메뉴 건너뛰기




Volumn 6, Issue 8, 2014, Pages 690-704

hNAG-1 increases lifespan by regulating energy metabolism and insulin/IGF-1/mTOR signaling

Author keywords

hNAG 1 GDF15; Insulin IGF 1 mTOR; Lifespan; Metabolism

Indexed keywords

GDF15 PROTEIN, HUMAN; GROWTH DIFFERENTIATION FACTOR 15; INSULIN; SOMATOMEDIN C; TARGET OF RAPAMYCIN KINASE;

EID: 84907097744     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100687     Document Type: Article
Times cited : (89)

References (36)
  • 1
    • 84876077532 scopus 로고    scopus 로고
    • Metabolic characteristics of longlived mice
    • Bartke A and Westbrook R. Metabolic characteristics of longlived mice. Front Genet. 2012; 3:288.
    • (2012) Front Genet , vol.3 , pp. 288
    • Bartke, A.1    Westbrook, R.2
  • 7
    • 77950200010 scopus 로고    scopus 로고
    • The genetics of ageing
    • Kenyon CJ. The genetics of ageing. Nature. 2010; 464:504-512.
    • (2010) Nature , vol.464 , pp. 504-512
    • Kenyon, C.J.1
  • 11
    • 77954604008 scopus 로고    scopus 로고
    • Divergent molecular mechanisms underlying the pleiotropic functions of macrophage inhibitory cytokine-1 in cancer
    • Mimeault M and Batra SK. Divergent molecular mechanisms underlying the pleiotropic functions of macrophage inhibitory cytokine-1 in cancer. J Cell Physiol. 2010; 224:626-635.
    • (2010) J Cell Physiol , vol.224 , pp. 626-635
    • Mimeault, M.1    Batra, S.K.2
  • 12
    • 33646076196 scopus 로고    scopus 로고
    • GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation
    • Xu J, Kimball TR, Lorenz JN, Brown DA, Bauskin AR, Klevitsky R, Hewett TE, Breit SN and Molkentin JD. GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation. Circ Res. 2006; 98:342-350.
    • (2006) Circ Res , vol.98 , pp. 342-350
    • Xu, J.1    Kimball, T.R.2    Lorenz, J.N.3    Brown, D.A.4    Bauskin, A.R.5    Klevitsky, R.6    Hewett, T.E.7    Breit, S.N.8    Molkentin, J.D.9
  • 16
    • 84907095793 scopus 로고    scopus 로고
    • Lower NLRP3 inflammasome activity in NAG-1 transgenic mice is linked to a resistance to obesity and increased insulin sensitivity
    • Wang X, Chrysovergis K, Kosak J and Eling TE. Lower NLRP3 inflammasome activity in NAG-1 transgenic mice is linked to a resistance to obesity and increased insulin sensitivity. Obesity (Silver Spring). 2013.
    • (2013) Obesity (Silver Spring)
    • Wang, X.1    Chrysovergis, K.2    Kosak, J.3    Eling, T.E.4
  • 19
    • 67649962967 scopus 로고    scopus 로고
    • High fat diet induced hepatic steatosis establishes a permissive microenvironment for colorectal metastases and promotes primary dysplasia in a murine model
    • VanSaun MN, Lee IK, Washington MK, Matrisian L and Gorden DL. High fat diet induced hepatic steatosis establishes a permissive microenvironment for colorectal metastases and promotes primary dysplasia in a murine model. Am J Pathol. 2009; 175:355-364.
    • (2009) Am J Pathol , vol.175 , pp. 355-364
    • VanSaun, M.N.1    Lee, I.K.2    Washington, M.K.3    Matrisian, L.4    Gorden, D.L.5
  • 21
    • 78651269800 scopus 로고    scopus 로고
    • Dietary effects on body composition, glucose metabolism, and longevity are modulated by skeletal muscle mitochondrial uncoupling in mice
    • Keipert S, Voigt A and Klaus S. Dietary effects on body composition, glucose metabolism, and longevity are modulated by skeletal muscle mitochondrial uncoupling in mice. Aging Cell. 2011; 10:122-136.
    • (2011) Aging Cell , vol.10 , pp. 122-136
    • Keipert, S.1    Voigt, A.2    Klaus, S.3
  • 22
    • 84893802111 scopus 로고    scopus 로고
    • Fasting: Molecular Mechanisms and Clinical Applications
    • Longo VD and Mattson MP. Fasting: Molecular Mechanisms and Clinical Applications. Cell Metab. 2014.
