메뉴 건너뛰기




Volumn 94, Issue 6, 2015, Pages 511-518

Altered erythropoiesis and iron metabolism in carriers of thalassemia

Author keywords

Erythropoiesis; Erythropoietin; Ferritin; GDF15; Hepcidin; Iron metabolism; Soluble transferrin receptor; Thalassemia

Indexed keywords

ERYTHROPOIETIN; FERRITIN; HEMOGLOBIN; HEPCIDIN; TRANSFERRIN RECEPTOR; HEMOGLOBIN ALPHA CHAIN; HEMOGLOBIN BETA CHAIN; IRON;

EID: 84929075013     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/ejh.12464     Document Type: Article
Times cited : (24)

References (49)
  • 1
    • 0033536288 scopus 로고    scopus 로고
    • The β-thalassemias
    • Olivieri NF. The β-thalassemias. N Eng J Med 1999;341:99-109.
    • (1999) N Eng J Med , vol.341 , pp. 99-109
    • Olivieri, N.F.1
  • 2
    • 24944465060 scopus 로고    scopus 로고
    • Medical progress beta-thalassemia
    • Rund D, Rachmilewitz E. Medical progress beta-thalassemia. N Engl J Med 2005;353:1135-46.
    • (2005) N Engl J Med , vol.353 , pp. 1135-1146
    • Rund, D.1    Rachmilewitz, E.2
  • 3
    • 36549046617 scopus 로고    scopus 로고
    • Disorders of globin synthesis: the thalassemias
    • In: Lichtman MA, eds., 7th edn. New York: McGraw-Hill Medical
    • Weatherall DJ. Disorders of globin synthesis: the thalassemias. In: Lichtman MA, Beutler E, Kaushansky K, Kipps TJ, eds. Williams Hematology, 7th edn. New York: McGraw-Hill Medical; 2006:633-56.
    • (2006) Williams Hematology , pp. 633-656
    • Weatherall, D.J.1    Beutler, E.2    Kaushansky, K.3    Kipps, T.J.4
  • 4
    • 0034307683 scopus 로고    scopus 로고
    • A correlation of erythrokinetics, ineffective erythropoiesis, and erythroid precursor apoptosis in Thai patients with thalassemia
    • Diego S, Pootrakul P, Sirankapracha P, et al. A correlation of erythrokinetics, ineffective erythropoiesis, and erythroid precursor apoptosis in Thai patients with thalassemia. Blood 2000;96:2606-12.
    • (2000) Blood , vol.96 , pp. 2606-2612
    • Diego, S.1    Pootrakul, P.2    Sirankapracha, P.3
  • 6
    • 44949128064 scopus 로고    scopus 로고
    • Global epidemiology of hemoglobin disorders and derived service indicators
    • Modell B, Darlison M. Global epidemiology of hemoglobin disorders and derived service indicators. Bull WHO 2008;86:480-7.
    • (2008) Bull WHO , vol.86 , pp. 480-487
    • Modell, B.1    Darlison, M.2
  • 7
    • 0021894844 scopus 로고
    • Molecular pathology of α-thalassemia
    • Kan YW. Molecular pathology of α-thalassemia. Ann NY Acad Sci 1985;445:28-36.
    • (1985) Ann NY Acad Sci , vol.445 , pp. 28-36
    • Kan, Y.W.1
  • 8
    • 77955914916 scopus 로고    scopus 로고
    • Complexity of alpha thalassemia: growing health problem with new approaches to screening, diagnosis, and therapy
    • Vichinsky E. Complexity of alpha thalassemia: growing health problem with new approaches to screening, diagnosis, and therapy. Ann NY Acad Sci 2010;1202:180-7.
    • (2010) Ann NY Acad Sci , vol.1202 , pp. 180-187
    • Vichinsky, E.1
  • 10
    • 0033155769 scopus 로고    scopus 로고
    • Hemoglobin screening: response of a Brazilian community to optional programs
    • Ramalho AS, Silva RBP, Teixeira RC, Compri MB. Hemoglobin screening: response of a Brazilian community to optional programs. Cad Saude Publica 1999;15:591-5.
    • (1999) Cad Saude Publica , vol.15 , pp. 591-595
    • Ramalho, A.S.1    Silva, R.B.P.2    Teixeira, R.C.3    Compri, M.B.4
  • 11
    • 0025776006 scopus 로고
    • High prevalence of alpha-thalassemia in a black population of Brazil
    • Sonati MF, Farah SB, Ramalho AS, Costa FF. High prevalence of alpha-thalassemia in a black population of Brazil. Hemoglobin 1991;15:309-11.
