-
1
-
-
20444435873
-
FGF-21 as a novel metabolic regulator
-
doi: 10.1172/JCI23606
-
Kharitonenkov A, Shiyanova TL, Koester A, Ford AM, Micanovic R, Galbreath EJ, et al. FGF-21 as a novel metabolic regulator. J Clin Invest (2005) 115:1627-35. doi: 10.1172/JCI23606.
-
(2005)
J Clin Invest
, vol.115
, pp. 1627-1635
-
-
Kharitonenkov, A.1
Shiyanova, T.L.2
Koester, A.3
Ford, A.M.4
Micanovic, R.5
Galbreath, E.J.6
-
2
-
-
33846418834
-
The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21
-
doi:10.1210/en.2006-1168
-
Kharitonenkov A, Wroblewski VJ, Koester A, Chen YF, Clutinger CK, Tigno XT, et al. The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21. Endocrinology (2007) 148:774-81. doi:10.1210/en.2006-1168.
-
(2007)
Endocrinology
, vol.148
, pp. 774-781
-
-
Kharitonenkov, A.1
Wroblewski, V.J.2
Koester, A.3
Chen, Y.F.4
Clutinger, C.K.5
Tigno, X.T.6
-
3
-
-
84883481988
-
The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes
-
doi:10.1016/j.cmet.2013.08.005
-
Gaich G, Chien JY, Fu H, Glass LC, Deeg MA, Holland WL, et al. The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes. Cell Metab (2013) 18:333-40. doi:10.1016/j.cmet.2013.08.005.
-
(2013)
Cell Metab
, vol.18
, pp. 333-340
-
-
Gaich, G.1
Chien, J.Y.2
Fu, H.3
Glass, L.C.4
Deeg, M.A.5
Holland, W.L.6
-
4
-
-
61649127208
-
Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice
-
doi:10.2337/db08-0392
-
Xu J, Lloyd DJ, Hale C, Stanislaus S, Chen M, Sivits G, et al. Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes (2009) 58:250-9. doi:10.2337/db08-0392.
-
(2009)
Diabetes
, vol.58
, pp. 250-259
-
-
Xu, J.1
Lloyd, D.J.2
Hale, C.3
Stanislaus, S.4
Chen, M.5
Sivits, G.6
-
5
-
-
61649100307
-
The FGF family: biology, pathophysiology and therapy
-
doi:10.1038/nrd2792
-
Beenken A, Mohammadi M. The FGF family: biology, pathophysiology and therapy. Nat Rev Drug Discov (2009) 8:235-53. doi:10.1038/nrd2792.
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 235-253
-
-
Beenken, A.1
Mohammadi, M.2
-
6
-
-
84870568785
-
Circulating fibroblast growth factors as metabolic regulators-a critical appraisal
-
doi:10.1016/j.cmet.2012.11.001
-
Angelin B, Larsson TE, Rudling M. Circulating fibroblast growth factors as metabolic regulators-a critical appraisal. Cell Metab (2012) 16:693-705. doi:10.1016/j.cmet.2012.11.001.
-
(2012)
Cell Metab
, vol.16
, pp. 693-705
-
-
Angelin, B.1
Larsson, T.E.2
Rudling, M.3
-
7
-
-
70350322694
-
Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis
-
doi:10.1210/en.2009-0532
-
Badman MK, Koester A, Flier JS, Kharitonenkov A, Maratos-Flier E. Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis. Endocrinology (2009) 150:4931-40. doi:10.1210/en.2009-0532.
-
(2009)
Endocrinology
, vol.150
, pp. 4931-4940
-
-
Badman, M.K.1
Koester, A.2
Flier, J.S.3
Kharitonenkov, A.4
Maratos-Flier, E.5
-
8
-
-
70349324370
-
Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver
-
doi:10.1210/en.2009-0119
-
Hotta Y, Nakamura H, Konishi M, Murata Y, Takagi H, Matsumura S, et al. Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver. Endocrinology (2009) 150:4625-33. doi:10.1210/en.2009-0119.
-
(2009)
Endocrinology
, vol.150
, pp. 4625-4633
-
-
Hotta, Y.1
Nakamura, H.2
Konishi, M.3
Murata, Y.4
Takagi, H.5
Matsumura, S.6
-
9
-
-
34249686631
-
Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21
-
doi:10.1016/j.cmet.2007.05.003
-
Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, et al. Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab (2007) 5:415-25. doi:10.1016/j.cmet.2007.05.003.
