VEGF non-angiogenic functions in adult organ homeostasis: Therapeutic implications

Journal of Molecular Medicine

Volumn 89, Issue 7, 2011, Pages 635-645

  Luo, Jincai ^a   Xiong, Yan ^a   Han, Xiaofan ^a   Lu, Yao ^a  

^a PEKING UNIVERSITY   (China)

Author keywords

Angiogenesis; Non angiogenic function; VEGF; VIEF (VEGF inducible endothelial factor)

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; EPITHELIAL CELL ADHESION MOLECULE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; NITRIC OXIDE; PADGEM PROTEIN; PANCREAS POLYPEPTIDE; PLATELET DERIVED GROWTH FACTOR B; PROSTACYCLIN; THROMBOCYTE ACTIVATING FACTOR; UROKINASE; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN; VON WILLEBRAND FACTOR;

ANGIOGENESIS; CARCINOGENESIS; CELL STIMULATION; ENDOTHELIUM CELL; EXOCYTOSIS; HOMEOSTASIS; HUMAN; INFLAMMATION; NONHUMAN; REVIEW; TISSUE REGENERATION; TISSUE REPAIR; WEIBEL PALADE BODY;

ANIMALS; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; EXOCYTOSIS; HOMEOSTASIS; HUMANS; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 79960002971     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-011-0739-1     Document Type: Review

References (135)

1. DR Senger SJ Galli AM Dvorak CA Perruzzi VS Harvey HF Dvorak 1983 Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid Science 219 983 985 6823562 1:STN:280:DyaL3s7hvF2mtw%3D%3D
2. HF Dvorak JA Nagy D Feng LF Brown AM Dvorak 1999 Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis Curr Top Microbiol Immunol 237 97 132 9893348 1:CAS:528:DyaK1MXitVKgsQ%3D%3D (Pubitemid 28554861)
3. N Ferrara WJ Henzel 1989 Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells Biochem Biophys Res Commun 161 851 858 2735925 1:CAS:528:DyaL1MXkslWhtbY%3D (Pubitemid 19162712)
4. DW Leung G Cachianes WJ Kuang DV Goeddel N Ferrara 1989 Vascular endothelial growth factor is a secreted angiogenic mitogen Science 246 1306 1309 2479986 1:CAS:528:DyaK3cXls1GltLo%3D (Pubitemid 20066716)
5. S Banai MT Jaklitsch M Shou DF Lazarous M Scheinowitz S Biro S Epstein E Unger 1994 Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs Circulation 89 2183 2189 7514110 1:CAS:528:DyaK2cXksFSkt7Y%3D (Pubitemid 24142797)
6. JD Pearlman MG Hibberd ML Chuang K Harada JJ Lopez SR Gladstone M Friedman FW Sellke M Simons 1995 Magnetic resonance mapping demonstrates benefits of VEGF-induced myocardial angiogenesis Nature Med 1 1085 1089 7489368 1:CAS:528:DyaK2MXosVGnsr0%3D
7. AK Olsson A Dimberg J Kreuger L Claesson-Welsh 2006 VEGF receptor signalling-in control of vascular function Nat Rev Mol Cell Biol 7 359 371 16633338 1:CAS:528:DC%2BD28XjslSktrc%3D
8. P Carmeliet V Ferreira G Breier S Pollefeyt L Kieckens M Gertsenstein M Fahrig A Vandenhoeck K Harpal C Eberhardt C Declercq J Pawling L Moons D Collen W Risau A Nagy 1996 Abnormal blood vessel developement and lethality in embryos lacking a single VEGF allele Nature 380 435 439 8602241 1:CAS:528: DyaK28XitVKqtLg%3D (Pubitemid 26102719)
9. N Ferrara K Carver-Moore H Chen M Dowd L Lu KS O'Shea L Powell-Braxton KJ Hillan MW Moore 1996 Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene Nature 380 439 442 8602242 1:CAS:528: DyaK28XitVKqtLk%3D (Pubitemid 26102720)
10. N Ferrara 2004 Vascular endothelial growth factor: basic science and clinical progress Endocr Rev 25 581 611 15294883 1:CAS:528:DC%2BD2cXns1Ght74%3D (Pubitemid 39099316)
11. H Takahashi M Shibuya 2005 The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions Clin Sci (Lond) 109 227 241 1:CAS:528:DC%2BD2MXoslKgu78%3D (Pubitemid 41337127)
12. H Roy S Bhardwaj S Ylä-Herttuala 2006 Biology of vascular endothelial growth factors FEBS Lett 580 2879 2887 16631753 1:CAS:528: DC%2BD28XltVKnt7g%3D (Pubitemid 43729175)
13. U Schmidt-Erfurth A Pollreisz C Mitsch M Bolz 2010 Antivascular endothelial growth factors in age-related macular degeneration Ophthalmol 46 21 38 1:CAS:528:DC%2BC3cXhtlemsb%2FP
14. N Ferrara L Damico N Shams H Lowman R Kim 2006 Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration Retina 26 859 870 17031284 (Pubitemid 44547437)
