi.1002715.
    • Zhang H, Vaksman Z, Litwin DB, Shi P, Kaplan HB, Igoshin OA. The mechanistic basis of Myxococcus xanthus rippling behavior and its physiological role during predation. PLoS Comput Biol 2012, 8:e1002715. doi:10.1371/journal.pcbi.1002715.
    • (2012) PLoS Comput Biol , vol.8
    • Zhang, H.1    Vaksman, Z.2    Litwin, D.B.3    Shi, P.4    Kaplan, H.B.5    Igoshin, O.A.6
  • 60
    • 4744344132 scopus 로고    scopus 로고
    • In silico experiments of existing and hypothetical cytokine-directed clinical trials using agent-based modeling
    • doi:10.1097/01.CCM.0000139707.13729.7D.
    • An G. In silico experiments of existing and hypothetical cytokine-directed clinical trials using agent-based modeling. Crit Care Med 2004, 32:2050-2060. doi:10.1097/01.CCM.0000139707.13729.7D.
    • (2004) Crit Care Med , vol.32 , pp. 2050-2060
    • An, G.1
  • 61
    • 79953894415 scopus 로고    scopus 로고
    • In silico augmentation of the drug development pipeline: examples from the study of acute inflammation
    • doi:10.1002/ddr.20415.
    • An G, Bartels J, Vodovotz Y. In silico augmentation of the drug development pipeline: examples from the study of acute inflammation. Drug Dev Res 2011, 72:187-200. doi:10.1002/ddr.20415.
    • (2011) Drug Dev Res , vol.72 , pp. 187-200
    • An, G.1    Bartels, J.2    Vodovotz, Y.3
  • 62
    • 84864232168 scopus 로고    scopus 로고
    • Data-parallel techniques for simulating a mega-scale agent-based model of systemic inflammatory response syndrome on graphics processing units
    • doi:10.1177/0037549711425180.
    • Alberts S, Keenan MK, D'Souza RM, An G. Data-parallel techniques for simulating a mega-scale agent-based model of systemic inflammatory response syndrome on graphics processing units. Simulation 2012, 88:895-907. doi:10.1177/0037549711425180.
    • (2012) Simulation , vol.88 , pp. 895-907
    • Alberts, S.1    Keenan, M.K.2    D'Souza, R.M.3    An, G.4
  • 63
    • 84859377308 scopus 로고    scopus 로고
    • Differential risk of tuberculosis reactivation among anti-TNF therapies is due to drug binding kinetics and permeability
    • doi:10.4049/jimmunol.1103298.
    • Fallahi-Sichani M, Flynn JL, Linderman JJ, Kirschner DE. Differential risk of tuberculosis reactivation among anti-TNF therapies is due to drug binding kinetics and permeability. J Immunol 2012, 188:3169-3178. doi:10.4049/jimmunol.1103298.
    • (2012) J Immunol , vol.188 , pp. 3169-3178
    • Fallahi-Sichani, M.1    Flynn, J.L.2    Linderman, J.J.3    Kirschner, D.E.4
  • 64
    • 79953890886 scopus 로고    scopus 로고
    • Moving beyond in silico tools to in silico science in support of drug development research
    • doi:10.1002/ddr.20412.
    • Hunt CA, Ropella GEP. Moving beyond in silico tools to in silico science in support of drug development research. Drug Dev Res 2011, 72:153-161. doi:10.1002/ddr.20412.
    • (2011) Drug Dev Res , vol.72 , pp. 153-161
    • Hunt, C.A.1    Ropella, G.E.P.2
  • 66
    • 84865540578 scopus 로고    scopus 로고
    • Individualized, discrete event, simulations provide insight into inter- and intra-subject variability of extended-release, drug products
    • doi:10.1186/1742-4682-9-39.
    • Kim SH, Jackson AJ, Hur R, Hunt CA. Individualized, discrete event, simulations provide insight into inter- and intra-subject variability of extended-release, drug products. Theor Biol Med Model 2012, 9:39. doi:10.1186/1742-4682-9-39.
    • (2012) Theor Biol Med Model , vol.9 , pp. 39
    • Kim, S.H.1    Jackson, A.J.2    Hur, R.3    Hunt, C.A.4
  • 67
    • 58149460398 scopus 로고    scopus 로고
    • Discovering plausible mechanistic details of hepatic drug interactions
    • doi:10.1124/dmd.108.023820.
    • Lam TN, Hunt CA. Discovering plausible mechanistic details of hepatic drug interactions. Drug Metab Dispos 2009, 37:237-246. doi:10.1124/dmd.108.023820.
    • (2009) Drug Metab Dispos , vol.37 , pp. 237-246
    • Lam, T.N.1    Hunt, C.A.2
  • 68
    • 79960290056 scopus 로고    scopus 로고
    • A multifaceted approach to modeling the immune response in tuberculosis
    • doi:10.1002/wsbm.131.
    • Marino S, Linderman JJ, Kirschner DE. A multifaceted approach to modeling the immune response in tuberculosis. Wiley Interdiscip Rev Syst Biol Med 2011, 3:479-489. doi:10.1002/wsbm.131.
    • (2011) Wiley Interdiscip Rev Syst Biol Med , vol.3 , pp. 479-489
    • Marino, S.1    Linderman, J.J.2    Kirschner, D.E.3
  • 69
    • 59149096719 scopus 로고    scopus 로고
    • Computational strategies unravel and trace how liver disease changes hepatic drug disposition
    • doi:10.1124/jpet.108.142497.
    • Park S, Ropella GE, Kim SH, Roberts MS, Hunt CA. Computational strategies unravel and trace how liver disease changes hepatic drug disposition. J Pharmacol Exp Ther 2009, 328:294-305. doi:10.1124/jpet.108.142497.
