Growth differentiation factor 15 production is necessary for normal erythroid differentiation and is increased in refractory anaemia with ring-sideroblasts

British Journal of Haematology

Volumn 144, Issue 2, 2009, Pages 251-262

  Ramirez, Jean Marie ^a   Schaad, Olivier ^b   Durual, Stephane ^a   Cossali, Dominique ^a   Docquier, Mylène ^b   Beris, Photis ^a   Descombes, Patrick ^b   Matthes, Thomas ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Apoptosis; Erythropoiesis; Gene expression; Growth differentiation factor 15; Sideroblastic anaemia

Indexed keywords

ARSENIC TRIOXIDE; ERYTHROPOIETIN; GROWTH DIFFERENTIATION FACTOR 15; SMALL INTERFERING RNA;

ADULT; AGED; ARTICLE; CELL DEATH; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; ERYTHROID CELL; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REFRACTORY ANEMIA; SIDEROBLASTIC ANEMIA;

AGED; AGED, 80 AND OVER; ANEMIA, REFRACTORY; ANEMIA, SIDEROBLASTIC; CASE-CONTROL STUDIES; CELL DIFFERENTIATION; CELL SEPARATION; ERYTHROID PRECURSOR CELLS; ERYTHROPOIESIS; GENE EXPRESSION PROFILING; GROWTH DIFFERENTIATION FACTOR 15; HUMANS; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS;

EID: 58149092194     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2008.07441.x     Document Type: Article

References (36)

