Identification of novel vascular targets in lung cancer

British Journal of Cancer

Volumn 112, Issue 3, 2015, Pages 485-494

  Zhuang, X ^a   Herbert, J M J ^a   Lodhia, P ^a   Bradford, J ^b   Turner, A M ^c,d   Newby, P M ^a   Thickett, D ^c   Naidu, U ^c,d   Blakey, D ^b   Barry, S ^b   Cross, D A E ^b   Bicknell, R ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^d BIRMINGHAM HEARTLANDS HOSPITAL   (United Kingdom)

Author keywords

microarray analysis; RNA seq; tumor endothelial marker

Indexed keywords

ANGIOGENIC FACTOR; MATRIX METALLOPROTEINASE; MEMBRANE PROTEIN; SMALL INTERFERING RNA; TUMOR MARKER;

ADULT; AGED; ARTICLE; BIOINFORMATICS; CANCER TISSUE; CELL MIGRATION; CELL SURFACE; CLINICAL ARTICLE; ENDOTHELIUM; ENDOTHELIUM CELL; ENZYME ASSAY; FEMALE; GENE EXPRESSION PROFILING; GENE SILENCING; HUMAN; HUMAN GENOME; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG CANCER; MALE; MICROARRAY ANALYSIS; MIDDLE AGED; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RNA SEQUENCE; TUMOR VASCULARIZATION; VASCULAR TUMOR; VERY ELDERLY; CARCINOMA, NON-SMALL-CELL LUNG; GENETIC ASSOCIATION; GENETICS; LUNG; LUNG NEOPLASMS; METABOLISM; MOLECULARLY TARGETED THERAPY; NEOVASCULARIZATION, PATHOLOGIC; PATHOLOGY; PROCEDURES; SEQUENCE ANALYSIS; VASCULAR ENDOTHELIUM; VASCULARIZATION;

AGED; AGED, 80 AND OVER; CARCINOMA, NON-SMALL-CELL LUNG; ENDOTHELIUM, VASCULAR; FEMALE; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION STUDIES; HUMANS; LUNG; LUNG NEOPLASMS; MALE; MICROARRAY ANALYSIS; MIDDLE AGED; MOLECULAR TARGETED THERAPY; NEOVASCULARIZATION, PATHOLOGIC; REAL-TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, RNA; TUMOR MARKERS, BIOLOGICAL;

EID: 84922268960     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2014.626     Document Type: Article

References (60)

