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Volumn 33, Issue 2, 2016, Pages 197-210

Anti-angiogenic alternatives to VEGF blockade

Author keywords

Angiogenesis; Anti angiogenesis; Cancer; Therapy; Tumour

Indexed keywords

ANGIOGENESIS INHIBITOR; ANGIOPOIETIN; CD146 ANTIGEN; CLEC14A PROTEIN; ENDOGLIN; EPHRIN; EPHRIN RECEPTOR; FIBROBLAST GROWTH FACTOR; INTEGRIN; LIGAND; NOTCH RECEPTOR; PLACENTAL GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL CADHERIN; VASCULOTROPIN; ANTINEOPLASTIC AGENT; VASCULOTROPIN A;

EID: 84958747810     PISSN: 02620898     EISSN: 15737276     Source Type: Journal    
DOI: 10.1007/s10585-015-9769-3     Document Type: Review
Times cited : (29)

References (135)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • COI: 1:CAS:528:DC%2BD3cXks1CktA%3D%3D, PID: 10647931
    • Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100(1):57–70
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 0026708632 scopus 로고
    • The vascular endothelial growth factor proteins: identification of biologically relevant regions by neutralizing monoclonal antibodies
    • COI: 1:STN:280:DyaK38zmvVKmtg%3D%3D, PID: 1380254
    • Kim KJ, Li B, Houck K, Winer J, Ferrara N (1992) The vascular endothelial growth factor proteins: identification of biologically relevant regions by neutralizing monoclonal antibodies. Growth Factors 7(1):53–64
    • (1992) Growth Factors , vol.7 , Issue.1 , pp. 53-64
    • Kim, K.J.1    Li, B.2    Houck, K.3    Winer, J.4    Ferrara, N.5
  • 3
    • 84903901969 scopus 로고    scopus 로고
    • Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions
    • COI: 1:CAS:528:DC%2BC2cXpsVGrtrk%3D, PID: 24482243
    • Vasudev NS, Reynolds AR (2014) Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions. Angiogenesis 17(3):471–494
    • (2014) Angiogenesis , vol.17 , Issue.3 , pp. 471-494
    • Vasudev, N.S.1    Reynolds, A.R.2
  • 4
    • 26644471951 scopus 로고    scopus 로고
    • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
    • COI: 1:CAS:528:DC%2BD2MXhtFOrtLrF, PID: 16226705
    • Casanovas O, Hicklin DJ, Bergers G, Hanahan D (2005) Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 8(4):299–309
    • (2005) Cancer Cell , vol.8 , Issue.4 , pp. 299-309
    • Casanovas, O.1    Hicklin, D.J.2    Bergers, G.3    Hanahan, D.4
  • 5
    • 60649087564 scopus 로고    scopus 로고
    • Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
    • COI: 1:CAS:528:DC%2BD1MXltFSmtbc%3D, PID: 19249681
    • Ebos JM, Lee CR, Cruz-Munoz W, Bjarnason GA, Christensen JG, Kerbel RS (2009) Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 15(3):232–239
    • (2009) Cancer Cell , vol.15 , Issue.3 , pp. 232-239
    • Ebos, J.M.1    Lee, C.R.2    Cruz-Munoz, W.3    Bjarnason, G.A.4    Christensen, J.G.5    Kerbel, R.S.6
  • 6
    • 60649106195 scopus 로고    scopus 로고
    • Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • COI: 1:CAS:528:DC%2BD1MXltFSmtbY%3D, PID: 19249680
    • Paez-Ribes M, Allen E, Hudock J et al (2009) Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 15(3):220–231
    • (2009) Cancer Cell , vol.15 , Issue.3 , pp. 220-231
    • Paez-Ribes, M.1    Allen, E.2    Hudock, J.3
  • 7
    • 34547941252 scopus 로고    scopus 로고
    • Autocrine VEGF signaling is required for vascular homeostasis
    • COI: 1:CAS:528:DC%2BD2sXhtVels7%2FK, PID: 17719546
    • Lee S, Chen TT, Barber CL et al (2007) Autocrine VEGF signaling is required for vascular homeostasis. Cell 130(4):691–703
    • (2007) Cell , vol.130 , Issue.4 , pp. 691-703
    • Lee, S.1    Chen, T.T.2    Barber, C.L.3
  • 8
    • 79960002971 scopus 로고    scopus 로고
    • VEGF non-angiogenic functions in adult organ homeostasis: therapeutic implications
    • COI: 1:CAS:528:DC%2BC3MXnt1Kru7w%3D
    • Luo J, Xiong Y, Han X, Lu Y (2011) VEGF non-angiogenic functions in adult organ homeostasis: therapeutic implications. J Mol Med (Berl) 89(7):635–645
    • (2011) J Mol Med (Berl) , vol.89 , Issue.7 , pp. 635-645
    • Luo, J.1    Xiong, Y.2    Han, X.3    Lu, Y.4
  • 9
    • 84887609331 scopus 로고    scopus 로고
    • Targeting tumor micro-environment for design and development of novel anti-angiogenic agents arresting tumor growth
    • COI: 1:CAS:528:DC%2BC3sXhs1OrtL3M, PID: 24139944
    • Gacche RN, Meshram RJ (2013) Targeting tumor micro-environment for design and development of novel anti-angiogenic agents arresting tumor growth. Prog Biophys Mol Biol 113(2):333–354
    • (2013) Prog Biophys Mol Biol , vol.113 , Issue.2 , pp. 333-354
    • Gacche, R.N.1    Meshram, R.J.2
  • 10
    • 0036789313 scopus 로고    scopus 로고
    • The role of fibroblast growth factors in vascular development
    • COI: 1:CAS:528:DC%2BD38XnsF2lsrg%3D, PID: 12383771
    • Javerzat S, Auguste P, Bikfalvi A (2002) The role of fibroblast growth factors in vascular development. Trends Mol Med 8(10):483–489
    • (2002) Trends Mol Med , vol.8 , Issue.10 , pp. 483-489
    • Javerzat, S.1    Auguste, P.2    Bikfalvi, A.3
  • 11
    • 75749096309 scopus 로고    scopus 로고
    • Phase II trial of infusional fluorouracil, irinotecan, and bevacizumab for metastatic colorectal cancer: efficacy and circulating angiogenic biomarkers associated with therapeutic resistance
    • COI: 1:CAS:528:DC%2BC3cXivFartLY%3D, PID: 20008624
    • Kopetz S, Hoff PM, Morris JS et al (2010) Phase II trial of infusional fluorouracil, irinotecan, and bevacizumab for metastatic colorectal cancer: efficacy and circulating angiogenic biomarkers associated with therapeutic resistance. J Clin Oncol 28(3):453–459
    • (2010) J Clin Oncol , vol.28 , Issue.3 , pp. 453-459
    • Kopetz, S.1    Hoff, P.M.2    Morris, J.S.3
  • 12
    • 0034671392 scopus 로고    scopus 로고
    • Fibroblast growth factors are required for efficient tumor angiogenesis
    • COI: 1:CAS:528:DC%2BD3MXjsVOgtQ%3D%3D, PID: 11156426
    • Compagni A, Wilgenbus P, Impagnatiello MA, Cotten M, Christofori G (2000) Fibroblast growth factors are required for efficient tumor angiogenesis. Cancer Res 60(24):7163–7169
    • (2000) Cancer Res , vol.60 , Issue.24 , pp. 7163-7169
    • Compagni, A.1    Wilgenbus, P.2    Impagnatiello, M.A.3    Cotten, M.4    Christofori, G.5
  • 13
    • 84904098885 scopus 로고    scopus 로고
    • A novel decoy receptor fusion protein for FGF-2 potently inhibits tumour growth
    • COI: 1:CAS:528:DC%2BC2cXovFCjt7c%3D, PID: 24874473
    • Li D, Wei X, Xie K, Chen K, Li J, Fang J (2014) A novel decoy receptor fusion protein for FGF-2 potently inhibits tumour growth. Br J Cancer 111(1):68–77
    • (2014) Br J Cancer , vol.111 , Issue.1 , pp. 68-77
    • Li, D.1    Wei, X.2    Xie, K.3    Chen, K.4    Li, J.5    Fang, J.6
  • 14
    • 84862751803 scopus 로고    scopus 로고
    • A novel monoclonal antibody to fibroblast growth factor 2 effectively inhibits growth of hepatocellular carcinoma xenografts
    • COI: 1:CAS:528:DC%2BC38Xltl2ntbo%3D, PID: 22351746
    • Wang L, Park H, Chhim S et al (2012) A novel monoclonal antibody to fibroblast growth factor 2 effectively inhibits growth of hepatocellular carcinoma xenografts. Mol Cancer Ther 11(4):864–872
    • (2012) Mol Cancer Ther , vol.11 , Issue.4 , pp. 864-872
    • Wang, L.1    Park, H.2    Chhim, S.3
  • 15
    • 33747336999 scopus 로고    scopus 로고
    • Identification of an antiangiogenic FGF2-binding site in the N terminus of the soluble pattern recognition receptor PTX3
    • COI: 1:CAS:528:DC%2BD28XnvVWjsro%3D, PID: 16769728
    • Camozzi M, Rusnati M, Bugatti A et al (2006) Identification of an antiangiogenic FGF2-binding site in the N terminus of the soluble pattern recognition receptor PTX3. J Biol Chem 281(32):22605–22613
    • (2006) J Biol Chem , vol.281 , Issue.32 , pp. 22605-22613
    • Camozzi, M.1    Rusnati, M.2    Bugatti, A.3
  • 16
    • 84877745098 scopus 로고    scopus 로고
    • Long pentraxin-3 as an epithelial-stromal fibroblast growth factor-targeting inhibitor in prostate cancer
    • COI: 1:CAS:528:DC%2BC3sXnsl2mtLo%3D, PID: 23424081
