Apoptosis, autophagy and unfolded protein response pathways in arbovirus replication and pathogenesis

Expert Reviews in Molecular Medicine

Volumn 18, Issue , 2016, Pages

  Iranpour, Mahmoud ^a   Moghadam, Adel Rezaei ^b   Yazdi, Mina ^c   Ande, Sudharsana R ^d   Alizadeh, Javad ^d   Wiechec, Emilia ^e   Lindsay, Robbin ^a   Drebot, Michael ^a   Coombs, Kevin M ^d,f   Ghavami, Saeid ^d,f  

^a PUBLIC HEALTH AGENCY OF CANADA   (Canada)

^b ISLAMIC AZAD UNIVERSITY   (Iran)

^c UNIVERSITY OF TEHRAN   (Iran)

^d UNIVERSITY OF MANITOBA   (Canada)

^e LINKÖPING UNIVERSITY   (Sweden)

^f Children's Hospital Foundation of Manitoba   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; AUTOPHAGY RELATED PROTEIN 12; AUTOPHAGY RELATED PROTEIN 5; BECLIN 1; CASPASE 3; CASPASE 8; CASPASE 9; INTERFERON INDUCED HELICASE C DOMAIN CONTAINING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MEMBRANE PROTEIN; PATTERN RECOGNITION RECEPTOR; PERK. ROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BID; PROTEIN IRE1; RETINOIC ACID INDUCIBLE PROTEIN I; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; CELL CYCLE PROTEIN;

APOPTOSIS; ARBOVIRUS; AUTOPHAGOSOME; AUTOPHAGY; CHIKUNGUNYA VIRUS; CRIMEAN CONGO HEMORRHAGIC FEVER; CRIMEAN-CONGO HEMORRHAGIC FEVER VIRUS; DENGUE HEMORRHAGIC FEVER; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; GEOGRAPHIC DISTRIBUTION; HUMAN; INNATE IMMUNITY; JAPANESE ENCEPHALITIS; LYSOSOME; NONHUMAN; REVIEW; RIFT VALLEY FEVER; SINDBIS VIRUS; UNFOLDED PROTEIN RESPONSE; VENEZUELAN EQUINE ENCEPHALITIS; VIRUS PATHOGENESIS; VIRUS RELEASE; VIRUS REPLICATION; VIRUS TRANSCRIPTION; VIRUS TRANSMISSION; WEST NILE FEVER; YELLOW FEVER; ANIMAL; ARACHNID VECTOR; ARBOVIRUS INFECTIONS; GENE EXPRESSION REGULATION; GENETICS; HOST PATHOGEN INTERACTION; INSECT VECTOR; MAMMAL; METABOLISM; PATHOGENICITY; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TRANSMISSION; VIROLOGY; ZOONOSES;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; ARACHNID VECTORS; ARBOVIRUS INFECTIONS; ARBOVIRUSES; AUTOPHAGY; CELL CYCLE PROTEINS; GENE EXPRESSION REGULATION; HOST-PATHOGEN INTERACTIONS; HUMANS; INSECT VECTORS; MAMMALS; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; ZOONOSES;

EID: 84954501980     PISSN: 14623994     EISSN: None     Source Type: Journal    
DOI: 10.1017/erm.2015.19     Document Type: Review

References (257)