-
(2007)
Cell Metab
, vol.5
, pp. 415-425
-
-
Inagaki, T.1
Dutchak, P.2
Zhao, G.3
Ding, X.4
Gautron, L.5
Parameswara, V.6
-
10
-
-
34249711964
-
Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states
-
doi:10.1016/j.cmet.2007.05.002
-
Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, Maratos-Flier E. Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab (2007) 5:426-37. doi:10.1016/j.cmet.2007.05.002.
-
(2007)
Cell Metab
, vol.5
, pp. 426-437
-
-
Badman, M.K.1
Pissios, P.2
Kennedy, A.R.3
Koukos, G.4
Flier, J.S.5
Maratos-Flier, E.6
-
11
-
-
79955052166
-
Elevated hepatic fatty acid oxidation, high plasma fibroblast growth factor 21, and fasting bile acids in nonalcoholic steatohepatitis
-
doi:10.1097/MEG.0b013e328345c8c7
-
Dasarathy S, Yang Y, McCullough AJ, Marczewski S, Bennett C, Kalhan SC. Elevated hepatic fatty acid oxidation, high plasma fibroblast growth factor 21, and fasting bile acids in nonalcoholic steatohepatitis. Eur J Gastroenterol Hepatol (2012) 23:382-8. doi:10.1097/MEG.0b013e328345c8c7.
-
(2012)
Eur J Gastroenterol Hepatol
, vol.23
, pp. 382-388
-
-
Dasarathy, S.1
Yang, Y.2
McCullough, A.J.3
Marczewski, S.4
Bennett, C.5
Kalhan, S.C.6
-
12
-
-
78349310229
-
Serum FGF21 levels are elevated in association with lipodystrophy, insulin resistance and biomarkers of liver injury in HIV-1-infected patients
-
doi:10.1097/QAD.0b013e3283400088
-
Domingo P, Gallego-Escuredo JM, Domingo JC, Gutierrez Mdel M, Mateo MG, Fernandez I, et al. Serum FGF21 levels are elevated in association with lipodystrophy, insulin resistance and biomarkers of liver injury in HIV-1-infected patients. AIDS (2010) 24:2629-37. doi:10.1097/QAD.0b013e3283400088.
-
(2010)
AIDS
, vol.24
, pp. 2629-2637
-
-
Domingo, P.1
Gallego-Escuredo, J.M.2
Domingo, J.C.3
Gutierrez Mdel, M.4
Mateo, M.G.5
Fernandez, I.6
-
13
-
-
77955474305
-
Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease
-
doi:10.1053/j.gastro.2010.04.054
-
Dushay J, Chui PC, Gopalakrishnan GS, Varela-Rey M, Crawley M, Fisher FM, et al. Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease. Gastroenterology (2010) 139:456-63. doi:10.1053/j.gastro.2010.04.054.
-
(2010)
Gastroenterology
, vol.139
, pp. 456-463
-
-
Dushay, J.1
Chui, P.C.2
Gopalakrishnan, G.S.3
Varela-Rey, M.4
Crawley, M.5
Fisher, F.M.6
-
14
-
-
77957359658
-
Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride
-
doi:10.1016/j.jhep.2010.05.018
-
Li H, Fang Q, Gao F, Fan J, Zhou J, Wang X, et al. Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride. J Hepatol (2010) 53:934-40. doi:10.1016/j.jhep.2010.05.018.
-
(2010)
J Hepatol
, vol.53
, pp. 934-940
-
-
Li, H.1
Fang, Q.2
Gao, F.3
Fan, J.4
Zhou, J.5
Wang, X.6
-
15
-
-
48349146527
-
Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans
-
doi:10.2337/db07-1476
-
Zhang X, Yeung DC, Karpisek M, Stejskal D, Zhou ZG, Liu F, et al. Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes (2008) 57:1246-53. doi:10.2337/db07-1476.
-
(2008)
Diabetes
, vol.57
, pp. 1246-1253
-
-
Zhang, X.1
Yeung, D.C.2
Karpisek, M.3
Stejskal, D.4
Zhou, Z.G.5
Liu, F.6
-
16
-
-
84876074055
-
Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress
-
doi:10.1186/1471-230X-13-67
-
Yang C, Lu W, Lin T, You P, Ye M, Huang Y, et al. Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress. BMC Gastroenterol (2013) 13:67. doi:10.1186/1471-230X-13-67.
