메뉴 건너뛰기




Volumn 172, Issue 4, 2016, Pages 512-523

Ineffective erythropoiesis and regulation of iron status in iron loading anaemias

Author keywords

Anaemia; Erythropoiesis; Iron; Iron overload; Thalassaemia

Indexed keywords

BONE MORPHOGENETIC PROTEIN 6; ERYTHROFERRONE; ERYTHROPOIETIN; FERROPORTIN; GROWTH DIFFERENTIATION FACTOR 15; HEAT SHOCK PROTEIN 70; HEMOGLOBIN E; HEPCIDIN; JANUS KINASE INHIBITOR; LUSPATERCEPT; REACTIVE OXYGEN METABOLITE; SOTATERCEPT; TRANSFERRIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; TWISTED GASTRULATION PROTEIN HOMOLOG 1; UNCLASSIFIED DRUG; ACTIVIN; ANTIANEMIC AGENT; IRON;

EID: 84956923279     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.13820     Document Type: Review
Times cited : (131)

References (100)
  • 6
    • 80052445124 scopus 로고    scopus 로고
    • The role of Smad signaling in hematopoiesis and translational hematology
    • Blank, U. & Karlsson, S. (2011) The role of Smad signaling in hematopoiesis and translational hematology. Leukemia, 25, 1379-1388.
    • (2011) Leukemia , vol.25 , pp. 1379-1388
    • Blank, U.1    Karlsson, S.2
  • 8
    • 84896718827 scopus 로고    scopus 로고
    • Modulators of erythropoiesis: emerging therapies for hemoglobinopathies and disorders of red cell production
    • Breda, L. & Rivella, S. (2014) Modulators of erythropoiesis: emerging therapies for hemoglobinopathies and disorders of red cell production. Hematology/Oncology Clinics of North America, 28, 375-386.
    • (2014) Hematology/Oncology Clinics of North America , vol.28 , pp. 375-386
    • Breda, L.1    Rivella, S.2
  • 10
    • 28444466958 scopus 로고    scopus 로고
    • Understanding iron homeostasis through genetic analysis of hemochromatosis and related disorders
    • Camaschella, C. (2005) Understanding iron homeostasis through genetic analysis of hemochromatosis and related disorders. Blood, 106, 3710-3717.
    • (2005) Blood , vol.106 , pp. 3710-3717
    • Camaschella, C.1
  • 11
    • 70349335786 scopus 로고    scopus 로고
    • Hereditary sideroblastic anemias: pathophysiology, diagnosis, and treatment
    • Camaschella, C. (2009) Hereditary sideroblastic anemias: pathophysiology, diagnosis, and treatment. Seminars in Hematology, 46, 371-377.
    • (2009) Seminars in Hematology , vol.46 , pp. 371-377
    • Camaschella, C.1
  • 15
    • 84871223663 scopus 로고    scopus 로고
    • The murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice
    • Casanovas, G., Vujic Spasic, M., Casu, C., Rivella, S., Strelau, J., Unsicker, K. & Muckenthaler, M.U. (2013) The murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice. Haematologica, 98, 444-447.
    • (2013) Haematologica , vol.98 , pp. 444-447
    • Casanovas, G.1    Vujic Spasic, M.2    Casu, C.3    Rivella, S.4    Strelau, J.5    Unsicker, K.6    Muckenthaler, M.U.7
  • 16
    • 84969380990 scopus 로고    scopus 로고
    • Concurrent treatment with minhepcidin and deferiprone improves anemia and enhances reduction of spleen iron in a mouse model of non-transfusion dependent thalassaemia
    • Casu, C., Oikonomidau, R., Shah, Y., Nemeth, E., Ganz, T., MacDonald, B. & Rivella, S. (2014a) Concurrent treatment with minhepcidin and deferiprone improves anemia and enhances reduction of spleen iron in a mouse model of non-transfusion dependent thalassaemia. Blood, 124, 748.
    • (2014) Blood , vol.124 , pp. 748
    • Casu, C.1    Oikonomidau, R.2    Shah, Y.3    Nemeth, E.4    Ganz, T.5    MacDonald, B.6    Rivella, S.7
  • 17
    • 84926290172 scopus 로고    scopus 로고
    • Combination of Tmprss6-ASO and the iron chelator deferiprone improves erythropoiesis and reduces iron overload in a mouse model of beta-thalassemia
    • Casu, C., Aghajan, M., Oikonomidau, R., Guo, S., Monia, B.P. & Rivella, S. (2014b) Combination of Tmprss6-ASO and the iron chelator deferiprone improves erythropoiesis and reduces iron overload in a mouse model of beta-thalassemia. Blood, 124, 4024.