    • (2009) J Pharmacol Exp Ther , vol.328 , pp. 294-305
    • Park, S.1    Ropella, G.E.2    Kim, S.H.3    Roberts, M.S.4    Hunt, C.A.5
  • 70
    • 84868244170 scopus 로고    scopus 로고
    • Drugs that target pathogen public goods are robust against evolved drug resistance
    • doi:10.1111/j.1752-4571.2012.00254.x.
    • Pepper JW. Drugs that target pathogen public goods are robust against evolved drug resistance. Evol Appl 2012, 5:757-761. doi:10.1111/j.1752-4571.2012.00254.x.
    • (2012) Evol Appl , vol.5 , pp. 757-761
    • Pepper, J.W.1
  • 71
    • 80053153848 scopus 로고    scopus 로고
    • Enabling clearance predictions to emerge from in silico actions of quasi-autonomous hepatocyte components
    • doi:10.1124/dmd.111.038703.
    • Sheikh-Bahaei S, Hunt CA. Enabling clearance predictions to emerge from in silico actions of quasi-autonomous hepatocyte components. Drug Metab Dispos 2011, 39:1910-1920. doi:10.1124/dmd.111.038703.
    • (2011) Drug Metab Dispos , vol.39 , pp. 1910-1920
    • Sheikh-Bahaei, S.1    Hunt, C.A.2
  • 72
    • 84865477904 scopus 로고    scopus 로고
    • Multi-scale agent-based brain cancer modeling and prediction of TKI treatment response: incorporating EGFR signaling pathway and angiogenesis
    • doi:10.1186/1471-2105-13-218.
    • Sun X, Zhang L, Tan H, Bao J, Strouthos C, Zhou X. Multi-scale agent-based brain cancer modeling and prediction of TKI treatment response: incorporating EGFR signaling pathway and angiogenesis. BMC Bioinform 2012, 13:218. doi:10.1186/1471-2105-13-218.
    • (2012) BMC Bioinform , vol.13 , pp. 218
    • Sun, X.1    Zhang, L.2    Tan, H.3    Bao, J.4    Strouthos, C.5    Zhou, X.6
  • 73
    • 77953809572 scopus 로고    scopus 로고
    • Next-generation model-based drug discovery and development: quantitative and systems pharmacology
    • doi:10.1038/clpt.2010.81.
    • Allerheiligen SR. Next-generation model-based drug discovery and development: quantitative and systems pharmacology. Clin Pharmacol Ther 2010, 88:135-137. doi:10.1038/clpt.2010.81.
    • (2010) Clin Pharmacol Ther , vol.88 , pp. 135-137
    • Allerheiligen, S.R.1
  • 74
    • 84859456583 scopus 로고    scopus 로고
    • Use of physiologically based pharmacokinetic modeling for assessment of drug-drug interactions
    • doi:10.4155/fmc.12.13.
    • Baneyx G, Fukushima Y, Parrott N. Use of physiologically based pharmacokinetic modeling for assessment of drug-drug interactions. Future Med Chem 2012, 4:681-693. doi:10.4155/fmc.12.13.
    • (2012) Future Med Chem , vol.4 , pp. 681-693
    • Baneyx, G.1    Fukushima, Y.2    Parrott, N.3
  • 75
    • 84858699365 scopus 로고    scopus 로고
    • Physiologically based pharmacokinetic (PBPK) modelling tools: how to fit with our needs?
    • doi:10.1002/bdd.1767.
    • Bouzom F, Ball K, Perdaems N, Walther B. Physiologically based pharmacokinetic (PBPK) modelling tools: how to fit with our needs? Biopharm Drug Dispos 2012, 33:55-71. doi:10.1002/bdd.1767.
    • (2012) Biopharm Drug Dispos , vol.33 , pp. 55-71
    • Bouzom, F.1    Ball, K.2    Perdaems, N.3    Walther, B.4
  • 76
    • 79960534115 scopus 로고    scopus 로고
    • Have physiologically-based pharmacokinetic models delivered?
    • doi:10.1517/17425255.2011.585968.
    • Edginton AN, Joshi G. Have physiologically-based pharmacokinetic models delivered? Expert Opin Drug Metab Toxicol 2011, 7:929-934. doi:10.1517/17425255.2011.585968.
    • (2011) Expert Opin Drug Metab Toxicol , vol.7 , pp. 929-934
    • Edginton, A.N.1    Joshi, G.2
  • 77
    • 65249191379 scopus 로고    scopus 로고
    • Quantitative disease, drug, and trial models
    • doi:10.1146/annurev.pharmtox.011008.145613.
    • Gobburu JV, Lesko LJ. Quantitative disease, drug, and trial models. Annu Rev Pharmacol Toxicol 2009, 49:291-301. doi:10.1146/annurev.pharmtox.011008.145613.
    • (2009) Annu Rev Pharmacol Toxicol , vol.49 , pp. 291-301
    • Gobburu, J.V.1    Lesko, L.J.2
  • 78
    • 77954887669 scopus 로고    scopus 로고
    • Improving productivity with model-based drug development: an enterprise perspective
    • doi:10.1038/clpt.2010.117.
    • Grasela TH, Slusser R. Improving productivity with model-based drug development: an enterprise perspective. Clin Pharmacol Ther 2010, 88:263-268. doi:10.1038/clpt.2010.117.
    • (2010) Clin Pharmacol Ther , vol.88 , pp. 263-268
    • Grasela, T.H.1    Slusser, R.2
  • 79
    • 84862776909 scopus 로고    scopus 로고
    • Utility of a physiologically-based pharmacokinetic (PBPK) modeling approach to quantitatively predict a complex drug-drug-disease interaction scenario for rivaroxaban during the drug review process: implications for clinical practice
    • doi:10.1002/bdd.1771.