    • (1991) Hemoglobin , vol.15 , pp. 309-311
    • Sonati, M.F.1    Farah, S.B.2    Ramalho, A.S.3    Costa, F.F.4
  • 12
    • 84929093277 scopus 로고    scopus 로고
    • Hemoglobinopatias em escolares de Ribeirão Preto, São Paulo
    • In: Congresso Brasileiro de Hematologia e Hemoterapia, Sao Paulo
    • Tavares CFF, Guimarães JS, Almeida MR, Souza AM. Hemoglobinopatias em escolares de Ribeirão Preto, São Paulo. In: Congresso Brasileiro de Hematologia e Hemoterapia, 2011, Sao Paulo, Rev Bras Hematol Hemoter 2011;33:52-52.
    • (2011) Rev Bras Hematol Hemoter 2011 , vol.33 , pp. 52-52
    • Tavares, C.F.F.1    Guimarães, J.S.2    Almeida, M.R.3    Souza, A.M.4
  • 13
    • 32644451935 scopus 로고    scopus 로고
    • Hemoglobinopathies in newborns from Salvador, Bahia, Northeast Brazil
    • Adorno EV, Couto FD, Moura Neto JP, et al. Hemoglobinopathies in newborns from Salvador, Bahia, Northeast Brazil. Rev Saúde Públ 2005;21:292-8.
    • (2005) Rev Saúde Públ , vol.21 , pp. 292-298
    • Adorno, E.V.1    Couto, F.D.2    Moura Neto, J.P.3
  • 14
    • 84865395986 scopus 로고    scopus 로고
    • Prevalence of α-thalassemia 3.7 kb deletion in the adult population of Rio Grande do Norte, Brazil
    • Alcoforado GHM, Bezerra CM, Lemos TMAM, et al. Prevalence of α-thalassemia 3.7 kb deletion in the adult population of Rio Grande do Norte, Brazil. Genet Mol Biol 2012;35:594-8.
    • (2012) Genet Mol Biol , vol.35 , pp. 594-598
    • Alcoforado, G.H.M.1    Bezerra, C.M.2    Lemos, T.M.A.M.3
  • 15
    • 67649411673 scopus 로고    scopus 로고
    • α-thalassemia (3.7 kb deletion) in a population from the Brazilian Amazon region: Santarem, Para State
    • Souza AES, Cardoso GL, Takanashi SYL, Guerreiro JF. α-thalassemia (3.7 kb deletion) in a population from the Brazilian Amazon region: Santarem, Para State. Genet Mol Res 2009;8:477-81.
    • (2009) Genet Mol Res , vol.8 , pp. 477-481
    • Souza, A.E.S.1    Cardoso, G.L.2    Takanashi, S.Y.L.3    Guerreiro, J.F.4
  • 16
    • 80054838641 scopus 로고    scopus 로고
    • Β-thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism
    • Ginzburg Y, Rivella S. Β-thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism. Blood 2011;118:4321-30.
    • (2011) Blood , vol.118 , pp. 4321-4330
    • Ginzburg, Y.1    Rivella, S.2
  • 18
    • 10944240130 scopus 로고    scopus 로고
    • Serum transferrin receptor levels in beta-thalassemia trait
    • Demir A, Yarali N, Fisgin T, Duru F, Kara A. Serum transferrin receptor levels in beta-thalassemia trait. J Trop Pediatr 2004;50:369-71.
    • (2004) J Trop Pediatr , vol.50 , pp. 369-371
    • Demir, A.1    Yarali, N.2    Fisgin, T.3    Duru, F.4    Kara, A.5
  • 19
    • 77954589300 scopus 로고    scopus 로고
    • Crosstalk between iron metabolism and erythropoiesis
    • Li H, Ginzburg YZ. Crosstalk between iron metabolism and erythropoiesis. Adv Hematol 2010;2010:605435.
    • (2010) Adv Hematol , vol.2010 , pp. 605435
    • Li, H.1    Ginzburg, Y.Z.2
  • 20
    • 79551583056 scopus 로고    scopus 로고
    • Hepcidin and disorders of iron metabolism
    • Ganz T, Nemeth E. Hepcidin and disorders of iron metabolism. Annu Rev Med 2011;62:347-60.