15. N Ferrara K Alitalo 1999 Clinical applications of angiogenic growth factors and their inhibitors Nat Med 5 1359 1364 10581076 1:CAS:528: DyaK1MXnvFCqtrw%3D
16. P Carmeliet RK Jain 2000 Angiogenesis in cancer and other diseases Nature 407 249 257 11001068 1:CAS:528:DC%2BD3cXmvVSls74%3D
17. JM Isner A Pieczek R Schainfeld R Blair L Haley T Asahara K Rosenfield S Razvi K Walsh JF Symes 1996 Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb Lancet 348 370 374 8709735 1:STN:280:DyaK28zit1agsg%3D%3D (Pubitemid 26261511)
18. K Makinen H Manninen M Hedman P Matsi H Mussalo E Alhava S Yla-Herttuala 2002 Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: a randomized, placebo-controlled, double blinded phase II study Mole Ther 6 127 133 1:CAS:528: DC%2BD38XltVGqsL8%3D (Pubitemid 36124280)
19. T Kamba DM McDonald 2007 Mechanisms of adverse effects of anti-VEGF therapy for cancer Br J Cancer 96 1788 1795 17519900 1:CAS:528: DC%2BD2sXmtlyqur4%3D (Pubitemid 46912024)
20. HX Chen JN Cleck 2009 Adverse effects of anticancer agents that target the VEGF pathway Nat Rev Clin Oncol 6 465 477 19581909 1:CAS:528: DC%2BD1MXpsFyhsbY%3D
21. S Ylä-Herttuala TT Rissanen I Vajanto J Hartikainen 2007 Vascular endothelial growth factors: biology and current status of clinical applications in cardiovascular medicine J Am Coll Cardiol 49 1015 1026 17349880 (Pubitemid 46349500)
22. J Denekamp 1984 Vascular endothelium as the vulnerable element in tumours Acta Radiol Oncol 23 217 225 6208746 1:STN:280:DyaL2M%2FktlWgtA%3D%3D (Pubitemid 15072794)
23. HG Augustin DH Kozian RC Johnson 1994 Differentiation of endothelial cells: analysis of the constitutive and activated endothelial cell phenotypes Bioessays 16 901 906 7840769 1:CAS:528:DyaK2MXjs1yrt7s%3D (Pubitemid 24974469)
24. B Berse LF Brown L Van de Water HF Dvorak DR Senger 1992 Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors Mol Biol Cell 3 211 220 1550962 1:CAS:528:DyaK38XitFajsL4%3D (Pubitemid 23084552)
25. AS Maharaj M Saint-Geniez AE Maldonado PA D'Amore 2006 Vascular endothelial growth factor localization in the adult Am J Pathol 168 639 648 16436677 1:CAS:528:DC%2BD28Xhs1agu7c%3D (Pubitemid 43271161)
26. J Pober RS Cotran 1990 Cytokines and endothelial cell biology Physiol Rev 70 427 451 1690903 1:CAS:528:DyaK3cXkvFGksrc%3D (Pubitemid 20140187)
27. T Inagami M Naruse R Hoover 1995 Endothelium as an endocrine organ Ann Rev Physiol 57 171 189 1:CAS:528:DyaK2MXksVeqs7w%3D
28. BE Sumpio JT Riley A Dardik 2002 Cells in focus: endothelial cell Int J Biochem Cell Biol 34 1508 1512 12379270 1:CAS:528:DC%2BD38XnvVGqurw%3D
29. JM Butler H Kobayashi S Rafii 2010 Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors Nat Rev Cancer 10 138 146 20094048 1:CAS:528:DC%2BC3cXps1Cnug%3D%3D
30. M Lu VL Perez N Ma K Miyamoto HB Peng JK Liao AP Adamis 1999 VEGF increases retinal vascular ICAM-1 expression in vivo Invest Ophthalmol Vis Sci 40 1808 1812 10393052 1:STN:280:DyaK1MzitVahsQ%3D%3D (Pubitemid 29297158)
31. W Kim SO Moon S Lee MJ Sung SH Kim SK Park 2003 Adrenomedullin reduces VEGF-induced endothelial adhesion molecules and adhesiveness through a phosphatidylinositol 3′-kinase pathway Arterioscler Thromb Vasc Biol 23 1377 1383 12805078 1:CAS:528:DC%2BD3sXlvFaqsLw%3D (Pubitemid 36994525)
32. TA Brock HF Dvorak DR Senger 1991 Tumor-secreted vascular permeability factor increases cytosolic Ca2+ and von Willebrand factor release in human endothelial cells Am J Pathol 138 213 221 1987767 1:CAS:528:DyaK3MXit1Kku7w%3D
33. DD Ku JK Zaleski S Liu TA Brock 1993 Vascular endothelial growth factor induces EDRF-dependent relaxation in coronary arteries Am J Physiol 265 H586 H592 8368362 1:CAS:528:DyaK3sXmtFygsbk%3D
34. BM Arkonac LC Foster NE Sibinga C Patterson K Lai JC Tsai ME Lee MA Perrella E Haber 1998 Vascular endothelial growth factor induces heparin-binding epidermal growth factor-like growth factor in vascular endothelial cells J Biol Chem 273 4400 4405 9468491 1:CAS:528:DyaK1cXhtlSrtLY%3D (Pubitemid 28103177)