    • Ronca R, Alessi P, Coltrini D et al (2013) Long pentraxin-3 as an epithelial-stromal fibroblast growth factor-targeting inhibitor in prostate cancer. J Pathol 230(2):228–238
    • (2013) J Pathol , vol.230 , Issue.2 , pp. 228-238
    • Ronca, R.1    Alessi, P.2    Coltrini, D.3
  • 17
    • 84939444543 scopus 로고    scopus 로고
    • Long-pentraxin 3 derivative as a small-molecule FGF trap for cancer therapy
    • COI: 1:CAS:528:DC%2BC2MXhtlWlsbrL, PID: 26267536
    • Ronca R, Giacomini A, Di SE et al (2015) Long-pentraxin 3 derivative as a small-molecule FGF trap for cancer therapy. Cancer Cell 28(2):225–239
    • (2015) Cancer Cell , vol.28 , Issue.2 , pp. 225-239
    • Ronca, R.1    Giacomini, A.2    Di, S.E.3
  • 18
    • 0024600971 scopus 로고
    • Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules
    • COI: 1:CAS:528:DyaL1MXovV2gtQ%3D%3D, PID: 2541764
    • Bashkin P, Doctrow S, Klagsbrun M, Svahn CM, Folkman J, Vlodavsky I (1989) Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules. Biochemistry 28(4):1737–1743
    • (1989) Biochemistry , vol.28 , Issue.4 , pp. 1737-1743
    • Bashkin, P.1    Doctrow, S.2    Klagsbrun, M.3    Svahn, C.M.4    Folkman, J.5    Vlodavsky, I.6
  • 19
    • 0035874067 scopus 로고    scopus 로고
    • An FGF-binding protein (FGF-BP) exerts its biological function by parallel paracrine stimulation of tumor cell and endothelial cell proliferation through FGF-2 release
    • COI: 1:CAS:528:DC%2BD3MXjs1eit78%3D, PID: 11304685
    • Aigner A, Butscheid M, Kunkel P et al (2001) An FGF-binding protein (FGF-BP) exerts its biological function by parallel paracrine stimulation of tumor cell and endothelial cell proliferation through FGF-2 release. Int J Cancer 92(4):510–517
    • (2001) Int J Cancer , vol.92 , Issue.4 , pp. 510-517
    • Aigner, A.1    Butscheid, M.2    Kunkel, P.3
  • 20
    • 81555232414 scopus 로고    scopus 로고
    • Anti-tumor effects of fibroblast growth factor-binding protein (FGF-BP) knockdown in colon carcinoma
    • COI: 1:CAS:528:DC%2BC38XjsFynt7k%3D, PID: 22111880
    • Schulze D, Plohmann P, Hobel S, Aigner A (2011) Anti-tumor effects of fibroblast growth factor-binding protein (FGF-BP) knockdown in colon carcinoma. Mol Cancer 10:144
    • (2011) Mol Cancer , vol.10 , pp. 144
    • Schulze, D.1    Plohmann, P.2    Hobel, S.3    Aigner, A.4
  • 21
    • 84976215825 scopus 로고    scopus 로고
    • Soluble production and function of vascular endothelial growth factor/basic fibroblast growth factor complex peptide
    • Zhang Q, Lao X, Huang J et al (2014) Soluble production and function of vascular endothelial growth factor/basic fibroblast growth factor complex peptide. Biotechnol Prog
    • (2014) Biotechnol Prog
    • Zhang, Q.1    Lao, X.2    Huang, J.3
  • 22
    • 0037085234 scopus 로고    scopus 로고
    • New members of the platelet-derived growth factor family of mitogens
    • COI: 1:CAS:528:DC%2BD38XhtVajt7s%3D, PID: 11831861
    • Heldin CH, Eriksson U, Ostman A (2002) New members of the platelet-derived growth factor family of mitogens. Arch Biochem Biophys 398(2):284–290
    • (2002) Arch Biochem Biophys , vol.398 , Issue.2 , pp. 284-290
    • Heldin, C.H.1    Eriksson, U.2    Ostman, A.3
  • 23
    • 18544366585 scopus 로고    scopus 로고
    • Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy
    • COI: 1:CAS:528:DC%2BD38Xms1KntLg%3D, PID: 12169633
    • Enge M, Bjarnegard M, Gerhardt H et al (2002) Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy. EMBO J 21(16):4307–4316
    • (2002) EMBO J , vol.21 , Issue.16 , pp. 4307-4316
    • Enge, M.1    Bjarnegard, M.2    Gerhardt, H.3
  • 24
    • 34547637867 scopus 로고    scopus 로고
    • Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102
    • COI: 1:CAS:528:DC%2BD2sXosVemt7c%3D, PID: 17671206
    • Sennino B, Falcon BL, McCauley D et al (2007) Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102. Cancer Res 67(15):7358–7367
    • (2007) Cancer Res , vol.67 , Issue.15 , pp. 7358-7367
    • Sennino, B.1    Falcon, B.L.2    McCauley, D.3
  • 25
    • 77953604802 scopus 로고    scopus 로고
    • Targeting pericytes with a PDGF-B aptamer in human ovarian carcinoma models
    • COI: 1:CAS:528:DC%2BC3cXpt1Onurk%3D, PID: 20009575
    • Lu C, Shahzad MM, Moreno-Smith M et al (2010) Targeting pericytes with a PDGF-B aptamer in human ovarian carcinoma models. Cancer Biol Ther 9(3):176–182
    • (2010) Cancer Biol Ther , vol.9 , Issue.3 , pp. 176-182
    • Lu, C.1    Shahzad, M.M.2    Moreno-Smith, M.3
  • 26
    • 84879288021 scopus 로고    scopus 로고
    • PlGF: a multitasking cytokine with disease-restricted activity
    • Dewerchin M, Carmeliet P (2012) PlGF: a multitasking cytokine with disease-restricted activity. Cold Spring Harb Perspect Med 2(8)
    • (2012) Cold Spring Harb Perspect Med , vol.2 , Issue.8
    • Dewerchin, M.1    Carmeliet, P.2
  • 27
    • 35548982639 scopus 로고    scopus 로고
    • Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels
    • COI: 1:CAS:528:DC%2BD2sXhtlWitr%2FK, PID: 17981115
    • Fischer C, Jonckx B, Mazzone M et al (2007) Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels. Cell 131(3):463–475
    • (2007) Cell , vol.131 , Issue.3 , pp. 463-475
    • Fischer, C.1    Jonckx, B.2    Mazzone, M.3
  • 28
    • 79952277312 scopus 로고    scopus 로고
    • Placental growth factor neutralising antibodies give limited anti-angiogenic effects in an in vitro organotypic angiogenesis model
    • COI: 1:CAS:528:DC%2BC3cXhsVWqt7zN, PID: 20953695
    • Brave SR, Eberlein C, Shibuya M, Wedge SR, Barry ST (2010) Placental growth factor neutralising antibodies give limited anti-angiogenic effects in an in vitro organotypic angiogenesis model. Angiogenesis 13(4):337–347
    • (2010) Angiogenesis , vol.13 , Issue.4 , pp. 337-347
    • Brave, S.R.1    Eberlein, C.2    Shibuya, M.3    Wedge, S.R.4    Barry, S.T.5
  • 29
    • 77950953984 scopus 로고    scopus 로고
    • PlGF blockade does not inhibit angiogenesis during primary tumor growth
    • COI: 1:CAS:528:DC%2BC3cXlsVSgtbc%3D, PID: 20371352
    • Bais C, Wu X, Yao J et al (2010) PlGF blockade does not inhibit angiogenesis during primary tumor growth. Cell 141(1):166–177
    • (2010) Cell , vol.141 , Issue.1 , pp. 166-177
    • Bais, C.1    Wu, X.2    Yao, J.3
  • 30
    • 60749096085 scopus 로고    scopus 로고
    • Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system
    • COI: 1:CAS:528:DC%2BD1MXitFKlu74%3D, PID: 19234476
    • Augustin HG, Koh GY, Thurston G, Alitalo K (2009) Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system. Nat Rev Mol Cell Biol 10(3):165–177
    • (2009) Nat Rev Mol Cell Biol , vol.10 , Issue.3 , pp. 165-177
    • Augustin, H.G.1    Koh, G.Y.2    Thurston, G.3    Alitalo, K.4
  • 31
    • 33749414768 scopus 로고    scopus 로고
    • Activation of Tie2 by angiopoietin-1 and angiopoietin-2 results in their release and receptor internalization
    • COI: 1:CAS:528:DC%2BD28XhtVymu7%2FO, PID: 16895971
    • Bogdanovic E, Nguyen VP, Dumont DJ (2006) Activation of Tie2 by angiopoietin-1 and angiopoietin-2 results in their release and receptor internalization. J Cell Sci 119(Pt 17):3551–3560
    • (2006) J Cell Sci , vol.119 , pp. 3551-3560
    • Bogdanovic, E.1    Nguyen, V.P.2    Dumont, D.J.3
  • 32
    • 64649084437 scopus 로고    scopus 로고
    • Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium
    • COI: 1:CAS:528:DC%2BD1MXks1Sku7c%3D, PID: 19223473
    • Yuan HT, Khankin EV, Karumanchi SA, Parikh SM (2009) Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium. Mol Cell Biol 29(8):2011–2022
    • (2009) Mol Cell Biol , vol.29 , Issue.8 , pp. 2011-2022
    • Yuan, H.T.1    Khankin, E.V.2    Karumanchi, S.A.3    Parikh, S.M.4
  • 33
    • 0034036689 scopus 로고    scopus 로고
    • Angiopoietin-1 protects the adult vasculature against plasma leakage
    • COI: 1:CAS:528:DC%2BD3cXisVygsbc%3D, PID: 10742156
    • Thurston G, Rudge JS, Ioffe E et al (2000) Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat Med 6(4):460–463
    • (2000) Nat Med , vol.6 , Issue.4 , pp. 460-463
