Skeletal muscle increases FGF21 expression in mitochondrial disorders to compensate for energy metabolic insufficiency by activating the mTOR-YY1-PGC1α pathway

Free Radical Biology and Medicine

Volumn 84, Issue , 2015, Pages 161-170

  Ji, Kunqian ^a   Zheng, Jinfan ^a   Lv, Jingwei ^a   Xu, Jingwen ^a   Ji, Xinbo ^a   Luo, Yue Bei ^a   Li, Wei ^a   Zhao, Yuying ^a   Yan, Chuanzhu ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Fibroblast growth factor 21; Free radicals; Mitochondrial diseases; Mitochondrial function; Oxidative stress; Skeletal muscle

Indexed keywords

ADENOSINE TRIPHOSPHATE; CITRATE SYNTHASE; FIBROBLAST GROWTH FACTOR 21; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; MITOCHONDRIAL DNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; TRANSCRIPTION FACTOR YY1; FIBROBLAST GROWTH FACTOR; MTOR PROTEIN, HUMAN; PPARGC1A PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR; YY1 PROTEIN, HUMAN;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENERGY METABOLISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SYNTHESIS; GENE DOSAGE; GLYCOLYSIS; HUMAN; HUMAN CELL; MELAS SYNDROME; MITOCHONDRIAL GENE; MITOCHONDRIAL MYOPATHY; MITOCHONDRIAL RESPIRATION; MYOBLAST; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RESPIRATORY CHAIN; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; ANIMAL; CELL LINE; METABOLISM; MOUSE; MUSCLE MITOCHONDRION; OXIDATION REDUCTION REACTION;

MAMMALIA; MUS;

ANIMALS; CELL LINE; ENERGY METABOLISM; FIBROBLAST GROWTH FACTORS; HUMANS; MELAS SYNDROME; MICE; MITOCHONDRIA, MUSCLE; MUSCLE, SKELETAL; OXIDATION-REDUCTION; OXYGEN CONSUMPTION; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS; YY1 TRANSCRIPTION FACTOR;

EID: 84928895286     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.03.020     Document Type: Article

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