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Volumn 5, Issue 6, 2014, Pages 445-456

Impaired tumor angiogenesis and VEGF-induced pathway in endothelial CD146 knockout mice

Author keywords

CD146; knockout mice; tumor angiogenesis; VEGF

Indexed keywords

ANTIBODY; CD146 ANTIGEN; CD31 ANTIGEN; GENOMIC DNA; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; SMALL INTERFERING RNA; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN A;

EID: 84901287170     PISSN: 1674800X     EISSN: 16748018     Source Type: Journal    
DOI: 10.1007/s13238-014-0047-y     Document Type: Article
Times cited : (54)

References (47)
  • 1
    • 0032500557 scopus 로고    scopus 로고
    • Activation of human endothelial cells via S-endo-1 antigen (CD146) stimulates the tyrosine phosphorylation of focal adhesion kinase p125 (FAK)
    • Anfosso F, Bardin N, Frances V, Vivier E, Camoin-Jau L, Sampol J, Dignat-George F (1998) Activation of human endothelial cells via S-endo-1 antigen (CD146) stimulates the tyrosine phosphorylation of focal adhesion kinase p125 (FAK). J Biol Chem 273: 26852-26856.
    • (1998) J Biol Chem , vol.273 , pp. 26852-26856
    • Anfosso, F.1    Bardin, N.2    Frances, V.3    Vivier, E.4    Camoin-Jau, L.5    Sampol, J.6    Dignat-George, F.7
  • 5
    • 0035895081 scopus 로고    scopus 로고
    • Identification of CD146 as a component of the endothelial junction involved in the control of cell-cell cohesion
    • Bardin N, Anfosso F, Masse JM, Cramer E, Sabatier F, Le Bivic A, Sampol J, Dignat-George F (2001) Identification of CD146 as a component of the endothelial junction involved in the control of cell-cell cohesion. Blood 98: 3677-3684.
    • (2001) Blood , vol.98 , pp. 3677-3684
    • Bardin, N.1    Anfosso, F.2    Masse, J.M.3    Cramer, E.4    Sabatier, F.5    Le Bivic, A.6    Sampol, J.7    Dignat-George, F.8
  • 6
    • 0034665166 scopus 로고    scopus 로고
    • Selective inhibition of vascular endothelial growth factor (VEGF) receptor 2 (KDR/Flk-1) activity by a monoclonal anti-VEGF antibody blocks tumor growth in mice
    • Brekken RA, Overholser JP, Stastny VA, Waltenberger J, Minna JD, Thorpe PE (2000) Selective inhibition of vascular endothelial growth factor (VEGF) receptor 2 (KDR/Flk-1) activity by a monoclonal anti-VEGF antibody blocks tumor growth in mice. Cancer Res 60: 5117-5124.
    • (2000) Cancer Res , vol.60 , pp. 5117-5124
    • Brekken, R.A.1    Overholser, J.P.2    Stastny, V.A.3    Waltenberger, J.4    Minna, J.D.5    Thorpe, P.E.6
  • 7
    • 33845192140 scopus 로고    scopus 로고
    • Anti-CD146 monoclonal antibody AA98 inhibits angiogenesis via suppression of nuclear factor-kappaB activation
    • Bu P, Gao L, Zhuang J, Feng J, Yang D, Yan X (2006) Anti-CD146 monoclonal antibody AA98 inhibits angiogenesis via suppression of nuclear factor-kappaB activation. Mol Cancer Ther 5: 2872-2878.
    • (2006) Mol Cancer Ther , vol.5 , pp. 2872-2878
    • Bu, P.1    Gao, L.2    Zhuang, J.3    Feng, J.4    Yang, D.5    Yan, X.6
  • 8
    • 79956328903 scopus 로고    scopus 로고
    • Molecular mechanisms and clinical applications of angiogenesis
    • Carmeliet P, Jain RK (2011) Molecular mechanisms and clinical applications of angiogenesis. Nature 473: 298-307.
    • (2011) Nature , vol.473 , pp. 298-307
    • Carmeliet, P.1    Jain, R.K.2
  • 10
    • 11244290381 scopus 로고    scopus 로고
    • Critical roles of CD146 in zebrafish vascular development
    • Chan B, Sinha S, Cho D, Ramchandran R, Sukhatme VP (2005) Critical roles of CD146 in zebrafish vascular development. Dev Dyn 232: 232-244.
    • (2005) Dev Dyn , vol.232 , pp. 232-244
    • Chan, B.1    Sinha, S.2    Cho, D.3    Ramchandran, R.4    Sukhatme, V.P.5
  • 11
    • 77953988924 scopus 로고    scopus 로고
    • Targeting the tumour vasculature: insights from physiological angiogenesis
