-
1
-
-
0037071383
-
Transcriptional regulation of erythropoiesis: An affair involving multiple partners
-
Cantor AB, Orkin SH. Transcriptional regulation of erythropoiesis: an affair involving multiple partners. Oncogene. 2002;21:3368-3376.
-
(2002)
Oncogene
, vol.21
, pp. 3368-3376
-
-
Cantor, A.B.1
Orkin, S.H.2
-
2
-
-
14744299761
-
Turning cells red: Signal transduction mediated by erythropoietin
-
Richmond TD, Chohan M, Barber DL. Turning cells red: signal transduction mediated by erythropoietin. Trends Cell Biol. 2005;15:146-155.
-
(2005)
Trends Cell Biol
, vol.15
, pp. 146-155
-
-
Richmond, T.D.1
Chohan, M.2
Barber, D.L.3
-
3
-
-
0030980933
-
Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors
-
Klingmuller U, Wu H, Hsiao JG, et al. Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. Proc Natl Acad Sci U S A. 1997;94:3016-3021.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 3016-3021
-
-
Klingmuller, U.1
Wu, H.2
Hsiao, J.G.3
-
4
-
-
3042794598
-
Erythropoietin regulation of Raf-1 and MEK: Evidence for a Ras-independent mechanism
-
Chen C, Sytkowski AJ. Erythropoietin regulation of Raf-1 and MEK: evidence for a Ras-independent mechanism. Blood. 2004;104:73-80.
-
(2004)
Blood
, vol.104
, pp. 73-80
-
-
Chen, C.1
Sytkowski, A.J.2
-
5
-
-
0034602388
-
Protein kinase C alpha controls erythropoietin receptor signaling
-
von Lindern M, Parren-van Amelsvoort M, van Dijk T, et al. Protein kinase C alpha controls erythropoietin receptor signaling. J Biol Chem. 2000; 275:34719-34727.
-
(2000)
J Biol Chem
, vol.275
, pp. 34719-34727
-
-
von Lindern, M.1
Parren-van Amelsvoort, M.2
van Dijk, T.3
-
6
-
-
8644289352
-
Erythropoietin-modulated calcium influx through TRPC2 is mediated by phospholipase Cgamma and IP3R
-
Tong Q, Chu X, Cheung JY, et al. Erythropoietin-modulated calcium influx through TRPC2 is mediated by phospholipase Cgamma and IP3R. Am J Physiol Cell Physiol. 2004;287:C1667-C1678.
-
(2004)
Am J Physiol Cell Physiol
, vol.287
-
-
Tong, Q.1
Chu, X.2
Cheung, J.Y.3
-
7
-
-
0000943469
-
Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses
-
Teglund S, McKay C, Schuetz E, et al. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell. 1998;93:841-850.
-
(1998)
Cell
, vol.93
, pp. 841-850
-
-
Teglund, S.1
McKay, C.2
Schuetz, E.3
-
8
-
-
4444268818
-
Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation
-
Cui Y, Riedlinger G, Miyoshi K, et al. Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation. Mol Cell Biol. 2004;24:8037-8047.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 8037-8047
-
-
Cui, Y.1
Riedlinger, G.2
Miyoshi, K.3
-
10
-
-
8644219660
-
c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation
-
Wilson A, Murphy MJ, Oskarsson T, et al. c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. Genes Dev. 2004;18:2747-2763.
-
(2004)
Genes Dev
, vol.18
, pp. 2747-2763
-
-
Wilson, A.1
Murphy, M.J.2
Oskarsson, T.3
-
11
-
-
0033635616
-
Conditional deletion of the Bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly
-
Wagner KU, Claudio E, Rucker EB 3rd, et al. Conditional deletion of the Bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly. Development. 2000;127: 4949-4958.
-
(2000)
Development
, vol.127
, pp. 4949-4958
-
-
Wagner, K.U.1
Claudio, E.2
Rucker 3rd, E.B.3
-
12
-
-
0034703097
-
CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2
-
Sasaki A, Yasukawa H, Shouda T, Kitamura T, Dikic I, Yoshimura A. CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2. J Biol Chem. 2000;275: 29338-29347.
-
(2000)
J Biol Chem
, vol.275
, pp. 29338-29347
-
-
Sasaki, A.1
Yasukawa, H.2
Shouda, T.3
Kitamura, T.4
Dikic, I.5
Yoshimura, A.6
-
13
-
-
4444307411
-
Mouse development and cell proliferation in the absence of D-cyclins
-
Kozar K, Ciemerych MA, Rebel VI, et al. Mouse development and cell proliferation in the absence of D-cyclins. Cell. 2004;118:477-491.