    • (2014) Blood , vol.124 , pp. 4024
    • Casu, C.1    Aghajan, M.2    Oikonomidau, R.3    Guo, S.4    Monia, B.P.5    Rivella, S.6
  • 20
    • 84888421123 scopus 로고    scopus 로고
    • Concise review: growth differentiation factor 15 in pathology: a clinical role?
    • Corre, J., Hebraud, B. & Bourin, P. (2013) Concise review: growth differentiation factor 15 in pathology: a clinical role? Stem Cells Translational Medicine, 2, 946-952.
    • (2013) Stem Cells Translational Medicine , vol.2 , pp. 946-952
    • Corre, J.1    Hebraud, B.2    Bourin, P.3
  • 25
    • 84875649042 scopus 로고    scopus 로고
    • Increased iron loading induces Bmp6 expression in the non-parenchymal cells of the liver independent of the BMP-signaling pathway
    • Enns, C.A., Ahmed, R., Wang, J., Ueno, A., Worthen, C., Tsukamoto, H. & Zhang, A.S. (2013) Increased iron loading induces Bmp6 expression in the non-parenchymal cells of the liver independent of the BMP-signaling pathway. PLoS ONE, 8, e60534.
    • (2013) PLoS ONE , vol.8 , pp. e60534
    • Enns, C.A.1    Ahmed, R.2    Wang, J.3    Ueno, A.4    Worthen, C.5    Tsukamoto, H.6    Zhang, A.S.7
  • 26
    • 84862527496 scopus 로고    scopus 로고
    • Selective toxicity towards myelodysplastic hematopoietic progenitors - another rationale for iron chelation in MDS
    • Fibach, E. & Rachmilewitz, E.A. (2012) Selective toxicity towards myelodysplastic hematopoietic progenitors - another rationale for iron chelation in MDS. Leukemia Research, 36, 962-963.
    • (2012) Leukemia Research , vol.36 , pp. 962-963
    • Fibach, E.1    Rachmilewitz, E.A.2
  • 29
    • 0028049495 scopus 로고
    • Regulators of iron balance in humans
    • Finch, C. (1994) Regulators of iron balance in humans. Blood, 84, 1697-1702.
    • (1994) Blood , vol.84 , pp. 1697-1702
    • Finch, C.1
  • 33
    • 84929154461 scopus 로고    scopus 로고
    • Reversal of hemochromatosis by apotransferrin in non-transfused and transfused Hbbth3/+ (heterozygous B1/B2 globin gene deletion) mice
    • Gelderman, M.P., Baek, J.H., Yalamanoglu, A., Puglia, M., Vallelian, F., Burla, B., Vostal, J., Schaer, D.J. & Buehler, P.W. (2015) Reversal of hemochromatosis by apotransferrin in non-transfused and transfused Hbbth3/+ (heterozygous B1/B2 globin gene deletion) mice. Haematologica, 100, 611-622.
    • (2015) Haematologica , vol.100 , pp. 611-622
    • Gelderman, M.P.1    Baek, J.H.2    Yalamanoglu, A.3    Puglia, M.4    Vallelian, F.5    Burla, B.6    Vostal, J.7    Schaer, D.J.8    Buehler, P.W.9
  • 34
    • 80054838641 scopus 로고    scopus 로고
    • Beta-thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism
    • Ginzburg, Y. & Rivella, S. (2011) Beta-thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism. Blood, 118, 4321-4330.
    • (2011) Blood , vol.118 , pp. 4321-4330
    • Ginzburg, Y.1    Rivella, S.2
  • 39
    • 77954249308 scopus 로고    scopus 로고
    • Two to tango: regulation of Mammalian iron metabolism
    • Hentze, M.W., Muckenthaler, M.U., Galy, B. & Camaschella, C. (2010) Two to tango: regulation of Mammalian iron metabolism. Cell, 142, 24-38.
