메뉴 건너뛰기




Volumn 5, Issue 2, 2016, Pages 79-90

Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action

Author keywords

Browning; FGF21; GDF15; Mitochondrial disease; Muscle mitohormesis; Myokine

Indexed keywords

CHOLESTEROL; FIBROBLAST GROWTH FACTOR 21; TRIACYLGLYCEROL;

EID: 84958052962     PISSN: 22128778     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmet.2015.11.002     Document Type: Article
Times cited : (63)

References (70)
  • 2
    • 34249686631 scopus 로고    scopus 로고
    • Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21
    • Inagaki T., Dutchak P., Zhao G., Ding X., Gautron L., Parameswara V., et al. Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metabolism 2007, 5:415-425.
    • (2007) Cell Metabolism , vol.5 , pp. 415-425
    • Inagaki, T.1    Dutchak, P.2    Zhao, G.3    Ding, X.4    Gautron, L.5    Parameswara, V.6
  • 3
    • 84908018672 scopus 로고    scopus 로고
    • FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss
    • Owen B.M., Ding X., Morgan D.A., Coate K.C., Bookout A.L., Rahmouni K., et al. FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss. Cell Metabolism 2014, 20:670-677.
    • (2014) Cell Metabolism , vol.20 , pp. 670-677
    • Owen, B.M.1    Ding, X.2    Morgan, D.A.3    Coate, K.C.4    Bookout, A.L.5    Rahmouni, K.6
  • 5
    • 34249711964 scopus 로고    scopus 로고
    • Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states
    • Badman M.K., Pissios P., Kennedy A.R., Koukos G., Flier J.S., Maratos-Flier E. Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metabolism 2007, 5:426-437.
    • (2007) Cell Metabolism , vol.5 , pp. 426-437
    • Badman, M.K.1    Pissios, P.2    Kennedy, A.R.3    Koukos, G.4    Flier, J.S.5    Maratos-Flier, E.6
  • 6
    • 47949111205 scopus 로고    scopus 로고
    • Adipose fibroblast growth factor 21 is up-regulated by peroxisome proliferator-activated receptor gamma and altered metabolic states
    • Muise E.S., Azzolina B., Kuo D.W., El-Sherbeini M., Tan Y., Yuan X., et al. Adipose fibroblast growth factor 21 is up-regulated by peroxisome proliferator-activated receptor gamma and altered metabolic states. Molecular Pharmacology 2008, 74:403-412.
    • (2008) Molecular Pharmacology , vol.74 , pp. 403-412
    • Muise, E.S.1    Azzolina, B.2    Kuo, D.W.3    El-Sherbeini, M.4    Tan, Y.5    Yuan, X.6
  • 9
    • 84872057896 scopus 로고    scopus 로고
    • Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine
    • Kim K.H., Jeong Y.T., Oh H., Kim S.H., Cho J.M., Kim Y.N., et al. Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine. Nature Medicine 2013, 19:83-92.
    • (2013) Nature Medicine , vol.19 , pp. 83-92
    • Kim, K.H.1    Jeong, Y.T.2    Oh, H.3    Kim, S.H.4    Cho, J.M.5    Kim, Y.N.6
  • 12
    • 73249138414 scopus 로고    scopus 로고
    • Fibroblast growth factor-21 is induced in human skeletal muscles by hyperinsulinemia
    • Hojman P., Pedersen M., Nielsen A.R., Krogh-Madsen R., Yfanti C., Akerstrom T., et al. Fibroblast growth factor-21 is induced in human skeletal muscles by hyperinsulinemia. Diabetes 2009, 58:2797-2801.