    • Grillo JA, Zhao P, Bullock J, Booth BP, Lu M, Robie-Suh K, Berglund EG, Pang KS, Rahman A, Zhang L, et al. Utility of a physiologically-based pharmacokinetic (PBPK) modeling approach to quantitatively predict a complex drug-drug-disease interaction scenario for rivaroxaban during the drug review process: implications for clinical practice. Biopharm Drug Dispos 2012, 33:99-110. doi:10.1002/bdd.1771.
    • (2012) Biopharm Drug Dispos , vol.33 , pp. 99-110
    • Grillo, J.A.1    Zhao, P.2    Bullock, J.3    Booth, B.P.4    Lu, M.5    Robie-Suh, K.6    Berglund, E.G.7    Pang, K.S.8    Rahman, A.9    Zhang, L.10
  • 80
    • 33747808216 scopus 로고    scopus 로고
    • The virtual laboratory approach to pharmacokinetics: design principles and concepts
    • Huisinga W, Telgmann R, Wulkow M. The virtual laboratory approach to pharmacokinetics: design principles and concepts. Drug Discov Today 2006, 11:800-805.
    • (2006) Drug Discov Today , vol.11 , pp. 800-805
    • Huisinga, W.1    Telgmann, R.2    Wulkow, M.3
  • 81
    • 84858784781 scopus 로고    scopus 로고
    • Merging systems biology with pharmacodynamics
    • doi:10.1126/scitranslmed.3003563.
    • Iyengar R, Zhao S, Chung SW, Mager DE, Gallo JM. Merging systems biology with pharmacodynamics. Sci Transl Med 2012, 4:126ps7. doi:10.1126/scitranslmed.3003563.
    • (2012) Sci Transl Med , vol.4
    • Iyengar, R.1    Zhao, S.2    Chung, S.W.3    Mager, D.E.4    Gallo, J.M.5
  • 82
    • 80052966613 scopus 로고    scopus 로고
    • The role of predictive biopharmaceutical modeling and simulation in drug development and regulatory evaluation
    • doi:10.1016/j.ijpharm.2011.07.024.
    • Jiang W, Kim S, Zhang X, Lionberger RA, Davit BM, Conner DP, Yu LX. The role of predictive biopharmaceutical modeling and simulation in drug development and regulatory evaluation. Int J Pharm 2011, 418:151-160. doi:10.1016/j.ijpharm.2011.07.024.
    • (2011) Int J Pharm , vol.418 , pp. 151-160
    • Jiang, W.1    Kim, S.2    Zhang, X.3    Lionberger, R.A.4    Davit, B.M.5    Conner, D.P.6    Yu, L.X.7
  • 84
    • 80052671545 scopus 로고    scopus 로고
    • Physiologically based pharmacokinetic modeling: methodology, applications, and limitations with a focus on its role in pediatric drug development
    • 2011: doi:10.1155/2011/907461.
    • Khalil F, Láer S. Physiologically based pharmacokinetic modeling: methodology, applications, and limitations with a focus on its role in pediatric drug development. J Biomed Biotechnol 2011, 2011:907461. doi:10.1155/2011/907461.
    • (2011) J Biomed Biotechnol , pp. 907461
    • Khalil, F.1    Láer, S.2
  • 85
    • 43949084744 scopus 로고    scopus 로고
    • Development of translational pharmacokinetic-pharmacodynamic models
    • doi:10.1038/clpt.2008.52.
    • Mager DE, Jusko WJ. Development of translational pharmacokinetic-pharmacodynamic models. Clin Pharmacol Ther 2008, 83:909-912. doi:10.1038/clpt.2008.52.
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 909-912
    • Mager, D.E.1    Jusko, W.J.2
  • 86
    • 68149157300 scopus 로고    scopus 로고
    • Model-based approaches to increase efficiency of drug development in schizophrenia: a can't miss opportunity
    • doi:10.1517/17460440903036073.
    • Nucci G, Gomeni R, Poggesi I. Model-based approaches to increase efficiency of drug development in schizophrenia: a can't miss opportunity. Expert Opin Drug Discovry 2009, 4:837-856. doi:10.1517/17460440903036073.
    • (2009) Expert Opin Drug Discovry , vol.4 , pp. 837-856
    • Nucci, G.1    Gomeni, R.2    Poggesi, I.3
  • 87
    • 84879319696 scopus 로고    scopus 로고
    • Development: multiscale CSB-simulation tools
    • Springer Briefs in Pharmaceutical Science and Drug Development, Springer, New York; doi:10.1007/978-94-007-2849-3_8.
    • Prokop A, Michelson S. Development: multiscale CSB-simulation tools. In: Systems Biology in Biotech and Pharma. Springer Briefs in Pharmaceutical Science and Drug Development, Springer, New York; vol 2; 2012, 87-102. doi:10.1007/978-94-007-2849-3_8.
    • (2012) Systems Biology in Biotech and Pharma , vol.2 , pp. 87-102
    • Prokop, A.1    Michelson, S.2
  • 88
    • 84862619047 scopus 로고    scopus 로고
    • Physiologically based pharmacokinetics joined with in vitro-in vivo extrapolation of ADME: a marriage under the arch of systems pharmacology
    • doi:10.1038/clpt.2012.65.
    • Rostami-Hodjegan A. Physiologically based pharmacokinetics joined with in vitro-in vivo extrapolation of ADME: a marriage under the arch of systems pharmacology. Clin Pharmacol Ther 2012, 92:50-61. doi:10.1038/clpt.2012.65.
    • (2012) Clin Pharmacol Ther , vol.92 , pp. 50-61
    • Rostami-Hodjegan, A.1
  • 89
    • 79951765993 scopus 로고    scopus 로고
    • Physiologically-based pharmacokinetics in drug development and regulatory science
    • doi:10.1146/annurev-pharmtox-010510-100540.
