Mechanisms and functions of Eph and ephrin signalling

Nature Reviews Molecular Cell Biology

Volumn 3, Issue 7, 2002, Pages 475-486

  Kullander, Klas ^a   Klein, Rüdiger ^b  

^a ASTRAZENECA R AND D   (Sweden)

^b MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EPHRIN; EPHRIN RECEPTOR; TYROSINE KINASE RECEPTOR;

ADULTHOOD; CELL COMMUNICATION; CELL MEMBRANE; DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CELL COMMUNICATION; CELL TRANSFORMATION, NEOPLASTIC; EPHRIN-B1; HUMANS; LIGANDS; MEMBRANE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, EPHA1; SIGNAL TRANSDUCTION;

EID: 0036303033     PISSN: 14710072     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrm856     Document Type: Review

References (117)

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5. Multiple in vivo tyrosine phosphorylation sites in EphB receptors
6. Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptors
7. Replacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responses
8. Kinase-dependent and kinase-independent functions of EphA4 receptors in major axon tract formation in vivo
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10. Full activation of the platelet-derived growth factor β-receptor kinase involves multiple events
11. Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons
12. Signaling through scaffold, anchoring, and adaptor proteins
13. Cycling, stressed-out and nervous: Cellular functions of c-Abl
14. Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor
15. C-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF
16. Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region
17. Essential roles for the Abl and Arg tyrosine kinases in neurulation
18. Regulation of repulsion versus adhesion by different splice forms of an Eph receptor
19. Rho GTPases and the actin cytoskeleton
20. Rho GTPases in neuronal morphogenesis
21. Rho family GTPases and neuronal growth cone remodelling: Relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid
22. EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin
23. EphrinA5 induces collapse of growth cones by activating Rho and Rho kinase
24. Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway
25. Downregulation of the ras-mitogen-activated protein kinase pathway by the ephb2 receptor tyrosine kinase is required for ephrin-induced neurite retraction
26. Membrane-bound LERK2 ligand can signal through three different Eph-related receptor tyrosine kinases
27. Biological and biochemical activities of a chimeric epidermal growth factor-Elk receptor tyrosine kinase
28. Functional activation of EphA5 receptor does not promote cell proliferation in the aberrant EphA5 expressing human glioblastoma U-118 MG cell line
29. A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos
30. An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro
31. Meaningful relationships: The regulation of the Ras/Raf/MEK/ERK pathway by protein interactions
32. Integrin signalling and tyrosine phosphorylation: Just the FAKs?
33. An Eph receptor regulates integrin activity through R-Ras
34. Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation
35. Surface densities of ephrinB1 determine EphB1-coupled activation of cell attachment through αvβ3 and α5β1 integrins
36. Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation
37. The EphA8 receptor regulates integrin inactivity through p110γ phosphatidlinositol 3-kinase in a tyrosine kinase activity-independent manner
38. Signaling by Eph receptors and their ephrin ligands
39. The ephrins and Eph receptors in neural development
40. Eph receptors and ephrins: Regulators of guidance and assembly
41. Nuk controls pathfinding of commissural axons in the mammalian central nervous system
42. In vivo tyrosine phosphorylation sites of activated ephrinB1 and ephB2 from neural tissue
43. EphrinB phosphorylation and reverse signaling: Regulation by Src kinases and PTP-BL phosphatase
44. Fibroblast growth factor receptor-mediated rescue of x-ephrin B1-induced cell dissociation in Xenopus embryos
45. PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands
46. EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains
47. The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif
48. The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals
49. A role for CAP, a novel, multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesions
50. Characterization of Grb4, an adapter protein interacting with Bcr-Abl
51. Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity
52. Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity
53. Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction
54. Vascular endothelial growth factor and basic fibroblast growth factor induce expression of CXCR4 on human endothelial cells: In vivo neovascularization induced by stromal-derived factor-1α
55. Chemokine receptors in human endothelial cells. Functional expression of CXCR4 and its transcriptional regulation by inflammatory cytokines
56. Multiple ephrins control cell organization in C. Elegans using kinase-dependent and-independent functions of the VAB-1 Eph receptor
57. Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion
58. Ephrin-A5 modulates cell adhesion and morphology in an integrin-dependent manner
59. An ephrin-A-dependent signaling pathway centrals integrin function and is linked to the tyrosine phosphorylation of a 120-kDa protein
60. Kinase independent function of EphB receptors in retinal axon pathfinding to the optic disc from dorsal but not ventral retina
61. Retinal axon growth cones respond to EphB extracellular domains as inhibitory axon guidance cues
62. The VAB-1 Eph receptor tyrosine kinase functions in neural and epithelial morphogenesis in C. Elegans
63. EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract
64. Ephrin-B3 is the midline barrier that prevents corticospinal tract axons from recrossing, allowing for unilateral motor control
65. Forward signaling mediated by ephrin-B3 prevents contralateral corticospinal axons from recrossing the spinal cord midline
66. Immunolocalization of the receptor tyrosine kinase EphA4 in the adult rat central nervous system
67. Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses
68. Solution structure of the receptor tyrosine kinase EphB2 SAM domain and identification of two distinct homotypic interaction sites
69. The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization
70. Oligomeric structure of the human EphB2 receptor SAM domain
71. EphB2 guides axons at the midline and is necessary for normal vestibular function
72. EphB receptors interact with NMDA receptors and regulate excitatory synapse formation
73. Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB receptors
74. EphB/syndecan-2 signaling in dendritic spine morphogenesis
75. Kinase-independent requirement of EphB2 receptors in hippocampal synaptic plasticity
76. The receptor tyrosine kinase EphB2 regulates NMDA-dependent synaptic function
77. Bidirectional signals establish boundaries
78. In vivo cell sorting in complementary segmental domains mediated by Eph receptors and ephrins
79. Eph receptors and ephrins restrict cell intermingling and communication
80. The cytoplasmic domain of the ligand ephrinB2 is required for vascular morphogenesis but not cranial neural crest migration
81. The EphA4 and EphB1 receptor tyrosine kinases and ephrin-B2 ligand regulate targeted migration of branchial neural crest cells
82. Eph family transmembrane ligands can mediate repulsive guidance of trunk neural crest migration and motor axon outgrowth
83. Interactions of Eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration
84. Functional organization of the yeast proteome by systematic analysis of protein complexes
85. Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry
86. Five novel avian Eph-related tyrosine kinases are differentially expressed
87. Isolation and characterization of Dek, a Drosophila eph receptor protein tyrosine kinase
88. Drosophila melanogaster Ephrin mRNA, complete cds
89. The ephrin VAB-2/EFN-1 functions in neuronal signaling to regulate epidermal morphogenesis in C. Elegans
90. Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation
91. Eph receptors and ephrins in neural development
92. A role for the EphA family in the topographic targeting of vomeronasal axons
93. Roles of ephrinB ligands and EphB receptors in cardiovascular development: Demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis
94. Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4
95. Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development
96. Cell-type specific and estrogen dependent expression of the receptor tyrosine kinase EphB4 and its ligand ephrin-B2 during mammary gland morphogenesis
97. Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells
98. The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization
99. Lipid rafts and signal transduction
100. Structure, development, and plasticity of dendritic spines
101. Dendritic spines shaped by synaptic activity
102. Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path
103. Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase
104. Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells
105. PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor
106. Ajuxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn
107. Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase
108. Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity
109. Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells
110. A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A
111. Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions
112. The junction-associated protein AF-6 interacts and clusters with specific Eph receptor tyrosine kinases at specialized sites of cell-cell contact in the brain
113. Crystal structure of an Eph receptor-ephrin complex
114. Crystal structure of the ligand-binding domain of the receptor tyrosine kinase EphB2
115. Crystal structure of an ephrin ectodomain
116. The N-terminal globular domain of Eph receptors is sufficient for ligand binding and receptor signalling
117. Signal transfer by Eph receptors