    • Chung AS, Lee J, Ferrara N (2010) Targeting the tumour vasculature: insights from physiological angiogenesis. Nat Rev Cancer 10: 505-514.
    • (2010) Nat Rev Cancer , vol.10 , pp. 505-514
    • Chung, A.S.1    Lee, J.2    Ferrara, N.3
  • 13
    • 0034912203 scopus 로고    scopus 로고
    • Interendothelial junctions and their role in the control of angiogenesis, vascular permeability and leukocyte transmigration
    • Dejana E, Spagnuolo R, Bazzoni G (2001) Interendothelial junctions and their role in the control of angiogenesis, vascular permeability and leukocyte transmigration. Thromb Haemost 86: 308-315.
    • (2001) Thromb Haemost , vol.86 , pp. 308-315
    • Dejana, E.1    Spagnuolo, R.2    Bazzoni, G.3
  • 15
    • 0032710319 scopus 로고    scopus 로고
    • Clinical applications of angiogenic growth factors and their inhibitors
    • Ferrara N, Alitalo K (1999) Clinical applications of angiogenic growth factors and their inhibitors. Nat Med 5: 1359-1364.
    • (1999) Nat Med , vol.5 , pp. 1359-1364
    • Ferrara, N.1    Alitalo, K.2
  • 16
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J (2003) The biology of VEGF and its receptors. Nat Med 9: 669-676.
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 17
    • 2442621619 scopus 로고    scopus 로고
    • Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
    • Ferrara N, Hillan KJ, Gerber HP, Novotny W (2004) Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov 3: 391-400.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 391-400
    • Ferrara, N.1    Hillan, K.J.2    Gerber, H.P.3    Novotny, W.4
  • 18
    • 1842346472 scopus 로고    scopus 로고
    • Molecular mechanisms of vasculogenesis and embryonic angiogenesis
    • Flamme I, Frolich T, Risau W (1997) Molecular mechanisms of vasculogenesis and embryonic angiogenesis. J Cell Physiol 173: 206-210.
    • (1997) J Cell Physiol , vol.173 , pp. 206-210
    • Flamme, I.1    Frolich, T.2    Risau, W.3
  • 19
    • 30744476478 scopus 로고    scopus 로고
    • Retinal angiogenesis in development and disease
    • Gariano RF, Gardner TW (2005) Retinal angiogenesis in development and disease. Nature 438: 960-966.
    • (2005) Nature , vol.438 , pp. 960-966
    • Gariano, R.F.1    Gardner, T.W.2
  • 21
    • 0037474515 scopus 로고    scopus 로고
    • Platelet-endothelial cell adhesion molecule-1 modulates endothelial migration through its immunoreceptor tyrosine-based inhibitory motif
    • Gratzinger D, Barreuther M, Madri JA (2003) Platelet-endothelial cell adhesion molecule-1 modulates endothelial migration through its immunoreceptor tyrosine-based inhibitory motif. Biochem Biophys Res Commun 301: 243-249.
    • (2003) Biochem Biophys Res Commun , vol.301 , pp. 243-249
    • Gratzinger, D.1    Barreuther, M.2    Madri, J.A.3
  • 22
    • 70450175957 scopus 로고    scopus 로고
    • Targeting angiogenesis: progress with anti-VEGF treatment with large molecules
    • Grothey A, Galanis E (2009) Targeting angiogenesis: progress with anti-VEGF treatment with large molecules. Nat Rev Clin Oncol 6: 507-518.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 507-518
    • Grothey, A.1    Galanis, E.2
  • 23
    • 0035844164 scopus 로고    scopus 로고
    • Cloning of an immunoglobulin family adhesion molecule selectively expressed by endothelial cells
    • Hirata K, Ishida T, Penta K, Rezaee M, Yang E, Wohlgemuth J, Quertermous T (2001) Cloning of an immunoglobulin family adhesion molecule selectively expressed by endothelial cells. J Biol Chem 276: 16223-16231.
    • (2001) J Biol Chem , vol.276 , pp. 16223-16231
    • Hirata, K.1    Ishida, T.2    Penta, K.3    Rezaee, M.4    Yang, E.5    Wohlgemuth, J.6    Quertermous, T.7
  • 24
    • 84865585143 scopus 로고    scopus 로고