    • (2009) Diabetes , vol.58 , pp. 2797-2801
    • Hojman, P.1    Pedersen, M.2    Nielsen, A.R.3    Krogh-Madsen, R.4    Yfanti, C.5    Akerstrom, T.6
  • 14
    • 84890389860 scopus 로고    scopus 로고
    • Elevated FGF21 secretion, PGC-1alpha and ketogenic enzyme expression are hallmarks of iron-sulfur cluster depletion in human skeletal muscle
    • Crooks D.R., Natarajan T.G., Jeong S.Y., Chen C., Park S.Y., Huang H., et al. Elevated FGF21 secretion, PGC-1alpha and ketogenic enzyme expression are hallmarks of iron-sulfur cluster depletion in human skeletal muscle. Human Molecular Genetics 2014, 23:24-39.
    • (2014) Human Molecular Genetics , vol.23 , pp. 24-39
    • Crooks, D.R.1    Natarajan, T.G.2    Jeong, S.Y.3    Chen, C.4    Park, S.Y.5    Huang, H.6
  • 15
    • 80051667626 scopus 로고    scopus 로고
    • FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study
    • Suomalainen A., Elo J.M., Pietilainen K.H., Hakonen A.H., Sevastianova K., Korpela M., et al. FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study. Lancet Neurology 2011, 10:806-818.
    • (2011) Lancet Neurology , vol.10 , pp. 806-818
    • Suomalainen, A.1    Elo, J.M.2    Pietilainen, K.H.3    Hakonen, A.H.4    Sevastianova, K.5    Korpela, M.6
  • 16
    • 84858376953 scopus 로고    scopus 로고
    • Mitochondria: in sickness and in health
    • Nunnari J., Suomalainen A. Mitochondria: in sickness and in health. Cell 2012, 148:1145-1159.
    • (2012) Cell , vol.148 , pp. 1145-1159
    • Nunnari, J.1    Suomalainen, A.2
  • 18
    • 84877260638 scopus 로고    scopus 로고
    • Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice
    • Lin Z., Tian H., Lam K.S., Lin S., Hoo R.C., Konishi M., et al. Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. Cell Metabolism 2013, 17:779-789.
    • (2013) Cell Metabolism , vol.17 , pp. 779-789
    • Lin, Z.1    Tian, H.2    Lam, K.S.3    Lin, S.4    Hoo, R.C.5    Konishi, M.6
  • 19
    • 84863012022 scopus 로고    scopus 로고
    • FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis
    • Fisher F.M., Kleiner S., Douris N., Fox E.C., Mepani R.J., Verdeguer F., et al. FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis. Genes & Development 2012, 26:271-281.
    • (2012) Genes & Development , vol.26 , pp. 271-281
    • Fisher, F.M.1    Kleiner, S.2    Douris, N.3    Fox, E.C.4    Mepani, R.J.5    Verdeguer, F.6
  • 20
    • 84930579383 scopus 로고    scopus 로고
    • Pharmacologic effects of FGF21 are independent of the "Browning" of white adipose tissue
    • Veniant M.M., Sivits G., Helmering J., Komorowski R., Lee J., Fan W., et al. Pharmacologic effects of FGF21 are independent of the "Browning" of white adipose tissue. Cell Metabolism 2015, 21:731-738.
    • (2015) Cell Metabolism , vol.21 , pp. 731-738
    • Veniant, M.M.1    Sivits, G.2    Helmering, J.3    Komorowski, R.4    Lee, J.5    Fan, W.6
  • 22
    • 84931577787 scopus 로고    scopus 로고
    • Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion
    • Keipert S., Kutschke M., Lamp D., Brachthauser L., Neff F., Meyer C.W., et al. Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion. Molecular Metabolism 2015, 4:537-542.
    • (2015) Molecular Metabolism , vol.4 , pp. 537-542
    • Keipert, S.1    Kutschke, M.2    Lamp, D.3    Brachthauser, L.4    Neff, F.5    Meyer, C.W.6
  • 24
    • 84892162004 scopus 로고    scopus 로고
    • Stressed liver and muscle call on adipocytes with FGF21
    • Luo Y., McKeehan W.L. Stressed liver and muscle call on adipocytes with FGF21. Frontiers in Endocrinology 2013, 4:194.