-
(2013)
BMC Gastroenterol
, vol.13
, pp. 67
-
-
Yang, C.1
Lu, W.2
Lin, T.3
You, P.4
Ye, M.5
Huang, Y.6
-
17
-
-
77956519052
-
Increased serum FGF21 levels in patients with nonalcoholic fatty liver disease
-
doi:10.1111/j.1365-2362.2010.02338.x
-
Yilmaz Y, Eren F, Yonal O, Kurt R, Aktas B, Celikel CA, et al. Increased serum FGF21 levels in patients with nonalcoholic fatty liver disease. Eur J Clin Invest (2010) 40:887-92. doi:10.1111/j.1365-2362.2010.02338.x.
-
(2010)
Eur J Clin Invest
, vol.40
, pp. 887-892
-
-
Yilmaz, Y.1
Eren, F.2
Yonal, O.3
Kurt, R.4
Aktas, B.5
Celikel, C.A.6
-
18
-
-
84880170528
-
High sugar intake and development of skeletal muscle insulin resistance and inflammation in mice: a protective role for PPAR-delta agonism
-
doi:10.1155/2013/509502
-
Benetti E, Mastrocola R, Rogazzo M, Chiazza F, Aragno M, Fantozzi R, et al. High sugar intake and development of skeletal muscle insulin resistance and inflammation in mice: a protective role for PPAR-delta agonism. Mediators Inflamm (2013) 2013:509502. doi:10.1155/2013/509502.
-
(2013)
Mediators Inflamm
, vol.2013
, pp. 509502
-
-
Benetti, E.1
Mastrocola, R.2
Rogazzo, M.3
Chiazza, F.4
Aragno, M.5
Fantozzi, R.6
-
19
-
-
68149091653
-
Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance
-
doi:10.2337/dc09-0684
-
Chavez AO, Molina-Carrion M, Abdul-Ghani MA, Folli F, Defronzo RA, Tripathy D. Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance. Diabetes Care (2009) 32:1542-6. doi:10.2337/dc09-0684.
-
(2009)
Diabetes Care
, vol.32
, pp. 1542-1546
-
-
Chavez, A.O.1
Molina-Carrion, M.2
Abdul-Ghani, M.A.3
Folli, F.4
Defronzo, R.A.5
Tripathy, D.6
-
20
-
-
84890389860
-
Elevated FGF21 secretion, PGC-1alpha and ketogenic enzyme expression are hallmarks of iron-sulfur cluster depletion in human skeletal muscle
-
doi:10.1093/hmg/ddt393. [Epub ahead of print]
-
Crooks DR, Natarajan TG, Jeong SY, Chen C, Park SY, Huang H, et al. Elevated FGF21 secretion, PGC-1alpha and ketogenic enzyme expression are hallmarks of iron-sulfur cluster depletion in human skeletal muscle. Hum Mol Genet (2013). doi:10.1093/hmg/ddt393. [Epub ahead of print].
-
(2013)
Hum Mol Genet
-
-
Crooks, D.R.1
Natarajan, T.G.2
Jeong, S.Y.3
Chen, C.4
Park, S.Y.5
Huang, H.6
-
21
-
-
84861655836
-
Exercise increases serum fibroblast growth factor 21 (FGF21) levels
-
doi:10.1371/journal.pone.0038022
-
Cuevas-Ramos D, Almeda-Valdes P, Meza-Arana CE, Brito-Cordova G, Gomez-Perez FJ, Mehta R, et al. Exercise increases serum fibroblast growth factor 21 (FGF21) levels. PLoS One (2012) 7:e38022. doi:10.1371/journal.pone.0038022.
-
(2012)
PLoS One
, vol.7
-
-
Cuevas-Ramos, D.1
Almeda-Valdes, P.2
Meza-Arana, C.E.3
Brito-Cordova, G.4
Gomez-Perez, F.J.5
Mehta, R.6
-
22
-
-
73249138414
-
Fibroblast growth factor-21 is induced in human skeletal muscles by hyperinsulinemia
-
doi:10.2337/db09-0713
-
Hojman P, Pedersen M, Nielsen AR, Krogh-Madsen R, Yfanti C, Akerstrom T, et al. Fibroblast growth factor-21 is induced in human skeletal muscles by hyperinsulinemia. Diabetes (2009) 58:2797-801. doi:10.2337/db09-0713.
-
(2009)
Diabetes
, vol.58
, pp. 2797-2801
-
-
Hojman, P.1
Pedersen, M.2
Nielsen, A.R.3
Krogh-Madsen, R.4
Yfanti, C.5
Akerstrom, T.6
-
23
-
-
54849438574
-
FGF21 is an Akt-regulated myokine
-
doi:10.1016/j.febslet.2008.10.021
-
Izumiya Y, Bina HA, Ouchi N, Akasaki Y, Kharitonenkov A, Walsh K. FGF21 is an Akt-regulated myokine. FEBS Lett (2008) 582:3805-10. doi:10.1016/j.febslet.2008.10.021.