    • Rowland M, Peck C, Tucker G. Physiologically-based pharmacokinetics in drug development and regulatory science. Ann Rev Pharmacol Toxicol 2011, 51:45-73. doi:10.1146/annurev-pharmtox-010510-100540.
    • (2011) Ann Rev Pharmacol Toxicol , vol.51 , pp. 45-73
    • Rowland, M.1    Peck, C.2    Tucker, G.3
  • 90
    • 84879312934 scopus 로고    scopus 로고
    • Recent developments in physiologically based pharmacokinetic modeling
    • doi:1.0.1007/978-1-4419-7415-0_21.
    • Sinha V, Kimko HHC. Recent developments in physiologically based pharmacokinetic modeling. Clin Trial Simul AAPS Adv Pharm Sci Series 2011, 1:483-499. doi:1.0.1007/978-1-4419-7415-0_21.
    • (2011) Clin Trial Simul AAPS Adv Pharm Sci Series , vol.1 , pp. 483-499
    • Sinha, V.1    Kimko, H.H.C.2
  • 91
    • 77950295526 scopus 로고    scopus 로고
    • The current role of model-based drug development
    • doi:10.1517/17460441003713470.
    • Suryawanshi S, Zhang L, Pfister M, Meibohm B. The current role of model-based drug development. Expert Opin Drug Discovry 2010, 5:311-321. doi:10.1517/17460441003713470.
    • (2010) Expert Opin Drug Discovry , vol.5 , pp. 311-321
    • Suryawanshi, S.1    Zhang, L.2    Pfister, M.3    Meibohm, B.4
  • 92
    • 65549156693 scopus 로고    scopus 로고
    • Concepts and challenges in quantitative pharmacology and model-based drug development
    • doi: 10.1208/s12248-008-9062-3.
    • Zhang L, Pfister M, Meibohm B. Concepts and challenges in quantitative pharmacology and model-based drug development. AAPS J 2008, 10:552-559. doi: 10.1208/s12248-008-9062-3.
    • (2008) AAPS J , vol.10 , pp. 552-559
    • Zhang, L.1    Pfister, M.2    Meibohm, B.3
  • 94
    • 84870569014 scopus 로고    scopus 로고
    • Systems toxicology from genes to organs
    • doi:10.1007/978-1-62703-059-5_17.
    • Jack J, Wambaugh J, Shah I. Systems toxicology from genes to organs. Methods Mol Biol (Clifton, NJ) 2013, 930:375-397. doi:10.1007/978-1-62703-059-5_17.
    • (2013) Methods Mol Biol (Clifton, NJ) , vol.930 , pp. 375-397
    • Jack, J.1    Wambaugh, J.2    Shah, I.3
  • 95
    • 84855923550 scopus 로고    scopus 로고
    • Multiscale mechanistic modeling in pharmaceutical research and development
    • doi:10.1007/978-1-4419-7210-1_32.
    • Kuepfer L, Lippert J, Eissing T. Multiscale mechanistic modeling in pharmaceutical research and development. Adv Exp Med Biol 2012, 736:543-561. doi:10.1007/978-1-4419-7210-1_32.
    • (2012) Adv Exp Med Biol , vol.736 , pp. 543-561
    • Kuepfer, L.1    Lippert, J.2    Eissing, T.3
  • 96
    • 78449284245 scopus 로고    scopus 로고
    • Model-based drug development: strengths, weaknesses, opportunities, and threats for broad application of pharmacometrics in drug development
    • doi:10.1177/0091270010377629
    • Wetherington JD, Pfister M, Banfield C, Stone JA, Krishna R, Allerheiligen S, Grasela DM. Model-based drug development: strengths, weaknesses, opportunities, and threats for broad application of pharmacometrics in drug development. J Clin Pharmacol 2010, 50(9 suppl):31S-46S. doi:10.1177/0091270010377629.
    • (2010) J Clin Pharmacol , vol.50 , Issue.9 SUPPL
    • Wetherington, J.D.1    Pfister, M.2    Banfield, C.3    Stone, J.A.4    Krishna, R.5    Allerheiligen, S.6    Grasela, D.M.7
  • 97
    • 79959900575 scopus 로고    scopus 로고
    • Systems pharmacology: bridging systems biology and pharmacokinetics-pharmacodynamics (PKPD) in drug discovery and development
    • doi:10.1007/s11095-011-0467-9.
    • van der Graaf PH, Benson N. Systems pharmacology: bridging systems biology and pharmacokinetics-pharmacodynamics (PKPD) in drug discovery and development. Pharmaceut Res 2011, 28:1460-1464. doi:10.1007/s11095-011-0467-9.
    • (2011) Pharmaceut Res , vol.28 , pp. 1460-1464
    • van der Graaf, P.H.1    Benson, N.2
  • 98
    • 84860690620 scopus 로고    scopus 로고
    • Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival
    • doi:10.1016/j.drudis.2011.12.020.
    • Morgan P, Van Der Graaf PH, Arrowsmith J, Feltner DE, Drummond KS, Wegner CD, Street SD. Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival. Drug Discov Today 2012, 17:419-424. doi:10.1016/j.drudis.2011.12.020.
    • (2012) Drug Discov Today , vol.17 , pp. 419-424
    • Morgan, P.1    Van Der Graaf, P.H.2    Arrowsmith, J.3    Feltner, D.E.4    Drummond, K.S.5    Wegner, C.D.6    Street, S.D.7
  • 99
    • 70449528780 scopus 로고    scopus 로고
    • In silico toxicology for the pharmaceutical sciences
    • doi:10.1016/j.taap.2009.08.022.