    • (2013) Frontiers in Endocrinology , vol.4 , pp. 194
    • Luo, Y.1    McKeehan, W.L.2
  • 28
    • 21244480070 scopus 로고    scopus 로고
    • Expression of uncoupling protein 1 in skeletal muscle decreases muscle energy efficiency and affects thermoregulation and substrate oxidation
    • Klaus S., Rudolph B., Dohrmann C., Wehr R. Expression of uncoupling protein 1 in skeletal muscle decreases muscle energy efficiency and affects thermoregulation and substrate oxidation. Physiological Genomics 2005, 21:193-200.
    • (2005) Physiological Genomics , vol.21 , pp. 193-200
    • Klaus, S.1    Rudolph, B.2    Dohrmann, C.3    Wehr, R.4
  • 29
    • 73549125253 scopus 로고    scopus 로고
    • UCP1 ectopically expressed in murine muscle displays native function and mitigates mitochondrial superoxide production
    • Keipert S., Klaus S., Heldmaier G., Jastroch M. UCP1 ectopically expressed in murine muscle displays native function and mitigates mitochondrial superoxide production. Biochimica Biophysica Acta 2010, 1797:324-330.
    • (2010) Biochimica Biophysica Acta , vol.1797 , pp. 324-330
    • Keipert, S.1    Klaus, S.2    Heldmaier, G.3    Jastroch, M.4
  • 30
    • 45549106810 scopus 로고    scopus 로고
    • Uncoupling protein 1 expression in murine skeletal muscle increases AMPK activation, glucose turnover, and insulin sensitivity in vivo
    • Neschen S., Katterle Y., Richter J., Augustin R., Scherneck S., Mirhashemi F., et al. Uncoupling protein 1 expression in murine skeletal muscle increases AMPK activation, glucose turnover, and insulin sensitivity in vivo. Physiological Genomics 2008, 33:333-340.
    • (2008) Physiological Genomics , vol.33 , pp. 333-340
    • Neschen, S.1    Katterle, Y.2    Richter, J.3    Augustin, R.4    Scherneck, S.5    Mirhashemi, F.6
  • 31
    • 84874546118 scopus 로고    scopus 로고
    • Skeletal muscle uncoupling-induced longevity in mice is linked to increased substrate metabolism and induction of the endogenous antioxidant defense system
    • Keipert S., Ost M., Chadt A., Voigt A., Ayala V., Portero-Otin M., et al. Skeletal muscle uncoupling-induced longevity in mice is linked to increased substrate metabolism and induction of the endogenous antioxidant defense system. American Journal of Physiology-Endocrinology and Metabolism 2013, 304:E495-E506.
    • (2013) American Journal of Physiology-Endocrinology and Metabolism , vol.304 , pp. E495-E506
    • Keipert, S.1    Ost, M.2    Chadt, A.3    Voigt, A.4    Ayala, V.5    Portero-Otin, M.6
  • 32
    • 78651269800 scopus 로고    scopus 로고
    • Dietary effects on body composition, glucose metabolism, and longevity are modulated by skeletal muscle mitochondrial uncoupling in mice
    • Keipert S., Voigt A., Klaus S. Dietary effects on body composition, glucose metabolism, and longevity are modulated by skeletal muscle mitochondrial uncoupling in mice. Aging Cell 2011, 10:122-136.
    • (2011) Aging Cell , vol.10 , pp. 122-136
    • Keipert, S.1    Voigt, A.2    Klaus, S.3
  • 35
    • 70349324370 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver
    • Hotta Y., Nakamura H., Konishi M., Murata Y., Takagi H., Matsumura S., et al. Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver. Endocrinology 2009, 150:4625-4633.