    • (2011) Annu Rev Med , vol.62 , pp. 347-360
    • Ganz, T.1    Nemeth, E.2
  • 21
    • 78249289938 scopus 로고    scopus 로고
    • Anemia, ineffective erythropoiesis, and hepcidin: interacting factors in abnormal iron metabolism leading to iron overload in β-thalassemia
    • Gardenghi S, Grady RW, Rivella S. Anemia, ineffective erythropoiesis, and hepcidin: interacting factors in abnormal iron metabolism leading to iron overload in β-thalassemia. Hematol Oncol Clin North Am 2010;24:1089-107.
    • (2010) Hematol Oncol Clin North Am , vol.24 , pp. 1089-1107
    • Gardenghi, S.1    Grady, R.W.2    Rivella, S.3
  • 22
    • 34948904750 scopus 로고    scopus 로고
    • High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin
    • Tanno T, Bhanu NV, Oneal PA, et al. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med 2007;13:1096-101.
    • (2007) Nat Med , vol.13 , pp. 1096-1101
    • Tanno, T.1    Bhanu, N.V.2    Oneal, P.A.3
  • 23
    • 84871223663 scopus 로고    scopus 로고
    • The murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice
    • Casanovas G, Spasic MV, Casu C, et al. The murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice. Haematologica 2013;98:444-7.
    • (2013) Haematologica , vol.98 , pp. 444-447
    • Casanovas, G.1    Spasic, M.V.2    Casu, C.3
  • 24
    • 82955187600 scopus 로고    scopus 로고
    • Levels of growth differentiation factor-15 are high and correlate with clinical severity in transfusion-independent patients with β thalassemia intermedia
    • Musallam KM, Taher AT, Duca L, Cesaretti C, Halawi R, Cappellini MD. Levels of growth differentiation factor-15 are high and correlate with clinical severity in transfusion-independent patients with β thalassemia intermedia. Blood Cells Mol Dis 2011;47:232-4.
    • (2011) Blood Cells Mol Dis , vol.47 , pp. 232-234
    • Musallam, K.M.1    Taher, A.T.2    Duca, L.3    Cesaretti, C.4    Halawi, R.5    Cappellini, M.D.6
  • 25
    • 34447306076 scopus 로고    scopus 로고
    • Liver iron concentrations and urinary hepcidin in beta-thalassemia
    • Origa R, Galanello R, Ganz T, Giagu N, Maccioni L, et al. Liver iron concentrations and urinary hepcidin in beta-thalassemia. Haematologica 2007;92:583-8.
    • (2007) Haematologica , vol.92 , pp. 583-588
    • Origa, R.1    Galanello, R.2    Ganz, T.3    Giagu, N.4    Maccioni, L.5
  • 26
    • 55549127206 scopus 로고    scopus 로고
    • Test of the month serum transferrin receptor
    • Skikne BS. Test of the month serum transferrin receptor. Am J Hematol 2008;83:872-5.
    • (2008) Am J Hematol , vol.83 , pp. 872-875
    • Skikne, B.S.1
  • 27
    • 84897401236 scopus 로고    scopus 로고
    • Erythropoiesis-driven regulation of hepcidin in human red cell disorders is better reflected through concentrations of soluble transferrin receptor rather than growth differentiation factor 15
    • Fertrin KY, Lanaro C, Franco-Penteado CF, de Albuquerque DM, de Mello MRB, Pallis FR, et al. Erythropoiesis-driven regulation of hepcidin in human red cell disorders is better reflected through concentrations of soluble transferrin receptor rather than growth differentiation factor 15. Am J Hematol 2014;89:385-90.
    • (2014) Am J Hematol , vol.89 , pp. 385-390
    • Fertrin, K.Y.1    Lanaro, C.2    Franco-Penteado, C.F.3    de Albuquerque, D.M.4    de Mello, M.R.B.5    Pallis, F.R.6
  • 28
    • 0027397913 scopus 로고
    • Rapid analysis of -α3.7 thalassaemia and αααanti 3.7 triplication by enzymatic amplification analysis
    • Dodé C, Krishnamoorthy R, Lamb J, Rochette J. Rapid analysis of -α3.7 thalassaemia and αααanti 3.7 triplication by enzymatic amplification analysis. Br J Haematol 1993;83:105-11.
    • (1993) Br J Haematol , vol.83 , pp. 105-111
    • Dodé, C.1    Krishnamoorthy, R.2    Lamb, J.3    Rochette, J.4
  • 29
    • 84929121738 scopus 로고    scopus 로고
    • WHO information for Iron Deficiency Anaemia. Assessment, prevention, and control. A guide for programme managers. .. Accessed 20 January 2014.