    • Valerio LG. In silico toxicology for the pharmaceutical sciences. Toxicol Appl Pharmacol 2009, 241:356-370. doi:10.1016/j.taap.2009.08.022.
    • (2009) Toxicol Appl Pharmacol , vol.241 , pp. 356-370
    • Valerio, L.G.1
  • 100
    • 77953806651 scopus 로고    scopus 로고
    • Multiscale modeling in drug discovery and development: future opportunities and present challenges
    • doi:10.1038/clpt.2010.87.
    • Vicini P. Multiscale modeling in drug discovery and development: future opportunities and present challenges. Clin Pharmacol Ther 2010, 88:126-129. doi:10.1038/clpt.2010.87.
    • (2010) Clin Pharmacol Ther , vol.88 , pp. 126-129
    • Vicini, P.1
  • 102
    • 77949655881 scopus 로고    scopus 로고
    • Novel opportunities for computational biology and sociology in drug discovery
    • doi:10.1016/j.tibtech.2009.06.003.
    • Yao L, Evans JA, Rzhetsky A. Novel opportunities for computational biology and sociology in drug discovery. Trends Biotechnol 2010, 28:161-170. doi:10.1016/j.tibtech.2009.06.003.
    • (2010) Trends Biotechnol , vol.28 , pp. 161-170
    • Yao, L.1    Evans, J.A.2    Rzhetsky, A.3
  • 103
    • 0032275839 scopus 로고    scopus 로고
    • Introduction to the art and science of simulation. In Simulation Conference Proceedings, 1998. Winter1
    • Shannon, RE. Introduction to the art and science of simulation. In Simulation Conference Proceedings, 1998. Winter; 1998 1:7-14.
    • (1998) , pp. 7-14
    • Shannon, R.E.1
  • 104
    • 80053362261 scopus 로고    scopus 로고
    • Relational grounding facilitates development of scientifically useful multiscale models
    • doi:10.1186/1742-4682-8-35.
    • Hunt CA, Ropella GEP, Lam TN, Gewitz AD. Relational grounding facilitates development of scientifically useful multiscale models. Theor Biol Med Model 2011, 8:35. doi:10.1186/1742-4682-8-35.
    • (2011) Theor Biol Med Model , vol.8 , pp. 35
    • Hunt, C.A.1    Ropella, G.E.P.2    Lam, T.N.3    Gewitz, A.D.4
  • 105
    • 46449119246 scopus 로고    scopus 로고
    • Introduction of an agent-based multi-scale modular architecture for dynamic knowledge representation of acute inflammation
    • doi:10.1186/1742-4682-5-11.
    • An G. Introduction of an agent-based multi-scale modular architecture for dynamic knowledge representation of acute inflammation. Theor Biol Med Model 2008, 5:11. doi:10.1186/1742-4682-5-11.
    • (2008) Theor Biol Med Model , vol.5 , pp. 11
    • An, G.1
  • 106
    • 65649091733 scopus 로고    scopus 로고
    • Dynamic knowledge representation using agent-based modeling: ontology instantiation and verification of conceptual models
    • doi:10.1007/978-1-59745-525-1_15.
    • An G. Dynamic knowledge representation using agent-based modeling: ontology instantiation and verification of conceptual models. Methods Mol Biol (Clifton, NJ) 2009, 500:445-468. doi:10.1007/978-1-59745-525-1_15.
    • (2009) Methods Mol Biol (Clifton, NJ) , vol.500 , pp. 445-468
    • An, G.1
  • 107
    • 74549209507 scopus 로고    scopus 로고
    • Translational systems biology using an agent-based approach for dynamic knowledge representation: an evolutionary paradigm for biomedical research
    • doi:10.1111/j.1524-475X.2009.00568.x.
    • An GC. Translational systems biology using an agent-based approach for dynamic knowledge representation: an evolutionary paradigm for biomedical research. Wound Repair Regen 2010, 18:8-12. doi:10.1111/j.1524-475X.2009.00568.x.
    • (2010) Wound Repair Regen , vol.18 , pp. 8-12
    • An, G.C.1
  • 108
    • 84879324281 scopus 로고    scopus 로고
    • Foundations for Extended Life Cycle Biological Models. CiteSeerX10.1.1.1.2664 Available at: (accessed January 3, 2013)
    • Ropella GEP, Hunt CA. Foundations for Extended Life Cycle Biological Models. CiteSeerX10.1.1.1.2664 2003. Available at: http://biosystems.ucsf.edu/publications/Ropella_UCITR_2003.pdf (accessed January 3, 2013).
    • (2003)
    • Ropella, G.E.P.1    Hunt, C.A.2
  • 110
    • 84859169880 scopus 로고    scopus 로고
    • Drug development: raise standards for preclinical cancer research
    • doi:10.1038/483531a.
    • Begley CG, Ellis LM. Drug development: raise standards for preclinical cancer research. Nature 2012, 483:531-533. doi:10.1038/483531a.
    • (2012) Nature , vol.483 , pp. 531-533
    • Begley, C.G.1    Ellis, L.M.2
  • 111
    • 80055088241 scopus 로고    scopus 로고
    • Believe it or not: how much can we rely on published data on potential drug targets?
    • doi:10.1038/nrd3439-c1.
    • Prinz F, Schlange T, Asadullah K. Believe it or not: how much can we rely on published data on potential drug targets? Nat Rev Drug Discov 2011, 10:712. doi:10.1038/nrd3439-c1.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 712
    • Prinz, F.1    Schlange, T.2    Asadullah, K.3
  • 112
    • 84869058694 scopus 로고    scopus 로고
    • Hedging against academic risk
    • doi:10.1038/scibx. 2011.416.
    • Osherovich L. Hedging against academic risk. Sci Business eXchange 2011, 4(15). doi:10.1038/scibx. 2011.416.