-
(2004)
Cell
, vol.118
, pp. 477-491
-
-
Kozar, K.1
Ciemerych, M.A.2
Rebel, V.I.3
-
14
-
-
19944431828
-
Stat5 tetramer formation is associated with leukemogenesis
-
Moriggl R, Sexl V, Kenner L, et al. Stat5 tetramer formation is associated with leukemogenesis. Cancer Cell. 2005;7:87-99.
-
(2005)
Cancer Cell
, vol.7
, pp. 87-99
-
-
Moriggl, R.1
Sexl, V.2
Kenner, L.3
-
15
-
-
33644647514
-
Signals for stress erythropoiesis are integrated via an erythropoietin receptor-phosphotyrosine-343-Stat5 axis
-
Menon MP, Karur V, Bogacheva O, Bogachev O, Cuetara B, Wojchowski DM. Signals for stress erythropoiesis are integrated via an erythropoietin receptor-phosphotyrosine-343-Stat5 axis. J Clin Invest. 2006;116:683-694.
-
(2006)
J Clin Invest
, vol.116
, pp. 683-694
-
-
Menon, M.P.1
Karur, V.2
Bogacheva, O.3
Bogachev, O.4
Cuetara, B.5
Wojchowski, D.M.6
-
16
-
-
0028880455
-
Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor
-
Wu H, Liu X, Jaenisch R, Lodish HF. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell. 1995;83:59-67.
-
(1995)
Cell
, vol.83
, pp. 59-67
-
-
Wu, H.1
Liu, X.2
Jaenisch, R.3
Lodish, H.F.4
-
17
-
-
0032076542
-
Jak2 is essential for signaling through a variety of cytokine receptors
-
Parganas E, Wang D, Stravopodis D, et al. Jak2 is essential for signaling through a variety of cytokine receptors. Cell. 1998;93:385-395.
-
(1998)
Cell
, vol.93
, pp. 385-395
-
-
Parganas, E.1
Wang, D.2
Stravopodis, D.3
-
18
-
-
18244432009
-
Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
-
Neubauer H, Cumano A, Muller M, Wu H, Huffstadt U, Pfeffer K. Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell. 1998;93:397-409.
-
(1998)
Cell
, vol.93
, pp. 397-409
-
-
Neubauer, H.1
Cumano, A.2
Muller, M.3
Wu, H.4
Huffstadt, U.5
Pfeffer, K.6
-
19
-
-
33645525963
-
Core erythropoietin receptor signals for late erythroblast development
-
Menon MP, Fang J, Wojchowski DM. Core erythropoietin receptor signals for late erythroblast development. Blood. 2006;107:2662-2672.
-
(2006)
Blood
, vol.107
, pp. 2662-2672
-
-
Menon, M.P.1
Fang, J.2
Wojchowski, D.M.3
-
20
-
-
0033597715
-
Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: A direct role for Stat5 in Bcl-X(L) in-duction
-
Socolovsky M, Fallon AE, Wang S, Brugnara C, Lodish HF. Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) in-duction. Cell. 1999;98:181-191.
-
(1999)
Cell
, vol.98
, pp. 181-191
-
-
Socolovsky, M.1
Fallon, A.E.2
Wang, S.3
Brugnara, C.4
Lodish, H.F.5
-
21
-
-
0035760889
-
Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythro-blasts
-
Socolovsky M, Nam H, Fleming MD, Haase VH, Brugnara C, Lodish HF. Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythro-blasts. Blood. 2001;98: 3261-3273.
-
(2001)
Blood
, vol.98
, pp. 3261-3273
-
-
Socolovsky, M.1
Nam, H.2
Fleming, M.D.3
Haase, V.H.4
Brugnara, C.5
Lodish, H.F.6
-
22
-
-
33646696616
-
Erythroid progenitor renewal versus differentiation: Genetic evidence for cell autonomous, essential functions of EpoR, Stat5 and the GR
-
Dolznig H, Grebien F, Deiner EM, et al. Erythroid progenitor renewal versus differentiation: genetic evidence for cell autonomous, essential functions of EpoR, Stat5 and the GR. Oncogene. 2006;25: 2890-2900.
-
(2006)
Oncogene
, vol.25
, pp. 2890-2900
-
-
Dolznig, H.1
Grebien, F.2
Deiner, E.M.3
-
23
-
-
33745111882
-
Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation
-
Hoelbl A, Kovacic B, Kerenyi MA, et al. Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation. Blood. 2006; 107:4898-4906.
