Transfusion suppresses erythropoiesis and increases hepcidin in adult patients with β-thalassemia major: A longitudinal study

Blood

Volumn 122, Issue 1, 2013, Pages 124-133

  Pasricha, Sant Rayn ^a,b,c   Frazer, David M ^d   Bowden, Donald K ^a   Anderson, Gregory J ^d  

^a Medical Therapy Unit (Thalassaemia Service)   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

DEFERASIROX; DEFEROXAMINE; ERYTHROPOIETIN; FERRITIN; GROWTH DIFFERENTIATION FACTOR 15; HEMOGLOBIN; HEPCIDIN; IRON; ANTIMICROBIAL CATIONIC PEPTIDE;

ADULT; ANALYTICAL PARAMETERS; ARTICLE; BLOOD TRANSFUSION; BLOOD VOLUME; CLINICAL ARTICLE; CONTROLLED STUDY; ERYTHROCYTE; ERYTHROPOIESIS; FEMALE; FERRITIN BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HUMAN; LONGITUDINAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; THALASSEMIA MAJOR; ANEMIA; BETA THALASSEMIA; BLOOD; BLOOD STORAGE; IRON OVERLOAD; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; SEX DIFFERENCE;

ADULT; ANEMIA; ANTIMICROBIAL CATIONIC PEPTIDES; BETA-THALASSEMIA; BLOOD PRESERVATION; BLOOD TRANSFUSION; ERYTHROPOIESIS; FEMALE; HEMOGLOBINS; HUMANS; IRON OVERLOAD; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; SEX FACTORS;

EID: 84883684492     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-12-471441     Document Type: Article

References (50)