1. Allport JR, Weissleder R (2003) Murine Lewis lung carcinoma-derived endothelium expresses markers of endothelial activation and requires tumor-specific extracellular matrix in vitro. Neoplasia 5: 205-217
2. Alves PM, Faure O, Graff-Dubois S, Cornet S, Bolonakis I, Gross DA Miconnet I, Chouaib S, Fizazi K, Soria JC, Lemonnier FA, Kosmatopoulos K (2006) STEAP, a prostate tumor antigen, is a target of human CD8+ T cells. Cancer Immunol Immunother 55: 1515-1523.
3. Anders S (2010) HTSeq: Analysing high-throughput sequencing data with Python [Online]. Available at http://www-huber.embl.de/users/anders/ HTSeq/doc/overview.html[Accessed].
4. Anders S, Huber W (2010) Differential expression analysis for sequence count data. Genome Biol 11: R106.
5. Ando J, Yamamoto K (2009) Vascular mechanobiology: endothelial cell responses to fluid shear stress. Circ J 73: 1983-1992.
6. Apps SA, Rankin WA, Kurmis AP (2007) Connexin 26 mutations in autosomal recessive deafness disorders: a review. Int J Audiol 46: 75-81.
7. Armstrong LJ, Heath VL, Sanderson S, Kaur S, Beesley JF, Herbert JM Legg JA, Poulsom R, Bicknell R (2008) ECSM2, an endothelial specific filamin a binding protein that mediates chemotaxis. Arterioscler Thromb Vasc Biol 28: 1640-1646.
8. Bach PB, Mirkin JN, Oliver TK, Azzoli CG, Berry DA, Brawley OW, Byers T Colditz GA, Gould MK, Jett JR, Sabichi AL, Smith-BINDMAN R Wood DE, Qaseem A, Detterbeck FC (2012) Benefits and harms of CT screening for lung cancer: a systematic review. JAMA 307: 2418-2429.
9. Baluk P, Hashizume H, Mcdonald DM (2005) Cellular abnormalities of blood vessels as targets in cancer. Curr Opin Genet Dev 15: 102-111.
10. Bergethon K, Shaw AT, Ou SH, Katayama R, Lovly CM, Mcdonald NT Massion PP, Siwak-Tapp C, Gonzalez A, Fang R, Mark EJ, Batten JM Chen H, Wilner KD, Kwak EL, Clark JW, Carbone DP, Ji H, Engelman JA Mino-Kenudson M, Pao W, Iafrate AJ (2012) ROS1 rearrangements define a unique molecular class of lung cancers. J Clin Oncol 30: 863-870.
11. Bhati R, Patterson C, Livasy CA, Fan C, Ketelsen D, Hu Z, Reynolds E, Tanner C, Moore DT, Gabrielli F, Perou CM, Klauber-Demore N (2008) Molecular characterization of human breast tumor vascular cells. Am J Pathol 172: 1381-1390.
12. Birchmeier C, Sharma S, Wigler M (1987) Expression and rearrangement of the ROS1 gene in human glioblastoma cells. Proc Natl Acad Sci USA 84: 9270-9274.
13. Blevins CJ, Emond MR, Biswas S, Jontes JD (2011) Differential expression alternative splicing, and adhesive properties of the zebrafish delta1-protocadherins. Neuroscience 199: 523-534.
14. Dachs GU, Chaplin DJ (1998) Microenvironmental control of gene expression: implications for tumor angiogenesis, progression, and metastasis. Semin Radiat Oncol 8: 208-216.
15. Dicke N, Pielensticker N, Degen J, Hecker J, Tress O, Bald T, Gellhaus A Winterhager E, Willecke K (2011) Peripheral lymphangiogenesis in mice depends on ectodermal connexin-26 (Gjb2). J Cell Sci 124: 2806-2815.
16. Favre CJ, Mancuso M, Maas K, Mclean JW, Baluk P, Mcdonald DM (2003) Expression of genes involved in vascular development and angiogenesis in endothelial cells of adult lung. Am J Physiol Heart Circ Physiol 285: H1917-H1938.
17. Ferlay J, Shin H, Bray F, Forman D, Mathers C, Parkin D (2010) GLOBOCAN 2008 v1.2, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10. International Agency for Research on Cancer: Lyon, France.
18. Garcia-Hernandez Mde L, Gray A, Hubby B, Kast WM (2007) In vivo effects of vaccination with six-transmembrane epithelial antigen of the prostate: a candidate antigen for treating prostate cancer. Cancer Res 67: 1344-1351.
19. Goffin JR, Anderson IC, Supko JG, Eder Jr JP, Shapiro GI, Lynch TJ Shipp M, Johnson BE, Skarin AT (2005) Phase I trial of the matrix metalloproteinase inhibitor marimastat combined with carboplatin and paclitaxel in patients with advanced non-small cell lung cancer. Clin Cancer Res 11: 3417-3424.
20. Goldstraw P, Ball D, Jett JR, Le Chevalier T, Lim E, Nicholson AG Shepherd FA (2011) Non-small-cell lung cancer. Lancet 378: 1727-1740.