-
(2006)
Blood
, vol.107
, pp. 4898-4906
-
-
Hoelbl, A.1
Kovacic, B.2
Kerenyi, M.A.3
-
24
-
-
32244444750
-
Stat5a/b are essential for normal lymphoid development and differentiation
-
Yao Z, Cui Y, Watford WT, et al. Stat5a/b are essential for normal lymphoid development and differentiation. Proc Natl Acad Sci U S A. 2006;103: 1000-1005.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 1000-1005
-
-
Yao, Z.1
Cui, Y.2
Watford, W.T.3
-
25
-
-
34249070257
-
Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression
-
Engblom D, Kornfeld JW, Schwake L, et al. Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression. Genes Dev. 2007;21:1157-1162.
-
(2007)
Genes Dev
, vol.21
, pp. 1157-1162
-
-
Engblom, D.1
Kornfeld, J.W.2
Schwake, L.3
-
26
-
-
34247564147
-
Nonredundant roles for Stat5a/b in directly regulating Foxp3
-
Yao Z, Kanno Y, Kerenyi M, et al. Nonredundant roles for Stat5a/b in directly regulating Foxp3. Blood. 2007;109:4368-4375.
-
(2007)
Blood
, vol.109
, pp. 4368-4375
-
-
Yao, Z.1
Kanno, Y.2
Kerenyi, M.3
-
27
-
-
4143051431
-
Transferrin receptor 1
-
Aisen P. Transferrin receptor 1. Int J Biochem Cell Biol. 2004;36:2137-2143.
-
(2004)
Int J Biochem Cell Biol
, vol.36
, pp. 2137-2143
-
-
Aisen, P.1
-
28
-
-
0024276911
-
A stem-loop in the 3′ untranslated region mediates iron-dependent regulation of transferrin receptor mRNA stability in the cytoplasm
-
Mullner EW, Kuhn LC. A stem-loop in the 3′ untranslated region mediates iron-dependent regulation of transferrin receptor mRNA stability in the cytoplasm. Cell. 1988;53:815-825.
-
(1988)
Cell
, vol.53
, pp. 815-825
-
-
Mullner, E.W.1
Kuhn, L.C.2
-
29
-
-
0028269856
-
Regulation of transferrin receptor mRNA expression. Distinct regulatory features in erythroid cells
-
Chan RY, Seiser C, Schulman HM, Kuhn LC, Ponka P. Regulation of transferrin receptor mRNA expression. Distinct regulatory features in erythroid cells. Eur J Biochem. 1994;220:683-692.
-
(1994)
Eur J Biochem
, vol.220
, pp. 683-692
-
-
Chan, R.Y.1
Seiser, C.2
Schulman, H.M.3
Kuhn, L.C.4
Ponka, P.5
-
30
-
-
2042546096
-
Balancing acts: Molecular control of mammalian iron metabolism
-
Hentze MW, Muckenthaler MU, Andrews NC. Balancing acts: molecular control of mammalian iron metabolism. Cell. 2004;117:285-297.
-
(2004)
Cell
, vol.117
, pp. 285-297
-
-
Hentze, M.W.1
Muckenthaler, M.U.2
Andrews, N.C.3
-
31
-
-
33746361251
-
The role of iron regulatory proteins in mammalian iron homeostasis and disease
-
Rouault TA. The role of iron regulatory proteins in mammalian iron homeostasis and disease. Nat Chem Biol. 2006;2:406-414.
-
(2006)
Nat Chem Biol
, vol.2
, pp. 406-414
-
-
Rouault, T.A.1
-
32
-
-
1842608845
-
Iron metabolism and the IRE/IRP regulatory system: An update
-
Pantopoulos K. Iron metabolism and the IRE/IRP regulatory system: an update. Ann N Y Acad Sci. 2004;1012:1-13.
-
(2004)
Ann N Y Acad Sci
, vol.1012
, pp. 1-13
-
-
Pantopoulos, K.1
-
33
-
-
0027050315
-
Cellular regulation of the iron-responsive element binding protein: Disassembly of the cubane iron-sulfur cluster results in high-affinity RNA binding
-
Haile DJ, Rouault TA, Harford JB, et al. Cellular regulation of the iron-responsive element binding protein: disassembly of the cubane iron-sulfur cluster results in high-affinity RNA binding. Proc Natl Acad Sci U S A. 1992;89:11735-11739.