35. TH Lee H Avraham SH Lee S Avraham 2002 Vascular endothelial growth factor modulates neutrophil transendothelial migration via up-regulation of interleukin-8 in human brain microvascular endothelial cells J Biol Chem 277 10445 10451 11784713 1:CAS:528:DC%2BD38XisVyksrw%3D (Pubitemid 34968165)
36. J LeCouter DR Moritz B Li GL Phillips XH Liang HP Gerber KJ Hillan N Ferrara 2003 Angiogenesis-independent endothelial protection of liver: role of VEGFR-1 Science 299 890 893 12574630 1:CAS:528:DC%2BD3sXpt1Shuw%3D%3D (Pubitemid 36182447)
37. K Matsushita M Yamakuchi CN Morrell M Ozaki B O'Rourke K Irani CJ Lowenstein 2005 Vascular endothelial growth factor regulation of Weibel-Palade-body exocytosis Blood 105 207 214 15345585 1:CAS:528: DC%2BD2MXis1GqsQ%3D%3D (Pubitemid 40053084)
38. Q Hao L Wang H Tang 2009 Vascular endothelial growth factor induces protein kinase D-dependent production of proinflammatory cytokines in endothelial cells Am J Physiol Cell Physiol 296 C821 C827 19176759 1:CAS:528:DC%2BD1MXkvVyhsLs%3D
39. ER Weibel GE Palade 1964 New cytoplasmic components in arterial endothelia J Cell Biol 23 101 112 14228505 1:STN:280:DyaF2M%2Fjt12itA%3D%3D
40. O Lorenzi M Frieden P Villemin M Fournier M Foti UM Vischer 2008 Protein kinase C-delta mediates von Willebrand factor secretion from endothelial cells in response to vascular endothelial growth factor (VEGF) but not histamine J Thromb Haemost 6 1962 1969 18752579 1:CAS:528:DC%2BD1cXhsVyqs73I
41. Y Xiong Y Huo C Chen H Zeng X Lu C Wei C Ruan X Zhang Z Hu M Shibuya J Luo 2009 Vascular endothelial growth factor (VEGF) receptor-2 tyrosine 1175 signaling controls VEGF-induced von Willebrand factor release from endothelial cells via phospholipase C-gamma 1- and protein kinase A-dependent pathways J Biol Chem 284 23217 23224 19570985 1:CAS:528:DC%2BD1MXhtVWqtrnK
42. DD Wagner 1993 The Weibel-Palade body: the storage granule for von Willebrand factor and P-selectin Thromb Haemost 70 105 110 7694385 1:STN:280:DyaK2c%2FlsVamug%3D%3D (Pubitemid 23225460)
43. CJ Lowenstein CN Morrell M Yamakuchi 2005 Regulation of Weibel-Palade body exocytosis Trends Cardiovasc Med 15 302 308 16297768 1:CAS:528: DC%2BD2MXht1ars7%2FK (Pubitemid 41613876)
44. S Rollin C Lemieux R Maliba J Favier LR Villeneuve BG Allen S Soker NG Bazan Y Merhi MG Sirois 2004 VEGF-mediated endothelial P-selectin translocation: role of VEGF receptors and endogenous PAF synthesis Blood 103 3789 3797 14764537 1:CAS:528:DC%2BD2cXjvF2iurk%3D (Pubitemid 38596297)
45. I Kim SO Moon SH Kim HJ Kim YS Koh GY Koh 2001 Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-κB activation in endothelial cells J Biol Chem 276 7614 7620 11108718 1:CAS:528:DC%2BD3MXisl2qs7k%3D
46. N Reinmuth S Rensinghoff M Raedel N Fehrmann C Schwöppe T Kessler G Bisping F Hilberg GJ Roth W Berdel M Thomas RM Mesters 2007 Paracrine interactions of vascular endothelial growth factor and platelet-derived growth factor in endothelial and lung cancer cells Int J Oncol 31 621 626 17671690 1:CAS:528:DC%2BD2sXhtVagurnP
47. BA Hesser XH Liang G Camenisch S Yang DA Lewin R Scheller N Ferrara HP Gerber 2004 Down syndrome critical region protein 1 (DSCR1), a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells Blood 104 149 158 15016650 1:CAS:528:DC%2BD2cXlslWgsL4%3D (Pubitemid 38879851)
48. JK Min YM Lee JH Kim YM Kim SW Kim SY Lee YS Gho GT Oh YG Kwon 2005 Hepatocyte growth factor suppresses vascular endothelial growth factor-induced expression of endothelial ICAM-1 and VCAM-1 by inhibiting the nuclear factor-kappaB pathway Circ Res 96 300 307 15637298 1:CAS:528: DC%2BD2MXhtF2ns7c%3D
49. A Papapetropoulos G García-Cardeña JA Madri WC Sessa 1997 Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells J Clin Invest 100 3131 3139 9399960 1:CAS:528:DyaK2sXotVyrs70%3D (Pubitemid 28022851)
