A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesis

Cancer Research

Volumn 68, Issue 12, 2008, Pages 4727-4735

  Funahashi, Yasuhiro ^a   Hernandez, Sonia L ^a   Das, Indranil ^a   Ahn, Audrey ^a   Huang, Jianzhong ^a   Vorontchikhina, Marina ^a   Sharma, Anshula ^a   Kanamaru, Emi ^a   Borisenko, Valeriya ^a   DeSilva, Dinuka M ^a   Suzuki, Akihiko ^b   Wang, Xing ^a   Shawber, Carrie J ^a   Kandel, Jessica J ^a   Yamashiro, Darrell J ^a   Kitajewski, Jan ^a  

^a NewYork Presbyterian Hospital   (United States)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 4; NOTCH1 RECEPTOR; VASCULOTROPIN; CALCIUM BINDING PROTEIN; DLK1 PROTEIN, MOUSE; FGF4 PROTEIN, MOUSE; MEMBRANE PROTEIN; NOTCH RECEPTOR; NOTCH4 PROTEIN, HUMAN; ONCOPROTEIN; SERRATE PROTEINS; SIGNAL PEPTIDE; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ANGIOGENESIS; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TUMOR GROWTH; ANIMAL; C3H MOUSE; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; ENZYME IMMUNOASSAY; EXPERIMENTAL NEOPLASM; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); NEUROBLASTOMA; NUDE MOUSE; PATHOLOGY; PHYSIOLOGY; SKIN; UMBILICAL VEIN; VASCULAR ENDOTHELIUM; VASCULARIZATION; WESTERN BLOTTING; XENOGRAFT;

ANIMALS; BLOTTING, WESTERN; CALCIUM-BINDING PROTEINS; ENDOTHELIUM, VASCULAR; FIBROBLAST GROWTH FACTOR 4; HUMANS; IMMUNOENZYME TECHNIQUES; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MAMMARY NEOPLASMS, ANIMAL; MEMBRANE PROTEINS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, NUDE; NEOVASCULARIZATION, PATHOLOGIC; NEUROBLASTOMA; PROTO-ONCOGENE PROTEINS; RECEPTOR, NOTCH1; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; SKIN; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED; UMBILICAL VEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 47949085649     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-6499     Document Type: Article

References (30)

1. Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev 2004;25:581-611.
2. Jain R, Duda D, Clark J, Loeffler J. Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nat Clin Pract Oncol 2006;3:24-40.
3. Kopan R. Notch: a membrane-bound transcription factor. J Cell Sci 2002;115:1095-7.
4. Shawber C, Kitajewski J. Notch function in the vasculature: insights from zebrafish, mouse and man. Bioessays 2004;26:225-34.
5. Gale NW, Dominguez MG, Noguera I, et al. Haploinsufficiency of y-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. Proc Natl Acad Sci U S A 2004;101:15949-54.
6. Patel NS, Li J-L, Generali D, Poulsom R, Cranston DW, Harris AL. Up-regulation of Delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function. Cancer Res 2005;65:8690-7.
7. Patel NS, Dobbie MS, Rochester M, et al. Up-regulation of endothelial Delta-like 4 expression correlates with vessel maturation in bladder cancer. Clin Cancer Res 2006;12:4836-44.
8. Ridgway J, Zhang G, Wu Y, et al. Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature 2006;444:1083-7.
9. Noguera-Troise I, Daly C, Papadopoulos NJ, et al. Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature 2006;444:1032-7.
10. Zeng Q, Li S, Chepeha DB, et al. Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling. Cancer Cell 2005;8:13-23.
11. Liu Z-J, Shirakawa T, Li Y, et al. Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. Mol Cell Biol 2003;23:14-25.
12. Williams CK, Li JL, Murga M, Harris AL, Tosato G. Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function. Blood 2006;107:931-9.
13. Shawber CJ, Funahashi Y, Francisco E, et al. Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression. J Clin Invest 2007;117:3369-82.
14. Panek RL, Lu GH, Dahring TK, et al. In vitro biological characterization and antiangiogenic effects of PD 166866, a selective inhibitor of the FGF-1 receptor tyrosine kinase. J Pharmacol Exp Ther 1998;286:569-77.
15. Das I, Craig C, Funahashi Y, et al. Notch oncoproteins depend on {g}-secretase/presenilin activity for processing and function. J Biol Chem 2004;279:30771-80.
16. Shawber CJ, Das I, Francisco E, Kitajewski JAN. Notch signaling in primary endothelial cells. Ann NY Acad Sci 2003;995:162-70.
17. Hardy S, Kitamura M, Harris-Stansil T, Dai Y, Phipps ML. Construction of adenovirus vectors through Cre-lox recombination. J Virol 1997;71:1842-9.
18. Jaffe E, Nachman R, Becker C, Minick C. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest 1973;52:2745-56.
19. Kato H, Sakai T, Tamura K, et al. Functional conservation of mouse Notch receptor family members. FEBS Lett 1996;395:221-4.
20. Funahashi Y, Wakabayashi T, Semba T, Sonoda J, Kitoh K, Yoshimatsu K. Establishment of a quantitative mouse dorsal air sac model and its application to evaluate a new angiogenesis inhibitor. Oncol Res 1999;11:319-29.
21. Vorontchikhina MA, Zimmermann RC, Shawber CJ, Tang H, Kitajewski J. Unique patterns of Notch1, Notch4 and Jagged1 expression in ovarian vessels during folliculogenesis and corpus luteum formation. Gene Expr Patterns 2005;5:701-9.
22. Kim ES, Serur A, Huang J, et al. Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma. Proc Natl Acad Sci U S A 2002;99:11399-404.
23. Montesano R. Phorbol esters induce angiogenesis in vitro from large-vessel endothelial cells. J Cell Physiol 1987;130:284-91.
24. Koolwijk P, van Erck MG, de Vree WJ, et al. Cooperative effect of TNFα, bFGF, and VEGF on the formation of tubular structures of human microvascular endothelial cells in a fibrin matrix. Role of urokinase activity. J Cell Biol 1996;132:1177-88.
25. Zimrin AB, Pepper MS, McMahon GA, Nguyen F, Montesano R, Maciag T. An antisense oligonucleotide to the notch ligand jagged enhances fibroblast growth factor-induced angiogenesis In vitro. J Biol Chem 1996;271:32499-502.
26. Funahashi Y, Wakabayashi T, Semba T, Sonoda J, Kitoh K. Establishment of a quantitative mouse dorsal air sac model and its application to evaluate a new angiogenesis inhibitor. Oncol Res 1999;11:319-29.
27. Shawber CJ, Das I, Francisco E, Kitajewski J. Notch signaling in primary endothelial cells. Ann N Y Acad Sci 2003;995:162-70.
28. Hainaud P, Contreres JO, Villemain A, et al. The role of the vascular endothelial growth factor-Delta-like 4 ligand/Notch4-ephrin B2 cascade in tumor vessel remodeling and endothelial cell functions. Cancer Res 2006;66:8501-10.
29. Nickoloff B, Osborne B, Miele L. Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents. Oncogene 2003;22:6598-608.
30. Radtke F, Raj K. The role of notch in tumorigenesis: oncogene or tumour suppressor? Nat Rev Cancer 2003;3:756-67.