-
(2008)
FEBS Lett
, vol.582
, pp. 3805-3810
-
-
Izumiya, Y.1
Bina, H.A.2
Ouchi, N.3
Akasaki, Y.4
Kharitonenkov, A.5
Walsh, K.6
-
24
-
-
84875327535
-
Expression of fibroblast growth factor-21 in muscle is associated with lipodystrophy, insulin resistance and lipid disturbances in patients with HIV
-
doi:10.1371/journal.pone.0055632
-
Lindegaard B, Hvid T, Grondahl T, Frosig C, Gerstoft J, Hojman P, et al. Expression of fibroblast growth factor-21 in muscle is associated with lipodystrophy, insulin resistance and lipid disturbances in patients with HIV. PLoS One (2013) 8:e55632. doi:10.1371/journal.pone.0055632.
-
(2013)
PLoS One
, vol.8
-
-
Lindegaard, B.1
Hvid, T.2
Grondahl, T.3
Frosig, C.4
Gerstoft, J.5
Hojman, P.6
-
25
-
-
80052522462
-
Effects of a three-month combined exercise programme on fibroblast growth factor 21 and fetuin-A levels and arterial stiffness in obese women
-
doi:10.1111/j.1365-2265.2011.04078.x
-
Yang SJ, Hong HC, Choi HY, Yoo HJ, Cho GJ, Hwang TG, et al. Effects of a three-month combined exercise programme on fibroblast growth factor 21 and fetuin-A levels and arterial stiffness in obese women. Clin Endocrinol (Oxf) (2011) 75:464-9. doi:10.1111/j.1365-2265.2011.04078.x.
-
(2011)
Clin Endocrinol (Oxf)
, vol.75
, pp. 464-469
-
-
Yang, S.J.1
Hong, H.C.2
Choi, H.Y.3
Yoo, H.J.4
Cho, G.J.5
Hwang, T.G.6
-
26
-
-
84872057896
-
Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine
-
doi:10.1038/nm.3014
-
Kim KH, Jeong YT, Oh H, Kim SH, Cho JM, Kim YN, et al. Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine. Nat Med (2013) 19:83-92. doi:10.1038/nm.3014.
-
(2013)
Nat Med
, vol.19
, pp. 83-92
-
-
Kim, K.H.1
Jeong, Y.T.2
Oh, H.3
Kim, S.H.4
Cho, J.M.5
Kim, Y.N.6
-
27
-
-
80051667626
-
FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study
-
doi:10.1016/S1474-4422(11)70155-7
-
Suomalainen A, Elo JM, Pietilainen KH, Hakonen AH, Sevastianova K, Korpela M, et al. FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study. Lancet Neurol (2011) 10:806-18. doi:10.1016/S1474-4422(11)70155-7.
-
(2011)
Lancet Neurol
, vol.10
, pp. 806-818
-
-
Suomalainen, A.1
Elo, J.M.2
Pietilainen, K.H.3
Hakonen, A.H.4
Sevastianova, K.5
Korpela, M.6
-
28
-
-
79953886306
-
Thermogenic activation induces FGF21 expression and release in brown adipose tissue
-
doi:10.1074/jbc.M110.215889
-
Hondares E, Iglesias R, Giralt A, Gonzalez FJ, Giralt M, Mampel T, et al. Thermogenic activation induces FGF21 expression and release in brown adipose tissue. J Biol Chem (2011) 286(15):12983-90. doi:10.1074/jbc.M110.215889.
-
(2011)
J Biol Chem
, vol.286
, Issue.15
, pp. 12983-12990
-
-
Hondares, E.1
Iglesias, R.2
Giralt, A.3
Gonzalez, F.J.4
Giralt, M.5
Mampel, T.6
-
29
-
-
77249099832
-
Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat
-
doi:10.1016/j.cmet.2010.02.001
-
Hondares E, Rosell M, Gonzalez FJ, Giralt M, Iglesias R, Villarroya F. Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat. Cell Metab (2010) 11:206-12. doi:10.1016/j.cmet.2010.02.001.