-
(1992)
Proc Natl Acad Sci U S A
, vol.89
, pp. 11735-11739
-
-
Haile, D.J.1
Rouault, T.A.2
Harford, J.B.3
-
34
-
-
0028982262
-
Iron regulates the intracellular degradation of iron regulatory protein 2 by the proteasome
-
Guo B, Phillips JD, Yu Y, Leibold EA. Iron regulates the intracellular degradation of iron regulatory protein 2 by the proteasome. J Biol Chem. 1995;270:21645-21651.
-
(1995)
J Biol Chem
, vol.270
, pp. 21645-21651
-
-
Guo, B.1
Phillips, J.D.2
Yu, Y.3
Leibold, E.A.4
-
35
-
-
0024669905
-
A cytosolic protein binds to structural elements within the iron regulatory region of the transferrin receptor mRNA
-
Koeller DM, Casey JL, Hentze MW, et al. A cytosolic protein binds to structural elements within the iron regulatory region of the transferrin receptor mRNA. Proc Natl Acad Sci U S A. 1989;86: 3574-3578.
-
(1989)
Proc Natl Acad Sci U S A
, vol.86
, pp. 3574-3578
-
-
Koeller, D.M.1
Casey, J.L.2
Hentze, M.W.3
-
36
-
-
0028266818
-
Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3 UTR and does not involve poly(A) tail shortening
-
Binder R, Horowitz JA, Basilion JP, Koeller DM, Klausner RD, Harford JB. Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3 UTR and does not involve poly(A) tail shortening. EMBO J. 1994;13:1969-1980.
-
(1994)
EMBO J
, vol.13
, pp. 1969-1980
-
-
Binder, R.1
Horowitz, J.A.2
Basilion, J.P.3
Koeller, D.M.4
Klausner, R.D.5
Harford, J.B.6
-
37
-
-
0024365045
-
A specific mRNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA
-
Mullner EW, Neupert B, Kuhn LC. A specific mRNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA. Cell. 1989;58:373-382.
-
(1989)
Cell
, vol.58
, pp. 373-382
-
-
Mullner, E.W.1
Neupert, B.2
Kuhn, L.C.3
-
38
-
-
27144467097
-
Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)
-
Galy B, Ferring D, Minana B, et al. Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2). Blood. 2005; 106:2580-2589.
-
(2005)
Blood
, vol.106
, pp. 2580-2589
-
-
Galy, B.1
Ferring, D.2
Minana, B.3
-
39
-
-
23044503950
-
Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2
-
Cooperman SS, Meyron-Holtz EG, Olivierre-Wilson H, Ghosh MC, McConnell JP, Rouault TA. Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2. Blood. 2005; 106:1084-1091.
-
(2005)
Blood
, vol.106
, pp. 1084-1091
-
-
Cooperman, S.S.1
Meyron-Holtz, E.G.2
Olivierre-Wilson, H.3
Ghosh, M.C.4
McConnell, J.P.5
Rouault, T.A.6
-
40
-
-
47149112573
-
Stat5 activation enables erythropoiesis in the absence of EpoR and Jak2
-
Grebien F, Kerenyi MA, Kovacic B, et al. Stat5 activation enables erythropoiesis in the absence of EpoR and Jak2. Blood. 2008;111:4511-4522.
-
(2008)
Blood
, vol.111
, pp. 4511-4522
-
-
Grebien, F.1
Kerenyi, M.A.2
Kovacic, B.3
-
41
-
-
0027772892
-
Iron-responsive element-binding protein. Phosphorylation by protein kinase C
-
Eisenstein RS, Tuazon PT, Schalinske KL, Anderson SA, Traugh JA. Iron-responsive element-binding protein. Phosphorylation by protein kinase C. J Biol Chem. 1993;268:27363-27370.
-
(1993)
J Biol Chem
, vol.268
, pp. 27363-27370
-
-
Eisenstein, R.S.1
Tuazon, P.T.2
Schalinske, K.L.3
Anderson, S.A.4
Traugh, J.A.5
-
42
-
-
13644260809
-
Evaluation of genomewide chromatin library of Stat5 binding sites in human breast cancer
-
LeBaron MJ, Xie J, Rui H. Evaluation of genomewide chromatin library of Stat5 binding sites in human breast cancer. Mol Cancer. 2005;4:6.
-
(2005)
Mol Cancer
, vol.4
, pp. 6
-
-
LeBaron, M.J.1
Xie, J.2
Rui, H.3
-
43
-
-
0035710746
-
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
-
Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25:402-408.