    • (2009) Endocrinology , vol.150 , pp. 4625-4633
    • Hotta, Y.1    Nakamura, H.2    Konishi, M.3    Murata, Y.4    Takagi, H.5    Matsumura, S.6
  • 37
    • 84861212358 scopus 로고    scopus 로고
    • Non-invasive quantification of white and brown adipose tissues and liver fat content by computed tomography in mice
    • Lubura M., Hesse D., Neumann N., Scherneck S., Wiedmer P., Schurmann A. Non-invasive quantification of white and brown adipose tissues and liver fat content by computed tomography in mice. PLoS One 2012, 7:e37026.
    • (2012) PLoS One , vol.7 , pp. e37026
    • Lubura, M.1    Hesse, D.2    Neumann, N.3    Scherneck, S.4    Wiedmer, P.5    Schurmann, A.6
  • 39
    • 84899623784 scopus 로고    scopus 로고
    • Activation of AMPKalpha2 is not crucial for mitochondrial uncoupling-induced metabolic effects but required to maintain skeletal muscle integrity
    • Ost M., Werner F., Dokas J., Klaus S., Voigt A. Activation of AMPKalpha2 is not crucial for mitochondrial uncoupling-induced metabolic effects but required to maintain skeletal muscle integrity. Plos One 2014, 9:e94689.
    • (2014) Plos One , vol.9 , pp. e94689
    • Ost, M.1    Werner, F.2    Dokas, J.3    Klaus, S.4    Voigt, A.5
  • 43
  • 44
    • 84893452569 scopus 로고    scopus 로고
    • Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans
    • Lee P., Linderman J.D., Smith S., Brychta R.J., Wang J., Idelson C., et al. Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans. Cell Metabolism 2014, 19:302-309.
    • (2014) Cell Metabolism , vol.19 , pp. 302-309
    • Lee, P.1    Linderman, J.D.2    Smith, S.3    Brychta, R.J.4    Wang, J.5    Idelson, C.6
  • 45
    • 84887431711 scopus 로고    scopus 로고
    • Brown and beige fat: development, function and therapeutic potential
    • Harms M., Seale P. Brown and beige fat: development, function and therapeutic potential. Nature Medicine 2013, 19:1252-1263.
    • (2013) Nature Medicine , vol.19 , pp. 1252-1263
    • Harms, M.1    Seale, P.2
  • 46
  • 47
    • 84928895286 scopus 로고    scopus 로고
    • Skeletal muscle increases FGF21 expression in mitochondrial disorders to compensate for energy metabolic insufficiency by activating the mTOR-YY1-PGC1alpha pathway
    • Ji K., Zheng J., Lv J., Xu J., Ji X., Luo Y.B., et al. Skeletal muscle increases FGF21 expression in mitochondrial disorders to compensate for energy metabolic insufficiency by activating the mTOR-YY1-PGC1alpha pathway. Free Radical Biology & Medicine 2015, 84:161-170.
    • (2015) Free Radical Biology & Medicine , vol.84 , pp. 161-170
    • Ji, K.1    Zheng, J.2    Lv, J.3    Xu, J.4    Ji, X.5    Luo, Y.B.6
  • 48
    • 48349146527 scopus 로고    scopus 로고
    • Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans
    • Zhang X., Yeung D.C., Karpisek M., Stejskal D., Zhou Z.G., Liu F., et al. Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes 2008, 57:1246-1253.
    • (2008) Diabetes , vol.57 , pp. 1246-1253
    • Zhang, X.1    Yeung, D.C.2    Karpisek, M.3    Stejskal, D.4    Zhou, Z.G.5    Liu, F.6
  • 49
    • 84931569401 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 is elevated in metabolically unhealthy obesity and affects lipid deposition, adipogenesis, and adipokine secretion of human abdominal subcutaneous adipocytes
    • Berti L., Irmler M., Zdichavsky M., Meile T., Bohm A., Stefan N., et al. Fibroblast growth factor 21 is elevated in metabolically unhealthy obesity and affects lipid deposition, adipogenesis, and adipokine secretion of human abdominal subcutaneous adipocytes. Molecular Metabolism 2015, 4:519-527.