-
(2010)
Cell Metab
, vol.11
, pp. 206-212
-
-
Hondares, E.1
Rosell, M.2
Gonzalez, F.J.3
Giralt, M.4
Iglesias, R.5
Villarroya, F.6
-
30
-
-
80052036925
-
Time-imposed daily restricted feeding induces rhythmic expression of Fgf21 in white adipose tissue of mice
-
doi:10.1016/j.bbrc.2011.07.125
-
Oishi K, Konishi M, Murata Y, Itoh N. Time-imposed daily restricted feeding induces rhythmic expression of Fgf21 in white adipose tissue of mice. Biochem Biophys Res Commun (2011) 412:396-400. doi:10.1016/j.bbrc.2011.07.125.
-
(2011)
Biochem Biophys Res Commun
, vol.412
, pp. 396-400
-
-
Oishi, K.1
Konishi, M.2
Murata, Y.3
Itoh, N.4
-
31
-
-
70350093621
-
Fibroblast growth factor 21 reduces the severity of cerulein-induced pancreatitis in mice
-
doi:10.1053/j.gastro.2009.07.064
-
Johnson CL, Weston JY, Chadi SA, Fazio EN, Huff MW, Kharitonenkov A, et al. Fibroblast growth factor 21 reduces the severity of cerulein-induced pancreatitis in mice. Gastroenterology (2009) 137:1795-804. doi:10.1053/j.gastro.2009.07.064.
-
(2009)
Gastroenterology
, vol.137
, pp. 1795-1804
-
-
Johnson, C.L.1
Weston, J.Y.2
Chadi, S.A.3
Fazio, E.N.4
Huff, M.W.5
Kharitonenkov, A.6
-
32
-
-
33750587755
-
Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways
-
doi:10.2337/db05-1435
-
Wente W, Efanov AM, Brenner M, Kharitonenkov A, Koster A, Sandusky GE, et al. Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways. Diabetes (2006) 55:2470-8. doi:10.2337/db05-1435.
-
(2006)
Diabetes
, vol.55
, pp. 2470-2478
-
-
Wente, W.1
Efanov, A.M.2
Brenner, M.3
Kharitonenkov, A.4
Koster, A.5
Sandusky, G.E.6
-
33
-
-
84858311217
-
Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation
-
doi:10.1042/BJ20111748
-
De Sousa-Coelho AL, Marrero PF, Haro D. Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation. Biochem J (2012) 443:165-71. doi:10.1042/BJ20111748.
-
(2012)
Biochem J
, vol.443
, pp. 165-171
-
-
De Sousa-Coelho, A.L.1
Marrero, P.F.2
Haro, D.3
-
34
-
-
84874664386
-
Fibroblast growth factor 21 is induced by endoplasmic reticulum stress
-
doi:10.1016/j.biochi.2012.10.019
-
Schaap FG, Kremer AE, Lamers WH, Jansen PL, Gaemers IC. Fibroblast growth factor 21 is induced by endoplasmic reticulum stress. Biochimie (2013) 95:692-9. doi:10.1016/j.biochi.2012.10.019.
-
(2013)
Biochimie
, vol.95
, pp. 692-699
-
-
Schaap, F.G.1
Kremer, A.E.2
Lamers, W.H.3
Jansen, P.L.4
Gaemers, I.C.5
-
35
-
-
84876238033
-
Retinoic acid receptor beta stimulates hepatic induction of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy homeostasis in mice
-
doi:10.1074/jbc.M112.429852
-
Li Y, Wong K, Walsh K, Gao B, Zang M. Retinoic acid receptor beta stimulates hepatic induction of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy homeostasis in mice. J Biol Chem (2013) 288:10490-504. doi:10.1074/jbc.M112.429852.
-
(2013)
J Biol Chem
, vol.288
, pp. 10490-10504
-
-
Li, Y.1
Wong, K.2
Walsh, K.3
Gao, B.4
Zang, M.5
-
36
-
-
84862323517
-
Liver X receptor negatively regulates fibroblast growth factor 21 in the fatty liver induced by cholesterol-enriched diet
-
doi:10.1016/j.jnutbio.2011.03.023
-
Uebanso T, Taketani Y, Yamamoto H, Amo K, Tanaka S, Arai H, et al. Liver X receptor negatively regulates fibroblast growth factor 21 in the fatty liver induced by cholesterol-enriched diet. J Nutr Biochem (2012) 23:785-90. doi:10.1016/j.jnutbio.2011.03.023.