-
(2001)
Methods
, vol.25
, pp. 402-408
-
-
Livak, K.J.1
Schmittgen, T.D.2
-
44
-
-
33847796951
-
Acute postnatal ablation of Hif2alpha results in anemia
-
Gruber M, Hu CJ, Johnson RS, Brown EJ, Keith B, Simon MC. Acute postnatal ablation of Hif2alpha results in anemia. Proc Natl Acad Sci U S A. 2007;104:2301-2306.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 2301-2306
-
-
Gruber, M.1
Hu, C.J.2
Johnson, R.S.3
Brown, E.J.4
Keith, B.5
Simon, M.C.6
-
45
-
-
0036098153
-
STAT5 promotes multilineage hematolymphoid development in vivo through effects on early hematopoietic progenitor cells
-
Snow JW, Abraham N, Ma MC, Abbey NW, Herndier B, Goldsmith MA. STAT5 promotes multilineage hematolymphoid development in vivo through effects on early hematopoietic progenitor cells. Blood. 2002;99:95-101.
-
(2002)
Blood
, vol.99
, pp. 95-101
-
-
Snow, J.W.1
Abraham, N.2
Ma, M.C.3
Abbey, N.W.4
Herndier, B.5
Goldsmith, M.A.6
-
46
-
-
0037079697
-
Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5
-
Bunting KD, Bradley HL, Hawley TS, Moriggl R, Sorrentino BP, Ihle JN. Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5. Blood. 2002;99:479-487.
-
(2002)
Blood
, vol.99
, pp. 479-487
-
-
Bunting, K.D.1
Bradley, H.L.2
Hawley, T.S.3
Moriggl, R.4
Sorrentino, B.P.5
Ihle, J.N.6
-
47
-
-
34248230733
-
Differential regulation of Foxo3a target genes in erythropoiesis
-
Bakker WJ, van Dijk TB, Parren-van Amelsvoort M, et al. Differential regulation of Foxo3a target genes in erythropoiesis. Mol Cell Biol. 2007;27: 3839-3854.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 3839-3854
-
-
Bakker, W.J.1
van Dijk, T.B.2
Parren-van Amelsvoort, M.3
-
48
-
-
4444343392
-
Directed differentiation and mass cultivation of pure erythroid progenitors from mouse embryonic stem cells
-
Carotta S, Pilat S, Mairhofer A, et al. Directed differentiation and mass cultivation of pure erythroid progenitors from mouse embryonic stem cells. Blood. 2004;104:1873-1880.
-
(2004)
Blood
, vol.104
, pp. 1873-1880
-
-
Carotta, S.1
Pilat, S.2
Mairhofer, A.3
-
49
-
-
0033866047
-
Differential expression of bcl-2 homologs in human CD34(+) hematopoietic progenitor cells induced to differentiate into erythroid or granulocytic cells
-
Josefsen D, Myklebust JH, Lomo J, Sioud M, Blomhoff HK, Smeland EB. Differential expression of bcl-2 homologs in human CD34(+) hematopoietic progenitor cells induced to differentiate into erythroid or granulocytic cells. Stem Cells. 2000;18:261-272.
-
(2000)
Stem Cells
, vol.18
, pp. 261-272
-
-
Josefsen, D.1
Myklebust, J.H.2
Lomo, J.3
Sioud, M.4
Blomhoff, H.K.5
Smeland, E.B.6
-
50
-
-
13844319184
-
Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells
-
Opferman JT, Iwasaki H, Ong CC, et al. Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells. Science. 2005;307:1101-1104.
-
(2005)
Science
, vol.307
, pp. 1101-1104
-
-
Opferman, J.T.1
Iwasaki, H.2
Ong, C.C.3
-
51
-
-
0037069942
-
Inhibition of Bcr-Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells
-
Huang M, Dorsey JF, Epling-Burnette PK, et al. Inhibition of Bcr-Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells. Oncogene. 2002;21:8804-8816.
-
(2002)
Oncogene
, vol.21
, pp. 8804-8816
-
-
Huang, M.1
Dorsey, J.F.2
Epling-Burnette, P.K.3
-
52
-
-
0348148880
-
Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1
-
Opferman JT, Letai A, Beard C, Sorcinelli MD, Ong CC, Korsmeyer SJ. Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature. 2003;426:671-676.