21. Gomes IM, Maia CJ, Santos CR (2012) STEAP proteins: from structure to applications in cancer therapy. Mol Cancer Res 10: 573-587.
22. Guduric-Fuchs J, Oconnor A, Cullen A, Harwood L, Medina RJ, Oneill CL Stitt AW, Curtis TM, Simpson DA (2012) Deep sequencing reveals predominant expression of miR-21 amongst the small noncoding RNAs in retinal microvascular endothelial cells. J Cell Biochem 113(6): 2098-2111.
23. Guo CB, Wang S, Deng C, Zhang DL, Wang FL, Jin XQ (2007) Relationship between matrix metalloproteinase 2 and lung cancer progression. Mol. Diagn Ther 11: 183-192.
24. Heath EI, Oreilly S, Humphrey R, Sundaresan P, Donehower RC, Sartorius S Kennedy MJ, Armstrong DK, Carducci MA, Sorensen JM, Kumor K Kennedy S, Grochow LB (2001) Phase I trial of the matrix metalloproteinase inhibitor BAY12-9566 in patients with advanced solid tumors. Cancer Chemother Pharmacol 48: 269-274.
25. Herbert JM, Stekel D, Sanderson S, Heath VL, Bicknell R (2008) A novel method of differential gene expression analysis using multiple cDNA libraries applied to the identification of tumour endothelial genes. BMC Genomics 9: 153.
26. Ho M, Yang E, Matcuk G, Deng D, Sampas N, Tsalenko A, Tabibiazar R Zhang Y, Chen M, Talbi S, Ho YD, Wang J, Tsao PS, Ben-Dor A Yakhini Z, Bruhn L, Quertermous T (2003) Identification of endothelial cell genes by combined database mining and microarray analysis. Physiol Genomics 13: 249-262.
27. Holthofer H, Virtanen I, Kariniemi AL, Hormia M, Linder E, Miettinen A (1982) Ulex europaeus I lectin as a marker for vascular endothelium in human tissues. Lab Invest 47: 60-66.
28. Huang YT, Heist RS, Chirieac LR, Lin X, Skaug V, Zienolddiny S, Haugen A Wu MC, Wang Z, Su L, Asomaning K, Christiani DC (2009) Genomewide analysis of survival in early-stage non-small-cell lung cancer. J Clin Oncol 27: 2660-2667.
29. Hubert RS, Vivanco I, Chen E, Rastegar S, Leong K, Mitchell SC, Madraswala R Zhou Y, Kuo J, Raitano AB, Jakobovits A, Saffran DC, Afar DE (1999) STEAP: a prostate-specific cell-surface antigen highly expressed in human prostate tumors. Proc Natl Acad Sci USA 96: 14523-14528.
30. Huminiecki L, Bicknell R (2000) In silico cloning of novel endothelial-specific genes. Genome Res 10: 1796-1806.
31. Jackson CJ, Garbett PK, Nissen B, Schrieber L (1990) Binding of human endothelium to Ulex europaeus I-coated Dynabeads: application to the isolation of microvascular endothelium. J Cell Sci 96(Pt 2): 257-262.
32. Janne PA, Meyerson M (2012) ROS1 rearrangements in lung cancer: a new genomic subset of lung adenocarcinoma. J Clin Oncol 30: 878-879.
33. John A, Tuszynski G (2001) The role of matrix metalloproteinases in tumor angiogenesis and tumor metastasis. Pathol Oncol Res 7: 14-23.
34. Johnson DH, Fehrenbacher L, Novotny WF, Herbst RS, Nemunaitis JJ Jablons DM, Langer CJ, Devore 3rd RF, Gaudreault J, Damico LA Holmgren E, Kabbinavar F (2004) Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 22: 2184-2191.
35. Jones DT, Lechertier T, Mitter R, Herbert JM, Bicknell R, Jones JL, Li JL Buffa F, Harris AL, Hodivala-Dilke K (2012) Gene expression analysis in human breast cancer associated blood vessels. PLoS One 7: e44294.
36. Kim SY, Chung HS, Sun W, Kim H (2007) Spatiotemporal expression pattern of non-clustered protocadherin family members in the developing rat brain. Neuroscience 147: 996-1021.
37. Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, Marth G Abecasis G, Durbin R (2009) The Sequence Alignment/Map format and SAMtools. Bioinformatics 25: 2078-2079.
38. Lovly CM, Carbone DP (2011) Lung cancer in 2010: One size does not fit all. Nat Rev Clin Oncol 8: 68-70.
39. Meyer T (2010) Vascular Disruptive Agents for the Treatment of Cancer. Springer.
40. Mura M, Swain RK, Zhuang X, Vorschmitt H, Reynolds G, Durant S Beesley JF, Herbert JM, Sheldon H, Andre M, Sanderson S, Glen K Luu NT, Mcgettrick HM, Antczak P, Falciani F, Nash GB, Nagy ZS Bicknell R (2012) Identification and angiogenic role of the novel tumor endothelial marker CLEC14A. Oncogene 31: 293-305.