    • (2015) Molecular Metabolism , vol.4 , pp. 519-527
    • Berti, L.1    Irmler, M.2    Zdichavsky, M.3    Meile, T.4    Bohm, A.5    Stefan, N.6
  • 51
    • 84883118811 scopus 로고    scopus 로고
    • Additive relationship between serum fibroblast growth factor 21 level and coronary artery disease
    • Shen Y., Ma X., Zhou J., Pan X., Hao Y., Zhou M., et al. Additive relationship between serum fibroblast growth factor 21 level and coronary artery disease. Cardiovascular Diabetology 2013, 12:124.
    • (2013) Cardiovascular Diabetology , vol.12 , pp. 124
    • Shen, Y.1    Ma, X.2    Zhou, J.3    Pan, X.4    Hao, Y.5    Zhou, M.6
  • 55
    • 84906934662 scopus 로고    scopus 로고
    • Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia
    • Kir S., White J.P., Kleiner S., Kazak L., Cohen P., Baracos V.E., et al. Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia. Nature 2014, 513:100-104.
    • (2014) Nature , vol.513 , pp. 100-104
    • Kir, S.1    White, J.P.2    Kleiner, S.3    Kazak, L.4    Cohen, P.5    Baracos, V.E.6
  • 57
    • 84891840977 scopus 로고    scopus 로고
    • Beta-Aminoisobutyric acid induces browning of white fat and hepatic beta-oxidation and is inversely correlated with cardiometabolic risk factors
    • Roberts L.D., Bostrom P., O'Sullivan J.F., Schinzel R.T., Lewis G.D., Dejam A., et al. beta-Aminoisobutyric acid induces browning of white fat and hepatic beta-oxidation and is inversely correlated with cardiometabolic risk factors. Cell Metabolism 2014, 19:96-108.
    • (2014) Cell Metabolism , vol.19 , pp. 96-108
    • Roberts, L.D.1    Bostrom, P.2    O'Sullivan, J.F.3    Schinzel, R.T.4    Lewis, G.D.5    Dejam, A.6
  • 58
    • 84862776702 scopus 로고    scopus 로고
    • A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
    • Bostrom P., Wu J., Jedrychowski M.P., Korde A., Ye L., Lo J.C., et al. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012, 481:463-468.
    • (2012) Nature , vol.481 , pp. 463-468
    • Bostrom, P.1    Wu, J.2    Jedrychowski, M.P.3    Korde, A.4    Ye, L.5    Lo, J.C.6
  • 59
    • 84913586856 scopus 로고    scopus 로고
    • The browning of white adipose tissue: some burning issues
    • Nedergaard J., Cannon B. The browning of white adipose tissue: some burning issues. Cell Metabolism 2014, 20:396-407.
    • (2014) Cell Metabolism , vol.20 , pp. 396-407
    • Nedergaard, J.1    Cannon, B.2
  • 61
    • 77953531909 scopus 로고    scopus 로고
    • Autophagy inhibition induces atrophy and myopathy in adult skeletal muscles
    • Masiero E., Sandri M. Autophagy inhibition induces atrophy and myopathy in adult skeletal muscles. Autophagy 2010, 6:307-309.
    • (2010) Autophagy , vol.6 , pp. 307-309
    • Masiero, E.1    Sandri, M.2
  • 62
    • 84922459687 scopus 로고    scopus 로고
    • Endocrine aspects of organelle stress-cell non-autonomous signaling of mitochondria and the ER
    • Schinzel R., Dillin A. Endocrine aspects of organelle stress-cell non-autonomous signaling of mitochondria and the ER. Current Opinion in Cell Biology 2015, 33:102-110.
    • (2015) Current Opinion in Cell Biology , vol.33 , pp. 102-110
    • Schinzel, R.1    Dillin, A.2
  • 63
    • 84930589100 scopus 로고    scopus 로고
    • AMPK activation of muscle autophagy prevents fasting-induced hypoglycemia and myopathy during aging
    • Bujak A.L., Crane J.D., Lally J.S., Ford R.J., Kang S.J., Rebalka I.A., et al. AMPK activation of muscle autophagy prevents fasting-induced hypoglycemia and myopathy during aging. Cell Metabolism 2015, 21:883-890.
