An FGF-binding protein (FGF-BP) exerts its biological function by parallel paracrine stimulation of tumor cell and endothelial cell proliferation through FGF-2 release

International Journal of Cancer

Volumn 92, Issue 4, 2001, Pages 510-517

  Aigner, Achim ^a   Butscheid, Moritz ^b   Kunkel, Philip ^c   Krause, Eberhard ^b   Lamszus, Katrin ^a   Wellstein, Anton ^d   Czubayko, Frank ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^d GEORGETOWN UNIVERSITY   (United States)

Author keywords

FGF 2; FGF binding protein; Tumor angiogenesis; Tumor growth

Indexed keywords

BINDING PROTEIN; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR BINDING PROTEIN; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL PROLIFERATION; CELL STIMULATION; CHEMOTAXIS; CONTROLLED STUDY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; IMMOBILIZED CELL; MOUSE; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN SECRETION; RECEPTOR UPREGULATION; SQUAMOUS CELL CARCINOMA;

ADRENAL GLAND NEOPLASMS; BLOTTING, WESTERN; CARCINOMA, SQUAMOUS CELL; CARRIER PROTEINS; CELL DIVISION; CELL MOVEMENT; CELLS, CULTURED; CHEMOTAXIS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM; ENDOTHELIUM, VASCULAR; EXTRACELLULAR MATRIX; FIBROBLAST GROWTH FACTOR 2; GLYCOSYLATION; HEPARIN; HUMANS; MALE; MASS SPECTROMETRY; NEOPLASM TRANSPLANTATION; PROSTATIC NEOPLASMS; PROTEIN BINDING; RECOMBINANT PROTEINS; SODIUM CHLORIDE; TUMOR CELLS, CULTURED; UMBILICAL CORD;

EID: 0035874067     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0215(20010515)92:4<510::AID-IJC1227>3.0.CO;2-H     Document Type: Article

References (38)

1. Angiogenic factors
2. The heparin-binding (fibroblast) growth factor family of proteins
3. Fibroblast growth factors
4. Purification of two distinct growth factors from bovine neural tissue by heparin affinity chromatography
5. Heparin binds endothelial cell growth factor, the principal endothelial cell mitogen in bovine brain
6. Developing brain produces an angiogenesis factor
7. Endothelial cell growth factors in embryonic and adult chick brain are related to human acidic fibroblast growth factor
8. Heparin affinity: Purification of a tumor-derived capillary endothelial cell growth factor
9. Primary structure of bovine pituitary basic fibroblast growth factor (FGF) and comparison with the aminoterminal sequence of bovine brain acidic FGF
10. Both normal and tumor cells produce basic fibroblast growth factor
11. The ins and outs of fibroblast growth factors
12. S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro
13. Synaptotagmin-1 is required for fibroblast growth factor-1 release
14. The extravesicular domain of synaptotagmin-1 is released with the latent fibroblast growth factor-1 homodimer in response to heat shock
15. Sequestration and release of basic fibroblast growth factor
16. Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules
17. Heparan sulfate degradation in tumor cell invasion and angiogensis
18. Basic fibroblast growth factor (bFGF) dissociates rapidly from heparan sulfates but slowly from receptors. Implications for mechanisms of bFGF release from pericellular matrix
19. Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors
20. Tumor growth and angiogenesis induced by a secreted binding protein for fibroblast growth factors
21. Inhibition of fibroblast growth factors
22. Tissue distribution and retinoid-mediated downregulation of an FGF-binding protein (FGF-BP) in the rat
23. Structural characterization of the fibroblast growth factor binding protein purified from bovine prepartum mammary gland secretion
24. Purification of heparinbinding protein HBp17 and identification of HBp17 heparin binding site
25. A tetracycline-responsive promoter system reveals the role of a secreted binding protein for FGFs during the early phase of tumor growth
26. Expression of a binding protein for FGF is associated with epithelial development and skin carcinogenesis
27. A secreted FGF-binding protein can serve as the angiogenic switch in human cancer
28. Phorbol ester-induced transcription of a fibroblast growth factor-binding protein is modulated by a complex interplay of positive and negative regulatory promoter elements
29. Regulation of gene expression of a binding protein for fibroblast growth factor by retinoic acid
30. In vivo inhibition of angiogenesis and induction of apoptosis by retinoic acid in squamous cell carcinoma
31. bFGF and tumor angiogenesis - Back in the limelight?
32. The dominance of arginine-containing peptides in MALDI-derived tryptic mass fingerprints of proteins
33. Microscale sample preparation
34. Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels
35. Autocrine growth stimulation by secreted Kaposi fibroblast growth factor but not by endogenous basic fibroblast growth factor
36. Reversal of HER-2 over-expression renders human ovarian cancer cells highly resistant to taxol
37. Assay of capillary endothelial cell migration
38. Basic fibroblast growth factor in human prostate cancer cells