Defective nuclear localization of Hsp70 is associated with dyserythropoiesis and GATA-1 cleavage in myelodysplastic syndromes

Blood

Volumn 119, Issue 6, 2012, Pages 1532-1542

  Frisan, Emilie ^a,b,c   Vandekerckhove, Julie ^c,d   De Thonel, Aurélie ^e   Pierre Eugène, Cécile ^a,b,c,f   Sternberg, Alexander ^g   Arlet, Jean Benoît ^c,d   Floquet, Célia ^a,b,c   Gyan, Emmanuel ^a,b,c,h   Kosmider, Olivier ^a,b,c,f   Dreyfus, François ^a,b,c,f   Gabet, Anne Sophie ^c,d   Courtois, Geneviève ^c,d   Vyas, Paresh ^g   Ribeil, Jean Antoine ^c,d   Zermati, Yael ^a,b,c   Lacombe, Catherine ^a,b,c,f   Mayeux, Patrick ^a,b,c   Solary, Eric ^e,i,j   Garrido, Carmen ^e,j,k   Hermine, Olivier ^c,d   Fontenay, Michaela ^a,b,c,f   more..

^a INSTITUT COCHIN   (France)

^b CNRS   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d HÔPITAL NECKER ENFANTS MALADES   (France)

^e boulevard Jeanne d'Arc   (France)

^f université Paris Cité   (France)

^g UNIVERSITY OF OXFORD   (United Kingdom)

^h UNIVERSITY HOSPITAL OF TOURS   (France)

ⁱ Universite Paris Sud   (France)

^j UNIVERSITÉ DE BOURGOGNE   (France)

^k DIJON UNIVERSITY HOSPITAL   (France)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; GLYCOPHORIN A; HEAT SHOCK PROTEIN 70; TRANSCRIPTION FACTOR GATA 1;

ADULT; AGED; APOPTOSIS; ARTICLE; BIOACCUMULATION; CELL DIFFERENTIATION; CELL MATURATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DYSERYTHROPOIESIS; DYSPLASIA; ENZYME ACTIVATION; ENZYME MECHANISM; ERYTHROBLAST; ERYTHROID CELL; ERYTHROID CELL DYSPLASIA; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MYELODYSPLASTIC SYNDROME; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

EID: 84856920241     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-03-343475     Document Type: Article

References (32)