    • Thurston, G.1    Rudge, J.S.2    Ioffe, E.3
  • 34
    • 14944377120 scopus 로고    scopus 로고
    • The Tie-2 ligand angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism
    • COI: 1:CAS:528:DC%2BD2MXislOhsb0%3D, PID: 15687104
    • Scharpfenecker M, Fiedler U, Reiss Y, Augustin HG (2005) The Tie-2 ligand angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism. J Cell Sci 118(Pt 4):771–780
    • (2005) J Cell Sci , vol.118 , pp. 771-780
    • Scharpfenecker, M.1    Fiedler, U.2    Reiss, Y.3    Augustin, H.G.4
  • 35
    • 84861820220 scopus 로고    scopus 로고
    • Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling
    • COI: 1:CAS:528:DC%2BC38XosFarurs%3D, PID: 22585576
    • Felcht M, Luck R, Schering A et al (2012) Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling. J Clin Invest 122(6):1991–2005
    • (2012) J Clin Invest , vol.122 , Issue.6 , pp. 1991-2005
    • Felcht, M.1    Luck, R.2    Schering, A.3
  • 36
    • 15144358851 scopus 로고    scopus 로고
    • Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
    • COI: 1:CAS:528:DyaK2sXksVyhu78%3D, PID: 9204896
    • Maisonpierre PC, Suri C, Jones PF et al (1997) Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 277(5322):55–60
    • (1997) Science , vol.277 , Issue.5322 , pp. 55-60
    • Maisonpierre, P.C.1    Suri, C.2    Jones, P.F.3
  • 37
    • 4544290590 scopus 로고    scopus 로고
    • Angiopoietins in tumours: the angiogenic switch
    • COI: 1:CAS:528:DC%2BD2cXot1alsLo%3D, PID: 15307132
    • Tait CR, Jones PF (2004) Angiopoietins in tumours: the angiogenic switch. J Pathol 204(1):1–10
    • (2004) J Pathol , vol.204 , Issue.1 , pp. 1-10
    • Tait, C.R.1    Jones, P.F.2
  • 38
    • 7944220649 scopus 로고    scopus 로고
    • Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2
    • COI: 1:CAS:528:DC%2BD2cXhtVGlurjP, PID: 15542434
    • Oliner J, Min H, Leal J et al (2004) Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2. Cancer Cell 6(5):507–516
    • (2004) Cancer Cell , vol.6 , Issue.5 , pp. 507-516
    • Oliner, J.1    Min, H.2    Leal, J.3
  • 39
    • 84903517779 scopus 로고    scopus 로고
    • Anti-angiopoietin therapy with trebananib for recurrent ovarian cancer (TRINOVA-1): a randomised, multicentre, double-blind, placebo-controlled phase 3 trial
    • COI: 1:CAS:528:DC%2BC2cXhtVamsLbJ, PID: 24950985
    • Monk BJ, Poveda A, Vergote I et al (2014) Anti-angiopoietin therapy with trebananib for recurrent ovarian cancer (TRINOVA-1): a randomised, multicentre, double-blind, placebo-controlled phase 3 trial. Lancet Oncol 15(8):799–808
    • (2014) Lancet Oncol , vol.15 , Issue.8 , pp. 799-808
    • Monk, B.J.1    Poveda, A.2    Vergote, I.3
  • 40
    • 84887831643 scopus 로고    scopus 로고
    • Directed evolution of an angiopoietin-2 ligand trap by somatic hypermutation and cell surface display
    • COI: 1:CAS:528:DC%2BC3sXhslyrsLvM, PID: 24106271
    • Brindle NP, Sale JE, Arakawa H et al (2013) Directed evolution of an angiopoietin-2 ligand trap by somatic hypermutation and cell surface display. J Biol Chem 288(46):33205–33212
    • (2013) J Biol Chem , vol.288 , Issue.46 , pp. 33205-33212
    • Brindle, N.P.1    Sale, J.E.2    Arakawa, H.3
  • 41
    • 84859488747 scopus 로고    scopus 로고
    • MEDI3617, a human anti-angiopoietin 2 monoclonal antibody, inhibits angiogenesis and tumor growth in human tumor xenograft models
    • COI: 1:CAS:528:DC%2BC38XmtlGltrY%3D, PID: 22327175
    • Leow CC, Coffman K, Inigo I et al (2012) MEDI3617, a human anti-angiopoietin 2 monoclonal antibody, inhibits angiogenesis and tumor growth in human tumor xenograft models. Int J Oncol 40(5):1321–1330
    • (2012) Int J Oncol , vol.40 , Issue.5 , pp. 1321-1330
    • Leow, C.C.1    Coffman, K.2    Inigo, I.3
  • 42
    • 84871989305 scopus 로고    scopus 로고
    • Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition
    • COI: 1:CAS:528:DC%2BC3sXjs1Wnuw%3D%3D, PID: 23149917
    • Daly C, Eichten A, Castanaro C et al (2013) Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition. Cancer Res 73(1):108–118
    • (2013) Cancer Res , vol.73 , Issue.1 , pp. 108-118
    • Daly, C.1    Eichten, A.2    Castanaro, C.3
  • 43
    • 84890667775 scopus 로고    scopus 로고
    • Ang-2-VEGF-A CrossMab, a novel bispecific human IgG1 antibody blocking VEGF-A and Ang-2 functions simultaneously, mediates potent antitumor, antiangiogenic, and antimetastatic efficacy
    • COI: 1:CAS:528:DC%2BC3sXhvFyrtrvK, PID: 24097868
    • Kienast Y, Klein C, Scheuer W et al (2013) Ang-2-VEGF-A CrossMab, a novel bispecific human IgG1 antibody blocking VEGF-A and Ang-2 functions simultaneously, mediates potent antitumor, antiangiogenic, and antimetastatic efficacy. Clin Cancer Res 19(24):6730–6740
    • (2013) Clin Cancer Res , vol.19 , Issue.24 , pp. 6730-6740
    • Kienast, Y.1    Klein, C.2    Scheuer, W.3
  • 44
    • 84924616997 scopus 로고    scopus 로고
    • Role of angiopoietin-2 in adaptive tumor resistance to VEGF signaling blockade
    • COI: 1:CAS:528:DC%2BC2cXht1ymt7bM, PID: 25088418
    • Rigamonti N, Kadioglu E, Keklikoglou I, Wyser RC, Leow CC, De PM (2014) Role of angiopoietin-2 in adaptive tumor resistance to VEGF signaling blockade. Cell Rep 8(3):696–706
    • (2014) Cell Rep , vol.8 , Issue.3 , pp. 696-706
    • Rigamonti, N.1    Kadioglu, E.2    Keklikoglou, I.3    Wyser, R.C.4    Leow, C.C.5    De, P.M.6
  • 45
    • 82655164839 scopus 로고    scopus 로고
    • Dll4-Notch signaling as a therapeutic target in tumor angiogenesis
    • COI: 1:CAS:528:DC%2BC3MXhtlSns7zN, PID: 21923938
    • Kuhnert F, Kirshner JR, Thurston G (2011) Dll4-Notch signaling as a therapeutic target in tumor angiogenesis. Vasc Cell 3(1):20
    • (2011) Vasc Cell , vol.3 , Issue.1 , pp. 20
    • Kuhnert, F.1    Kirshner, J.R.2    Thurston, G.3
  • 46
    • 0037390452 scopus 로고    scopus 로고
    • Notch signaling in vascular development
    • COI: 1:CAS:528:DC%2BD3sXisFKgtLo%3D, PID: 12615665
    • Iso T, Hamamori Y, Kedes L (2003) Notch signaling in vascular development. Arterioscler Thromb Vasc Biol 23(4):543–553
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , Issue.4 , pp. 543-553
    • Iso, T.1    Hamamori, Y.2    Kedes, L.3
  • 47
  • 48
    • 31544448010 scopus 로고    scopus 로고
    • Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function
    • COI: 1:CAS:528:DC%2BD28Xht1Onsbg%3D, PID: 16219802
    • Williams CK, Li JL, Murga M, Harris AL, Tosato G (2006) Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function. Blood 107(3):931–939
    • (2006) Blood , vol.107 , Issue.3 , pp. 931-939
    • Williams, C.K.1    Li, J.L.2    Murga, M.3    Harris, A.L.4    Tosato, G.5
  • 49
    • 33847046849 scopus 로고    scopus 로고
    • Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
    • PID: 17259973
    • Hellstrom M, Phng LK, Hofmann JJ et al (2007) Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 445(7129):776–780
    • (2007) Nature , vol.445 , Issue.7129 , pp. 776-780
    • Hellstrom, M.1    Phng, L.K.2    Hofmann, J.J.3
  • 50
    • 0035753241 scopus 로고    scopus 로고
    • Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis
    • COI: 1:CAS:528:DC%2BD38XovVOluw%3D%3D, PID: 11798067
    • Mailhos C, Modlich U, Lewis J, Harris A, Bicknell R, Ish-Horowicz D (2001) Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis. Differentiation 69(2–3):135–144
    • (2001) Differentiation , vol.69 , Issue.2-3 , pp. 135-144
    • Mailhos, C.1    Modlich, U.2    Lewis, J.3    Harris, A.4    Bicknell, R.5    Ish-Horowicz, D.6
  • 51
    • 25444506836 scopus 로고    scopus 로고
    • Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function
    • COI: 1:CAS:528:DC%2BD2MXhtVKiu77E, PID: 16204037
    • Patel NS, Li JL, Generali D, Poulsom R, Cranston DW, Harris AL (2005) Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function. Cancer Res 65(19):8690–8697
    • (2005) Cancer Res , vol.65 , Issue.19 , pp. 8690-8697
    • Patel, N.S.1    Li, J.L.2    Generali, D.3    Poulsom, R.4    Cranston, D.W.5    Harris, A.L.6