-
(2012)
J Nutr Biochem
, vol.23
, pp. 785-790
-
-
Uebanso, T.1
Taketani, Y.2
Yamamoto, H.3
Amo, K.4
Tanaka, S.5
Arai, H.6
-
37
-
-
84862958488
-
Growth hormone stimulates transcription of the fibroblast growth factor 21 gene in the liver through the signal transducer and activator of transcription 5
-
doi:10.1210/en.2011-1591
-
Yu J, Zhao L, Wang A, Eleswarapu S, Ge X, Chen D, et al. Growth hormone stimulates transcription of the fibroblast growth factor 21 gene in the liver through the signal transducer and activator of transcription 5. Endocrinology (2012) 153:750-8. doi:10.1210/en.2011-1591.
-
(2012)
Endocrinology
, vol.153
, pp. 750-758
-
-
Yu, J.1
Zhao, L.2
Wang, A.3
Eleswarapu, S.4
Ge, X.5
Chen, D.6
-
38
-
-
79960844094
-
The link between fibroblast growth factor 21 and sterol regulatory element binding protein 1c during lipogenesis in hepatocytes
-
doi:10.1016/j.mce.2011.05.003
-
Zhang Y, Lei T, Huang JF, Wang SB, Zhou LL, Yang ZQ, et al. The link between fibroblast growth factor 21 and sterol regulatory element binding protein 1c during lipogenesis in hepatocytes. Mol Cell Endocrinol (2011) 342:41-7. doi:10.1016/j.mce.2011.05.003.
-
(2011)
Mol Cell Endocrinol
, vol.342
, pp. 41-47
-
-
Zhang, Y.1
Lei, T.2
Huang, J.F.3
Wang, S.B.4
Zhou, L.L.5
Yang, Z.Q.6
-
39
-
-
69249238074
-
Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes
-
doi:10.1016/j.febslet.2009.07.053
-
Iizuka K, Takeda J, Horikawa Y. Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes. FEBS Lett (2009) 583:2882-6. doi:10.1016/j.febslet.2009.07.053.
-
(2009)
FEBS Lett
, vol.583
, pp. 2882-2886
-
-
Iizuka, K.1
Takeda, J.2
Horikawa, Y.3
-
40
-
-
84905679771
-
The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue
-
doi:10.1016/j.molmet.2012.08.007
-
Adams AC, Coskun T, Cheng CC, Gimeno RE, Luo Y, Kharitonenkov A. The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue. Mol Metab (2012) 2:31-7. doi:10.1016/j.molmet.2012.08.007.
-
(2012)
Mol Metab
, vol.2
, pp. 31-37
-
-
Adams, A.C.1
Coskun, T.2
Cheng, C.C.3
Gimeno, R.E.4
Luo, Y.5
Kharitonenkov, A.6
-
41
-
-
84865741904
-
betaKlotho is required for fibroblast growth factor 21 effects on growth and metabolism
-
doi:10.1016/j.cmet.2012.08.002
-
Ding X, Boney-Montoya J, Owen BM, Bookout AL, Coate KC, Mangelsdorf DJ, et al. betaKlotho is required for fibroblast growth factor 21 effects on growth and metabolism. Cell Metab (2012) 16:387-93. doi:10.1016/j.cmet.2012.08.002.
-
(2012)
Cell Metab
, vol.16
, pp. 387-393
-
-
Ding, X.1
Boney-Montoya, J.2
Owen, B.M.3
Bookout, A.L.4
Coate, K.C.5
Mangelsdorf, D.J.6
-
42
-
-
83655165300
-
Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1
-
doi:10.1126/scitranslmed.3002669
-
Wu AL, Kolumam G, Stawicki S, Chen Y, Li J, Zavala-Solorio J, et al. Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1. Sci Transl Med (2011) 3:113ra26. doi:10.1126/scitranslmed.3002669.
-
(2011)
Sci Transl Med
, vol.3
-
-
Wu, A.L.1
Kolumam, G.2
Stawicki, S.3
Chen, Y.4
Li, J.5
Zavala-Solorio, J.6
-
43
-
-
84870359606
-
Treating diabetes and obesity with an FGF21-mimetic antibody activating the betaKlotho/FGFR1c receptor complex
-
doi:10.1126/scitranslmed.3004690
-
Foltz IN, Hu S, King C, Wu X, Yang C, Wang W, et al. Treating diabetes and obesity with an FGF21-mimetic antibody activating the betaKlotho/FGFR1c receptor complex. Sci Transl Med (2012) 4:162ra53. doi:10.1126/scitranslmed.3004690.
-
(2012)
Sci Transl Med
, vol.4
-
-
Foltz, I.N.1
Hu, S.2
King, C.3
Wu, X.4
Yang, C.5
Wang, W.6
-
44
-
-
84863637593
-
FGF21 promotes metabolic homeostasis via white adipose and leptin in mice
-
doi:10.1371/journal.pone.0040164
-
Veniant MM, Hale C, Helmering J, Chen MM, Stanislaus S, Busby J, et al. FGF21 promotes metabolic homeostasis via white adipose and leptin in mice. PLoS One (2012) 7:e40164. doi:10.1371/journal.pone.0040164.
