HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemia

Nature

Volumn 514, Issue 7521, 2014, Pages 242-246

  Arlet, Jean Benoît ^a,b,c,d   Ribeil, Jean Antoine ^a,c,d,e   Guillem, Flavia ^a,c,d   Negre, Olivier ^f   Hazoume, Adonis ^g,h   Marcion, Guillaume ^g,h   Beuzard, Yves ^f   Dussiot, Michaël ^a,c,d,i   Moura, Ivan Cruz ^a,c,d,i,j   Demarest, Samuel ^a   De Beauchêne, Isaure Chauvot ^a,k   Belaid Choucair, Zakia ^a,c,d   Sevin, Margaux ^g,h   Maciel, Thiago Trovati ^a,c,d,i,j   Auclair, Christian ^a,k   Leboulch, Philippe ^f,l   Chretien, Stany ^f   Tchertanov, Luba ^a,k   Baudin Creuza, Véronique ^g   Seigneuric, Renaud ^h   Fontenay, Michaela ^d,m,n   Garrido, Carmen ^g,h,o   Hermine, Olivier ^a,c,d,p   Courtois, Geneviève ^a,c,d   more..

^a CNRS   (France)

^b HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^c PARIS DESCARTES SORBONNE PARIS CITÉ UNIVERSITY   (France)

^d Laboratory of Excellence GR Ex   (France)

^e HÔPITAL NECKER ENFANTS MALADES   (France)

^f INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

^g INSERM   (France)

^h UNIVERSITÉ DE BOURGOGNE   (France)

ⁱ BICHAT HOSPITAL   (France)

^j UNIVERSITÉ PARIS DESCARTES   (France)

^k Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique LERMIT   (France)

^l BRIGHAM AND WOMEN S HOSPITAL   (United States)

^m INSTITUT COCHIN   (France)

ⁿ université Paris Cité   (France)

^o Georges Francois Leclerc Center   (France)

^p ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; GATA1 PROTEIN, HUMAN; HEAT SHOCK PROTEIN 70; HEMOGLOBIN ALPHA CHAIN; TRANSCRIPTION FACTOR GATA 1;

APOPTOSIS; ARTICLE; BETA THALASSEMIA; BLOOD; BONE MARROW; CELL CULTURE; CELL NUCLEUS; CELL SURVIVAL; CYTOLOGY; CYTOPLASM; ENZYME ACTIVATION; ERYTHROBLAST; ERYTHROPOIESIS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; KINETICS; METABOLISM; MOLECULARLY TARGETED THERAPY; PATHOLOGY; PROTEIN BINDING; PROTEIN REFOLDING;

ALPHA-GLOBINS; APOPTOSIS; BETA-THALASSEMIA; BONE MARROW; CASPASE 3; CELL NUCLEUS; CELL SURVIVAL; CELLS, CULTURED; CYTOPLASM; ENZYME ACTIVATION; ERYTHROBLASTS; ERYTHROPOIESIS; GATA1 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; HSP70 HEAT-SHOCK PROTEINS; HUMANS; KINETICS; MOLECULAR TARGETED THERAPY; PROTEIN BINDING; PROTEIN REFOLDING;

EID: 84908377214     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13614     Document Type: Article

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