  • 52
    • 33845907380 scopus 로고    scopus 로고
    • Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
    • COI: 1:CAS:528:DC%2BD28XhtlemtLnP, PID: 17183323
    • Ridgway J, Zhang G, Wu Y et al (2006) Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature 444(7122):1083–1087
    • (2006) Nature , vol.444 , Issue.7122 , pp. 1083-1087
    • Ridgway, J.1    Zhang, G.2    Wu, Y.3
  • 53
    • 33845877157 scopus 로고    scopus 로고
    • Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
    • COI: 1:CAS:528:DC%2BD28XhtlemtLnL, PID: 17183313
    • Noguera-Troise I, Daly C, Papadopoulos NJ et al (2006) Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature 444(7122):1032–1037
    • (2006) Nature , vol.444 , Issue.7122 , pp. 1032-1037
    • Noguera-Troise, I.1    Daly, C.2    Papadopoulos, N.J.3
  • 54
    • 34247479498 scopus 로고    scopus 로고
    • Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion
    • COI: 1:CAS:528:DC%2BD2sXmt1Ogtbs%3D, PID: 17311993
    • Scehnet JS, Jiang W, Kumar SR et al (2007) Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion. Blood 109(11):4753–4760
    • (2007) Blood , vol.109 , Issue.11 , pp. 4753-4760
    • Scehnet, J.S.1    Jiang, W.2    Kumar, S.R.3
  • 55
    • 34247539127 scopus 로고    scopus 로고
    • The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth
    • COI: 1:CAS:528:DC%2BD2sXksFSiu7k%3D, PID: 17457300
    • Thurston G, Noguera-Troise I, Yancopoulos GD (2007) The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth. Nat Rev Cancer 7(5):327–331
    • (2007) Nat Rev Cancer , vol.7 , Issue.5 , pp. 327-331
    • Thurston, G.1    Noguera-Troise, I.2    Yancopoulos, G.D.3
  • 56
    • 77951139188 scopus 로고    scopus 로고
    • Therapeutic antibody targeting of individual Notch receptors
    • COI: 1:CAS:528:DC%2BC3cXkslarur8%3D, PID: 20393564
    • Wu Y, Cain-Hom C, Choy L et al (2010) Therapeutic antibody targeting of individual Notch receptors. Nature 464(7291):1052–1057
    • (2010) Nature , vol.464 , Issue.7291 , pp. 1052-1057
    • Wu, Y.1    Cain-Hom, C.2    Choy, L.3
  • 57
    • 47949085649 scopus 로고    scopus 로고
    • A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesis
    • COI: 1:CAS:528:DC%2BD1cXnt1aqu7k%3D, PID: 18559519
    • Funahashi Y, Hernandez SL, Das I et al (2008) A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesis. Cancer Res 68(12):4727–4735
    • (2008) Cancer Res , vol.68 , Issue.12 , pp. 4727-4735
    • Funahashi, Y.1    Hernandez, S.L.2    Das, I.3
  • 58
    • 84942905295 scopus 로고    scopus 로고
    • Notch decoys that selectively block Dll/Notch or Jagged/Notch disrupt angiogenesis by unique mechanisms to inhibit tumor growth
    • Kangsamaksin T, Murtomaki A, Kofler NM et al (2014) Notch decoys that selectively block Dll/Notch or Jagged/Notch disrupt angiogenesis by unique mechanisms to inhibit tumor growth. Cancer Discov 2014
    • (2014) Cancer Discov , pp. 2014
    • Kangsamaksin, T.1    Murtomaki, A.2    Kofler, N.M.3
  • 59
    • 76749157186 scopus 로고    scopus 로고
    • Chronic DLL4 blockade induces vascular neoplasms
    • COI: 1:CAS:528:DC%2BC3cXhvVKrtbs%3D, PID: 20147986
    • Yan M, Callahan CA, Beyer JC et al (2010) Chronic DLL4 blockade induces vascular neoplasms. Nature 463(7282):E6–E7
    • (2010) Nature , vol.463 , Issue.7282 , pp. E6-E7
    • Yan, M.1    Callahan, C.A.2    Beyer, J.C.3
  • 60
    • 79551510137 scopus 로고    scopus 로고
    • Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice
    • COI: 1:CAS:528:DC%2BC3MXhsl2qs74%3D, PID: 21266774
    • Liu Z, Turkoz A, Jackson EN et al (2011) Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice. J Clin Investig 121(2):800–808
    • (2011) J Clin Investig , vol.121 , Issue.2 , pp. 800-808
    • Liu, Z.1    Turkoz, A.2    Jackson, E.N.3
  • 61
    • 0033960562 scopus 로고    scopus 로고
    • Integrins alpha(v)beta3 and alpha(v)beta5 are expressed by endothelium of high-risk neuroblastoma and their inhibition is associated with increased endogenous ceramide
    • COI: 1:CAS:528:DC%2BD3cXht1GmtbY%3D, PID: 10676658
    • Erdreich-Epstein A, Shimada H, Groshen S et al (2000) Integrins alpha(v)beta3 and alpha(v)beta5 are expressed by endothelium of high-risk neuroblastoma and their inhibition is associated with increased endogenous ceramide. Cancer Res 60(3):712–721
    • (2000) Cancer Res , vol.60 , Issue.3 , pp. 712-721
    • Erdreich-Epstein, A.1    Shimada, H.2    Groshen, S.3
  • 62
    • 47649119224 scopus 로고    scopus 로고
    • Cell-autonomous requirement for beta1 integrin in endothelial cell adhesion, migration and survival during angiogenesis in mice
    • COI: 1:CAS:528:DC%2BD1cXovVGhsL0%3D, PID: 18480158
    • Carlson TR, Hu H, Braren R, Kim YH, Wang RA (2008) Cell-autonomous requirement for beta1 integrin in endothelial cell adhesion, migration and survival during angiogenesis in mice. Development 135(12):2193–2202
    • (2008) Development , vol.135 , Issue.12 , pp. 2193-2202
    • Carlson, T.R.1    Hu, H.2    Braren, R.3    Kim, Y.H.4    Wang, R.A.5
  • 63
    • 84868143439 scopus 로고    scopus 로고
    • alphaV integrins in angiogenesis and cancer
    • PID: 22229119
    • Weis SM, Cheresh DA (2011) alphaV integrins in angiogenesis and cancer. Cold Spring Harb Perspect Med 1(1):a006478
    • (2011) Cold Spring Harb Perspect Med , vol.1 , Issue.1 , pp. a006478
    • Weis, S.M.1    Cheresh, D.A.2
  • 64
    • 0021271957 scopus 로고
    • Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule
    • COI: 1:CAS:528:DyaL2cXksFSgsrY%3D, PID: 6325925
    • Pierschbacher MD, Ruoslahti E (1984) Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. Nature 309(5963):30–33
    • (1984) Nature , vol.309 , Issue.5963 , pp. 30-33
    • Pierschbacher, M.D.1    Ruoslahti, E.2
  • 65
    • 0029610677 scopus 로고
    • Definition of two angiogenic pathways by distinct alpha v integrins
    • COI: 1:CAS:528:DyaK2MXps12hs7k%3D, PID: 7491498
    • Friedlander M, Brooks PC, Shaffer RW, Kincaid CM, Varner JA, Cheresh DA (1995) Definition of two angiogenic pathways by distinct alpha v integrins. Science 270(5241):1500–1502
    • (1995) Science , vol.270 , Issue.5241 , pp. 1500-1502
    • Friedlander, M.1    Brooks, P.C.2    Shaffer, R.W.3    Kincaid, C.M.4    Varner, J.A.5    Cheresh, D.A.6
  • 66
    • 0028362876 scopus 로고
    • Requirement of vascular integrin alpha v beta 3 for angiogenesis
    • COI: 1:CAS:528:DyaK2cXjt1Sis7w%3D, PID: 7512751
    • Brooks PC, Clark RA, Cheresh DA (1994) Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science 264(5158):569–571
    • (1994) Science , vol.264 , Issue.5158 , pp. 569-571
    • Brooks, P.C.1    Clark, R.A.2    Cheresh, D.A.3
  • 67
    • 0035158628 scopus 로고    scopus 로고
    • Integrin alpha(v)beta(3) expression in colon carcinoma correlates with survival
    • COI: 1:STN:280:DC%2BD3Mnltlaruw%3D%3D, PID: 11706074
    • Vonlaufen A, Wiedle G, Borisch B, Birrer S, Luder P, Imhof BA (2001) Integrin alpha(v)beta(3) expression in colon carcinoma correlates with survival. Mod Pathol 14(11):1126–1132
    • (2001) Mod Pathol , vol.14 , Issue.11 , pp. 1126-1132
    • Vonlaufen, A.1    Wiedle, G.2    Borisch, B.3    Birrer, S.4    Luder, P.5    Imhof, B.A.6
  • 68
    • 0028972105 scopus 로고
    • Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin
    • COI: 1:CAS:528:DyaK2MXosFyhtr8%3D, PID: 7560073
    • Brooks PC, Stromblad S, Klemke R, Visscher D, Sarkar FH, Cheresh DA (1995) Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin. J Clin Investig 96(4):1815–1822
    • (1995) J Clin Investig , vol.96 , Issue.4 , pp. 1815-1822
    • Brooks, P.C.1    Stromblad, S.2    Klemke, R.3    Visscher, D.4    Sarkar, F.H.5    Cheresh, D.A.6
  • 69
    • 0033870756 scopus 로고    scopus 로고
    • Targeted antiangiogenic therapy for cancer using Vitaxin: a humanized monoclonal antibody to the integrin alphavbeta3
    • COI: 1:CAS:528:DC%2BD3cXmsVOmsbo%3D, PID: 10955784