-
(2012)
PLoS One
, vol.7
-
-
Veniant, M.M.1
Hale, C.2
Helmering, J.3
Chen, M.M.4
Stanislaus, S.5
Busby, J.6
-
45
-
-
84863338708
-
Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB
-
doi:10.1371/journal.pone.0033870
-
Yang C, Jin C, Li X, Wang F, McKeehan WL, Luo Y. Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB. PLoS One (2012) 7:e33870. doi:10.1371/journal.pone.0033870.
-
(2012)
PLoS One
, vol.7
-
-
Yang, C.1
Jin, C.2
Li, X.3
Wang, F.4
McKeehan, W.L.5
Luo, Y.6
-
46
-
-
84867898251
-
Control of lipid metabolism by adipocyte FGFR1-mediated adipohepatic communication during hepatic stress
-
doi:10.1186/1743-7075-9-94
-
Yang C, Wang C, Ye M, Jin C, He W, Wang F, et al. Control of lipid metabolism by adipocyte FGFR1-mediated adipohepatic communication during hepatic stress. Nutr Metab (Lond) (2012) 9:94. doi:10.1186/1743-7075-9-94.
-
(2012)
Nutr Metab (Lond)
, vol.9
, pp. 94
-
-
Yang, C.1
Wang, C.2
Ye, M.3
Jin, C.4
He, W.5
Wang, F.6
-
47
-
-
72449191699
-
Adipose tissue as an endocrine organ
-
doi:10.1016/j.mce.2009.08.018
-
Galic S, Oakhill JS, Steinberg GR. Adipose tissue as an endocrine organ. Mol Cell Endocrinol (2010) 316:129-39. doi:10.1016/j.mce.2009.08.018.
-
(2010)
Mol Cell Endocrinol
, vol.316
, pp. 129-139
-
-
Galic, S.1
Oakhill, J.S.2
Steinberg, G.R.3
-
48
-
-
33747356154
-
Adipose tissue: from lipid storage compartment to endocrine organ
-
doi:10.2337/db06-0263
-
Scherer PE. Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes (2006) 55:1537-45. doi:10.2337/db06-0263.
-
(2006)
Diabetes
, vol.55
, pp. 1537-1545
-
-
Scherer, P.E.1
-
49
-
-
84863012022
-
FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis
-
doi:10.1101/gad.177857.111
-
Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, Verdeguer F, et al. FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis. Genes Dev (2012) 26:271-81. doi:10.1101/gad.177857.111.
-
(2012)
Genes Dev
, vol.26
, pp. 271-281
-
-
Fisher, F.M.1
Kleiner, S.2
Douris, N.3
Fox, E.C.4
Mepani, R.J.5
Verdeguer, F.6
-
50
-
-
84877272187
-
An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice
-
doi:10.1016/j.cmet.2013.03.019
-
Holland WL, Adams AC, Brozinick JT, Bui HH, Miyauchi Y, Kusminski CM, et al. An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice. Cell Metab (2013) 17:790-7. doi:10.1016/j.cmet.2013.03.019.
-
(2013)
Cell Metab
, vol.17
, pp. 790-797
-
-
Holland, W.L.1
Adams, A.C.2
Brozinick, J.T.3
Bui, H.H.4
Miyauchi, Y.5
Kusminski, C.M.6
-
51
-
-
84877260638
-
Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice
-
doi:10.1016/j.cmet.2013.04.005
-
Lin Z, Tian H, Lam KS, Lin S, Hoo RC, Konishi M, et al. Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. Cell Metab (2013) 17:779-89. doi:10.1016/j.cmet.2013.04.005.
-
(2013)
Cell Metab
, vol.17
, pp. 779-789
-
-
Lin, Z.1
Tian, H.2
Lam, K.S.3
Lin, S.4
Hoo, R.C.5
Konishi, M.6
-
52
-
-
65349162789
-
Adiponectin in health and disease: evaluation of adiponectin-targeted drug development strategies
-
doi:10.1016/j.tips.2009.02.004
-
Shetty S, Kusminski CM, Scherer PE. Adiponectin in health and disease: evaluation of adiponectin-targeted drug development strategies. Trends Pharmacol Sci (2009) 30:234-9. doi:10.1016/j.tips.2009.02.004.