    • (2010) Cell , vol.142 , pp. 24-38
    • Hentze, M.W.1    Muckenthaler, M.U.2    Galy, B.3    Camaschella, C.4
  • 40
    • 84868539376 scopus 로고    scopus 로고
    • How I treat transfusional iron overload
    • Hoffbrand, A.V., Taher, A. & Cappellini, M.D. (2012) How I treat transfusional iron overload. Blood, 120, 3657-3669.
    • (2012) Blood , vol.120 , pp. 3657-3669
    • Hoffbrand, A.V.1    Taher, A.2    Cappellini, M.D.3
  • 42
    • 84887325599 scopus 로고    scopus 로고
    • Congenital dyserythropoietic anemias: molecular insights and diagnostic approach
    • Iolascon, A., Heimpel, H., Wahlin, A. & Tamary, H. (2013) Congenital dyserythropoietic anemias: molecular insights and diagnostic approach. Blood, 122, 2162-2166.
    • (2013) Blood , vol.122 , pp. 2162-2166
    • Iolascon, A.1    Heimpel, H.2    Wahlin, A.3    Tamary, H.4
  • 45
    • 84904865496 scopus 로고    scopus 로고
    • Molecular liaisons between erythropoiesis and iron metabolism
    • Kautz, L. & Nemeth, E. (2014) Molecular liaisons between erythropoiesis and iron metabolism. Blood, 124, 479-482.
    • (2014) Blood , vol.124 , pp. 479-482
    • Kautz, L.1    Nemeth, E.2
  • 47
    • 84903578007 scopus 로고    scopus 로고
    • Identification of erythroferrone as an erythroid regulator of iron metabolism
    • Kautz, L., Jung, G., Valore, E.V., Rivella, S., Nemeth, E. & Ganz, T. (2014) Identification of erythroferrone as an erythroid regulator of iron metabolism. Nature Genetics, 46, 678-684.
    • (2014) Nature Genetics , vol.46 , pp. 678-684
    • Kautz, L.1    Jung, G.2    Valore, E.V.3    Rivella, S.4    Nemeth, E.5    Ganz, T.6
  • 48
    • 84944930727 scopus 로고    scopus 로고
    • Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of beta-thalassemia
    • blood-2015-07-658419
    • Kautz, L., Jung, G., Du, X., Gabayan, V., Chapman, J., Nasoff, M., Nemeth, E. & Ganz, T. (2015) Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of beta-thalassemia. Blood, doi:blood-2015-07-658419
    • (2015) Blood
    • Kautz, L.1    Jung, G.2    Du, X.3    Gabayan, V.4    Chapman, J.5    Nasoff, M.6    Nemeth, E.7    Ganz, T.8
  • 51
    • 0032959574 scopus 로고    scopus 로고
    • Transferrin receptor is necessary for development of erythrocytes and the nervous system
    • Levy, J.E., Jin, O., Fujiwara, Y., Kuo, F. & Andrews, N.C. (1999) Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nature Genetics, 21, 396-399.
    • (1999) Nature Genetics , vol.21 , pp. 396-399
    • Levy, J.E.1    Jin, O.2    Fujiwara, Y.3    Kuo, F.4    Andrews, N.C.5
  • 54
    • 34548825938 scopus 로고    scopus 로고
    • Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4
    • Lin, L., Valore, E.V., Nemeth, E., Goodnough, J.B., Gabayan, V. & Ganz, T. (2007) Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood, 110, 2182-2189.
    • (2007) Blood , vol.110 , pp. 2182-2189
    • Lin, L.1    Valore, E.V.2    Nemeth, E.3    Goodnough, J.B.4    Gabayan, V.5    Ganz, T.6
  • 58
    • 84855848552 scopus 로고    scopus 로고
    • Fetal hemoglobin levels and morbidity in untransfused patients with beta-thalassemia intermedia
    • Musallam, K.M., Sankaran, V.G., Cappellini, M.D., Duca, L., Nathan, D.G. & Taher, A.T. (2012) Fetal hemoglobin levels and morbidity in untransfused patients with beta-thalassemia intermedia. Blood, 119, 364-367.
    • (2012) Blood , vol.119 , pp. 364-367
    • Musallam, K.M.1    Sankaran, V.G.2    Cappellini, M.D.3    Duca, L.4    Nathan, D.G.5    Taher, A.T.6
  • 62
    • 84883737290 scopus 로고    scopus 로고
    • Hepcidin and beta-thalassemia major
    • Nemeth, E. (2013) Hepcidin and beta-thalassemia major. Blood, 122, 3-4.