50. JR Horowitz A Rivard R van der Zee M Hariawala DD Sheriff DD Esakof GM Chaudhry JF Symes JM Isner 1997 Vascular endothelial growth factor/vascular permeability factor produces nitric oxide-dependent hypotension Evidence for a maintenance role in quiescent adult endothelium Arterioscler Thromb Vasc Biol 17 2793 2800 9409257 1:CAS:528:DyaK1cXisV2jtg%3D%3D (Pubitemid 28016023)
51. C Wheeler-Jones R Abu-Ghazaleh R Cospedal RA Houliston J Martin I Zachary 1997 Vascular endothelial growth factor stimulates prostacyclin production and activation of cytosolic phospholipase A2 in endothelial cells via p42/p44 mitogen-activated protein kinase FEBS Lett 420 28 32 9450544 1:CAS:528:DyaK2sXotVyjtrk%3D (Pubitemid 28037194)
52. T Murohara JR Horowitz M Silver Y Tsurumi D Chen A Sullivan JM Isner 1998 Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin Circulation 97 99 107 9443437 1:CAS:528:DyaK1cXlvVeitg%3D%3D (Pubitemid 28036160)
53. AL Armesilla E Lorenzo P Gómez del Arco S Martínez- Martínez A Alfranca JM Redondo 1999 Vascular endothelial growth factor activates nuclear factor of activated T cells in human endothelial cells: a role for tissue factor gene expression Mol Cell Biol 19 2032 2043 10022890 1:CAS:528:DyaK1MXhsFequr4%3D (Pubitemid 29098261)
54. R Kumar J Yoneda CD Bucana IJ Fidler 1998 Regulation of distinct steps of angiogenesis by different angiogenic molecules Int J Oncol 12 749 757 9499433 1:CAS:528:DyaK1cXitlejtrs%3D (Pubitemid 28133565)
55. J Yu D Bian C Mahanivong RK Cheng W Zhou S Huang 2004 p38 mitogen-activated protein kinase regulation of endothelial cell migration depends on urokinase plasminogen activator expression J Biol Chem 279 50446 50454 15371454 1:CAS:528:DC%2BD2cXhtVWjs7fL (Pubitemid 39577863)
56. MG Sirois ER Edelman 1997 VEGF effect on vascular permeability is mediated by synthesis of platelet-activating factor Am J Physiol 272 H2746 H2756 9227554 1:CAS:528:DyaK2sXksVSms7k%3D
57. A Mayumi S Yasufumi 2001 cDNA microarray analysis of the gene expression profile of VEGF-activated human umbilical vein endothelial cells Angiogenesis 4 289 298
58. E Ekblad F Sunbdler 2002 Distribution of pancreatic polypeptide and peptide YY Peptides 23 251 261 11825640 1:CAS:528:DC%2BD38XovFCrtA%3D%3D (Pubitemid 34127963)
59. DM Dudzinski T Michel 2007 Life history of eNOS: partners and pathways Cardiovasc Res 75 247 260 17466957 1:CAS:528:DC%2BD2sXntFKhu70%3D (Pubitemid 46961923)
60. R Botting JR Vane 1989 Mediators and the anti-thrombotic properties of the vascular endothelium Ann Med 21 31 38 2647108 1:CAS:528:DyaL1MXktFOktLk%3D (Pubitemid 19121849)
61. JA Mitchell F Ali L Bailey L Moreno LS Harrington 2008 Role of nitric oxide and prostacyclin as vasoactive hormones released by the endothelium Exp Physiol 93 141 147 17965142 1:CAS:528:DC%2BD1cXivFKksrs%3D (Pubitemid 350293980)
62. K Matsushita CN Morrell B Cambien SX Yang M Yamakuchi C Bao MR Hara RA Quick W Cao B O'Rourke JM Lowenstein J Pevsner DD Wagner CJ Lowenstein 2003 Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide- sensitive factor Cell 115 127 129
63. A Matsuura W Yamochi K Hirata S Kawashima M Yokoyama 1998 Stimulatory interaction between vascular endothelial growth factor and endothelin-1 on each gene expression Hypertension 32 89 95 9674643 1:CAS:528:DyaK1cXkvVOksr4%3D (Pubitemid 28324130)
64. TF Lüscher M Barton 2000 Endothelins and endothelin receptor antagonists: therapeutic considerations for a novel class of cardiovascular drugs Circulation 102 2434 2440 11067800
65. G Montrucchio G Alloatti G Camussi 2000 Role of platelet-activating factor in cardiovascular pathophysiology Physiol Rev 80 1669 1699 11015622 1:CAS:528:DC%2BD3cXnsVKisb4%3D
66. JK Liao 2008 Fine-tuning the angiogenic response to vascular endothelial growth factor Circ Res 103 229 230 18669928 1:CAS:528:DC%2BD1cXhtV2iu7rM
67. RR Turner JH Beckstead RA Warnke GA Wood 1985 Endothelial cell phenotypic diversity in situ demonstration of immunologic and enzymatic heterogeneity that correlates with specific morphologic subtypes Am J Clin Pathol 87 569 575 (Pubitemid 17076593)