    • (2015) Cell Metabolism , vol.21 , pp. 883-890
    • Bujak, A.L.1    Crane, J.D.2    Lally, J.S.3    Ford, R.J.4    Kang, S.J.5    Rebalka, I.A.6
  • 65
    • 84896708393 scopus 로고    scopus 로고
    • Transcriptomic profiling of TK2 deficient human skeletal muscle suggests a role for the p53 signalling pathway and identifies growth and differentiation factor-15 as a potential novel biomarker for mitochondrial myopathies
    • Kalko S.G., Paco S., Jou C., Rodriguez M.A., Meznaric M., Rogac M., et al. Transcriptomic profiling of TK2 deficient human skeletal muscle suggests a role for the p53 signalling pathway and identifies growth and differentiation factor-15 as a potential novel biomarker for mitochondrial myopathies. BMC Genomics 2014, 15:91.
    • (2014) BMC Genomics , vol.15 , pp. 91
    • Kalko, S.G.1    Paco, S.2    Jou, C.3    Rodriguez, M.A.4    Meznaric, M.5    Rogac, M.6
  • 67
    • 84907097744 scopus 로고    scopus 로고
    • HNAG-increases lifespan by regulating energy metabolism and insulin/IGF-1/mTOR signaling
    • Wang X., Chrysovergis K., Kosak J., Kissling G., Streicker M., Moser G., et al. hNAG-increases lifespan by regulating energy metabolism and insulin/IGF-1/mTOR signaling. Aging (Albany NY) 2014, 6:690-704.
    • (2014) Aging (Albany NY) , vol.6 , pp. 690-704
    • Wang, X.1    Chrysovergis, K.2    Kosak, J.3    Kissling, G.4    Streicker, M.5    Moser, G.6
  • 68
    • 84923176920 scopus 로고    scopus 로고
    • Increased expression of GDF-15 may mediate ICU-acquired weakness by down-regulating muscle microRNAs
    • Bloch S.A., Lee J.Y., Syburra T., Rosendahl U., Griffiths M.J., Kemp P.R., et al. Increased expression of GDF-15 may mediate ICU-acquired weakness by down-regulating muscle microRNAs. Thorax 2015, 70:219-228.
    • (2015) Thorax , vol.70 , pp. 219-228
    • Bloch, S.A.1    Lee, J.Y.2    Syburra, T.3    Rosendahl, U.4    Griffiths, M.J.5    Kemp, P.R.6
  • 69
    • 35948981520 scopus 로고    scopus 로고
    • Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1
    • Johnen H., Lin S., Kuffner T., Brown D.A., Tsai V.W., Bauskin A.R., et al. Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1. Nature Medicine 2007, 13:1333-1340.
    • (2007) Nature Medicine , vol.13 , pp. 1333-1340
    • Johnen, H.1    Lin, S.2    Kuffner, T.3    Brown, D.A.4    Tsai, V.W.5    Bauskin, A.R.6
  • 70
    • 80052907593 scopus 로고    scopus 로고
    • The TGF-beta superfamily cytokine, MIC-1/GDF15: a pleotrophic cytokine with roles in inflammation, cancer and metabolism
    • Breit S.N., Johnen H., Cook A.D., Tsai V.W., Mohammad M.G., Kuffner T., et al. The TGF-beta superfamily cytokine, MIC-1/GDF15: a pleotrophic cytokine with roles in inflammation, cancer and metabolism. Growth Factors 2011, 29:187-195.
    • (2011) Growth Factors , vol.29 , pp. 187-195
    • Breit, S.N.1    Johnen, H.2    Cook, A.D.3    Tsai, V.W.4    Mohammad, M.G.5    Kuffner, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.