    • (2014) Cell Metab
    • Longo, V.D.1    Mattson, M.P.2
  • 23
    • 35348972430 scopus 로고    scopus 로고
    • Genetic links between diet and lifespan: shared mechanisms from yeast to humans
    • Bishop NA and Guarente L. Genetic links between diet and lifespan: shared mechanisms from yeast to humans. Nat Rev Genet. 2007; 8:835-844.
    • (2007) Nat Rev Genet , vol.8 , pp. 835-844
    • Bishop, N.A.1    Guarente, L.2
  • 24
    • 84872527628 scopus 로고    scopus 로고
    • mTOR is a key modulator of ageing and age-related disease
    • Johnson SC, Rabinovitch PS and Kaeberlein M. mTOR is a key modulator of ageing and age-related disease. Nature. 2013; 493:338-345.
    • (2013) Nature , vol.493 , pp. 338-345
    • Johnson, S.C.1    Rabinovitch, P.S.2    Kaeberlein, M.3
  • 27
    • 45549096918 scopus 로고    scopus 로고
    • SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons
    • Li Y, Xu W, McBurney MW and Longo VD. SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab. 2008; 8:38-48.
    • (2008) Cell Metab , vol.8 , pp. 38-48
    • Li, Y.1    Xu, W.2    McBurney, M.W.3    Longo, V.D.4
  • 28
    • 16344376370 scopus 로고    scopus 로고
    • Inflammageing and lifelong antigenic load as major determinants of ageing rate and longevity
    • De Martinis M, Franceschi C, Monti D and Ginaldi L. Inflammageing and lifelong antigenic load as major determinants of ageing rate and longevity. FEBS Lett. 2005; 579:2035-2039.
    • (2005) FEBS Lett , vol.579 , pp. 2035-2039
    • De Martinis, M.1    Franceschi, C.2    Monti, D.3    Ginaldi, L.4
  • 29
    • 4544322522 scopus 로고    scopus 로고
    • Inflammatory exposure and historical changes in human life-spans
    • Finch CE and Crimmins EM. Inflammatory exposure and historical changes in human life-spans. Science. 2004; 305:1736-1739.
    • (2004) Science , vol.305 , pp. 1736-1739
    • Finch, C.E.1    Crimmins, E.M.2
  • 32
    • 84873413504 scopus 로고    scopus 로고
    • The diverse roles of nonsteroidal anti-inflammatory drug activated gene (NAG-1/GDF15) in cancer
    • Wang X, Baek SJ and Eling TE. The diverse roles of nonsteroidal anti-inflammatory drug activated gene (NAG-1/GDF15) in cancer. Biochem Pharmacol. 2013; 85:597-606.
    • (2013) Biochem Pharmacol , vol.85 , pp. 597-606
    • Wang, X.1    Baek, S.J.2    Eling, T.E.3
  • 35
    • 84857048733 scopus 로고    scopus 로고
    • Chronic HO-1 induction with cobalt protoporphyrin (CoPP) treatment increases oxygen consumption, activity, heat production and lowers body weight in obese melanocortin-4 receptor-deficient mice
    • Csongradi E, Docarmo JM, Dubinion JH, Vera T and Stec DE. Chronic HO-1 induction with cobalt protoporphyrin (CoPP) treatment increases oxygen consumption, activity, heat production and lowers body weight in obese melanocortin-4 receptor-deficient mice. Int J Obes (Lond). 2012; 36:244-253.
    • (2012) Int J Obes (Lond) , vol.36 , pp. 244-253
    • Csongradi, E.1    Docarmo, J.M.2    Dubinion, J.H.3    Vera, T.4    Stec, D.E.5
  • 36
    • 78649964341 scopus 로고    scopus 로고
    • Comparative phenotypic assessment of cardiac pathology, physiology, and gene expression in C3H/HeJ, C57BL/6J, and B6C3F1/J mice
    • Auerbach SS, Thomas R, Shah R, Xu H, Vallant MK, Nyska A and Dunnick JK. Comparative phenotypic assessment of cardiac pathology, physiology, and gene expression in C3H/HeJ, C57BL/6J, and B6C3F1/J mice. Toxicol Pathol. 2010; 38:923-942.
    • (2010) Toxicol Pathol , vol.38 , pp. 923-942
    • Auerbach, S.S.1    Thomas, R.2    Shah, R.3    Xu, H.4    Vallant, M.K.5    Nyska, A.6    Dunnick, J.K.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.