    • Gutheil JC, Campbell TN, Pierce PR et al (2000) Targeted antiangiogenic therapy for cancer using Vitaxin: a humanized monoclonal antibody to the integrin alphavbeta3. Clin Cancer Res 6(8):3056–3061
    • (2000) Clin Cancer Res , vol.6 , Issue.8 , pp. 3056-3061
    • Gutheil, J.C.1    Campbell, T.N.2    Pierce, P.R.3
  • 70
    • 77949394260 scopus 로고    scopus 로고
    • A randomized phase 2 study of etaracizumab, a monoclonal antibody against integrin alpha(v)beta(3), + or—dacarbazine in patients with stage IV metastatic melanoma
    • COI: 1:CAS:528:DC%2BC3cXktFGgsLk%3D, PID: 20108344
    • Hersey P, Sosman J, O’Day S et al (2010) A randomized phase 2 study of etaracizumab, a monoclonal antibody against integrin alpha(v)beta(3), + or—dacarbazine in patients with stage IV metastatic melanoma. Cancer 116(6):1526–1534
    • (2010) Cancer , vol.116 , Issue.6 , pp. 1526-1534
    • Hersey, P.1    Sosman, J.2    O’Day, S.3
  • 71
    • 0033549864 scopus 로고    scopus 로고
    • N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists
    • COI: 1:CAS:528:DyaK1MXksFGhsr0%3D, PID: 10447947
    • Dechantsreiter MA, Planker E, Matha B et al (1999) N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists. J Med Chem 42(16):3033–3040
    • (1999) J Med Chem , vol.42 , Issue.16 , pp. 3033-3040
    • Dechantsreiter, M.A.1    Planker, E.2    Matha, B.3
  • 72
    • 0036682030 scopus 로고    scopus 로고
    • Cilengitide targeting of alpha(v)beta(3) integrin receptor synergizes with radioimmunotherapy to increase efficacy and apoptosis in breast cancer xenografts
    • COI: 1:CAS:528:DC%2BD38XlvFeltbw%3D, PID: 12154028
    • Burke PA, DeNardo SJ, Miers LA, Lamborn KR, Matzku S, DeNardo GL (2002) Cilengitide targeting of alpha(v)beta(3) integrin receptor synergizes with radioimmunotherapy to increase efficacy and apoptosis in breast cancer xenografts. Cancer Res 62(15):4263–4272
    • (2002) Cancer Res , vol.62 , Issue.15 , pp. 4263-4272
    • Burke, P.A.1    DeNardo, S.J.2    Miers, L.A.3    Lamborn, K.R.4    Matzku, S.5    DeNardo, G.L.6
  • 73
    • 84908563697 scopus 로고    scopus 로고
    • Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial
    • COI: 1:CAS:528:DC%2BC2cXhsVSmt73E, PID: 25163906
    • Stupp R, Hegi ME, Gorlia T et al (2014) Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol 15(10):1100–1108
    • (2014) Lancet Oncol , vol.15 , Issue.10 , pp. 1100-1108
    • Stupp, R.1    Hegi, M.E.2    Gorlia, T.3
  • 74
    • 64149106522 scopus 로고    scopus 로고
    • Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors
    • COI: 1:CAS:528:DC%2BD1MXjsVCqtb4%3D, PID: 19305413
    • Reynolds AR, Hart IR, Watson AR et al (2009) Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors. Nat Med 15(4):392–400
    • (2009) Nat Med , vol.15 , Issue.4 , pp. 392-400
    • Reynolds, A.R.1    Hart, I.R.2    Watson, A.R.3
  • 75
    • 84922180322 scopus 로고    scopus 로고
    • Dual-action combination therapy enhances angiogenesis while reducing tumor growth and spread
    • COI: 1:CAS:528:DC%2BC2MXntVKnsw%3D%3D, PID: 25584895
    • Wong PP, Demircioglu F, Ghazaly E et al (2015) Dual-action combination therapy enhances angiogenesis while reducing tumor growth and spread. Cancer Cell 27(1):123–137
    • (2015) Cancer Cell , vol.27 , Issue.1 , pp. 123-137
    • Wong, P.P.1    Demircioglu, F.2    Ghazaly, E.3
  • 76
    • 33749349945 scopus 로고    scopus 로고
    • Preclinical evaluation of an anti-alpha5beta1 integrin antibody as a novel anti-angiogenic agent
    • COI: 1:CAS:528:DC%2BD28XhtV2ru77K, PID: 17024968
    • Ramakrishnan V, Bhaskar V, Law DA et al (2006) Preclinical evaluation of an anti-alpha5beta1 integrin antibody as a novel anti-angiogenic agent. J Exp Ther Oncol 5(4):273–286
    • (2006) J Exp Ther Oncol , vol.5 , Issue.4 , pp. 273-286
    • Ramakrishnan, V.1    Bhaskar, V.2    Law, D.A.3
  • 77
    • 39049171151 scopus 로고    scopus 로고
    • A function blocking anti-mouse integrin alpha5beta1 antibody inhibits angiogenesis and impedes tumor growth in vivo
    • PID: 18042290
    • Bhaskar V, Zhang D, Fox M et al (2007) A function blocking anti-mouse integrin alpha5beta1 antibody inhibits angiogenesis and impedes tumor growth in vivo. J Transl Med 5:61
    • (2007) J Transl Med , vol.5 , pp. 61
    • Bhaskar, V.1    Zhang, D.2    Fox, M.3
  • 78
    • 84871568127 scopus 로고    scopus 로고
    • Phase Ib safety and pharmacokinetic study of volociximab, an anti-alpha5beta1 integrin antibody, in combination with carboplatin and paclitaxel in advanced non-small-cell lung cancer
    • COI: 1:STN:280:DC%2BC38fptFCgtQ%3D%3D, PID: 22904239
    • Besse B, Tsao LC, Chao DT et al (2013) Phase Ib safety and pharmacokinetic study of volociximab, an anti-alpha5beta1 integrin antibody, in combination with carboplatin and paclitaxel in advanced non-small-cell lung cancer. Ann Oncol 24(1):90–96
    • (2013) Ann Oncol , vol.24 , Issue.1 , pp. 90-96
    • Besse, B.1    Tsao, L.C.2    Chao, D.T.3
  • 79
    • 0033543988 scopus 로고    scopus 로고
    • Vascular endothelial (VE)-cadherin: only an intercellular glue?
    • COI: 1:CAS:528:DyaK1MXmt1Wqtr8%3D, PID: 10502395
    • Dejana E, Bazzoni G, Lampugnani MG (1999) Vascular endothelial (VE)-cadherin: only an intercellular glue? Exp Cell Res 252(1):13–19
    • (1999) Exp Cell Res , vol.252 , Issue.1 , pp. 13-19
    • Dejana, E.1    Bazzoni, G.2    Lampugnani, M.G.3
  • 80
    • 18344364910 scopus 로고    scopus 로고
    • The human VE-cadherin promoter is subjected to organ-specific regulation and is activated in tumour angiogenesis
    • COI: 1:CAS:528:DC%2BD2MXjsVeqt78%3D, PID: 15735710
    • Prandini MH, Dreher I, Bouillot S, Benkerri S, Moll T, Huber P (2005) The human VE-cadherin promoter is subjected to organ-specific regulation and is activated in tumour angiogenesis. Oncogene 24(18):2992–3001
    • (2005) Oncogene , vol.24 , Issue.18 , pp. 2992-3001
    • Prandini, M.H.1    Dreher, I.2    Bouillot, S.3    Benkerri, S.4    Moll, T.5    Huber, P.6
  • 81
    • 0036682484 scopus 로고    scopus 로고
    • A monoclonal antibody to vascular endothelial-cadherin inhibits tumor angiogenesis without side effects on endothelial permeability
    • COI: 1:CAS:528:DC%2BD38XlvVCltL0%3D, PID: 12130501
    • Corada M, Zanetta L, Orsenigo F et al (2002) A monoclonal antibody to vascular endothelial-cadherin inhibits tumor angiogenesis without side effects on endothelial permeability. Blood 100(3):905–911
    • (2002) Blood , vol.100 , Issue.3 , pp. 905-911
    • Corada, M.1    Zanetta, L.2    Orsenigo, F.3
  • 82
    • 21144433924 scopus 로고    scopus 로고
    • Identification of a transiently exposed VE-cadherin epitope that allows for specific targeting of an antibody to the tumor neovasculature
    • COI: 1:CAS:528:DC%2BD2MXks12is70%3D, PID: 15701713
    • May C, Doody JF, Abdullah R et al (2005) Identification of a transiently exposed VE-cadherin epitope that allows for specific targeting of an antibody to the tumor neovasculature. Blood 105(11):4337–4344
    • (2005) Blood , vol.105 , Issue.11 , pp. 4337-4344
    • May, C.1    Doody, J.F.2    Abdullah, R.3
  • 83
    • 77956886193 scopus 로고    scopus 로고
    • The soluble fragment of VE-cadherin inhibits angiogenesis by reducing endothelial cell proliferation and tube capillary formation
    • COI: 1:CAS:528:DC%2BC3cXnsFKjs7o%3D, PID: 20559333
    • Li H, Shi X, Liu J et al (2010) The soluble fragment of VE-cadherin inhibits angiogenesis by reducing endothelial cell proliferation and tube capillary formation. Cancer Gene Ther 17(10):700–707
    • (2010) Cancer Gene Ther , vol.17 , Issue.10 , pp. 700-707
    • Li, H.1    Shi, X.2    Liu, J.3
  • 84
    • 0036303033 scopus 로고    scopus 로고
    • Mechanisms and functions of Eph and ephrin signalling
    • COI: 1:CAS:528:DC%2BD38XkvFKmtbk%3D, PID: 12094214
    • Kullander K, Klein R (2002) Mechanisms and functions of Eph and ephrin signalling. Nat Rev Mol Cell Biol 3(7):475–486
    • (2002) Nat Rev Mol Cell Biol , vol.3 , Issue.7 , pp. 475-486
    • Kullander, K.1    Klein, R.2
  • 85
    • 0029851690 scopus 로고    scopus 로고
    • Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands
    • COI: 1:CAS:528:DyaK28XmsVGnsrc%3D, PID: 8878483
    • Holland SJ, Gale NW, Mbamalu G, Yancopoulos GD, Henkemeyer M, Pawson T (1996) Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands. Nature 383(6602):722–725
    • (1996) Nature , vol.383 , Issue.6602 , pp. 722-725
    • Holland, S.J.1    Gale, N.W.2    Mbamalu, G.3    Yancopoulos, G.D.4    Henkemeyer, M.5    Pawson, T.6
  • 86
    • 77951677126 scopus 로고    scopus 로고
    • Eph receptors and ephrin ligands: important players in angiogenesis and tumor angiogenesis
    • PID: 20224755
    • Mosch B, Reissenweber B, Neuber C, Pietzsch J (2010) Eph receptors and ephrin ligands: important players in angiogenesis and tumor angiogenesis. J Oncol 2010:135285
    • (2010) J Oncol , vol.2010 , pp. 135285
    • Mosch, B.1    Reissenweber, B.2    Neuber, C.3    Pietzsch, J.4
  • 87
    • 0031787110 scopus 로고    scopus 로고
    • Ephrin-A1 is expressed at sites of vascular development in the mouse
    • COI: 1:CAS:528:DyaK1cXmvFWmsLw%3D, PID: 9831653
    • McBride JL, Ruiz JC (1998) Ephrin-A1 is expressed at sites of vascular development in the mouse. Mech Dev 77(2):201–204
    • (1998) Mech Dev , vol.77 , Issue.2 , pp. 201-204
    • McBride, J.L.1    Ruiz, J.C.2
  • 88
    • 0034619758 scopus 로고    scopus 로고
    • The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization
    • COI: 1:CAS:528:DC%2BD3MXhsFCrsw%3D%3D, PID: 11146556
    • Ogawa K, Pasqualini R, Lindberg RA, Kain R, Freeman AL, Pasquale EB (2000) The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization. Oncogene 19(52):6043–6052
    • (2000) Oncogene , vol.19 , Issue.52 , pp. 6043-6052
    • Ogawa, K.1    Pasqualini, R.2    Lindberg, R.A.3    Kain, R.4    Freeman, A.L.5    Pasquale, E.B.6
  • 89
    • 0345269144 scopus 로고    scopus 로고
    • Blockade of EphA receptor tyrosine kinase activation inhibits vascular endothelial cell growth factor-induced angiogenesis
    • COI: 1:CAS:528:DC%2BD38Xps1yqs7s%3D, PID: 12496364
    • Cheng N, Brantley DM, Liu H et al (2002) Blockade of EphA receptor tyrosine kinase activation inhibits vascular endothelial cell growth factor-induced angiogenesis. Mol Cancer Res 1(1):2–11
    • (2002) Mol Cancer Res , vol.1 , Issue.1 , pp. 2-11
    • Cheng, N.1    Brantley, D.M.2    Liu, H.3
  • 90
    • 18644379904 scopus 로고    scopus 로고
    • Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo
    • COI: 1:CAS:528:DC%2BD38XnsFyltb4%3D, PID: 12370823
    • Brantley DM, Cheng N, Thompson EJ et al (2002) Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo. Oncogene 21(46):7011–7026
    • (2002) Oncogene , vol.21 , Issue.46 , pp. 7011-7026
    • Brantley, D.M.1    Cheng, N.2    Thompson, E.J.3
  • 91
    • 0842282623 scopus 로고    scopus 로고
    • Antiangiogenic and antitumor efficacy of EphA2 receptor antagonist
    • COI: 1:CAS:528:DC%2BD2cXhtFCgtbg%3D, PID: 14871820
    • Dobrzanski P, Hunter K, Jones-Bolin S et al (2004) Antiangiogenic and antitumor efficacy of EphA2 receptor antagonist. Cancer Res 64(3):910–919
    • (2004) Cancer Res , vol.64 , Issue.3 , pp. 910-919
    • Dobrzanski, P.1    Hunter, K.2    Jones-Bolin, S.3
  • 92
    • 0032577446 scopus 로고    scopus 로고
    • Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4
    • COI: 1:CAS:528:DyaK1cXjsl2ktrs%3D, PID: 9630219
    • Wang HU, Chen ZF, Anderson DJ (1998) Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell 93(5):741–753
    • (1998) Cell , vol.93 , Issue.5 , pp. 741-753
    • Wang, H.U.1    Chen, Z.F.2    Anderson, D.J.3
  • 93
    • 1842732148 scopus 로고    scopus 로고
    • Interplay between EphB4 on tumor cells and vascular ephrin-B2 regulates tumor growth
    • COI: 1:CAS:528:DC%2BD2cXjsVagu7g%3D, PID: 15067119
    • Noren NK, Lu M, Freeman AL, Koolpe M, Pasquale EB (2004) Interplay between EphB4 on tumor cells and vascular ephrin-B2 regulates tumor growth. Proc Natl Acad Sci USA 101(15):5583–5588
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.15 , pp. 5583-5588
    • Noren, N.K.1    Lu, M.2    Freeman, A.L.3    Koolpe, M.4    Pasquale, E.B.5
  • 94
    • 77953022206 scopus 로고    scopus 로고
    • Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis
    • COI: 1:CAS:528:DC%2BC3cXls12qurw%3D, PID: 20445540
    • Sawamiphak S, Seidel S, Essmann CL et al (2010) Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis. Nature 465(7297):487–491
    • (2010) Nature , vol.465 , Issue.7297 , pp. 487-491
    • Sawamiphak, S.1    Seidel, S.2    Essmann, C.L.3
  • 95
    • 78549253191 scopus 로고    scopus 로고
    • Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis
    • COI: 1:CAS:528:DC%2BC3cXhsFSktrfI, PID: 21092311
    • Djokovic D, Trindade A, Gigante J et al (2010) Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis. BMC Cancer 10:641
    • (2010) BMC Cancer , vol.10 , pp. 641
    • Djokovic, D.1    Trindade, A.2    Gigante, J.3
  • 96
    • 84929054410 scopus 로고    scopus 로고
    • The differential expression of EphB2 and EphB4 receptor kinases in normal bladder and in transitional cell carcinoma of the bladder
    • PID: 25148033
    • Li X, Choi WW, Yan R et al (2014) The differential expression of EphB2 and EphB4 receptor kinases in normal bladder and in transitional cell carcinoma of the bladder. PLoS ONE 9(8):e105326
    • (2014) PLoS ONE , vol.9 , Issue.8 , pp. e105326
    • Li, X.1    Choi, W.W.2    Yan, R.3
  • 97
    • 84855915831 scopus 로고    scopus 로고
    • Identification and angiogenic role of the novel tumor endothelial marker CLEC14A
    • COI: 1:CAS:528:DC%2BC3MXotV2isrk%3D, PID: 21706054
    • Mura M, Swain RK, Zhuang X et al (2012) Identification and angiogenic role of the novel tumor endothelial marker CLEC14A. Oncogene 31(3):293–305
    • (2012) Oncogene , vol.31 , Issue.3 , pp. 293-305
    • Mura, M.1    Swain, R.K.2    Zhuang, X.3
  • 98
    • 84947870788 scopus 로고    scopus 로고
    • Blocking CLEC14A-MMRN2 binding inhibits sprouting angiogenesis and tumour growth
    • Noy PJ, Lodhia P, Khan K et al (2015) Blocking CLEC14A-MMRN2 binding inhibits sprouting angiogenesis and tumour growth. Oncogene
    • (2015) Oncogene
    • Noy, P.J.1    Lodhia, P.2    Khan, K.3
  • 99
    • 84890616064 scopus 로고    scopus 로고
    • SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers
    • COI: 1:CAS:528:DC%2BC3sXhvFWrtb3L, PID: 23979707
    • Zanivan S, Maione F, Hein MY et al (2013) SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers. Mol Cell Proteomics 12(12):3599–3611
    • (2013) Mol Cell Proteomics , vol.12 , Issue.12 , pp. 3599-3611
    • Zanivan, S.1    Maione, F.2    Hein, M.Y.3
  • 100
    • 78650868374 scopus 로고    scopus 로고
    • Clec14a is specifically expressed in endothelial cells and mediates cell to cell adhesion
    • COI: 1:CAS:528:DC%2BC3MXksFOnsw%3D%3D, PID: 21095181
    • Rho SS, Choi HJ, Min JK et al (2011) Clec14a is specifically expressed in endothelial cells and mediates cell to cell adhesion. Biochem Biophys Res Commun 404(1):103–108
    • (2011) Biochem Biophys Res Commun , vol.404 , Issue.1 , pp. 103-108
    • Rho, S.S.1    Choi, H.J.2    Min, J.K.3
  • 101
    • 84889083761 scopus 로고    scopus 로고
    • Human antibodies targeting the C-type lectin-like domain of the tumor endothelial cell marker clec14a regulate angiogenic properties in vitro
    • COI: 1:CAS:528:DC%2BC3sXntVartLw%3D, PID: 23644659
    • Ki MK, Jeoung MH, Choi JR et al (2013) Human antibodies targeting the C-type lectin-like domain of the tumor endothelial cell marker clec14a regulate angiogenic properties in vitro. Oncogene 32(48):5449–5457
    • (2013) Oncogene , vol.32 , Issue.48 , pp. 5449-5457
    • Ki, M.K.1    Jeoung, M.H.2    Choi, J.R.3
  • 102
    • 0034682892 scopus 로고    scopus 로고
    • Genes expressed in human tumor endothelium
    • St CB, Rago C, Velculescu V et al (2000) Genes expressed in human tumor endothelium. Science 289(5482):1197–1202
    • (2000) Science , vol.289 , Issue.5482 , pp. 1197-1202