68. S Kumar DC West A Ager 1987 Heterogeneity in endothelial cells from large vessels and microvessels Differentiation 36 57 70 2451631 1:STN:280: DyaL1c7osFOitA%3D%3D (Pubitemid 18034786)
69. EG Levin KG Osborn 1997 The expression of endothelial cell tissue plasminogen activator in vivo: a function defined by vessel size and anatomic location J Cell Sci 11 139 148 (Pubitemid 27075858)
70. I ∅ynebråten N Barois K Hagelsteen FE Johansen O Bakke G Haraldsen 2005 Characterization of a novel chemokine-containing storage granule in endothelial cells: evidence for preferential exocytosis mediated by protein kinase A and diacylglycerol J Immunol 175 5358 5369 16210642 (Pubitemid 41456422)
71. MG Rondaij R Bierings A Kragt JA van Mourik J Voorberg 2006 Dynamics and plasticity of Weibel-Palade bodies in endothelial cells Arterioscler Thromb Vasc Biol 26 1002 1007 16469951 1:CAS:528:DC%2BD28XjsVersrk%3D (Pubitemid 43732104)
72. J Hol L Wilhelmsen G Haraldsen 2010 The murine IL-8 homologues KC, MIP-2, and LIX are found in endothelial cytoplasmic granules but not in Weibel-Palade bodies J Leukoc Biol 87 501 508 20007247 1:CAS:528:DC%2BC3cXmslKrs7k%3D
73. JD Levine JM Harlan LA Harker ML Joseph RB Counts 1982 Thrombin-mediated release of factor VIII antigen from human umbilical vein endothelial cells in culture Blood 60 531 534 6807373 1:CAS:528:DyaL38XlsVarsLk%3D (Pubitemid 12048705)
74. UM Vischer CB Wollheim 1997 Epinephrine induces von Willebrand factor release from cultured endothelial cells: involvement of cyclic AMP-dependent signalling in exocytosis Thromb Haemost 77 1182 1188 9241755 (Pubitemid 27311992)
75. DJ Pinsky Y Naka H Liao MC Oz DD Wagner TN Mayadas RC Johnson RO Hynes M Heath CA Lawson DM Stern 1996 Hypoxia-induced exocytosis of endothelial cell Weibel-Palade bodies. A mechanism for rapid neutrophil recruitment after cardiac preservation J Clin Invest 97 493 500 8567972 1:CAS:528:DyaK28Xht1Olsro%3D
76. T Mayadas DD Wagner PJ Simpson 1989 von Willebrand factor (vWF) biosynthesis and partitioning between constitutive and regulated pathways of secretion after thrombin stimulation Blood 73 706 711 2783866 1:CAS:528:DyaL1MXhslSrsr4%3D (Pubitemid 19069173)
77. DD Wagner JB Olmsted VJ Marder 1982 Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells J Cell Biol 95 355 360 6754744 1:CAS:528:DyaL38Xlsl2htb8%3D (Pubitemid 13208536)
78. MS Pepper N Ferrara L Orci R Montesano 1991 Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells Biochem Biophys Res Commun 181 902 906 1755866 1:CAS:528:DyaK38XhtVSjt7w%3D
79. N Quirici D Soligo L Caneva F Servida P Bossolasco GL Deliliers 2001 Differentiation and expansion of endothelial cells from human bone marrow CD133(+) cells Br J Haematol 115 186 194 11722432 1:CAS:528:DC%2BD3MXotFWmtrg%3D (Pubitemid 32995115)
80. M Detmar LF Brown MP Schön BM Elicker P Velasco L Richard D Fukumura W Monsky KP Claffey RK Jain 1998 Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice J Invest Dermatol 111 1 6 9665379 1:CAS:528:DyaK1cXks1emt7o%3D (Pubitemid 28309201)
81. SI Zittermann AC Issekutz 2006 Endothelial growth factors VEGF and bFGF differentially enhance monocyte and neutrophil recruitment to inflammation J Leukoc Biol 80 247 257 16818728 1:CAS:528:DC%2BD28Xot1OnsLw%3D (Pubitemid 44835498)
82. JE Sadler DJ Mancuso AM Randi EA Tuley LA Westfield 1991 Molecular biology of von Willebrand factor Ann N Y Acad Sci 614 114 124 2024879 1:CAS:528:DyaK3MXlsFWqsb0%3D
83. K Mahadev X Wu S Donnelly R Ouedraogo AD Eckhart BJ Goldstein 2008 Adiponectin inhibits vascular endothelial growth factor-induced migration of human coronary artery endothelial cells Cardiovasc Res 78 376 384 18267956 1:CAS:528:DC%2BD1cXmt1Wru7o%3D (Pubitemid 351556105)
84. T Mirzapoiazova I Kolosova PV Usatyuk V Natarajan AD Verin 2006 Diverse effects of vascular endothelial growth factor on human pulmonary endothelial barrier and migration Am J Physiol Lung Cell Mol Physiol 291 L718 L724 16679383 1:CAS:528:DC%2BD28XhtFarsLnL
85. A Brockington C Lewis S Wharton PJ Shaw 2004 Vascular endothelial growth factor and the nervous system Neuropathol Appl Neurobiol 30 427 446 15488020 1:CAS:528:DC%2BD2cXhtVektLnI (Pubitemid 39423031)