-
(2009)
Trends Pharmacol Sci
, vol.30
, pp. 234-239
-
-
Shetty, S.1
Kusminski, C.M.2
Scherer, P.E.3
-
53
-
-
84863012730
-
Sustained activation of PPARalpha by endogenous ligands increases hepatic fatty acid oxidation and prevents obesity in ob/ob mice
-
doi:10.1096/fj.11-194019
-
Huang J, Jia Y, Fu T, Viswakarma N, Bai L, Rao MS, et al. Sustained activation of PPARalpha by endogenous ligands increases hepatic fatty acid oxidation and prevents obesity in ob/ob mice. FASEB J (2012) 26:628-38. doi:10.1096/fj.11-194019.
-
(2012)
FASEB J
, vol.26
, pp. 628-638
-
-
Huang, J.1
Jia, Y.2
Fu, T.3
Viswakarma, N.4
Bai, L.5
Rao, M.S.6
-
54
-
-
79960726293
-
Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo
-
doi:10.1210/en.2011-0281
-
Fisher FM, Estall JL, Adams AC, Antonellis PJ, Bina HA, Flier JS, et al. Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo. Endocrinology (2011) 152:2996-3004. doi:10.1210/en.2011-0281.
-
(2011)
Endocrinology
, vol.152
, pp. 2996-3004
-
-
Fisher, F.M.1
Estall, J.L.2
Adams, A.C.3
Antonellis, P.J.4
Bina, H.A.5
Flier, J.S.6
-
55
-
-
84883778996
-
FGF21 regulates metabolism and circadian behavior by acting on the nervous system
-
doi:10.1038/nm.3249
-
Bookout AL, de Groot MH, Owen BM, Lee S, Gautron L, Lawrence HL, et al. FGF21 regulates metabolism and circadian behavior by acting on the nervous system. Nat Med (2013) 19:1147-52. doi:10.1038/nm.3249.
-
(2013)
Nat Med
, vol.19
, pp. 1147-1152
-
-
Bookout, A.L.1
de Groot, M.H.2
Owen, B.M.3
Lee, S.4
Gautron, L.5
Lawrence, H.L.6
-
56
-
-
84883763046
-
FGF21 contributes to neuroendocrine control of female reproduction
-
doi:10.1038/nm.3250
-
Owen BM, Bookout AL, Ding X, Lin VY, Atkin SD, Gautron L, et al. FGF21 contributes to neuroendocrine control of female reproduction. Nat Med (2013) 19:1153-6. doi:10.1038/nm.3250.
-
(2013)
Nat Med
, vol.19
, pp. 1153-1156
-
-
Owen, B.M.1
Bookout, A.L.2
Ding, X.3
Lin, V.Y.4
Atkin, S.D.5
Gautron, L.6
-
57
-
-
80052092418
-
Hepatosteatosis in peroxisome deficient liver despite increased beta-oxidation capacity and impaired lipogenesis
-
doi:10.1016/j.biochi.2011.06.034
-
Peeters A, Swinnen JV, Van Veldhoven PP, Baes M. Hepatosteatosis in peroxisome deficient liver despite increased beta-oxidation capacity and impaired lipogenesis. Biochimie (2011) 93:1828-38. doi:10.1016/j.biochi.2011.06.034.
-
(2011)
Biochimie
, vol.93
, pp. 1828-1838
-
-
Peeters, A.1
Swinnen, J.V.2
Van Veldhoven, P.P.3
Baes, M.4
-
58
-
-
27844546989
-
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
-
doi:10.1016/j.cmet.2005.09.001
-
Inagaki T, Choi M, Moschetta A, Peng L, Cummins CL, McDonald JG, et al. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab (2005) 2:217-25. doi:10.1016/j.cmet.2005.09.001.
-
(2005)
Cell Metab
, vol.2
, pp. 217-225
-
-
Inagaki, T.1
Choi, M.2
Moschetta, A.3
Peng, L.4
Cummins, C.L.5
McDonald, J.G.6
-
59
-
-
33845631059
-
Klotho converts canonical FGF receptor into a specific receptor for FGF23
-
doi:10.1038/nature05315
-
Urakawa I, Yamazaki Y, Shimada T, Iijima K, Hasegawa H, Okawa K, et al. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature (2006) 444:770-4. doi:10.1038/nature05315.
-
(2006)
Nature
, vol.444
, pp. 770-774
-
-
Urakawa, I.1
Yamazaki, Y.2
Shimada, T.3
Iijima, K.4
Hasegawa, H.5
Okawa, K.6
|