    • CD146 expression in human breast cancer cell lines induces phenotypic and functional changes observed in Epithelial to Mesenchymal Transition
    • Imbert AM, Garulli C, Choquet E, Koubi M, Aurrand-Lions M, Chabannon C (2012) CD146 expression in human breast cancer cell lines induces phenotypic and functional changes observed in Epithelial to Mesenchymal Transition. PLoS ONE 7: e43752.
    • (2012) PLoS ONE , vol.7
    • Imbert, A.M.1    Garulli, C.2    Choquet, E.3    Koubi, M.4    Aurrand-Lions, M.5    Chabannon, C.6
  • 26
    • 79957902010 scopus 로고    scopus 로고
    • Signal transduction by vascular endothelial growth factor receptors
    • Koch S, Tugues S, Li XJ, Gualandi L, Claesson-Welsh L (2011) Signal transduction by vascular endothelial growth factor receptors. Biochem J 437: 169-183.
    • (2011) Biochem J , vol.437 , pp. 169-183
    • Koch, S.1    Tugues, S.2    Li, X.J.3    Gualandi, L.4    Claesson-Welsh, L.5
  • 28
    • 33845953426 scopus 로고    scopus 로고
    • Phosphorylation of Tyr(1214) within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF
    • Lamalice L, Houle F, Huot J (2006) Phosphorylation of Tyr(1214) within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF. J Biol Chem 281: 34009-34020.
    • (2006) J Biol Chem , vol.281 , pp. 34009-34020
    • Lamalice, L.1    Houle, F.2    Huot, J.3
  • 29
    • 0024791128 scopus 로고
    • MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily
    • Lehmann JM, Riethmuller G, Johnson JP (1989) MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily. Proc Natl Acad Sci USA 86: 9891-9895.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 9891-9895
    • Lehmann, J.M.1    Riethmuller, G.2    Johnson, J.P.3
  • 30
    • 0141961138 scopus 로고    scopus 로고
    • Differential expression of CD146 in tissues and endothelial cells derived from infantile haemangioma and normal human skin
    • Li Q, Yu Y, Bischoff J, Mulliken JB, Olsen BR (2003) Differential expression of CD146 in tissues and endothelial cells derived from infantile haemangioma and normal human skin. J Pathol 201: 296-302.
    • (2003) J Pathol , vol.201 , pp. 296-302
    • Li, Q.1    Yu, Y.2    Bischoff, J.3    Mulliken, J.B.4    Olsen, B.R.5
  • 31
    • 84861566371 scopus 로고    scopus 로고
    • CD146 expression correlates with epithelial-mesenchymal transition markers and a poor prognosis in gastric cancer
    • Liu WF, Ji SR, Sun JJ, Zhang Y, Liu ZY, Liang AB, Zeng HZ (2012) CD146 expression correlates with epithelial-mesenchymal transition markers and a poor prognosis in gastric cancer. Int J Mol Sci 13: 6399-6406.
    • (2012) Int J Mol Sci , vol.13 , pp. 6399-6406
    • Liu, W.F.1    Ji, S.R.2    Sun, J.J.3    Zhang, Y.4    Liu, Z.Y.5    Liang, A.B.6    Zeng, H.Z.7
  • 32
    • 0035966004 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induction of the angiogenic phenotype requires Ras activation
    • Meadows KN, Bryant P, Pumiglia K (2001) Vascular endothelial growth factor induction of the angiogenic phenotype requires Ras activation. J Biol Chem 276: 49289-49298.
    • (2001) J Biol Chem , vol.276 , pp. 49289-49298
    • Meadows, K.N.1    Bryant, P.2    Pumiglia, K.3
  • 33
    • 0033119861 scopus 로고    scopus 로고
    • Structure and function of cell adhesion molecules
    • Petruzzelli L, Takami M, Humes HD (1999) Structure and function of cell adhesion molecules. Am J Med 106: 467-476.
    • (1999) Am J Med , vol.106 , pp. 467-476
    • Petruzzelli, L.1    Takami, M.2    Humes, H.D.3
  • 35
    • 0032817282 scopus 로고    scopus 로고
    • The role of CD146 (Mel-CAM) in biology and pathology
    • Shih IM (1999) The role of CD146 (Mel-CAM) in biology and pathology. J Pathol 189: 4-11.
    • (1999) J Pathol , vol.189 , pp. 4-11
    • Shih, I.M.1
  • 38
    • 0030778359 scopus 로고    scopus 로고