86. GH Fong J Rossant M Gertsenstein ML Breitman 1995 Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium Nature 376 66 70 7596436 1:CAS:528:DyaK2MXmvVKjsrs%3D
87. F Shalaby J Rossant TP Yamaguchi M Gertsenstein XF Wu ML Breitman AC Schuh 1995 Failure of blood-island formation and vasculogenesis in flk-1-deficient mice Nature 376 62 66 7596435 1:CAS:528:DyaK2MXmvVKjsro%3D
88. P Carmeliet YS Ng D Nuyens G Theilmeier K Brusselmans I Cornelissen E Ehler VV Kakkar I Stalmans V Mattot JC Perriard M Dewerchin W Flameng A Nagy F Lupu L Moons D Collen PA D'Amore DT Shima 1999 Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188 Nat Med 5 495 502 10229225 1:CAS:528:DyaK1MXivVKks70%3D (Pubitemid 29220207)
89. FJ Giordano HP Gerber SP Williams N VanBruggen S Bunting P Ruiz-Lozano Y Gu AK Nath Y Huang R Hickey N Dalton KL Peterson J Ross Jr KR Chien N Ferrara 2001 A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function Proc Natl Acad Sci USA 98 5780 5785 11331753 1:CAS:528:DC%2BD3MXjs1Wntr4%3D (Pubitemid 32435719)
90. S Lee TT Chen CL Barber MC Jordan J Murdock S Desai N Ferrara A Nagy KP Roos ML Iruela-Arispe 2007 Autocrine VEGF signaling is required for vascular homeostasis Cell 130 691 703 17719546 1:CAS:528:DC%2BD2sXhtVels7%2FK (Pubitemid 47268059)
91. H Gille J Kowalski B Li J LeCouter B Moffat TF Zioncheck N Pelletier N Ferrara 2001 Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants J Biol Chem 276 3222 3230 11058584 1:CAS:528:DC%2BD3MXhtFWjuro%3D
92. A Yamane L Seetharam S Yamaguchi N Gotoh T Takahashi G Neufeld M Shibuya 1994 A new communication system between hepatocytes and sinusoidal endothelial cells in liver through vascular endothelial growth factor and Flt tyrosine kinase receptor family (Flt-1 and KDR/Flk-1) Oncogene 9 2683 2690 8058332 1:CAS:528:DyaK2cXlsV2ktbY%3D (Pubitemid 24254045)
93. BS Ding DJ Nolan JM Butler D James AO Babazadeh Z Rosenwaks V Mittal H Kobayashi K Shido D Lyden TN Sato SY Rabbany S Rafii 2010 Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration Nature 468 310 315 21068842 1:CAS:528:DC%2BC3cXhsVWjsbzP
94. NL Bucher 1967 Experimental aspects of hepatic regeneration N Engl J Med 277 686 696 6039881 1:STN:280:DyaF2s3ksVersg%3D%3D
95. V Eremina JA Jefferson J Kowalewska H Hochster M Haas J Weisstuch C Richardson JB Kopp MG Kabir PH Backx HP Gerber N Ferrara L Barisoni CE Alpers SE Quaggin 2008 VEGF inhibition and renal thrombotic microangiopathy N Engl J 358 1129 1136 1:CAS:528:DC%2BD1cXjt1ahs7o%3D (Pubitemid 351398487)
96. A Gödecke T Heinicke A Kamkin I Kiseleva RH Strasser UK Decking T Stumpe G Isenberg J Schrader 2001 Inotropic response to β-adrenergic receptor stimulation and anti-adrenergic effect of ACh in endothelial NO synthase-deficient mouse hearts J Physiol 532 195 204 11368026 (Pubitemid 32303282)
97. S Rich VV McLaughlin 2003 Endothelin receptor blockers in cardiovascular disease Circulation 108 2184 2190 14597580 1:CAS:528:DC%2BD3sXosVShsLg%3D (Pubitemid 37363032)
98. PC Hsieh ME Davis LK Lisowski RT Lee 2006 Endothelial-cardiomyocyte interactions in cardiac development and repair Annu Rev Physiol 68 51 66 16460266 1:CAS:528:DC%2BD28XksFWksr8%3D
99. D Tirziu FJ Giordano M Simons 2010 Cell communications in the heart Circulation 122 928 937 20805439
100. M Bjarnegård M Enge J Norlin S Gustafsdottir S Fredriksson A Abramsson M Takemoto E Gustafsson R Fässler C Betsholtz 2004 Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental abnormalities Development 131 1847 1857 15084468 (Pubitemid 38559851)
101. T Nakayama W Sato T Kosugi L Zhang M Campbell-Thompson A Yoshimura BP Croker RJ Johnson T Nakagawa 2009 Endothelial injury due to eNOS deficiency accelerates the progression of chronic renal disease in the mouse Am J Physiol Renal Physiol 296 F317 F327 19036847 1:CAS:528:DC%2BD1MXitVejur8%3D