1. Alcindor, T. Bridges, K.R. (2002) Sideroblastic anaemias. British Journal Haematology, 116, 733 743.
2. Baek, S.J., Kim, J.S., Moore, S.M., Lee, S.H., Martinez, J. Eling, T.E. (2005) Cyclooxygenase inhibitors induce the expression of the tumor suppressor gene EGR-1, which results in the up-regulation of NAG-1, an antitumorigenic protein. Molecular Pharmacology, 67, 356 364.
3. Bauskin, A.R., Brown, D.A., Kuffner, T., Johnen, H., Luo, X.W., Hunter, M. Breit, S.N. (2006) Role of macrophage inhibitory cytokine-1 in tumorigenesis and diagnosis of cancer. Cancer Research, 66, 4983 4986.
4. Bennett, B.D., Solar, G.P., Yuan, J.Q., Mathias, J., Thomas, G.R. Matthews, W. (1996) A role for leptin and its cognate receptor in hematopoiesis. Current Biology, 6, 1170 1180.
5. Bolstad, B.M., Irizarry, R.A., Astrand, M. Speed, T.P. (2003) A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics, 19, 185 193.
6. Brown, D.A., Ward, R.L., Buckhaults, P., Liu, T., Romans, K.E., Hawkins, N.J., Bauskin, A.R., Kinzler, K.W., Vogelstein, B. Breit, S.N. (2003) MIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma. Clinical Cancer Research, 9, 2642 2650.
7. Brown, D.A., Stephan, C., Ward, R.L., Law, M., Hunter, M., Bauskin, A.R., Amin, J., Jung, K., Diamandis, E.P., Hampton, G.M., Russell, P.J., Giles, G.G. Breit, S.N. (2006) Measurement of serum levels of macrophage inhibitory cytokine 1 combined with prostate-specific antigen improves prostate cancer diagnosis. Clinical Cancer Research, 12, 89 96.
8. Brunning, R., Bennett, J., Flandrin, G. Matutes, E. (2001) Tumors of Haematopoietic and Lymphoid Tissues. IARC Press, Lyon (France).
9. Cai, X., Shen, Y.L., Zhu, Q., Jia, P.M., Yu, Y., Zhou, L., Huang, Y., Zhang, J.W., Xiong, S.M., Chen, S.J., Wang, Z.Y., Chen, Z. Chen, G.Q. (2000) Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia. Leukemia, 14, 262 270.
10. Corey, S.J., Minden, M.D., Barber, D.L., Kantarjian, H., Wang, J.C. Schimmer, A.D. (2007) Myelodysplastic syndromes: the complexity of stem-cell diseases. Nature Reviews. Cancer, 7, 118 129.
11. Detmer, K., Steele, T.A., Shoop, M.A. Dannawi, H. (1999) Lineage-restricted expression of bone morphogenetic protein genes in human hematopoietic cell lines. Blood Cells, Molecules, and Diseases, 25, 310 323.
12. Fairlie, W.D., Moore, A.G., Bauskin, A.R., Russell, P.K., Zhang, H.P. Breit, S.N. (1999) MIC-1 is a novel TGF-beta superfamily cytokine associated with macrophage activation. Journal of Leukocyte Biology, 65, 2 5.
13. Ferrari, N., Pfeffer, U., Dell'Eva, R., Ambrosini, C., Noonan, D.M. Albini, A. (2005) The transforming growth factor-beta family members bone morphogenetic protein-2 and macrophage inhibitory cytokine-1 as mediators of the antiangiogenic activity of N-(4-hydroxyphenyl)retinamide. Clinical Cancer Research, 11, 4610 4619.
14. Grasso, J.A., Myers, T.J., Hines, J.D. Sullivan, A.L. (1980) Energy-dispersive X-ray analysis of the mitochondria of sideroblastic anaemia. British Journal Haematology, 46, 57 72.
15. Hofmann, W.K., de Vos, S., Komor, M., Hoelzer, D., Wachsman, W. Koeffler, H.P. (2002) Characterization of gene expression of CD34+ cells from normal and myelodysplastic bone marrow. Blood, 100, 3553 3560.
16. Hromas, R., Hufford, M., Sutton, J., Xu, D., Li, Y. Lu, L. (1997) PLAB, a novel placental bone morphogenetic protein. Biochimica et Biophysica Acta, 1354, 40 44.
17. Irizarry, R.A., Bolstad, B.M., Collin, F., Cope, L.M., Hobbs, B. Speed, T.P. (2003) Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Research, 31, e15.
18. Kerbauy, D.B. Deeg, H.J. (2007) Apoptosis and antiapoptotic mechanisms in the progression of myelodysplastic syndrome. Experimental Hematology, 35, 1739 1746.
19. Komor, M., Guller, S., Baldus, C.D., de Vos, S., Hoelzer, D., Ottmann, O.G. Hofmann, W.K. (2005) Transcriptional profiling of human hematopoiesis during in vitro lineage-specific differentiation. Stem Cells, 23, 1154 1169.