    • Structure of intercellular junctions in the endothelium
    • Telo P, Lostaglio S, Dejana E (1997) Structure of intercellular junctions in the endothelium. Therapie 52: 395-398.
    • (1997) Therapie , vol.52 , pp. 395-398
    • Telo, P.1    Lostaglio, S.2    Dejana, E.3
  • 40
    • 0030913615 scopus 로고    scopus 로고
    • Expression of MCAM/MUC18 by human melanoma cells leads to increased tumor growth and metastasis
    • Xie S, Luca M, Huang S, Gutman M, Reich R, Johnson JP, Bar-Eli M (1997) Expression of MCAM/MUC18 by human melanoma cells leads to increased tumor growth and metastasis. Cancer Res 57: 2295-2303.
    • (1997) Cancer Res , vol.57 , pp. 2295-2303
    • Xie, S.1    Luca, M.2    Huang, S.3    Gutman, M.4    Reich, R.5    Johnson, J.P.6    Bar-Eli, M.7
  • 42
    • 0034979275 scopus 로고    scopus 로고
    • Signaling mechanisms mediating vascular protective actions of vascular endothelial growth factor
    • Zachary I (2001) Signaling mechanisms mediating vascular protective actions of vascular endothelial growth factor. Am J Physiol Cell Physiol 280: C1375-C1386.
    • (2001) Am J Physiol Cell Physiol , vol.280
    • Zachary, I.1
  • 43
    • 0035895711 scopus 로고    scopus 로고
    • Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family
    • Zachary I, Gliki G (2001) Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family. Cardiovasc Res 49: 568-581.
    • (2001) Cardiovasc Res , vol.49 , pp. 568-581
    • Zachary, I.1    Gliki, G.2
  • 44
    • 84863012785 scopus 로고    scopus 로고
    • CD146, an epithelial-mesenchymal transition inducer, is associated with triple-negative breast cancer
    • Zeng Q, Li W, Lu D, Wu Z, Duan H, Luo Y, Feng J, Yang D, Fu L, Yan X (2012) CD146, an epithelial-mesenchymal transition inducer, is associated with triple-negative breast cancer. Proc Natl Acad Sci USA 109: 1127-1132.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 1127-1132
    • Zeng, Q.1    Li, W.2    Lu, D.3    Wu, Z.4    Duan, H.5    Luo, Y.6    Feng, J.7    Yang, D.8    Fu, L.9    Yan, X.10
  • 45
    • 54249110331 scopus 로고    scopus 로고
    • Generation and characterization of a panel of monoclonal antibodies against distinct epitopes of human CD146
    • Zhang Y, Zheng C, Zhang J, Yang D, Feng J, Lu D, Yan X (2008) Generation and characterization of a panel of monoclonal antibodies against distinct epitopes of human CD146. Hybridoma (Larchmt) 27: 345-352.
    • (2008) Hybridoma (Larchmt) , vol.27 , pp. 345-352
    • Zhang, Y.1    Zheng, C.2    Zhang, J.3    Yang, D.4    Feng, J.5    Lu, D.6    Yan, X.7
  • 46
    • 70349299880 scopus 로고    scopus 로고
    • Endothelial CD146 is required for in vitro tumor-induced angiogenesis: the role of a disulfide bond in signaling and dimerization
    • Zheng C, Qiu Y, Zeng Q, Zhang Y, Lu D, Yang D, Feng J, Yan X (2009) Endothelial CD146 is required for in vitro tumor-induced angiogenesis: the role of a disulfide bond in signaling and dimerization. Int J Biochem Cell Biol 41: 2163-2172.
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 2163-2172
    • Zheng, C.1    Qiu, Y.2    Zeng, Q.3    Zhang, Y.4    Lu, D.5    Yang, D.6    Feng, J.7    Yan, X.8
  • 47
    • 77953542905 scopus 로고    scopus 로고
    • NADPH oxidase 4 mediates reactive oxygen species induction of CD146 dimerization in VEGF signal transduction
    • Zhuang J, Jiang T, Lu D, Luo Y, Zheng C, Feng J, Yang D, Chen C, Yan X (2010) NADPH oxidase 4 mediates reactive oxygen species induction of CD146 dimerization in VEGF signal transduction. Free Radic Biol Med 49: 227-236.
    • (2010) Free Radic Biol Med , vol.49 , pp. 227-236
    • Zhuang, J.1    Jiang, T.2    Lu, D.3    Luo, Y.4    Zheng, C.5    Feng, J.6    Yang, D.7    Chen, C.8    Yan, X.9


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