102. Y Kasahara RM Tuder L Taraseviciene-Stewart TD Le Cras S Abman PK Hirth J Waltenberger NF Voelkel 2000 Inhibition of VEGF receptors causes lung cell apoptosis and emphysema J Clin Invest 106 1311 1319 11104784 1:CAS:528:DC%2BD3cXosFKlsL8%3D
103. L Taraseviciene-Stewart Y Kasahara L Alger P Hirth G McMahon J Waltenberger NF Voelkel RM Tuder 2001 Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension FASEB 15 427 438 1:CAS:528:DC%2BD3MXhsFemsrw%3D (Pubitemid 32141434)
104. KA Fagan I McMurtry DM Rodman 2000 Nitric oxide synthase in pulmonary hypertension: lessons from knockout mice Physiol Res 49 539 548 11191358 1:CAS:528:DC%2BD3MXoslKk
105. CG Lee H Link P Baluk RJ Homer S Chapoval V Bhandari MJ Kang L Cohn YK Kim DM McDonald JA Elias 2004 Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung Nat Med 10 1095 1103 15378055 1:CAS:528:DC%2BD2cXnvFyntb4%3D (Pubitemid 39424871)
106. A Louissaint Jr S Rao C Leventhal SA Goldman 2002 Coordinated interaction of neurogenesis and angiogenesis in the adult songbird brain Neuron 34 945 960 12086642 1:CAS:528:DC%2BD38XltVygu74%3D (Pubitemid 34722284)
107. NO Schmidt D Koeder M Messing FJ Mueller KS Aboody SU Kim PM Black RS Carroll M Westphal K Lamszus 2009 Vascular endothelial growth factor-stimulated cerebral microvascular endothelial cells mediate the recruitment of neural stem cells to the neurovascular niche Brain Res 1268 24 37 19285048 1:CAS:528:DC%2BD1MXksVansrY%3D
108. JD Hood CJ Meininger M Ziche HJ Granger 1998 VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells Am J Physiol Heart Circ Physiol 274 H1054 H1058 1:CAS:528:DyaK1cXitVSjs7c%3D
109. SM Eppler DL Combs TD Henry JJ Lopez SG Ellis JH Yi BH Annex ER McCluskey TF Zioncheck 2002 A target-mediated model to describe the pharmacokinetics and hemodynamic effects of recombinant human vascular endothelial growth factor in humans Clin Pharmacol Ther 72 20 32 12152001 1:CAS:528:DC%2BD38Xms1alsb0%3D (Pubitemid 34833184)
110. HS Rugo RS Herbst G Liu JW Park MS Kies HM Steinfeldt YK Pithavala SD Reich JL Freddo G Wilding 2005 Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: pharmacokinetic and clinical results J Clin Oncol 23 5474 5483 16027439 1:CAS:528:DC%2BD2MXhtVersr7F
111. S Faivre C Delbaldo K Vera C Robert S Lozahic N Lassau C Bello S Deprimo N Brega G Massimini JP Armand P Scigalla E Raymond 2006 Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer J Clin Oncol 24 25 35 16314617 1:CAS:528:DC%2BD28Xot1ChtQ%3D%3D (Pubitemid 46630490)
112. DA Sica 2006 Angiogenesis inhibitors and hypertension: an emerging issue J Clin Oncol 24 1329 1331 16446321 (Pubitemid 46621994)
113. HM Verheul HM Pinedo 2007 Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition Nat Rev Cancer 7 475 485 17522716 1:CAS:528:DC%2BD2sXls1Kjsb4%3D (Pubitemid 46809172)
114. B Li AK Ogasawara R Yang W Wei GW He TF Zioncheck S Bunting AM de Vos H Jin 2002 KDR (VEGF receptor 2) is the major mediator for the hypotensive effect of VEGF Hypertension 39 1095 1100 12052848 1:CAS:528:DC%2BD38XksFWgt7w%3D (Pubitemid 34620130)
115. FA Scappaticci JR Skillings SN Holden HP Gerber K Miller F Kabbinavar E Bergsland J Ngai E Holmgren J Wang H Hurwitz 2007 Arterial Thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab J Natl Cancer Inst 99 1232 1239 17686822 (Pubitemid 47299901)
116. P Bhargava 2009 VEGF kinase inhibitors: how do they cause hypertension? Am J Physiol Regul Integr Comp Physiol 297 R1 R5 19439616 1:CAS:528: DC%2BD1MXovVKitbY%3D
117. M Shoji WW Hancock K Abe C Micko KA Casper RM Baine JN Wilcox I Danave DL Dillehay E Matthews J Contrino JH Morrissey S Gordon TS Edgington B Kudryk DL Kreutzer FR Rickles 1998 Activation of coagulation and angiogenesis in cancer: immunohistochemical localization in situ of clotting proteins and vascular endothelial growth factor in human cancer Am J Pathol 152 399 411 9466566 1:STN:280:DyaK1c7is1SnsA%3D%3D (Pubitemid 28106386)