    • (2013) Blood , vol.122 , pp. 3-4
    • Nemeth, E.1
  • 64
    • 33845245942 scopus 로고    scopus 로고
    • Suppression of hepcidin during anemia requires erythropoietic activity
    • Pak, M., Lopez, M.A., Gabayan, V., Ganz, T. & Rivera, S. (2006) Suppression of hepcidin during anemia requires erythropoietic activity. Blood, 108, 3730-3735.
    • (2006) Blood , vol.108 , pp. 3730-3735
    • Pak, M.1    Lopez, M.A.2    Gabayan, V.3    Ganz, T.4    Rivera, S.5
  • 66
    • 84883684492 scopus 로고    scopus 로고
    • Transfusion suppresses erythropoiesis and increases hepcidin in adult patients with beta-thalassemia major: a longitudinal study
    • Pasricha, S.R., Frazer, D.M., Bowden, D.K. & Anderson, G.J. (2013) Transfusion suppresses erythropoiesis and increases hepcidin in adult patients with beta-thalassemia major: a longitudinal study. Blood, 122, 124-133.
    • (2013) Blood , vol.122 , pp. 124-133
    • Pasricha, S.R.1    Frazer, D.M.2    Bowden, D.K.3    Anderson, G.J.4
  • 70
    • 58149092194 scopus 로고    scopus 로고
    • Growth differentiation factor 15 production is necessary for normal erythroid differentiation and is increased in refractory anaemia with ring-sideroblasts
    • Ramirez, J.M., Schaad, O., Durual, S., Cossali, D., Docquier, M., Beris, P., Descombes, P. & Matthes, T. (2009) Growth differentiation factor 15 production is necessary for normal erythroid differentiation and is increased in refractory anaemia with ring-sideroblasts. British Journal of Haematology, 144, 251-262.
    • (2009) British Journal of Haematology , vol.144 , pp. 251-262
    • Ramirez, J.M.1    Schaad, O.2    Durual, S.3    Cossali, D.4    Docquier, M.5    Beris, P.6    Descombes, P.7    Matthes, T.8
  • 71
    • 84868545645 scopus 로고    scopus 로고
    • Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis
    • Ramos, E., Ruchala, P., Goodnough, J.B., Kautz, L., Preza, G.C., Nemeth, E. & Ganz, T. (2012) Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis. Blood, 120, 3829-3836.
    • (2012) Blood , vol.120 , pp. 3829-3836
    • Ramos, E.1    Ruchala, P.2    Goodnough, J.B.3    Kautz, L.4    Preza, G.C.5    Nemeth, E.6    Ganz, T.7
  • 72
    • 84929492922 scopus 로고    scopus 로고
    • Bmp6 expression in murine liver non parenchymal cells: a mechanism to control their high iron exporter activity and protect hepatocytes from iron overload?
    • Rausa, M., Pagani, A., Nai, A., Campanella, A., Gilberti, M.E., Apostoli, P., Camaschella, C. & Silvestri, L. (2015) Bmp6 expression in murine liver non parenchymal cells: a mechanism to control their high iron exporter activity and protect hepatocytes from iron overload? PLoS ONE, 10, e0122696.
    • (2015) PLoS ONE , vol.10 , pp. e0122696
    • Rausa, M.1    Pagani, A.2    Nai, A.3    Campanella, A.4    Gilberti, M.E.5    Apostoli, P.6    Camaschella, C.7    Silvestri, L.8
  • 74
    • 84926317302 scopus 로고    scopus 로고
    • Beta-thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapies
    • Rivella, S. (2015) Beta-thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapies. Haematologica, 100, 418-430.
    • (2015) Haematologica , vol.100 , pp. 418-430
    • Rivella, S.1
  • 76
    • 84874066920 scopus 로고    scopus 로고
    • An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine beta-thalassemia intermedia
    • Schmidt, P.J., Toudjarska, I., Sendamarai, A.K., Racie, T., Milstein, S., Bettencourt, B.R., Hettinger, J., Bumcrot, D. & Fleming, M.D. (2013) An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine beta-thalassemia intermedia. Blood, 121, 1200-1208.