    • St, C.B.1    Rago, C.2    Velculescu, V.3
  • 103
    • 0842304298 scopus 로고    scopus 로고
    • TEM8 interacts with the cleaved C5 domain of collagen alpha 3(VI)
    • COI: 1:CAS:528:DC%2BD2cXhtFCgtL8%3D, PID: 14871805
    • Nanda A, Carson-Walter EB, Seaman S et al (2004) TEM8 interacts with the cleaved C5 domain of collagen alpha 3(VI). Cancer Res 64(3):817–820
    • (2004) Cancer Res , vol.64 , Issue.3 , pp. 817-820
    • Nanda, A.1    Carson-Walter, E.B.2    Seaman, S.3
  • 104
    • 68049120477 scopus 로고    scopus 로고
    • Host-derived tumor endothelial marker 8 promotes the growth of melanoma
    • COI: 1:CAS:528:DC%2BD1MXpt1Cgt78%3D, PID: 19622764
    • Cullen M, Seaman S, Chaudhary A et al (2009) Host-derived tumor endothelial marker 8 promotes the growth of melanoma. Cancer Res 69(15):6021–6026
    • (2009) Cancer Res , vol.69 , Issue.15 , pp. 6021-6026
    • Cullen, M.1    Seaman, S.2    Chaudhary, A.3
  • 105
    • 84863012047 scopus 로고    scopus 로고
    • TEM8/ANTXR1 blockade inhibits pathological angiogenesis and potentiates tumoricidal responses against multiple cancer types
    • COI: 1:CAS:528:DC%2BC38Xit12isbw%3D, PID: 22340594
    • Chaudhary A, Hilton MB, Seaman S et al (2012) TEM8/ANTXR1 blockade inhibits pathological angiogenesis and potentiates tumoricidal responses against multiple cancer types. Cancer Cell 21(2):212–226
    • (2012) Cancer Cell , vol.21 , Issue.2 , pp. 212-226
    • Chaudhary, A.1    Hilton, M.B.2    Seaman, S.3
  • 106
    • 35548936103 scopus 로고    scopus 로고
    • Antitumor activities of TEM8-Fc: an engineered antibody-like molecule targeting tumor endothelial marker 8
    • COI: 1:CAS:528:DC%2BD2sXhtlCqsbnM, PID: 17925540
    • Duan HF, Hu XW, Chen JL et al (2007) Antitumor activities of TEM8-Fc: an engineered antibody-like molecule targeting tumor endothelial marker 8. J Natl Cancer Inst 99(20):1551–1555
    • (2007) J Natl Cancer Inst , vol.99 , Issue.20 , pp. 1551-1555
    • Duan, H.F.1    Hu, X.W.2    Chen, J.L.3
  • 107
    • 84873087237 scopus 로고    scopus 로고
    • CD146, a multi-functional molecule beyond adhesion
    • COI: 1:CAS:528:DC%2BC3sXnt1ahsw%3D%3D, PID: 23266426
    • Wang Z, Yan X (2013) CD146, a multi-functional molecule beyond adhesion. Cancer Lett 330(2):150–162
    • (2013) Cancer Lett , vol.330 , Issue.2 , pp. 150-162
    • Wang, Z.1    Yan, X.2
  • 108
    • 84901287170 scopus 로고    scopus 로고
    • Impaired tumor angiogenesis and VEGF-induced pathway in endothelial CD146 knockout mice
    • COI: 1:CAS:528:DC%2BC2cXntFOltbw%3D, PID: 24756564
    • Zeng Q, Wu Z, Duan H et al (2014) Impaired tumor angiogenesis and VEGF-induced pathway in endothelial CD146 knockout mice. Protein Cell 5(6):445–456
    • (2014) Protein Cell , vol.5 , Issue.6 , pp. 445-456
    • Zeng, Q.1    Wu, Z.2    Duan, H.3
  • 109
    • 84863713142 scopus 로고    scopus 로고
    • Laminin-411 is a vascular ligand for MCAM and facilitates TH17 cell entry into the CNS
    • COI: 1:CAS:528:DC%2BC38XhtVemsrrM, PID: 22792325
    • Flanagan K, Fitzgerald K, Baker J et al (2012) Laminin-411 is a vascular ligand for MCAM and facilitates TH17 cell entry into the CNS. PLoS ONE 7(7):e40443
    • (2012) PLoS ONE , vol.7 , Issue.7 , pp. e40443
    • Flanagan, K.1    Fitzgerald, K.2    Baker, J.3
  • 110
    • 84924521970 scopus 로고    scopus 로고
    • CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development
    • COI: 1:CAS:528:DC%2BC2MXitlShsbw%3D, PID: 25656845
    • Tu T, Zhang C, Yan H et al (2015) CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development. Cell Res 25(3):275–287
    • (2015) Cell Res , vol.25 , Issue.3 , pp. 275-287
    • Tu, T.1    Zhang, C.2    Yan, H.3
  • 111
    • 84866343239 scopus 로고    scopus 로고
    • CD146 is a coreceptor for VEGFR-2 in tumor angiogenesis
    • COI: 1:CAS:528:DC%2BC38Xhtl2mu77E, PID: 22718841
    • Jiang T, Zhuang J, Duan H et al (2012) CD146 is a coreceptor for VEGFR-2 in tumor angiogenesis. Blood 120(11):2330–2339
    • (2012) Blood , vol.120 , Issue.11 , pp. 2330-2339
    • Jiang, T.1    Zhuang, J.2    Duan, H.3
  • 112
    • 0026646785 scopus 로고
    • Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells
    • COI: 1:CAS:528:DyaK38Xlt1Ggurg%3D, PID: 1326540
    • Cheifetz S, Bellon T, Cales C et al (1992) Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells. J Biol Chem 267(27):19027–19030
    • (1992) J Biol Chem , vol.267 , Issue.27 , pp. 19027-19030
    • Cheifetz, S.1    Bellon, T.2    Cales, C.3
  • 113
    • 0029035687 scopus 로고
    • Differential expression of endoglin on fetal and adult hematopoietic cells in human bone marrow
    • COI: 1:CAS:528:DyaK2MXltF2gtbo%3D, PID: 7722302
    • Rokhlin OW, Cohen MB, Kubagawa H, Letarte M, Cooper MD (1995) Differential expression of endoglin on fetal and adult hematopoietic cells in human bone marrow. J Immunol 154(9):4456–4465
    • (1995) J Immunol , vol.154 , Issue.9 , pp. 4456-4465
    • Rokhlin, O.W.1    Cohen, M.B.2    Kubagawa, H.3    Letarte, M.4    Cooper, M.D.5
  • 114
    • 0033612141 scopus 로고    scopus 로고
    • Defective angiogenesis in mice lacking endoglin
    • COI: 1:CAS:528:DyaK1MXjs1WhsrY%3D, PID: 10348742
    • Li DY, Sorensen LK, Brooke BS et al (1999) Defective angiogenesis in mice lacking endoglin. Science 284(5419):1534–1537
    • (1999) Science , vol.284 , Issue.5419 , pp. 1534-1537
    • Li, D.Y.1    Sorensen, L.K.2    Brooke, B.S.3
  • 115
    • 0029611184 scopus 로고
    • Up-regulation of endoglin on vascular endothelial cells in human solid tumors: implications for diagnosis and therapy
    • COI: 1:CAS:528:DyaK28XmvVWgsg%3D%3D, PID: 9815965
    • Burrows FJ, Derbyshire EJ, Tazzari PL et al (1995) Up-regulation of endoglin on vascular endothelial cells in human solid tumors: implications for diagnosis and therapy. Clin Cancer Res 1(12):1623–1634
    • (1995) Clin Cancer Res , vol.1 , Issue.12 , pp. 1623-1634
    • Burrows, F.J.1    Derbyshire, E.J.2    Tazzari, P.L.3
  • 116
    • 0037113959 scopus 로고    scopus 로고
    • Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-beta pathways
    • COI: 1:CAS:528:DC%2BD38Xos1alu7s%3D, PID: 12228247
    • Sanchez-Elsner T, Botella LM, Velasco B, Langa C, Bernabeu C (2002) Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-beta pathways. J Biol Chem 277(46):43799–43808
    • (2002) J Biol Chem , vol.277 , Issue.46 , pp. 43799-43808
    • Sanchez-Elsner, T.1    Botella, L.M.2    Velasco, B.3    Langa, C.4    Bernabeu, C.5
  • 117
    • 0141566683 scopus 로고    scopus 로고
    • Differential vascular and transcriptional responses to anti-vascular endothelial growth factor antibody in orthotopic human pancreatic cancer xenografts
    • COI: 1:CAS:528:DC%2BD3sXns1Ojurw%3D, PID: 14519649
    • Bockhorn M, Tsuzuki Y, Xu L, Frilling A, Broelsch CE, Fukumura D (2003) Differential vascular and transcriptional responses to anti-vascular endothelial growth factor antibody in orthotopic human pancreatic cancer xenografts. Clin Cancer Res 9(11):4221–4226
    • (2003) Clin Cancer Res , vol.9 , Issue.11 , pp. 4221-4226
    • Bockhorn, M.1    Tsuzuki, Y.2    Xu, L.3    Frilling, A.4    Broelsch, C.E.5    Fukumura, D.6
  • 118
    • 0035503538 scopus 로고    scopus 로고
    • Antiangiogenic therapy of established tumors in human skin/severe combined immunodeficiency mouse chimeras by anti-endoglin (CD105) monoclonal antibodies, and synergy between anti-endoglin antibody and cyclophosphamide
    • COI: 1:CAS:528:DC%2BD3MXotlaku70%3D, PID: 11691802
    • Takahashi N, Haba A, Matsuno F, Seon BK (2001) Antiangiogenic therapy of established tumors in human skin/severe combined immunodeficiency mouse chimeras by anti-endoglin (CD105) monoclonal antibodies, and synergy between anti-endoglin antibody and cyclophosphamide. Cancer Res 61(21):7846–7854
    • (2001) Cancer Res , vol.61 , Issue.21 , pp. 7846-7854
    • Takahashi, N.1    Haba, A.2    Matsuno, F.3    Seon, B.K.4
  • 119
    • 42149083332 scopus 로고    scopus 로고
    • Anti-tumor activity of an anti-endoglin monoclonal antibody is enhanced in immunocompetent mice