20. Koopmann, J., Buckhaults, P., Brown, D.A., Zahurak, M.L., Sato, N., Fukushima, N., Sokoll, L.J., Chan, D.W., Yeo, C.J., Hruban, R.H., Breit, S.N., Kinzler, K.W., Vogelstein, B. Goggins, M. (2004) Serum macrophage inhibitory cytokine 1 as a marker of pancreatic and other periampullary cancers. Clinical Cancer Research, 10, 2386 2392.
21. Lee, N.H. Saeed, A.I. (2007) Microarrays: an overview. Methods in Molecular Biology, 353, 265 300.
22. Lee, Y.T., Miller, L.D., Gubin, A.N., Makhlouf, F., Wojda, U., Barrett, A.J., Liu, E.T. Miller, J.L. (2001) Transcription patterning of uncoupled proliferation and differentiation in myelodysplastic bone marrow with erythroid-focused arrays. Blood, 98, 1914 1921.
23. Matthes, T.W., Meyer, G., Samii, K. Beris, P. (2000) Increased apoptosis in acquired sideroblastic anaemia. British Journal Haematology, 111, 843 852.
24. Matthes, T.W., Kindler, V., Leuba, F., French, L.E., Chapuis, B., Beris, P. Piguet, V. (2002) Optimized lentiviral transduction of erythroid precursors from healthy adults and patients with myelodysplastic syndromes. Leukemia, 16, 1319 1323.
25. Miyazato, A., Ueno, S., Ohmine, K., Ueda, M., Yoshida, K., Yamashita, Y., Kaneko, T., Mori, M., Kirito, K., Toshima, M., Nakamura, Y., Saito, K., Kano, Y., Furusawa, S., Ozawa, K. Mano, H. (2001) Identification of myelodysplastic syndrome-specific genes by DNA microarray analysis with purified hematopoietic stem cell fraction. Blood, 98, 422 427.
26. Nakai, M., Fujita, M., Waragai, M., Sugama, S., Wei, J., Akatsu, H., Ohtaka-Maruyama, C., Okado, H. Hashimoto, M. (2007) Expression of alpha-synuclein, a presynaptic protein implicated in Parkinson's disease, in erythropoietic lineage. Biochemical and Biophysical Research Communications, 358, 104 110.
27. Parker, J.E. Mufti, G.J. (2000) Excessive apoptosis in low risk myelodysplastic syndromes (MDS). Leukaemia & Lymphoma, 40, 1 24.
28. Pellagatti, A., Cazzola, M., Giagounidis, A.A., Malcovati, L., Porta, M.G., Killick, S., Campbell, L.J., Wang, L., Langford, C.F., Fidler, C., Oscier, D., Aul, C., Wainscoat, J.S. Boultwood, J. (2006) Gene expression profiles of CD34+ cells in myelodysplastic syndromes: involvement of interferon-stimulated genes and correlation to FAB subtype and karyotype. Blood, 108, 337 345.
29. Perez-Diez, A., Morgun, A. Shulzhenko, N. (2007) Microarrays for cancer diagnosis and classification. Advances in Experimental Medicine and Biology, 593, 74 85.
30. Schober, A., Bottner, M., Strelau, J., Kinscherf, R., Bonaterra, G.A., Barth, M., Schilling, L., Fairlie, W.D., Breit, S.N. Unsicker, K. (2001) Expression of growth differentiation factor-15/macrophage inhibitory cytokine-1 (GDF-15/MIC-1) in the perinatal, adult, and injured rat brain. Journal of Comparative Neurology, 439, 32 45.
31. Tanno, T., Bhanu, N.V., Oneal, P.A., Goh, S.H., Staker, P., Lee, Y.T., Moroney, J.W., Reed, C.H., Luban, N.L., Wang, R.H., Eling, T.E., Childs, R., Ganz, T., Leitman, S.F., Fucharoen, S. Miller, J.L. (2007) High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nature Medicine, 13, 1096 1101.
32. Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A. Speleman, F. (2002) Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biology, 3, RESEARCH0034.
33. Welsh, J.B., Sapinoso, L.M., Kern, S.G., Brown, D.A., Liu, T., Bauskin, A.R., Ward, R.L., Hawkins, N.J., Quinn, D.I., Russell, P.J., Sutherland, R.L., Breit, S.N., Moskaluk, C.A., Frierson, Jr., H.F. Hampton, G.M. (2003) Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum. Proceedings of the National Academy of Sciences of the United States of America, 100, 3410 3415.
34. Westwood, N.B. Mufti, G.J. (2003) Apoptosis in the myelodysplastic syndromes. Current Hematology Reports, 2, 186 192.
35. Yamaguchi, K., Lee, S.H., Eling, T.E. Baek, S.J. (2004) Identification of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) as a novel downstream target of phosphatidylinositol 3-kinase/AKT/GSK-3beta pathway. Journal of Biological Chemistry, 279, 49617 49623.
36. Yang, H., Filipovic, Z., Brown, D., Breit, S.N. Vassilev, L.T. (2003) Macrophage inhibitory cytokine-1: a novel biomarker for p53 pathway activation. Molecular Cancer Therapeutics, 2, 1023 1029.