Differential vascular and transcriptional responses to anti-vascular endothelial growth factor antibody in orthotopic human pancreatic cancer xenografts

Clinical Cancer Research

Volumn 9, Issue 11, 2003, Pages 4221-4226

  Bockhorn, Maximilian ^a,b   Tsuzuki, Yoshikazu ^a,c   Xu, Lei ^a   Frilling, Andreja ^b   Broelsch, Christoph E ^b   Fukumura, Dai ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

^c NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOGLIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FIBROBLAST GROWTH FACTOR 1; GROWTH FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN G; PLACENTAL GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR; PROTEIN; PROTEIN C ETS1; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; VASCULOTROPIN ANTIBODY;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL DIAMETER; BLOOD VESSEL PERMEABILITY; CANCER GROWTH; CANCER TRANSPLANTATION; CONTROLLED STUDY; DNA MICROARRAY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; NORTHERN BLOTTING; PANCREAS CANCER; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCID MOUSE; TUMOR GROWTH; TUMOR XENOGRAFT;

ANIMALS; ANTIBODIES; BASE SEQUENCE; CAPILLARY PERMEABILITY; CELL DIVISION; DNA PRIMERS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICE; MICE, SCID; NEOVASCULARIZATION, PATHOLOGIC; NEUTRALIZATION TESTS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PANCREATIC NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION, GENETIC; TRANSPLANTATION, HETEROLOGOUS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 0141566683     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Parker, S. L., Tong, T., Bolden, S., and Wingo, P. A. Cancer statistics, 1997. CA Cancer J. Clin., 47: 5-27, 1997.
2. Yeo, C. J., and Cameron, J. L. Pancreatic cancer. Curr. Probl. Surg., 36: 59-152, 1999.
3. Folkman, J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med., 1: 27-31, 1995.
4. Ferrara, N. Molecular and biological properties of vascular endothelial growth factor. J. Mol. Med., 77: 527-543, 1999.
5. Dvorak, H. F., Nagy, J. A., Feng, D., Brown, L. F., and Dvorak, A. M. Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis. Curr. Top. Microbiol. Immunol., 237: 97-132, 1999.
6. Melder, R. J., Koenig, G. C., Witwer, B. P., Safabakhsh, N., Munn, L. L., and Jain, R. K. During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium. Nat. Med., 2: 992-997, 1996.
7. Itakura, J., Ishiwata, T., Friess, H., Fujii, H., Matsumoto, Y., Buchler, M. W., and Korc, M. Enhanced expression of vascular endothelial growth factor in human pancreatic cancer correlates with local disease progression. Clin. Cancer Res., 3: 1309-1316, 1997.
8. Carmeliet, P., and Jain, R. K. Angiogenesis in cancer and other diseases. Nature (Lond.), 407: 249-257, 2000.
9. Fidler, I. J. Angiogenic heterogeneity: regulation of neoplastic angiogenesis by the organ microenvironment. J. Natl. Cancer Inst. (Bethesda), 93: 1040-1041, 2001.
10. Tsuzuki, Y., Mouta Carreira, C., Bockhorn, M., Xu, L., Jain, R. K., and Fukumura, D. Pancreas microenvironment promotes VEGF expression and tumor growth: novel window models for pancreatic tumor angiogenesis and microcirculation. Lab. Investig., 81: 1439-1451, 2001.
11. Leunig, M., Yuan, F., Menger, M. D., Boucher, Y., Goetz, A. E., Messmer, K., and Jain, R. K. Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice. Cancer Res., 52: 6553-6560, 1992.
12. Fukumura, D., Yuan, F., Endo, M., and Jain, R. K. Role of nitric oxide in tumor microcirculation. Blood flow, vascular permeability, and leukocyte-endothelial interactions. Am. J. Pathol., 150: 713-725, 1997.