    • (2011) Sci Business eXchange , vol.4 , Issue.15
    • Osherovich, L.1
  • 113
    • 76749131557 scopus 로고    scopus 로고
    • Mechanistic insight from in silico pharmacokinetic experiments: roles of P-glycoprotein, Cyp3A4 enzymes, and microenvironments
    • doi:10.1124/jpet.109.160739.
    • Lam TN, Hunt CA. Mechanistic insight from in silico pharmacokinetic experiments: roles of P-glycoprotein, Cyp3A4 enzymes, and microenvironments. J Pharmacol Exp Ther 2010, 332(2):398-412. doi:10.1124/jpet.109.160739.
    • (2010) J Pharmacol Exp Ther , vol.332 , Issue.2 , pp. 398-412
    • Lam, T.N.1    Hunt, C.A.2
  • 114
    • 84879288849 scopus 로고    scopus 로고
    • OpenABM. Available at. Accessed January 5
    • OpenABM. Available at: http://www.openabm.org/standards. (Accessed January 5, 2013).
    • (2013)
  • 115
    • 84891573642 scopus 로고    scopus 로고
    • Wiley Series in Systems Engineering and Management. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, ISBN: 978-3-527-40781-1
    • Yilmaz L, Óren T, eds. Agent-directed Simulation and Systems Engineering, Wiley Series in Systems Engineering and Management. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, ISBN: 978-3-527-40781-1; 2009.
    • (2009) Agent-directed Simulation and Systems Engineering
    • Yilmaz, L.1    Óren, T.2
  • 116
    • 77649207414 scopus 로고    scopus 로고
    • Identifying the rules of engagement enabling leukocyte rolling, activation, and adhesion
    • doi:10.1371/journal.pcbi.1000681.
    • Tang J, Hunt CA. Identifying the rules of engagement enabling leukocyte rolling, activation, and adhesion. PLoS Comput Biol 2010, 6:e1000681. doi:10.1371/journal.pcbi.1000681.
    • (2010) PLoS Comput Biol , vol.6
    • Tang, J.1    Hunt, C.A.2
  • 117
    • 77953739657 scopus 로고    scopus 로고
    • Tracing multiscale mechanisms of drug disposition in normal and diseased livers
    • doi:10.1124/jpet.110.168526.
    • Park S, Kim SH, Ropella GEP, Roberts MS, Hunt CA. Tracing multiscale mechanisms of drug disposition in normal and diseased livers. J Pharmacol Exp Ther 2010, 334:124-136. doi:10.1124/jpet.110.168526.
    • (2010) J Pharmacol Exp Ther , vol.334 , pp. 124-136
    • Park, S.1    Kim, S.H.2    Ropella, G.E.P.3    Roberts, M.S.4    Hunt, C.A.5
  • 118
    • 79955559185 scopus 로고    scopus 로고
    • MDCK cystogenesis driven by cell stabilization within computational analogues
    • doi:10.1371/journal.pcbi.1002030.
    • Engelberg JA, Datta A, Mostov KE, Hunt CA. MDCK cystogenesis driven by cell stabilization within computational analogues. PLoS Comput Biol 2011, 7:e1002030. doi:10.1371/journal.pcbi.1002030.
    • (2011) PLoS Comput Biol , vol.7
    • Engelberg, J.A.1    Datta, A.2    Mostov, K.E.3    Hunt, C.A.4
  • 119
    • 84879284130 scopus 로고    scopus 로고
    • 2002. Implications of multi-resolution modeling (MRM) and exploratory analysis for validation. Proceedings of Foundations, 2002 V&V Workshop. Accessed February 17
    • Bigelow JH, Davis PK. (2002). Implications of multi-resolution modeling (MRM) and exploratory analysis for validation. Proceedings of Foundations, 2002 V&V Workshop. http://citeseerx.ist.psu.edu/viewdoc/download?doi:10.1.1.118.9430&rep=rep1&type=pdf. (Accessed February 17, 2013).
    • (2013)
    • Bigelow, J.H.1    Davis, P.K.2
  • 120
    • 38149083357 scopus 로고    scopus 로고
    • Rule-based modelling of cellular signalling. CONCUR 2007-concurrency theory
    • doi:10.1007/978-3-540-74407-8_3.
    • Danos V, Feret J, Fontana W, Harmer R, Krivine J. Rule-based modelling of cellular signalling. CONCUR 2007-concurrency theory. Lect Notes Comput Sci 2007, 4703:17-41. doi:10.1007/978-3-540-74407-8_3.
    • (2007) Lect Notes Comput Sci , vol.4703 , pp. 17-41
    • Danos, V.1    Feret, J.2    Fontana, W.3    Harmer, R.4    Krivine, J.5
  • 121
    • 41549093231 scopus 로고    scopus 로고
    • Predictions of hepatic disposition properties using a mechanistically realistic, physiologically based model
    • doi:10.1124/dmd.107.019067.
    • Yan L, Sheihk-Bahaei S, Park S, Ropella GEP, Hunt CA. Predictions of hepatic disposition properties using a mechanistically realistic, physiologically based model. Drug Metab Dispos 2008, 36:759-768. doi:10.1124/dmd.107.019067.
    • (2008) Drug Metab Dispos , vol.36 , pp. 759-768
    • Yan, L.1    Sheihk-Bahaei, S.2    Park, S.3    Ropella, G.E.P.4    Hunt, C.A.5
  • 122
    • 77954484528 scopus 로고    scopus 로고
    • Computational experiments reveal plausible mechanisms for changing patterns of hepatic zonation of xenobiotic clearance and hepatotoxicity
    • Sheikh-Bahaei S, Maher JJ, Hunt CA. Computational experiments reveal plausible mechanisms for changing patterns of hepatic zonation of xenobiotic clearance and hepatotoxicity. J Theor Biol 2010, 265:718-733.
