Increased expression of GDF-15 may mediate ICU-acquired weakness by down-regulating muscle micrornas

Thorax

Volumn 70, Issue 3, 2015, Pages 219-228

  Bloch, S A A ^a   Lee, J Y ^a   Syburra, T ^b   Rosendahl, U ^b   Griffiths, M J D ^a,b   Kemp, P R ^a   Polkey, M I ^b  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b ROYAL BROMPTON AND HAREFIELD NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH DIFFERENTIATION FACTOR 15; MESSENGER RNA; MICRORNA; MICRORNA 1; MICRORNA 133A; MICRORNA 181A; MICRORNA 206; MICRORNA 449; MICRORNA 49; MUSCLE RING FINGER 1 PROTEIN; MYOSTATIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SOMATOMEDIN C; UNCLASSIFIED DRUG; CYR61 PROTEIN, HUMAN; CYSTEINE RICH PROTEIN 61; GDF15 PROTEIN, HUMAN; MIRN181 MICRORNA, HUMAN; SMAD2 PROTEIN, HUMAN; SMAD3 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; GENE REPRESSION; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INTENSIVE CARE UNIT ACQUIRED WEAKNESS; MALE; MOLECULAR MECHANICS; MUSCLE ATROPHY; MUSCLE BIOPSY; MYOTUBE; OBSERVATIONAL STUDY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RECTUS FEMORIS MUSCLE; SIGNAL TRANSDUCTION; WEAKNESS; ATROPHY; BLOOD; CELL CULTURE; DRUG EFFECTS; GENETICS; INTENSIVE CARE; METABOLISM; MIDDLE AGED; MUSCLE WEAKNESS; PATHOLOGY; QUADRICEPS FEMORIS MUSCLE; SKELETAL MUSCLE CELL; UPREGULATION;

AGED; ATROPHY; CELLS, CULTURED; CRITICAL CARE; CYSTEINE-RICH PROTEIN 61; DOWN-REGULATION; FEMALE; GROWTH DIFFERENTIATION FACTOR 15; HUMANS; MALE; MICRORNAS; MIDDLE AGED; MUSCLE FIBERS, SKELETAL; MUSCLE WEAKNESS; QUADRICEPS MUSCLE; RNA, MESSENGER; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 84923176920     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thoraxjnl-2014-206225     Document Type: Article

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