1. Weatherall DJ, Provan AB. Red cells I: inherited anaemias. Lancet. 2000;355(9210):1169-1175. (Pubitemid 30172945)
2. Gardenghi S, Marongiu MF, Ramos P, et al. Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and upregulation of ferroportin. Blood. 2007;109(11): 5027-5035. (Pubitemid 46827803)
3. Nemeth E, Tuttle MS, Powelson J, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306(5704):2090-2093. (Pubitemid 40007660)
4. Talbot NP, Lakhal S, Smith TG, et al. Regulation of hepcidin expression at high altitude. Blood. 2012;119(3):857-860.
5. Pasricha SR, McQuilten Z, Westerman M, et al. Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors. Haematologica. 2011;96(8): 1099-1105.
6. Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood. 2003;101(7): 2461-2463. (Pubitemid 36857598)
7. Ginzburg Y, Rivella S. beta-thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism. Blood. 2011;118(16):4321-4330.
8. Tanno T, Bhanu NV, Oneal PA, et al. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med. 2007;13(9):1096-1101. (Pubitemid 47517510)
9. Cavill I, Ricketts C, Jacobs A, Letsky E. Erythropoiesis and the effect of transfusion in homozygous beta-thalassemia. N Engl J Med. 1978;298(14):776-778.
10. Origa R, Galanello R, Ganz T, Giagu N, Maccioni L, Faa G, Nemeth E. Liver iron concentrations and urinary hepcidin in beta-thalassemia. Haematologica. 2007;92(5): 583-588. (Pubitemid 350144260)
11. Camberlein E, Zanninelli G, Detivaud L, et al. Anemia in beta-thalassemia patients targets hepatic hepcidin transcript levels independently of iron metabolism genes controlling hepcidin expression. Haematologica. 2008;93(1): 111-115. (Pubitemid 351156158)
12. Kearney SL, Nemeth E, Neufeld EJ, et al. Urinary hepcidin in congenital chronic anemias. Pediatr Blood Cancer. 2007;48(1):57-63. (Pubitemid 44871594)
13. Waalen J, Felitti V, Beutler E. Haemoglobin and ferritin concentrations in men and women: cross sectional study. BMJ. 2002;325(7356):137. (Pubitemid 34800124)
14. Cappellini M-D, Cohen A, Eleftheriou A, Piga A, Porter J, Taher A. Guidelines for the Clinical Management of Thalassaemia. 2nd ed. Nicosia, Cyprus; Thalassaemia International Foundation; 2008.
15. Pasricha SR, Rooney P, Schneider H. Soluble transferrin receptor and depth of bone marrow suppression following high dose chemotherapy. Support Care Cancer. 2009;17(7):847-850.
16. Tanno T, Noel P, Miller JL. Growth differentiation factor 15 in erythroid health and disease. Curr Opin Hematol. 2010;17(3):184-190.
17. Piperno A, Galimberti S, Mariani R, et al. Modulation of hepcidin production during hypoxiainduced erythropoiesis in humans in vivo: data from the HIGHCARE project. Blood. 2011; 117(10):2953-2959.
18. Cazzola M, De Stefano P, Ponchio L, et al. Relationship between transfusion regimen and suppression of erythropoiesis in betathalassaemia major. Br J Haematol. 1995;89(3): 473-478.
19. Kroot JJ, van Herwaarden AE, Tjalsma H, Jansen RT, Hendriks JC, Swinkels DW. Second round robin for plasma hepcidin methods: first steps toward harmonization. Am J Hematol. 2012; 87(10):977-983.
20. Choi HS, Song SH, Lee JH, Kim HJ, Yang HR. Serum hepcidin levels and iron parameters in children with iron deficiency. Korean J Hepatol. 2012;47(4):286-292.
21. Nemeth E, Roetto A, Garozzo G, Ganz T, Camaschella C. Hepcidin is decreased in TFR2 hemochromatosis. Blood. 2005;105(4): 1803-1806. (Pubitemid 40223705)
22. Hardison RC, Chui DH, Riemer C, Giardine B, Lehväslaiho H, Wajcman H, Miller W. Databases of human hemoglobin variants and other resources at the globin gene server. Hemoglobin. 2001;25(2):183-193. (Pubitemid 32660539)
23. McPherson RA, Pincus MR, Abraham NZ. APPENDIX 3 Approximations of Total Blood Volume. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. Philadelphia, PA: W. B. Saunders Company; 2011
24. Piperno A, Girelli D, Nemeth E, et al. Blunted hepcidin response to oral iron challenge in HFErelated hemochromatosis. Blood. 2007;110(12): 4096-4100. (Pubitemid 350248467)
25. Jenkins ZA, Hagar W, Bowlus CL, et al. Iron homeostasis during transfusional iron overload in beta-thalassemia and sickle cell disease: changes in iron regulatory protein, hepcidin, and ferritin expression. Pediatr Blood Cancer. 2007;24(4): 237-243. (Pubitemid 47026969)
26. Kemna EH, Kartikasari AE, van Tits LJ, Pickkers P, Tjalsma H, Swinkels DW. Regulation of hepcidin: insights from biochemical analyses on human serum samples. Blood Cells Mol Dis. 2008;40(3):339-346. (Pubitemid 351508446)