    • (2013) Blood , vol.121 , pp. 1200-1208
    • Schmidt, P.J.1    Toudjarska, I.2    Sendamarai, A.K.3    Racie, T.4    Milstein, S.5    Bettencourt, B.R.6    Hettinger, J.7    Bumcrot, D.8    Fleming, M.D.9
  • 77
    • 84925303329 scopus 로고    scopus 로고
    • Combination therapy with a Tmprss6 RNAi-therapeutic and the oral iron chelator deferiprone additively diminishes secondary iron overload in a mouse model of beta-thalassemia intermedia
    • Schmidt, P.J., Racie, T., Westerman, M., Fitzgerald, K., Butler, J.S. & Fleming, M.D. (2015) Combination therapy with a Tmprss6 RNAi-therapeutic and the oral iron chelator deferiprone additively diminishes secondary iron overload in a mouse model of beta-thalassemia intermedia. American Journal of Hematology, 90, 310-313.
    • (2015) American Journal of Hematology , vol.90 , pp. 310-313
    • Schmidt, P.J.1    Racie, T.2    Westerman, M.3    Fitzgerald, K.4    Butler, J.S.5    Fleming, M.D.6
  • 79
    • 84859488137 scopus 로고    scopus 로고
    • Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis
    • Seldin, M.M., Peterson, J.M., Byerly, M.S., Wei, Z. & Wong, G.W. (2012) Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis. The Journal of Biological Chemistry, 287, 11968-11980.
    • (2012) The Journal of Biological Chemistry , vol.287 , pp. 11968-11980
    • Seldin, M.M.1    Peterson, J.M.2    Byerly, M.S.3    Wei, Z.4    Wong, G.W.5
  • 80
    • 84890319864 scopus 로고    scopus 로고
    • Skeletal muscle-derived myonectin activates the mammalian target of rapamycin (mTOR) pathway to suppress autophagy in liver
    • Seldin, M.M., Lei, X., Tan, S.Y., Stanson, K.P., Wei, Z. & Wong, G.W. (2013) Skeletal muscle-derived myonectin activates the mammalian target of rapamycin (mTOR) pathway to suppress autophagy in liver. The Journal of Biological Chemistry, 288, 36073-36082.
    • (2013) The Journal of Biological Chemistry , vol.288 , pp. 36073-36082
    • Seldin, M.M.1    Lei, X.2    Tan, S.Y.3    Stanson, K.P.4    Wei, Z.5    Wong, G.W.6
  • 81
    • 58749094789 scopus 로고    scopus 로고
    • Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency
    • Shah, Y.M., Matsubara, T., Ito, S., Yim, S.H. & Gonzalez, F.J. (2009) Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency. Cell Metabolism, 9, 152-164.
    • (2009) Cell Metabolism , vol.9 , pp. 152-164
    • Shah, Y.M.1    Matsubara, T.2    Ito, S.3    Yim, S.H.4    Gonzalez, F.J.5
  • 83
    • 84905748509 scopus 로고    scopus 로고
    • Impact of iron overload and potential benefit from iron chelation in low-risk myelodysplastic syndrome
    • Shenoy, N., Vallumsetla, N., Rachmilewitz, E., Verma, A. & Ginzburg, Y. (2014) Impact of iron overload and potential benefit from iron chelation in low-risk myelodysplastic syndrome. Blood, 124, 873-881.
    • (2014) Blood , vol.124 , pp. 873-881
    • Shenoy, N.1    Vallumsetla, N.2    Rachmilewitz, E.3    Verma, A.4    Ginzburg, Y.5
  • 84
    • 84892903671 scopus 로고    scopus 로고
    • Multiple-dose, safety, pharmacokinetic, and pharmacodynamic study of sotatercept (ActRIIA-IgG1), a novel erythropoietic agent, in healthy postmenopausal women
    • Sherman, M.L., Borgstein, N.G., Mook, L., Wilson, D., Yang, Y., Chen, N., Kumar, R., Kim, K. & Laadem, A. (2013) Multiple-dose, safety, pharmacokinetic, and pharmacodynamic study of sotatercept (ActRIIA-IgG1), a novel erythropoietic agent, in healthy postmenopausal women. Journal of Clinical Pharmacology, 53, 1121-1130.