13. Fujimoto, K., Hosotani, R., Wada, M., Lee, J. U., Koshiba, T., Miyamoto, Y., Tsuji, S., Nakajima, S., Doi, R., Imamura, M., von Marschall, Z., Cramer, T., Hocker, M., Burde, R., Plath, T., Schirner, M., Heidenreich, R., Breier, G., Riecken, E. O., Wiedenmann, B., and Rosewicz, S. Expression of two angiogenic factors, vascular endothelial growth factor and platelet-derived endothelial cell growth factor, in human pancreatic cancer, and its relationship to angiogenesis. De novo expression of vascular endothelial growth factor in human pancreatic cancer: evidence for an autocrine mitogenic loop. Eur. J. Cancer, 34: 1439-1447, 1998.
14. Yuan, F., Chen, Y., Dellian, M., Safabakhsh, N., Ferrara, N., and Jain, R. K. Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor anti-body. Proc. Natl. Acad. Sci. USA, 93: 14765-14770, 1996.
15. Lee, C. G., Heijn, M., di Tomaso, E., Griffon-Etienne, G., Ancukiewicz, M., Koike, C., Park, K. R., Ferrara, N., Jain, R. K., Suit, H. D., and Boucher, Y. Anti-vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions. Cancer Res., 60: 5565-5570, 2000.
16. Fukumura, D., Xavier, R., Sugiura, T., Chen, Y., Park, E. C., Lu, N., Selig, M., Nielsen, G., Taksir, T., Jain, R. K., and Seed, B. Tumor induction of VEGF promoter activity in stromal cells. Cell, 94: 715-725, 1998.
17. Tsuzuki, Y., Fukumura, D., Oosthuyse, B., Koike, C., Carmeliet, P., and Jain, R. K. Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1α→hypoxia response element→ VEGF cascade differentially regulates vascular response and growth rate in tumors. Cancer Res., 60: 6248-6252, 2000.
18. Monsky, W. L., Fukumura, D., Gohongi, T., Ancukiewcz, M., Weich, H. A., Torchilin, V. P., Yuan, F., and Jain, R. K. Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor. Cancer Res., 59: 4129-4135, 1999.
19. Itakura, J., Ishiwata, T., Shen, B., Kornmann, M., and Korc, M. Concomitant over-expression of vascular endothelial growth factor and its receptors in pancreatic cancer. Int. J. Cancer, 85: 27-34, 2000.
20. von Marschall, Z., Cramer, T., Hocker, M., Burde, R., Plath, T., Schirner, M., Heidenreich, R., Breier, G., Riecken, E. O., Wiedenmann, B., and Rosewicz, S. De novo expression of vascular endothelial growth factor in human pancreatic cancer: evidence for an autocrine mitogenic loop. Gastroenterology, 119: 1358-1372, 2000.
21. Gerber, H. P., Kowalski, J., Sherman, D., Eberhard, D. A., and Ferrara, N. Complete inhibition of rhabdomyosarcoma xenograft growth and neovascularization requires blockade of both tumor and host vascular endothelial growth factor. Cancer Res., 60: 6253-6258, 2000.
22. Carmeliet, P., Moons, L., Luttun, A., Vincenti, V., Compernolle, V., De Mol, M., Wu, Y., Bono, F., Devy, L., Beck, H., Scholz, D., Acker, T., DiPalma, T., Dewerchin, M., Noel, A., Stalmans, I., Barra, A., Blacher, S., Vandendriessche, T., Ponten, A., Eriksson, U., Plate, K. H., Foidart, J. M., Schaper, W., Charnock-Jones, D. S., Hicklin, D. J., Herbert, J. M., Collen, D., and Persico, M. G. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat. Med., 7: 575-583, 2001.
23. Green, C. J., Lichtlen, P., Huynh, N. T., Yanovsky, M., Laderoute, K. R., Schaffner, W., and Murphy, B. J. Placenta growth factor gene expression is induced by hypoxia in fibroblasts: a central role for metal transcription factor-1. Cancer Res., 61: 2696-2703, 2001.
24. Dull, R. O., Yuan, J., Chang, Y. S., Tarbell, J., Jain, R. K., and Munn, L. L. Kinetics of placenta growth factor/vascular endothelial growth factor synergy in endothelial hydraulic conductivity and proliferation. Microvasc. Res., 61: 203-210, 2001.
25. Gerber, H. P., Hillan, K. J., Ryan, A. M., Kowalski, J., Keller, G. A., Rangell, L., Wright, B. D., Radtke, F., Aguet, M., and Ferrara, N. VEGF is required for growth and survival in neonatal mice. Development (Cambr.), 126: 1149-1159, 1999.