    • (2010) J Theor Biol , vol.265 , pp. 718-733
    • Sheikh-Bahaei, S.1    Maher, J.J.2    Hunt, C.A.3
  • 124
    • 0003699334 scopus 로고    scopus 로고
    • The Logic of Scientific Discovery
    • London, UK: RoutledgeISBN 0-203-99462-0.
    • Popper K. The Logic of Scientific Discovery. The Logic of Scientific Discovery. London, UK: Routledge; 2002 ISBN 0-203-99462-0.
    • (2002) The Logic of Scientific Discovery
    • Popper, K.1
  • 125
    • 84879313163 scopus 로고    scopus 로고
    • Overview of the Ptolemy project, Technical Report UCB/ERL M01/11, University of California, Berkeley, Available at: (Accessed January 5, 2013)
    • Hylands C, Lee EA, Liu J, Liu X, Neuendorffer S, Xiong Y, Zhao Y, Zheng H. Overview of the Ptolemy project, Technical Report UCB/ERL M01/11, University of California, Berkeley, 2001. Available at: http://ptolemy.berkeley.edu/publications/papers/03/overview/overview03.pdf. (Accessed January 5, 2013).
    • (2001)
    • Hylands, C.1    Lee, E.A.2    Liu, J.3    Liu, X.4    Neuendorffer, S.5    Xiong, Y.6    Zhao, Y.7    Zheng, H.8
  • 126
    • 84879309355 scopus 로고    scopus 로고
    • Formalizing common sense for scalable inconsistency-robust information integration using Direct Logic (TM) reasoning and the Actor Model. arXiv:0812.4852 v82
    • Hewitt C. Formalizing common sense for scalable inconsistency-robust information integration using Direct Logic (TM) reasoning and the Actor Model. arXiv:0812.4852 v82, 2008.
    • (2008)
    • Hewitt, C.1
  • 127
    • 84885458329 scopus 로고    scopus 로고
    • Advanced concepts and generative simulation formalisms for creative discovery systems engineering
    • Springer Berlin, Germany;, doi:10.1007/978-3-642-17931-0_9 (Chapter 9).
    • Yilmaz Y, Hunt CA. Advanced concepts and generative simulation formalisms for creative discovery systems engineering. In: A. Tolk, and L.C. Jain, eds. Intelligent-Based Systems Engineering ISRL 10. Springer Berlin, Germany; 2011, 233-258. doi:10.1007/978-3-642-17931-0_9 (Chapter 9).
    • (2011) Intelligent-Based Systems Engineering ISRL 10 , pp. 233-258
    • Yilmaz, Y.1    Hunt, C.A.2    Tolk, A.3    Jain, L.C.4
  • 128
    • 84876477084 scopus 로고    scopus 로고
    • Agent-directed tracing of multi-scale drug disposition events within normal and diseased In Silico Livers
    • doi:10.4018/jats/2010070101.
    • Kim SH, Park S, Ropella GEP, Hunt CA. Agent-directed tracing of multi-scale drug disposition events within normal and diseased In Silico Livers. Int J Agent Technol Syst 2010, 2:1-17. doi:10.4018/jats/2010070101.
    • (2010) Int J Agent Technol Syst , vol.2 , pp. 1-17
    • Kim, S.H.1    Park, S.2    Ropella, G.E.P.3    Hunt, C.A.4
  • 129
    • 78649574884 scopus 로고    scopus 로고
    • Cloud computing and validation of expandable in silico livers
    • doi:10.1186/1752-0509-4-168.
    • Ropella GEP, Hunt CA. Cloud computing and validation of expandable in silico livers. BMC Syst Biol 2010, 4:168. doi:10.1186/1752-0509-4-168.
    • (2010) BMC Syst Biol , vol.4 , pp. 168
    • Ropella, G.E.P.1    Hunt, C.A.2
  • 130
    • 84879289377 scopus 로고    scopus 로고
    • Falsifying an enzyme induction mechanism within a validated, multiscale liver model
    • doi:10.4018/jats.2012070101.
    • Ropella GEP, Kennedy RC, Hunt CA. Falsifying an enzyme induction mechanism within a validated, multiscale liver model. Int J Agent Technol Syst 2012, 4, 1-14. doi:10.4018/jats.2012070101.
    • (2012) Int J Agent Technol Syst , vol.4 , pp. 1-14
    • Ropella, G.E.P.1    Kennedy, R.C.2    Hunt, C.A.3
  • 131
    • 59849126108 scopus 로고    scopus 로고
    • Heterogeneous composition of models of computation
    • 2009. doi:10.1016/j.future.2008.06.014.
    • Goderis A, Brooks C, Altintas I, Lee EA, Goble C. Heterogeneous composition of models of computation. Future Gener Comput Syst 2009, 25:552-560, 2009. doi:10.1016/j.future.2008.06.014.
    • (2009) Future Gener Comput Syst , vol.25 , pp. 552-560
    • Goderis, A.1    Brooks, C.2    Altintas, I.3    Lee, E.A.4    Goble, C.5
  • 132
    • 84155164677 scopus 로고    scopus 로고
    • Distributed real-time software for cyber-physical systems
    • doi:10.1109/JPROC.2011.2161237. (Accessed January 5, 2013).
    • Eidson JE, Lee EA, Matic S, Seshia SA, Zou J. Distributed real-time software for cyber-physical systems. Proc IEEE 2011, 100: 45-59. doi:10.1109/JPROC.2011.2161237. (Accessed January 5, 2013).
    • (2011) Proc IEEE , vol.100 , pp. 45-59
    • Eidson, J.E.1    Lee, E.A.2    Matic, S.3    Seshia, S.A.4    Zou, J.5
  • 133
    • 84872736004 scopus 로고    scopus 로고
    • Actor model of computation: scalable robust information systems
    • v28, arXiv
    • Hewitt, C. Actor model of computation: scalable robust information systems. arXiv:1008.1459 v28, 2010.