    • COI: 1:CAS:528:DC%2BD1cXkslynsbs%3D, PID: 18224682
    • Tsujie M, Tsujie T, Toi H et al (2008) Anti-tumor activity of an anti-endoglin monoclonal antibody is enhanced in immunocompetent mice. Int J Cancer 122(10):2266–2273
    • (2008) Int J Cancer , vol.122 , Issue.10 , pp. 2266-2273
    • Tsujie, M.1    Tsujie, T.2    Toi, H.3
  • 120
    • 84871655253 scopus 로고    scopus 로고
    • Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-endoglin antibodies
    • COI: 1:CAS:528:DC%2BC3sXmvFKmsQ%3D%3D, PID: 23300529
    • Nolan-Stevaux O, Zhong W, Culp S et al (2012) Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-endoglin antibodies. PLoS ONE 7(12):e50920
    • (2012) PLoS ONE , vol.7 , Issue.12 , pp. e50920
    • Nolan-Stevaux, O.1    Zhong, W.2    Culp, S.3
  • 121
    • 84925409921 scopus 로고    scopus 로고
    • Effects of the combination of TRC105 and bevacizumab on endothelial cell biology
    • COI: 1:CAS:528:DC%2BC2cXhtFWit7rM
    • Liu Y, Tian H, Blobe GC, Theuer CP, Hurwitz HI, Nixon AB (2014) Effects of the combination of TRC105 and bevacizumab on endothelial cell biology. Investig New Drugs 32(5):851–859
    • (2014) Investig New Drugs , vol.32 , Issue.5 , pp. 851-859
    • Liu, Y.1    Tian, H.2    Blobe, G.C.3    Theuer, C.P.4    Hurwitz, H.I.5    Nixon, A.B.6
  • 122
    • 84918799506 scopus 로고    scopus 로고
    • An open-label phase Ib dose-escalation study of TRC105 (anti-endoglin antibody) with bevacizumab in patients with advanced cancer
    • COI: 1:CAS:528:DC%2BC2cXitVGku73J, PID: 25261556
    • Gordon MS, Robert F, Matei D et al (2014) An open-label phase Ib dose-escalation study of TRC105 (anti-endoglin antibody) with bevacizumab in patients with advanced cancer. Clin Cancer Res 20(23):5918–5926
    • (2014) Clin Cancer Res , vol.20 , Issue.23 , pp. 5918-5926
    • Gordon, M.S.1    Robert, F.2    Matei, D.3
  • 123
    • 0032493654 scopus 로고    scopus 로고
    • 2′-Fluoropyrimidine RNA-based aptamers to the 165-amino acid form of vascular endothelial growth factor (VEGF165). Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domain
    • COI: 1:CAS:528:DyaK1cXlsVWgu70%3D, PID: 9685413
    • Ruckman J, Green LS, Beeson J et al (1998) 2′-Fluoropyrimidine RNA-based aptamers to the 165-amino acid form of vascular endothelial growth factor (VEGF165). Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domain. J Biol Chem 273(32):20556–20567
    • (1998) J Biol Chem , vol.273 , Issue.32 , pp. 20556-20567
    • Ruckman, J.1    Green, L.S.2    Beeson, J.3
  • 124
    • 84876336136 scopus 로고    scopus 로고
    • Monoclonal antibody therapeutics with up to five specificities: functional enhancement through fusion of target-specific peptides
    • PID: 23575268
    • LaFleur DW, Abramyan D, Kanakaraj P et al (2013) Monoclonal antibody therapeutics with up to five specificities: functional enhancement through fusion of target-specific peptides. MAbs 5(2):208–218
    • (2013) MAbs , vol.5 , Issue.2 , pp. 208-218
    • LaFleur, D.W.1    Abramyan, D.2    Kanakaraj, P.3
  • 126
    • 67649240336 scopus 로고    scopus 로고
    • The vascular basement membrane as “soil” in brain metastasis
    • PID: 19516901
    • Carbonell WS, Ansorge O, Sibson N, Muschel R (2009) The vascular basement membrane as “soil” in brain metastasis. PLoS ONE 4(6):e5857
    • (2009) PLoS ONE , vol.4 , Issue.6 , pp. e5857
    • Carbonell, W.S.1    Ansorge, O.2    Sibson, N.3    Muschel, R.4
  • 127
    • 84896690172 scopus 로고    scopus 로고
    • Serpins promote cancer cell survival and vascular co-option in brain metastasis
    • COI: 1:CAS:528:DC%2BC2cXjsVWnsLs%3D, PID: 24581498
    • Valiente M, Obenauf AC, Jin X et al (2014) Serpins promote cancer cell survival and vascular co-option in brain metastasis. Cell 156(5):1002–1016
    • (2014) Cell , vol.156 , Issue.5 , pp. 1002-1016
    • Valiente, M.1    Obenauf, A.C.2    Jin, X.3
  • 128
    • 84898959067 scopus 로고    scopus 로고
    • Role of endothelial progenitor cells in cancer progression
    • COI: 1:CAS:528:DC%2BC2cXht1OqsrzK, PID: 24709008
    • Moschetta M, Mishima Y, Sahin I et al (2014) Role of endothelial progenitor cells in cancer progression. Biochim Biophys Acta 1846(1):26–39
    • (2014) Biochim Biophys Acta , vol.1846 , Issue.1 , pp. 26-39
    • Moschetta, M.1    Mishima, Y.2    Sahin, I.3
  • 129
    • 84883375630 scopus 로고    scopus 로고
    • Preclinical recapitulation of antiangiogenic drug clinical efficacies using models of early or late stage breast cancer metastatis
    • PID: 24074794
    • Kerbel RS, Guerin E, Francia G et al (2013) Preclinical recapitulation of antiangiogenic drug clinical efficacies using models of early or late stage breast cancer metastatis. Breast 22(Suppl 2):S57–S65
    • (2013) Breast , vol.22 , pp. S57-S65
    • Kerbel, R.S.1    Guerin, E.2    Francia, G.3
  • 130
    • 33847615623 scopus 로고    scopus 로고
    • Mice expressing a humanized form of VEGF-A may provide insights into the safety and efficacy of anti-VEGF antibodies
    • COI: 1:CAS:528:DC%2BD2sXjtVWltbw%3D, PID: 17360669
    • Gerber HP, Wu X, Yu L et al (2007) Mice expressing a humanized form of VEGF-A may provide insights into the safety and efficacy of anti-VEGF antibodies. Proc Natl Acad Sci USA 104(9):3478–3483
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.9 , pp. 3478-3483
    • Gerber, H.P.1    Wu, X.2    Yu, L.3
  • 131
    • 84921742499 scopus 로고    scopus 로고
    • Facilitation of endoglin-targeting cancer therapy by development/utilization of a novel genetically engineered mouse model expressing humanized endoglin (CD105)
    • COI: 1:CAS:528:DC%2BC2cXps1yksLY%3D, PID: 24866768
    • Toi H, Tsujie M, Haruta Y, Fujita K, Duzen J, Seon BK (2015) Facilitation of endoglin-targeting cancer therapy by development/utilization of a novel genetically engineered mouse model expressing humanized endoglin (CD105). Int J Cancer 136(2):452–461
    • (2015) Int J Cancer , vol.136 , Issue.2 , pp. 452-461
    • Toi, H.1    Tsujie, M.2    Haruta, Y.3    Fujita, K.4    Duzen, J.5    Seon, B.K.6
  • 132
    • 84877707375 scopus 로고    scopus 로고
    • One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering
    • COI: 1:CAS:528:DC%2BC3sXmvF2nt7w%3D, PID: 23643243
    • Wang H, Yang H, Shivalila CS et al (2013) One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell 153(4):910–918
    • (2013) Cell , vol.153 , Issue.4 , pp. 910-918
    • Wang, H.1    Yang, H.2    Shivalila, C.S.3
  • 133
    • 84922268960 scopus 로고    scopus 로고
    • Identification of novel vascular targets in lung cancer
    • COI: 1:CAS:528:DC%2BC2MXit1antb0%3D, PID: 25535734
    • Zhuang X, Herbert JM, Lodhia P et al (2015) Identification of novel vascular targets in lung cancer. Br J Cancer 112(3):485–494
    • (2015) Br J Cancer , vol.112 , Issue.3 , pp. 485-494
    • Zhuang, X.1    Herbert, J.M.2    Lodhia, P.3
  • 134
    • 33749332105 scopus 로고    scopus 로고
    • Gene expression of tumor angiogenesis dissected: specific targeting of colon cancer angiogenic vasculature
    • PID: 16794251
    • van Beijnum JR, Dings RP, van der Linden E et al (2006) Gene expression of tumor angiogenesis dissected: specific targeting of colon cancer angiogenic vasculature. Blood 108(7):2339–2348
    • (2006) Blood , vol.108 , Issue.7 , pp. 2339-2348
    • van Beijnum, J.R.1    Dings, R.P.2    van der Linden, E.3
  • 135
    • 84871528483 scopus 로고    scopus 로고
    • Gene-expression profiling of microdissected breast cancer microvasculature identifies distinct tumor vascular subtypes
    • COI: 1:CAS:528:DC%2BC3sXjsFSjtLs%3D, PID: 22906178
    • Pepin F, Bertos N, Laferriere J et al (2012) Gene-expression profiling of microdissected breast cancer microvasculature identifies distinct tumor vascular subtypes. Breast Cancer Res 14(4):R120
    • (2012) Breast Cancer Res , vol.14 , Issue.4 , pp. R120
    • Pepin, F.1    Bertos, N.2    Laferriere, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.