-
(2003)
Nature
, vol.426
, pp. 671-676
-
-
Opferman, J.T.1
Letai, A.2
Beard, C.3
Sorcinelli, M.D.4
Ong, C.C.5
Korsmeyer, S.J.6
-
53
-
-
20144388297
-
Identification of mcl-1 as a BCR/ABL-dependent target in chronic myeloid leukemia (CML): Evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotides
-
Aichberger KJ, Mayerhofer M, Krauth MT, et al. Identification of mcl-1 as a BCR/ABL-dependent target in chronic myeloid leukemia (CML): evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotides. Blood. 2005;105:3303-3311.
-
(2005)
Blood
, vol.105
, pp. 3303-3311
-
-
Aichberger, K.J.1
Mayerhofer, M.2
Krauth, M.T.3
-
54
-
-
0033082138
-
Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells
-
Moriggl R, Topham DJ, Teglund S, et al. Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity. 1999;10:249-259.
-
(1999)
Immunity
, vol.10
, pp. 249-259
-
-
Moriggl, R.1
Topham, D.J.2
Teglund, S.3
-
55
-
-
34948895031
-
EPO modulation of cell cycle regulatory genes, and cell division, division, in primary bone marrow erythroblasts
-
Fang J, Menon M, Kapelle W, et al. EPO modulation of cell cycle regulatory genes, and cell division, division, in primary bone marrow erythroblasts. Blood. 2007;110:2361-2370.
-
(2007)
Blood
, vol.110
, pp. 2361-2370
-
-
Fang, J.1
Menon, M.2
Kapelle, W.3
-
56
-
-
0034624828
-
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
-
Akashi K, Traver D, Miyamoto T, Weissman IL. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature. 2000;404: 193-197.
-
(2000)
Nature
, vol.404
, pp. 193-197
-
-
Akashi, K.1
Traver, D.2
Miyamoto, T.3
Weissman, I.L.4
-
57
-
-
0035437127
-
Fetal liver myelopoiesis occurs through distinct, prospectively isolatable progenitor subsets
-
Traver D, Miyamoto T, Christensen J, Iwasaki-Arai J, Akashi K, Weissman IL. Fetal liver myelopoiesis occurs through distinct, prospectively isolatable progenitor subsets. Blood. 2001;98:627-635.
-
(2001)
Blood
, vol.98
, pp. 627-635
-
-
Traver, D.1
Miyamoto, T.2
Christensen, J.3
Iwasaki-Arai, J.4
Akashi, K.5
Weissman, I.L.6
-
58
-
-
0344826470
-
Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: Functional analysis by a flow cytometry-based novel culture system
-
Zhang J, Socolovsky M, Gross AW, Lodish HF. Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry-based novel culture system. Blood. 2003;102:3938-3946.
-
(2003)
Blood
, vol.102
, pp. 3938-3946
-
-
Zhang, J.1
Socolovsky, M.2
Gross, A.W.3
Lodish, H.F.4
-
59
-
-
52649091181
-
Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression
-
Zhu BM, McLaughlin SK, Na R, et al. Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression. Blood. 2008;112;2071-2080.
-
(2008)
Blood
, vol.112
, pp. 2071-2080
-
-
Zhu, B.M.1
McLaughlin, S.K.2
Na, R.3
-
60
-
-
3142722152
-
The heme synthesis defect of mutants impaired in mitochondrial iron-sulfur protein biogenesis is caused by reversible inhibition of ferrochelatase
-
Lange H, Muhlenhoff U, Denzel M, Kispal G, Lill R. The heme synthesis defect of mutants impaired in mitochondrial iron-sulfur protein biogenesis is caused by reversible inhibition of ferrochelatase. J Biol Chem. 2004;279:29101-29108.
-
(2004)
J Biol Chem
, vol.279
, pp. 29101-29108
-
-
Lange, H.1
Muhlenhoff, U.2
Denzel, M.3
Kispal, G.4
Lill, R.5
-
61
-
-
33947584856
-
Regulation of protein synthesis by the heme-regulated eIF2alpha kinase: Relevance to anemias
-
Chen JJ. Regulation of protein synthesis by the heme-regulated eIF2alpha kinase: relevance to anemias. Blood. 2007;109:2693-2699.
-
(2007)
Blood
, vol.109
, pp. 2693-2699
-
-
Chen, J.J.1
-
62
-
-
0031018874
-
Regulation of cellular iron metabolism by erythropoietin: Activation of iron-regulatory protein and upregulation of transferrin receptor expression in erythroid cells
-
Weiss G, Houston T, Kastner S, Johrer K, Grunewald K, Brock JH. Regulation of cellular iron metabolism by erythropoietin: activation of iron-regulatory protein and upregulation of transferrin receptor expression in erythroid cells. Blood. 1997;89:680-687.