    • (2010) , pp. 10081459
    • Hewitt, C.1
  • 134
    • 84879315660 scopus 로고    scopus 로고
    • Listed below are available, open-source tools of the type that can be used now to begin satisfying the listed interactive Knowledge Repository requirements.
    • Listed below are available, open-source tools of the type that can be used now to begin satisfying the listed interactive Knowledge Repository requirements.
  • 135
    • 84879306563 scopus 로고    scopus 로고
    • Databases
    • Databases
  • 136
    • 84879311042 scopus 로고    scopus 로고
    • PostgreSQL (relational)
    • PostgreSQL (relational): http://www.postgresql.org/
  • 137
    • 84879307276 scopus 로고    scopus 로고
    • ZOBD
    • ZOBD: http://zodb.org/
  • 138
    • 84879308912 scopus 로고    scopus 로고
    • NoSQL
    • NoSQL: http://nosql-database.org/
  • 139
    • 84879322016 scopus 로고    scopus 로고
    • RDF/SPARQL
    • RDF/SPARQL: http://www.w3.org/TR/rdf-sparql-query/
  • 140
    • 84879315322 scopus 로고    scopus 로고
    • Data [de]composition
    • Data [de]composition
  • 141
    • 84879320713 scopus 로고    scopus 로고
    • R
    • R: http://www.r-project.org/
  • 142
    • 84879324113 scopus 로고    scopus 로고
    • HDF
    • HDF: http://www.hdfgroup.org/HDF5/
  • 143
    • 84879288433 scopus 로고    scopus 로고
    • Semantics
    • Semantics
  • 144
    • 84879308139 scopus 로고    scopus 로고
    • Protoge
    • Protoge: http://protege.stanford.edu/
  • 145
    • 84879292151 scopus 로고    scopus 로고
    • Ontopia
    • Ontopia: http://www.ontopia.net/
  • 146
    • 84879314967 scopus 로고    scopus 로고
    • Jena
    • Jena: https://jena.apache.org/
  • 147
    • 84879290325 scopus 로고    scopus 로고
    • Pellet, (complete)
    • Pellet: http://clarkparsia.com/pellet/ (complete)
  • 148
    • 84879304853 scopus 로고    scopus 로고
    • Racer, (complete)
    • Racer: http://www.sts.tu-harburg.de/~r.f.moeller/racer/ (complete)
  • 149
    • 84879291404 scopus 로고    scopus 로고
    • Hermit
    • Hermit: http://hermit-reasoner.com/
  • 150
    • 84879289278 scopus 로고    scopus 로고
    • Executable models
    • Executable models
  • 151
    • 84879300075 scopus 로고    scopus 로고
    • Code
    • Code
  • 152
    • 84879313269 scopus 로고    scopus 로고
    • Eclipse
    • Eclipse: http://eclipse.org/
  • 153
    • 84879315187 scopus 로고    scopus 로고
    • Netbeans
    • Netbeans: http://netbeans.org/
  • 154
    • 84879287960 scopus 로고    scopus 로고
    • Graphical programming
    • Graphical programming
  • 155
    • 84879306903 scopus 로고    scopus 로고
    • Ptolemy II
    • Ptolemy II: http://ptolemy.eecs.berkeley.edu/ptolemyII/index.htm
  • 156
    • 84879318472 scopus 로고    scopus 로고
    • NetLogo
    • NetLogo: http://ccl.northwestern.edu/netlogo/
  • 157
    • 84879318341 scopus 로고    scopus 로고
    • ArgoUML
    • ArgoUML: http://argouml.tigris.org/
  • 158
    • 84879309768 scopus 로고    scopus 로고
    • Modeling infrastructure
    • Modeling infrastructure
  • 159
    • 84879306317 scopus 로고    scopus 로고
    • JAMES II
    • JAMES II: http://wwwmosi.informatik.uni-rostock.de/mosi/projects/cosa/james-ii
  • 160
    • 84879320352 scopus 로고    scopus 로고
    • CC3D
    • CC3D: http://www.compucell3d.org/
  • 161
    • 84879318037 scopus 로고    scopus 로고
    • MASON
    • MASON: http://cs.gmu.edu/~eclab/projects/mason/
  • 162
    • 84879293305 scopus 로고    scopus 로고
    • Actor model133
    • Actor model133
  • 163
    • 84879286673 scopus 로고    scopus 로고
    • Erlang
    • Erlang: http://www.erlang.org/
  • 164
    • 84879290879 scopus 로고    scopus 로고
    • Scala
    • Scala: http://www.scala-lang.org/node/242
  • 165
    • 84879320545 scopus 로고    scopus 로고
    • Workflow
    • Workflow
  • 166
    • 84879305301 scopus 로고    scopus 로고
    • Kepler
    • Kepler: http://kepler-project.org/
  • 167
    • 84879295584 scopus 로고    scopus 로고
    • Taverna
    • Taverna: http://www.taverna.org.uk/
  • 168
    • 84879303899 scopus 로고    scopus 로고
    • Galaxy
    • Galaxy: http://galaxyproject.org/
  • 169
    • 84879315997 scopus 로고    scopus 로고
    • Triana
    • Triana: http://www.trianacode.org/
  • 170
    • 84879310846 scopus 로고    scopus 로고
    • Graphs
    • Graphs
  • 171
    • 84879313654 scopus 로고    scopus 로고
    • NetworkX
    • NetworkX: http://networkx.lanl.gov/
  • 172
    • 84879304403 scopus 로고    scopus 로고
    • JUNG
    • JUNG: http://jung.sourceforge.net/


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.