Transcriptomic profiling of TK2 deficient human skeletal muscle suggests a role for the p53 signalling pathway and identifies growth and differentiation factor-15 as a potential novel biomarker for mitochondrial myopathies

BMC Genomics

Volumn 15, Issue 1, 2014, Pages

  Kalko, Susana G ^a   Paco, Sonia ^b   Jou, Cristina ^b   Rodríguez, Maria A ^b   Meznaric, Marija ^c   Rogac, Mihael ^d   Jekovec Vrhovsek, Maja ^d   Sciacco, Monica ^e   Moggio, Maurizio ^e   Fagiolari, Gigliola ^e   De Paepe, Boel ^f   De Meirleir, Linda ^f   Ferrer, Isidre ^g   Roig Quilis, Manel ^h   Munell, Francina ^h   Montoya, Julio ^i,j   López Gallardo, Ester ^i,j   Ruiz Pesini, Eduardo ^i,j   Artuch, Rafael ^b,j   Montero, Raquel ^b,j   Torner, Ferran ^b   Nascimento, Andres ^b,j   Ortez, Carlos ^b   Colomer, Jaume ^b,j   Jimenez Mallebrera, Cecilia ^b,j   more..

^a HOSPITAL CLÍNIC   (Spain)

^b HOSPITAL SANT JOAN DE DÉU   (Spain)

^c UNIVERSITY OF LJUBLJANA   (Slovenia)

^d UNIVERSITY MEDICAL CENTRE LJUBLJANA   (Slovenia)

^e FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^f GHENT UNIVERSITY HOSPITAL   (Belgium)

^g HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^h HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

ⁱ UNIVERSITY OF ZARAGOZA   (Spain)

^j CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

more..

Author keywords

Apoptosis; Bioinformatics; GDF 15; Gene expression; Microarrays; Mitochondrial DNA; Mitochondrial DNA depletion; Mitochondrial encephalomyopathy; p53; Skeletal muscle; Thymidine kinase 2

Indexed keywords

AMINO ACID; BIOLOGICAL MARKER; COMPLEMENTARY DNA; GLUCOSE; GLYCOGEN; GROWTH DIFFERENTIATION FACTOR 15; LIPID; MITOCHONDRIAL DNA; PROTEIN P53; THYMIDINE KINASE; THYMIDINE KINASE 2; TRANSCRIPTOME; UNCLASSIFIED DRUG; CASPASE 3; TP53 PROTEIN, HUMAN;

ADOLESCENT; ADULT; AMINO ACID METABOLISM; APOPTOSIS; ARTICLE; BIOINFORMATICS; CELL DEATH; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE REGULATORY NETWORK; GLUCOSE UTILIZATION; GLYCOGEN METABOLISM; HUMAN; HUMAN CELL; HUMAN TISSUE; INFANT; INFLAMMATION; LIPID METABOLISM; MITOCHONDRIAL DNA DEPLETION SYNDROME; MITOCHONDRIAL MYOPATHY; MUSCLE CELL; MUSCLE METABOLISM; PRESCHOOL CHILD; PROTEIN DETERMINATION; PROTEIN FUNCTION; SCHOOL CHILD; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; TRANSCRIPTOMICS; TUMOR SUPPRESSOR GENE; BIOLOGY; BLOOD; GENETICS; METABOLISM; PATHOLOGY;

ADOLESCENT; ADULT; BIOLOGICAL MARKERS; CASPASE 3; CHILD; CHILD, PRESCHOOL; COMPUTATIONAL BIOLOGY; DNA, MITOCHONDRIAL; GENE EXPRESSION PROFILING; GROWTH DIFFERENTIATION FACTOR 15; HUMANS; INFANT; MITOCHONDRIAL MYOPATHIES; MUSCLE, SKELETAL; SIGNAL TRANSDUCTION; THYMIDINE KINASE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84896708393     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-15-91     Document Type: Article

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