41. Nair A, Klusmann MJ, Jogeesvaran KH, Grubnic S, Green SJ, Vlahos I (2011) Revisions to the TNM staging of non-small cell lung cancer: rationale clinicoradiologic implications, and persistent limitations. Radiographics 31: 215-238.
42. Office for National Statistics (2011) Births and Deaths in England and Wales 2010 (Statistical Bulletin). Office for National Statistics: London, UK.
43. Oh P, Li Y, Yu J, Durr E, Krasinska KM, Carver LA, Testa JE, Schnitzer JE (2004) Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy. Nature 429: 629-635.
44. Pallis AG, Syrigos KN (2013) Targeting tumor neovasculature in non-smallcell lung cancer. Crit Rev Oncol Hematol 86: 130-142.
45. Relf M, Lejeune S, Scott PA, Fox S, Smith K, Leek R, Moghaddam A Whitehouse R, Bicknell R, Harris AL (1997) Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis. Cancer Res 57: 963-969.
46. Safranek J, Pesta M, Holubec L, Kulda V, Dreslerova J, Vrzalova J, Topolcan O Pesek M, Finek J, Treska V (2009) Expression of MMP-7, MMP-9 TIMP-1 and TIMP-2 mRNA in lung tissue of patients with non-small cell lung cancer (NSCLC) and benign pulmonary disease. Anticancer Res 29: 2513-2517.
47. Sah NK, Khan Z, Khan GJ, Bisen PS (2006) Structural, functional and therapeutic biology of survivin. Cancer Lett 244: 164-171.
48. Sasaroli D, Gimotty PA, Pathak HB, Hammond R, Kougioumtzidou E Katsaros D, Buckanovich R, Devarajan K, Sandaltzopoulos R, Godwin AK Scholler N, Coukos G (2011) Novel surface targets and serum biomarkers from the ovarian cancer vasculature. Cancer Biol Ther 12: 169-180.
49. Scagliotti G, Brodowicz T, Shepherd FA, Zielinski C, Vansteenkiste J Manegold C, Simms L, Fossella F, Sugarman K, Belani CP (2011) Treatment-by-histology interaction analyses in three phase III trials show superiority of pemetrexed in nonsquamous non-small cell lung cancer. J Thorac Oncol 6: 64-70.
50. Sharma S, Birchmeier C, Nikawa J, Oneill K, Rodgers L, Wigler M (1989) Characterization of the ros1-gene products expressed in human glioblastoma cell lines. Oncogene Res 5: 91-100.
51. Sottile J (2004) Regulation of angiogenesis by extracellular matrix. Biochim Biophys Acta 1654: 13-22.
52. ST Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW (2000) Genes expressed in human tumor endothelium. Science 289: 1197-1202.
53. Trapnell C, Pachter L, Salzberg SL (2009) TopHat: discovering splice junctions with RNA-Seq. Bioinformatics 25: 1105-1111.
54. Van Beijnum JR, Dings RP, Van Der Linden E, Zwaans BM, Ramaekers FC Mayo KH, Griffioen AW (2006) Gene expression of tumor angiogenesis dissected: specific targeting of colon cancer angiogenic vasculature. Blood 108: 2339-2348.
55. Vasudev NS, Reynolds AR (2014) Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions. Angiogenesis 17: 471-494.
56. Voellenkle C, Rooij J, Guffanti A, Brini E, Fasanaro P, Isaia E, Croft L David M, Capogrossi MC, Moles A, Felsani A, Martelli F (2012) Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs. RNA 18: 472-484.
57. Wang F, Wang LD, Li B, Sheng ZX (2012) Gefitinib compared with systemic chemotherapy as first-line treatment for chemotherapy-naive patients with advanced non-small cell lung cancer: a meta-analysis of randomised controlled trials. Clin Oncol (R Coll Radiol) 24: 396-401.
58. Wasserman SM, Topper JN (2004) Adaptation of the endothelium to fluid flow: in vitro analyses of gene expression and in vivo implications. Vasc Med 9: 35-45.
59. Yang D, Holt GE, Velders MP, Kwon ED, Kast WM (2001) Murine six-transmembrane epithelial antigen of the prostate prostate stem cell antigen, and prostate-specific membrane antigen: prostate-specific cell-surface antigens highly expressed in prostate cancer of transgenic adenocarcinoma mouse prostate mice. Cancer Res 61: 5857-5860.
60. Yoshida K, Yoshitomo-Nakagawa K, Seki N, Sasaki M, Sugano S (1998) Cloning, expression analysis, and chromosomal localization of BHprotocadherin (PCDH7), a novel member of the cadherin superfamily. Genomics 49: 458-461.