    • World Health Organization. WHO information for Iron Deficiency Anaemia. Assessment, prevention, and control. A guide for programme managers. 2001. http://www.who.int/nutrition/publications/micronutrientsanaemia_iron_deficiency/WHO_NHD_01.3/en/. Accessed 20 January 2014.
    • (2001)
  • 30
    • 0032532635 scopus 로고    scopus 로고
    • Serum transferrin receptor and transferrin receptor-ferritin index identify healthy subjects with subclinical iron deficits
    • Suominen P, Punnonen K, Rajamäki A, Irjala K. Serum transferrin receptor and transferrin receptor-ferritin index identify healthy subjects with subclinical iron deficits. Blood 1998;92:2934-9.
    • (1998) Blood , vol.92 , pp. 2934-2939
    • Suominen, P.1    Punnonen, K.2    Rajamäki, A.3    Irjala, K.4
  • 31
    • 26244438799 scopus 로고    scopus 로고
    • CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: application to Clinical and Public Health Practice: clinical use of inflammatory markers in patients with cardiovascular diseases: a background paper
    • Biasucci LM. CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: application to Clinical and Public Health Practice: clinical use of inflammatory markers in patients with cardiovascular diseases: a background paper. Circulation 2004;110:e560-7.
    • (2004) Circulation , vol.110 , pp. e560-e567
    • Biasucci, L.M.1
  • 33
    • 77952313581 scopus 로고    scopus 로고
    • Determinants of hepcidin in patients on maintenance hemodialysis: role of inflammation
    • Kuragano T, Shimonaka Y, Kida A, Furuta M, Nanami M, et al. Determinants of hepcidin in patients on maintenance hemodialysis: role of inflammation. Am J Nephrol 2010;31:534-40.
    • (2010) Am J Nephrol , vol.31 , pp. 534-540
    • Kuragano, T.1    Shimonaka, Y.2    Kida, A.3    Furuta, M.4    Nanami, M.5
  • 34
    • 77954619494 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled trial of an iron-fortified food product in female soldiers during military training: relations between iron status, serum hepcidin, and inflammation 1-5
    • Karl JP, Lieberman HR, Cable SJ, Williams KW, Young AJ, Mcclung JP. Randomized, double-blind, placebo-controlled trial of an iron-fortified food product in female soldiers during military training: relations between iron status, serum hepcidin, and inflammation 1-5. Am J Clinial Nutr 2010;92:93-100.
    • (2010) Am J Clinial Nutr , vol.92 , pp. 93-100
    • Karl, J.P.1    Lieberman, H.R.2    Cable, S.J.3    Williams, K.W.4    Young, A.J.5    Mcclung, J.P.6
  • 35
    • 79953108427 scopus 로고    scopus 로고
    • Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project
    • Piperno A, Galimberti S, Mariani R, Pelucchi S, Ravasi G, et al. Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project. Blood 2011;117:2953-9.
    • (2011) Blood , vol.117 , pp. 2953-2959
    • Piperno, A.1    Galimberti, S.2    Mariani, R.3    Pelucchi, S.4    Ravasi, G.5
  • 36
    • 79961085126 scopus 로고    scopus 로고
    • Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors
    • Pasricha S, Mcquilten Z, Westerman M, Keller A, Nemeth E, et al. Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors. Haematologica 2011;96:1099-105.
    • (2011) Haematologica , vol.96 , pp. 1099-1105
    • Pasricha, S.1    Mcquilten, Z.2    Westerman, M.3    Keller, A.4    Nemeth, E.5
  • 37
    • 84881006013 scopus 로고    scopus 로고
    • Hepcidin level predicts hemoglobin concentration in individuals undergoing repeated phlebotomy
    • Mast AE, Schlumpf KS, Wright DJ, Johnson B, Glynn SA, et al. Hepcidin level predicts hemoglobin concentration in individuals undergoing repeated phlebotomy. Haematologica 2013;98:1324-30.
    • (2013) Haematologica , vol.98 , pp. 1324-1330
    • Mast, A.E.1    Schlumpf, K.S.2    Wright, D.J.3    Johnson, B.4    Glynn, S.A.5
  • 38
    • 34249658982 scopus 로고    scopus 로고
    • Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin
    • Gardenghi S, Marongiu MF, Ramos P, Guy E, Breda L, et al. Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin. Blood 2007;109:5027-35.