118. M Inoue H Itoh M Ueda T Naruko A Kojima R Komatsu K Doi Y Ogawa N Tamura K Takaya T Igaki J Yamashita TH Chun K Masatsugu AE Becker K Nakao 1998 Vascular endothelial growth factor (VEGF) expression in human coronary atherosclerotic lesions: possible pathophysiological significance of VEGF in progression of atherosclerosis Circulation 98 2108 2116 9815864 1:CAS:528:DyaK1cXnvFaqsrw%3D (Pubitemid 28527469)
119. HM Verheul AS Jorna K Hoekman HJ Broxterman MF Gebbink HM Pinedo 2000 Vascular endothelial growth factor-stimulated endothelial cells promote adhesion and activation of platelets Blood 96 4216 4221 11110694 1:CAS:528: DC%2BD3cXosl2ht7w%3D
120. U Förstermann M Nakane WR Tracey JS Pollock 1993 Isoforms of nitric oxide synthase: functions in the cardiovascular system Eur Heart J 14 SuppII 10 15 7507435 (Pubitemid 23362587)
121. S Lindemann C Gierer H Darius 2003 Prostacyclin inhibits adhesion of polymorphonuclear leukocytes to human vascular endothelial cells due to adhesion molecule independent regulatory mechanisms Basic Res Cardiol 98 8 15 12494264 1:CAS:528:DC%2BD3sXhsFygtrw%3D (Pubitemid 36163512)
122. M Canavese F Altruda T Ruzicka J Schauber 2010 Vascular endothelial growth factor (VEGF) in the pathogenesis of psoriasis-a possible target for novel therapies? J Dermatol Sci 58 171 176 20430590 1:CAS:528: DC%2BC3cXmvVSrs70%3D
123. JA Nagy L Benjamin H Zeng AM Dvorak HF Dvorak 2008 Vascular permeability, vascular hyperpermeability and angiogenesis Angiogenesis 11 109 119 18293091 1:CAS:528:DC%2BD1cXmvVCgu7w%3D
124. M Lucerna A Zernecke R de Nooijer SC de Jager I Bot C van der Lans I Kholova EA Liehn TJ van Berkel S Yla-Herttuala C Weber EA Biessen 2007 Vascular endothelial growth factor-A induces plaque expansion in ApoE knock-out mice by promoting de novo leukocyte recruitment Blood 109 122 129 16990600 1:CAS:528:DC%2BD2sXivVyrtb4%3D (Pubitemid 46053052)
125. D Fukumura RK Jain 2007 Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization Microvasc Res 74 72 84 17560615 1:CAS:528:DC%2BD2sXht1ykur7E (Pubitemid 350051025)
126. R van der Voort TE Taher PW Derksen M Spaargaren R van der Neut ST Pals 2000 The hepatocyte growth factor/Met pathway in development, tumorigenesis, and B-cell differentiation Adv Cancer Res 79 39 90 10818677 (Pubitemid 30228120)
127. D George 2001 Platelet-derived growth factor receptors: a therapeutic target in solid tumors Semin Oncol 28 27 33 11740804 1:STN:280: DC%2BD3MnptlOgtw%3D%3D (Pubitemid 33140515)
128. K Danø PA Andreasen J Grøndahl-Hansen P Kristensen LS Nielsen L Skriver 1985 Plasminogen activators, tissue degradation, and cancer Adv Cancer Res 44 139 266 2930999
129. JP Stone DD Wagner 1993 P-selectin mediates adhesion of platelets to neuroblastoma and small cell lung cancer J Clin Invest 92 804 813 7688763 1:CAS:528:DyaK2cXltFekuw%3D%3D (Pubitemid 23262402)
130. RF Furchgott JV Zawadzki 1980 The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine Nature 288 373 376 6253831 1:CAS:528:DyaL3MXhtFCktbY%3D (Pubitemid 11169009)
131. ME Gerritsen JE Tomlinson C Zlot M Ziman S Hwang 2003 Using gene expression profiling to identify the molecular basis of the synergistic actions of hepatocyte growth factor and vascular endothelial growth factor in human endothelial cells Br J Pharmacol 140 595 610 14504135 1:CAS:528: DC%2BD3sXovVagu7c%3D (Pubitemid 37386423)
132. TT Chou JQ Trojanowski VM Lee 1997 Neurotrophin signal transduction in medulloblastoma J Neurosci Res 49 522 527 9302073 1:CAS:528:DyaK2sXlslKjsbo%3D (Pubitemid 27381239)
133. AK Stannard R Khurana IM Evans V Sofra DIR Holmes I Zachary 2007 Vascular endothelial growth factor synergistically enhances induction of e-selectin by tumor necrosis factor-{alpha} Arterioscler Thromb Vasc Biol 27 494 502 17170373 1:CAS:528:DC%2BD2sXhsVSit78%3D
134. C Milsom J Rak 2008 Tissue factor and cancer Pathophysiol Haemost Thromb 36 160 176 19176989
135. S Niida T Kondo S Hiratsuka S Hayashi N Amizuka T Noda K Ikeda M Shibuya 2005 VEGF receptor 1 signaling is essential for osteoclast development and bone marrow formation in colony-stimulating factor 1-deficient mice Proc Natl Acad Sci USA 102 14016 14021 16172397 1:CAS:528:DC%2BD2MXhtVOqsbnE (Pubitemid 41377695)