27. Kattamis A, Papassotiriou I, Palaiologou D, et al. The effects of erythropoetic activity and iron burden on hepcidin expression in patients with thalassemia major. Haematologica. 2006;91(6): 809-812. (Pubitemid 44014549)
28. Jelkmann W. Regulation of erythropoietin production. J Physiol. 2011;589(Pt 6):1251-1258.
29. Cazzola M, Guarnone R, Cerani P, Centenara E, Rovati A, Beguin Y. Red blood cell precursor mass as an independent determinant of serum erythropoietin level. Blood. 1998;91(6): 2139-2145. (Pubitemid 28185519)
30. Beguin Y. Soluble transferrin receptor for the evaluation of erythropoiesis and iron status. Clin Chim Acta. 2003;329(1-2):9-22. (Pubitemid 36183479)
31. Huebers HA, Beguin Y, Pootrakul P, Einspahr D, Finch CA. Intact transferrin receptors in human plasma and their relation to erythropoiesis. Blood. 1990;75(1):102-107. (Pubitemid 20031496)
32. Centis F, Tabellini L, Lucarelli G, et al. The importance of erythroid expansion in determining the extent of apoptosis in erythroid precursors in patients with beta-thalassemia major. Blood. 2000;96(10):3624-3629.
33. Tamary H, Shalev H, Perez-Avraham G, et al. Elevated growth differentiation factor 15 expression in patients with congenital dyserythropoietic anemia type I. Blood. 2008; 112(13):5241-5244.
34. Finkenstedt A, Bianchi P, Theurl I, et al. Regulation of iron metabolism through GDF15 and hepcidin in pyruvate kinase deficiency. Br J Haematol. 2009;144(5):789-793.
35. Ashby DR, Gale DP, Busbridge M, et al. Erythropoietin administration in humans causes a marked and prolonged reduction in circulating hepcidin. Haematologica. 2010;95(3):505-508.
36. Weizer-Stern O, Adamsky K, Amariglio N, et al. Downregulation of hepcidin and haemojuvelin expression in the hepatocyte cell-line HepG2 induced by thalassaemic sera. Br J Haematol. 2006;135(1):129-138. (Pubitemid 44337673)
37. Frazer DM, Wilkins SJ, Darshan D, Badrick AC, McLaren GD, Anderson GJ. Stimulated erythropoiesis with secondary iron loading leads to a decrease in hepcidin despite an increase in bone morphogenetic protein 6 expression. Br J Haematol. 2012;157(5):615-626.
38. Pak M, Lopez MA, Gabayan V, Ganz T, Rivera S. Suppression of hepcidin during anemia requires erythropoietic activity. Blood. 2006;108(12):3730-3735. (Pubitemid 44864551)
39. Liu Q, Davidoff O, Niss K, Haase VH. Hypoxiainducible factor regulates hepcidin via erythropoietin-induced erythropoiesis. J Clin Invest. 2012;122(12):4635-4644.
40. Casanovas G, Vujic Spasic M, Casu C, et al. The murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice. Haematologica. 2012;98(3): 444-447.
41. Finkenstedt A, Widschwendter A, Brasse-Lagnel CG, et al. Hepcidin is correlated to soluble hemojuvelin but not to increased GDF15 during pregnancy. Blood Cells Mol Dis. 2012;48(4): 233-237.
42. Kanda J, Mizumoto C, Kawabata H, et al. Serum hepcidin level and erythropoietic activity after hematopoietic stem cell transplantation. Haematologica. 2008;93(10):1550-1554.
43. Tanno T, Porayette P, Sripichai O, et al. Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood. 2009;114(1): 181-186.
44. Cazzola M, Borgna-Pignatti C, Locatelli F, Ponchio L, Beguin Y, De Stefano P. A moderate transfusion regimen may reduce iron loading in beta-thalassemia major without producing excessive expansion of erythropoiesis. Transfusion. 1997;37(2):135-140. (Pubitemid 27091897)
45. Miller ME, Chandra M, Garcia JF. Clinical applications of measurement of serum immunoreactive levels of erythropoietin. Ann N Y Acad Sci. 1985;459:375-381. (Pubitemid 16055223)
46. Erlandson ME, Walden B, Stern G, Hilgartner MW, Wehman J, Smith CH. Studies on congenital hemolytic syndromes, IV. Gastrointestinal absorption of iron. Blood. 1962;19:359-378.
47. Heinrich HC, Gabbe EE, Oppitz KH, et al. Absorption of inorganic and food iron in children with heterozygous and homozygous betathalassemia. Z Kinderheilkd. 1973;115(1):1-22.
48. Prentice AM, Doherty CP, Abrams SA, et al. Hepcidin is the major predictor of erythrocyte iron incorporation in anemic African children. Blood. 2012;119(8):1922-1928.
49. Hod EA, Brittenham GM, Billote GB, et al. Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating nontransferrin-bound iron. Blood. 2011;118(25): 6675-6682.
50. Australian Red Cross Blood Service. Blood Component Information: Circular of Information. Melbourne, Australia: Australian Red Cross Blood Service; 2012.