    • (2007) Blood , vol.109 , pp. 5027-5035
    • Gardenghi, S.1    Marongiu, M.F.2    Ramos, P.3    Guy, E.4    Breda, L.5
  • 39
    • 33745755350 scopus 로고    scopus 로고
    • The effects of erythropoetic activity and iron burden on hepcidin expression in patients with thalassemia major
    • Kattamis A, Papassotiriou I, Palaiologou D, Apostolakou F, Galani A, et al. The effects of erythropoetic activity and iron burden on hepcidin expression in patients with thalassemia major. Haematologica 2006;91:809-12.
    • (2006) Haematologica , vol.91 , pp. 809-812
    • Kattamis, A.1    Papassotiriou, I.2    Palaiologou, D.3    Apostolakou, F.4    Galani, A.5
  • 40
    • 84861397221 scopus 로고    scopus 로고
    • Advances in the treatment of alpha-thalassemia
    • Vichinsky E. Advances in the treatment of alpha-thalassemia. Blood Rev 2012;26(Suppl 1):S31-4.
    • (2012) Blood Rev , vol.26 , pp. S31-S34
    • Vichinsky, E.1
  • 41
    • 84861350562 scopus 로고    scopus 로고
    • Recent advances in the molecular understanding of non-transfusion-dependent thalassemia
    • Galanello R. Recent advances in the molecular understanding of non-transfusion-dependent thalassemia. Blood Rev 2012;26(Suppl 1):S7-11.
    • (2012) Blood Rev , vol.26 , pp. S7-11
    • Galanello, R.1
  • 42
    • 84879035265 scopus 로고    scopus 로고
    • Clinical manifestations of α-thalassemia
    • Vichinsky EP. Clinical manifestations of α-thalassemia. Cold Spring Harb Perspect Med 2013;3:a011742.
    • (2013) Cold Spring Harb Perspect Med , vol.3 , pp. a011742
    • Vichinsky, E.P.1
  • 44
    • 84929087022 scopus 로고    scopus 로고
    • New insight on the management of ineffective erythropoiesis and iron overload in β-thalassemia and related hemoglobinopathies
    • Gardenghi S, Rivella S. New insight on the management of ineffective erythropoiesis and iron overload in β-thalassemia and related hemoglobinopathies. Hematol Educ 2012;6:331-8.
    • (2012) Hematol Educ , vol.6 , pp. 331-338
    • Gardenghi, S.1    Rivella, S.2
  • 45
    • 76349118307 scopus 로고    scopus 로고
    • Transferrin therapy ameliorates disease in beta-thalassemic mice
    • Li H, Rybicki AC, Suzuka SM, Bonsdorff L, Breuer W, et al. Transferrin therapy ameliorates disease in beta-thalassemic mice. Nat Med 2010;16:177-82.
    • (2010) Nat Med , vol.16 , pp. 177-182
    • Li, H.1    Rybicki, A.C.2    Suzuka, S.M.3    Bonsdorff, L.4    Breuer, W.5
  • 46
    • 78649813036 scopus 로고    scopus 로고
    • Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice
    • Gardenghi S, Ramos P, Marongiu MF, Melchiori L, Breda L, et al. Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice. J Clin Invest 2010;120:4466-77.
    • (2010) J Clin Invest , vol.120 , pp. 4466-4477
    • Gardenghi, S.1    Ramos, P.2    Marongiu, M.F.3    Melchiori, L.4    Breda, L.5
  • 47
    • 79959262524 scopus 로고    scopus 로고
    • Prospects for a hepcidin mimic to treat β-thalassemia and hemochromatosis
    • Parrow NL, Gardenghi S, Rivella S. Prospects for a hepcidin mimic to treat β-thalassemia and hemochromatosis. Expert Rev Hematol 2011;4:233-5.
    • (2011) Expert Rev Hematol , vol.4 , pp. 233-235
    • Parrow, N.L.1    Gardenghi, S.2    Rivella, S.3
  • 48
    • 84875849962 scopus 로고    scopus 로고
    • Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice
    • Guo S, Casu C, Gardenghi S, Booten S, Aghajan M, et al. Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice. J Clin Invest 2013;123:1531-41.
    • (2013) J Clin Invest , vol.123 , pp. 1531-1541
    • Guo, S.1    Casu, C.2    Gardenghi, S.3    Booten, S.4    Aghajan, M.5
  • 49
    • 84890288632 scopus 로고    scopus 로고
    • Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia
    • Anderson ER, Taylor M, Xue X, Ramakrishnan SK, Martin A, et al. Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia. Proc Natl Acad Sci USA 2013;110:E4922-30.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. E4922-E4930
    • Anderson, E.R.1    Taylor, M.2    Xue, X.3    Ramakrishnan, S.K.4    Martin, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.