-
(1997)
Blood
, vol.89
, pp. 680-687
-
-
Weiss, G.1
Houston, T.2
Kastner, S.3
Johrer, K.4
Grunewald, K.5
Brock, J.H.6
-
63
-
-
0033724650
-
Mechanisms of differential transferrin receptor expression in normal hematopoiesis
-
Sposi NM, Cianetti L, Tritarelli E, et al. Mechanisms of differential transferrin receptor expression in normal hematopoiesis. Eur J Biochem. 2000;267:6762-6774.
-
(2000)
Eur J Biochem
, vol.267
, pp. 6762-6774
-
-
Sposi, N.M.1
Cianetti, L.2
Tritarelli, E.3
-
64
-
-
33646548593
-
Remodeling the regulation of iron metabolism during erythroid differentiation to ensure efficient heme biosynthesis
-
Schranzhofer M, Schifrer M, Cabrera JA, et al. Remodeling the regulation of iron metabolism during erythroid differentiation to ensure efficient heme biosynthesis. Blood. 2006;107:4159-4167.
-
(2006)
Blood
, vol.107
, pp. 4159-4167
-
-
Schranzhofer, M.1
Schifrer, M.2
Cabrera, J.A.3
-
65
-
-
0035794217
-
DNA binding specificity of different STAT proteins: Comparison of in vitro specificity with natural target sites
-
Ehret GB, Reichenbach P, Schindler U, et al. DNA binding specificity of different STAT proteins: comparison of in vitro specificity with natural target sites. J Biol Chem. 2001;276:6675-6688.
-
(2001)
J Biol Chem
, vol.276
, pp. 6675-6688
-
-
Ehret, G.B.1
Reichenbach, P.2
Schindler, U.3
-
66
-
-
34548807675
-
Stat5 is essential for early B cell development but not for B cell maturation and function
-
Dai X, Chen Y, Di L, et al. Stat5 is essential for early B cell development but not for B cell maturation and function. J Immunol. 2007;179:1068-1079.
-
(2007)
J Immunol
, vol.179
, pp. 1068-1079
-
-
Dai, X.1
Chen, Y.2
Di, L.3
-
67
-
-
34548321210
-
Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration
-
Cui Y, Hosui A, Sun R, et al. Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration. Hepatology. 2007;46:504-513.
-
(2007)
Hepatology
, vol.46
, pp. 504-513
-
-
Cui, Y.1
Hosui, A.2
Sun, R.3
-
68
-
-
34548488987
-
The transcription factors Stat5a/b are not required for islet development but modulate pancreatic beta-cell physiology upon aging
-
Lee JY, Gavrilova O, Davani B, Na R, Robinson GW, Hennighausen L. The transcription factors Stat5a/b are not required for islet development but modulate pancreatic beta-cell physiology upon aging. Biochim Biophys Acta. 2007;1773: 1455-1461.
-
(2007)
Biochim Biophys Acta
, vol.1773
, pp. 1455-1461
-
-
Lee, J.Y.1
Gavrilova, O.2
Davani, B.3
Na, R.4
Robinson, G.W.5
Hennighausen, L.6
-
69
-
-
33947362429
-
Postnatal body growth is dependent on the transcription factors signal transducers and activators of transcription 5a/b in muscle: A role for autocrine/paracrine insulin-like growth factor I
-
Klover P, Hennighausen L. Postnatal body growth is dependent on the transcription factors signal transducers and activators of transcription 5a/b in muscle: a role for autocrine/paracrine insulin-like growth factor I. Endocrinology. 2007;148:1489-1497.
-
(2007)
Endocrinology
, vol.148
, pp. 1489-1497
-
-
Klover, P.1
Hennighausen, L.2
-
70
-
-
49049110327
-
Genomic dissection of the cytokine controlled STAT5 signaling network in liver
-
Hosui A, Hennighausen L. Genomic dissection of the cytokine controlled STAT5 signaling network in liver. Physiol Genomics. 2008;34:135-143.
-
(2008)
Physiol Genomics
, vol.34
, pp. 135-143
-
-
Hosui, A.1
Hennighausen, L.2
-
71
-
-
41149149301
-
Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B
-
Hennighausen L, Robinson GW. Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B. Genes Dev. 2008;22: 711-721.