    • (2013) Journal of Clinical Pharmacology , vol.53 , pp. 1121-1130
    • Sherman, M.L.1    Borgstein, N.G.2    Mook, L.3    Wilson, D.4    Yang, Y.5    Chen, N.6    Kumar, R.7    Kim, K.8    Laadem, A.9
  • 85
    • 38349194098 scopus 로고    scopus 로고
    • Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis
    • Silvestri, L., Pagani, A. & Camaschella, C. (2008) Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis. Blood, 111, 924-931.
    • (2008) Blood , vol.111 , pp. 924-931
    • Silvestri, L.1    Pagani, A.2    Camaschella, C.3
  • 89
    • 77950420281 scopus 로고    scopus 로고
    • Overview on practices in thalassemia intermedia management aiming for lowering complication rates across a region of endemicity: the OPTIMAL CARE study
    • Taher, A.T., Musallam, K.M., Karimi, M., El-Beshlawy, A., Belhoul, K., Daar, S., Saned, M.S., El-Chafic, A.H., Fasulo, M.R. & Cappellini, M.D. (2010) Overview on practices in thalassemia intermedia management aiming for lowering complication rates across a region of endemicity: the OPTIMAL CARE study. Blood, 115, 1886-1892.
    • (2010) Blood , vol.115 , pp. 1886-1892
    • Taher, A.T.1    Musallam, K.M.2    Karimi, M.3    El-Beshlawy, A.4    Belhoul, K.5    Daar, S.6    Saned, M.S.7    El-Chafic, A.H.8    Fasulo, M.R.9    Cappellini, M.D.10
  • 92
    • 58149399349 scopus 로고    scopus 로고
    • Elevated growth differentiation factor 15 expression in patients with congenital dyserythropoietic anemia type I
    • Tamary, H., Shalev, H., Perez-Avraham, G., Zoldan, M., Levi, I., Swinkels, D.W., Tanno, T. & Miller, J.L. (2008) Elevated growth differentiation factor 15 expression in patients with congenital dyserythropoietic anemia type I. Blood, 112, 5241-5244.
    • (2008) Blood , vol.112 , pp. 5241-5244
    • Tamary, H.1    Shalev, H.2    Perez-Avraham, G.3    Zoldan, M.4    Levi, I.5    Swinkels, D.W.6    Tanno, T.7    Miller, J.L.8
  • 94
    • 77951494122 scopus 로고    scopus 로고
    • Growth differentiation factor 15 in erythroid health and disease
    • Tanno, T., Noel, P. & Miller, J.L. (2010) Growth differentiation factor 15 in erythroid health and disease. Current Opinion in Hematology, 17, 184-190.
    • (2010) Current Opinion in Hematology , vol.17 , pp. 184-190
    • Tanno, T.1    Noel, P.2    Miller, J.L.3
  • 96
    • 84861381296 scopus 로고    scopus 로고
    • The definition and epidemiology of non-transfusion-dependent thalassemia
    • Weatherall, D.J. (2012) The definition and epidemiology of non-transfusion-dependent thalassemia. Blood Reviews, 26, S3-S6.
    • (2012) Blood Reviews , vol.26 , pp. S3-S6
    • Weatherall, D.J.1
  • 97
    • 31544481433 scopus 로고    scopus 로고
    • Erythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase/AKT signaling pathway
    • Zhao, W., Kitidis, C., Fleming, M.D., Lodish, H.F. & Ghaffari, S. (2006) Erythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase/AKT signaling pathway. Blood, 107, 907-915.
    • (2006) Blood , vol.107 , pp. 907-915
    • Zhao, W.1    Kitidis, C.2    Fleming, M.D.3    Lodish, H.F.4    Ghaffari, S.5
  • 100
    • 84888133550 scopus 로고    scopus 로고
    • Serum hepcidin measured with an improved ELISA correlates with parameters of iron metabolism in patients with myelodysplastic syndrome
    • Zipperer, E., Post, J.G., Herkert, M., Kundgen, A., Fox, F., Haas, R., Gattermann, N. & Germing, U. (2013) Serum hepcidin measured with an improved ELISA correlates with parameters of iron metabolism in patients with myelodysplastic syndrome. Annals of Hematology, 92, 1617-1623.
    • (2013) Annals of Hematology , vol.92 , pp. 1617-1623
    • Zipperer, E.1    Post, J.G.2    Herkert, M.3    Kundgen, A.4    Fox, F.5    Haas, R.6    Gattermann, N.7    Germing, U.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.