1. Vardiman JW, Thiele J, Arber DA, et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood. 2009;114(5):937-951.
2. Rajapaksa R, Ginzton N, Rott LS, Greenberg PL. Altered oncoprotein expression and apoptosis in myelodysplastic syndrome marrow cells. Blood. 1996;88(11):4275-4287. (Pubitemid 26399175)
3. Claessens Y-E, Bouscary D, Dupont JM, et al. In vitro proliferation and differentiation of erythroid progenitors from patients with myelodysplastic syndromes: evidence for Fas-dependent apoptosis. Blood. 2002;99(5):1594-1601. (Pubitemid 34533031)
4. Ebert BL, Galili N, Tamayo P, et al. An erythroid differentiation signature predicts. response to lenalidomide in myelodysplastic syndrome. PLoS Med. 2008;5(2):e35.
5. Ebert BL, Pretz J, Bosco J, et al. Identification of RPS14 as a 5q- syndrome gene by RNA interference screen. Nature. 2008;451(7176):335-339.
6. Dutt S, Narla A, Lin K, et al. Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells. Blood. 2011;117(9):2567-2576.
7. Tehranchi R, Invernizzi R, Grandien A, et al. Aberrant mitochondrial iron distribution and maturation arrest characterize early erythroid precursors in low-risk myelodysplastic syndromes. Blood. 2005;106(1):247-253. (Pubitemid 40967200)
8. Ferreira R, Ohneda K, Yamamoto M, Philipsen S. GATA-1 function, a paradigm for transcription factors in haematopoiesis. Mol Cell Biol. 2005;25(4): 1215-1227. (Pubitemid 40204902)
9. Pevny L, Simon MC, Robertson E, et al. Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature. 1991;349(6306):257-260. (Pubitemid 21912061)
10. Fujiwara Y, Browne CP, Cunniff K, Goff SC, Orkin SH. Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1. Proc Natl Acad Sci U S A. 1996;93(22):12355-12358. (Pubitemid 26367147)
11. De Maria R, Zeuner A, Eramo A, et al. Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1. Nature. 1999;401(6752): 489-493.
12. Zermati Y, Garrido C, Amsellem S, et al. Caspase activation is required for terminal erythroid differentiation. J Exp Med. 2001;193(2):247-254. (Pubitemid 32524456)
13. Carlile GW, Smith DH, Wiedmann M. Caspase-3 has a nonapoptotic function in erythroid maturation. Blood. 2004;103(11):4310-4316. (Pubitemid 38685378)
14. Ribeil JA, Zermati Y, Vandekerckhove J, et al. Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1. Nature. 2007;445(7123):102-105. (Pubitemid 46067309)
15. Sternberg A, Killick S, Littlewood T, et al. Evidence for reduced B-cell progenitors in early (low-risk) myelodysplastic syndrome. Blood. 2005; 106(9):2982-2991. (Pubitemid 41565889)
16. Golub TR, Slonim DK, Tamayo P, et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science. 1999;286(5439):531-537.
17. Welch JJ,Watts JA, Vakoc CR, et al. Global regulation of erythroid gene expression by transcription factor GATA-1. Blood. 2004;104(10):3136-3147. (Pubitemid 39507127)
18. Hernandez-Hernandez A, Ray P, Litos G, et al. Acetylation and MAPK phosphorylation cooperate to regulate the degradation of active GATA-1. EMBO J. 2006;25(14):3264-3274. (Pubitemid 44141785)
19. Gyan E, Frisan E, Beyne-Rauzy O, et al. Spontaneous and Fas-induced apoptosis of low-grade MDS erythroid precursors involves the endoplasmic reticulum. Leukemia. 2008;22(10):1864-1873.
20. Tsukahara F, Maru Y. Identification of novel nuclear export and nuclear localization-related signals in human heat shock cognate protein 70. J Biol Chem. 2004;279(10):8867-8872. (Pubitemid 38295946)
21. Vyas P, Ault K, JacksonCW, Orkin SH, Shivdasani RA. Consequences of GATA-1 deficiency in megakaryocytes and platelets. Blood. 1999; 93(9):2867-2875. (Pubitemid 29200777)
22. Xu G, Nagano M, Kanezaki R, et al. Frequent mutations in the GATA-1 gene in the transient myeloproliferative disorder of Down syndrome. Blood. 2003;102(8):2960-2968. (Pubitemid 37248871)
23. Del Vecchio GC, Giordani L, De Santis A, De Mattia D. Dyserythropoietic anemia and thrombocytopenia due to a novel mutation in GATA-1. Acta Haematol. 2005;114(2):113-116. (Pubitemid 41160941)
24. Nichols KE, Crispino JD, Poncz M, et al. Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1. Nat Genet. 2000;24(3):266-270. (Pubitemid 30132195)
25. Gregory T, Yu C, Ma A, Orkin SH, Blobel GA, Weiss MJ. GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-xL expression. Blood. 1999;94(1):87-96. (Pubitemid 29300137)
26. Socolovsky M, Fallon AE,Wang S, Brugnara C, Lodish HF. Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction. Cell. 1999;98(2):181-191.
27. Garrido C, Brunet M, Didelot C, Zermati Y, Schmitt E, Kroemer G. Heat shock proteins 27 and 70: anti-apoptotic proteins with tumorigenic properties. Cell Cycle. 2006;5(22):2592-2601. (Pubitemid 44785803)
28. Vasikova A, Belickova M, Budinska E, Cermak J. A distinct expression of various gene subsets in CD34+ cells from patients with early and advanced myelodysplastic syndrome. Leuk Res. 2010;34(12):1566-1572.
29. Duval A, Olaru D, Campos L, Flandrin P, Nadal N, Guyotat D. Expression and prognostic significance of heat-shock proteins in myelodysplastic syndromes. Haematologica. 2006;91(5):713-714. (Pubitemid 43799480)
30. Chu A, Matusiewicz N, Stochaj U. Heat-induced nuclear accumulation of hsc70s is regulated by phosphorylation and inhibited in confluent cells. FASEB J. 2001;15(8):1478-1480.
31. Claessens Y-E, Park S, Dubart-Kupperschmitt A, et al. Rescue of early-stage myelodysplastic syndrome- deriving erythroid precursors by the ectopic expression of a dominant-negative form of FADD. Blood. 2005;105(10):4035-4042. (Pubitemid 40656153)
32. Frisan E, Pawlikowska P, Pierre-Eugène C, et al. p-ERK1/2 is a predictive factor of response to erythropoiesis-stimulating agents in low/int-1 myelodysplastic syndromes. Haematologica. 2010; 95(11):1964-1968.