-
(2008)
Genes Dev
, vol.22
, pp. 711-721
-
-
Hennighausen, L.1
Robinson, G.W.2
-
72
-
-
20444464807
-
Heme-regulated eIF2alpha kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and beta-thalassemia
-
Han AP, Fleming MD, Chen JJ. Heme-regulated eIF2alpha kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and beta-thalassemia. J Clin Invest. 2005; 115:1562-1570.
-
(2005)
J Clin Invest
, vol.115
, pp. 1562-1570
-
-
Han, A.P.1
Fleming, M.D.2
Chen, J.J.3
-
73
-
-
0032959574
-
Transferrin receptor is necessary for development of erythrocytes and the nervous system
-
Levy JE, Jin O, Fujiwara Y, Kuo F, Andrews NC. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nat Genet. 1999;21:396-399.
-
(1999)
Nat Genet
, vol.21
, pp. 396-399
-
-
Levy, J.E.1
Jin, O.2
Fujiwara, Y.3
Kuo, F.4
Andrews, N.C.5
-
74
-
-
34548594676
-
Hepcidin and its role in regulating systemic iron metabolism
-
Ganz T. Hepcidin and its role in regulating systemic iron metabolism. Hematology Am Soc Hematol Educ Program. 2006:29-35, 507.
-
(2006)
Hematology Am Soc Hematol Educ Program
, pp. 29-35
-
-
Ganz, T.1
-
75
-
-
33751175421
-
Interleukin-6 induces hepcidin expression through STAT3
-
Wrighting DM, Andrews NC. Interleukin-6 induces hepcidin expression through STAT3. Blood. 2006; 108:3204-3209.
-
(2006)
Blood
, vol.108
, pp. 3204-3209
-
-
Wrighting, D.M.1
Andrews, N.C.2
-
76
-
-
47049116150
-
Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalpha
-
Pinto JP, Ribeiro S, Pontes H, et al. Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalpha. Blood. 2008;111:5727-5733.
-
(2008)
Blood
, vol.111
, pp. 5727-5733
-
-
Pinto, J.P.1
Ribeiro, S.2
Pontes, H.3
-
77
-
-
23944463463
-
Bcl-x(L) prevents apoptosis of late-stage erythroblasts but does not mediate the antiapoptotic effect of erythropoietin
-
Rhodes MM, Kopsombut P, Bondurant MC, Price JO, Koury MJ. Bcl-x(L) prevents apoptosis of late-stage erythroblasts but does not mediate the antiapoptotic effect of erythropoietin. Blood. 2005; 106:1857-1863.
-
(2005)
Blood
, vol.106
, pp. 1857-1863
-
-
Rhodes, M.M.1
Kopsombut, P.2
Bondurant, M.C.3
Price, J.O.4
Koury, M.J.5
-
78
-
-
0036554816
-
Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention
-
Buettner R, Mora LB, Jove R. Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin Cancer Res. 2002;8:945-954.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 945-954
-
-
Buettner, R.1
Mora, L.B.2
Jove, R.3
-
79
-
-
34547949167
-
Translational repression of MCL-1 couples stress-induced eIF2alpha phosphorylation to mitochondrial apoptosis initiation
-
Fritsch RM, Schneider G, Saur D, Scheibel M, Schmid RM. Translational repression of MCL-1 couples stress-induced eIF2alpha phosphorylation to mitochondrial apoptosis initiation. J Biol Chem. 2007;282:22551-22562.
-
(2007)
J Biol Chem
, vol.282
, pp. 22551-22562
-
-
Fritsch, R.M.1
Schneider, G.2
Saur, D.3
Scheibel, M.4
Schmid, R.M.5
-
80
-
-
34547197343
-
The kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress
-
Rahmani M, Davis EM, Crabtree TR, et al. The kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress. Mol Cell Biol. 2007;27: 5499-5513.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 5499-5513
-
-
Rahmani, M.1
Davis, E.M.2
Crabtree, T.R.3
-
81
-
-
0042664038
-
Transcriptional and translational control of Mcl-1 during apoptosis
-
Iglesias-Serret D, Pique M, Gil J, Pons G, Lopez JM. Transcriptional and translational control of Mcl-1 during apoptosis. Arch Biochem Biophys. 2003;417:141-152.
-
(2003)
Arch Biochem Biophys
, vol.417
, pp. 141-152
-
-
Iglesias-Serret, D.1
Pique, M.2
Gil, J.3
Pons, G.4
Lopez, J.M.5
|