1. Gubler D. J. (2002) The global emergence/resurgence of arboviral diseases as public health problems. Archives of Medical Research 33, 330-342
2. Pfeffer M. and Dobler G. (2010) Emergence of zoonotic arboviruses by animal trade and migration. Parasites & Vectors 3, 35
3. Calisher C. and Karabatsos N. (1988) Arbovirus serogroups: definition and geographic distribution. The Arboviruses: Epidemiology and Ecology 1, 19-57
4. Heinz F. X. et al. (2000) Family Flaviviridae, Academic Press, San Diego, California
5. Weaver S. et al. (2000) Family Togaviridae, Academic Press, San Diego, CA, USA
6. Rehle T. (1989) Classification, distribution and importance of arboviruses. Tropical Medicine and Parasitology 40, 391-395
7. Knipe D. and Howley P. (2013) Fields Virology (6 edn), Wolters Kluwer Health/Lippincott Williams and Wilkins, Philadelphia, PA
8. Gubler D. J. (1997). Dengue and dengue hemorrhagic fever: its history and resurgence as a global public health problem. In Dengue and Dengue Hemorrhagic (Gubler, D. J. and Kuno, G., eds), pp. 1-22, CAB International, London
9. Weaver S. C. (2013) Urbanization and geographic expansion of zoonotic arboviral diseases: mechanisms and potential strategies for prevention. Trends In Microbiology 21, 360-363
10. Weaver S. (2005) Host range, amplification and arboviral disease emergence. In Infectious Diseases from Nature: Mechanisms of Viral Emergence and Persistence (Peters, C. J. and Calisher, C. H., eds), pp. 33-44, Springer, Vienna, Austria
11. Cavrini F. et al. (2009) Chikungunya: an emerging and spreading arthropod-borne viral disease. Journal of Infection in Developing Countries 3, 744-752
12. Lo Presti A. et al. (2014) Chikungunya virus, epidemiology, clinics and phylogenesis: a review. Asian Pacific Journal of Tropical Medicine 7, 925-932
13. Suhrbier A., Jaffar-Bandjee M. C. and Gasque P. (2012) Arthritogenic alphaviruses-an overview. Nature Reviews Rheumatology 8, 420-429
14. Jacups S. P., Whelan P. I. and Currie B. J. (2008) Ross River virus and Barmah forest virus infections: a review of history, ecology, and predictive models, with implications for tropical northern Australia. Vector Borne Zoonotic Diseases 8, 283-297
15. Tappe D. et al. (2014) O'nyong-nyong virus infection imported to Europe from Kenya by a traveler. Emerging Infectious Diseases 20, 1766-1767
16. Armstrong P. M. and Andreadis T. G. (2010) Eastern equine encephalitis virus in mosquitoes and their role as bridge vectors. Emerging Infectious Diseases 16, 1869-1874
17. Sherman M. B. and Weaver S. C. (2010) Structure of the recombinant alphavirus Western equine encephalitis virus revealed by cryoelectron microscopy. Journal of Virology 84, 9775-9782
18. Pisano M. B. et al. (2013) Venezuelan equine encephalitis viruses (VEEV) in Argentina: serological evidence of human infection. PLoS Negleted Tropical Disease 7, e2551
19. Gould E. A. and Solomon T. (2008) Pathogenic flaviviruses. Lancet 371, 500-509
20. Guzman M. G. et al. (2010) Dengue: a continuing global threat. Nature Reviews Microbiology 8(12 Suppl), S7-S16
21. Barnett E. D. (2007) Yellow fever: epidemiology and prevention. Clinical Infectious Disease 44, 850-856
22. Agampodi S. B. and Wickramage K. (2013) Is there a risk of yellow fever virus transmission in South Asian countries with hyperendemic dengue? Biomedical Research International 2013, 905043
23. Erlanger T. E. et al. (2009) Past, present, and future of Japanese encephalitis. Emerging Infectious Diseases 15, 1-7
24. Selvey L. A. et al. (2014) The changing epidemiologyof Murray Valley encephalitis in Australia: the 2011 outbreak and a review of the literature. PLoS Neglected Tropical Disease 8, e2656
25. McCarthy M. (2001) St. Louis encephalitis and West Nile virus encephalitis. Current Treatment Options in Neurology 3, 433-438
26. Petersen L. R., Brault A. C. and Nasci R. S. (2013) West Nile virus: review of the literature. JAMA 310, 308-315
27. Kiran S. K. et al. (2015) Kyasanur forest disease outbreak and vaccination strategy, Shimoga District, India, 2013-2014. Emerging Infectious Diseases 21, 146-149
28. Ruzek D. et al. (2010) Omsk haemorrhagic fever. Lancet 376, 2104-2113
29. Gresikova M. and Kaluzova M. (1997) Biology of tick-borne encephalitis virus. Acta Virologica 41, 115-124
30. Depaquit J. et al. (2010) Arthropod-borne viruses transmitted by Phlebotomine sandflies in Europe: a review. Euro Surveillance 15, 19507
31. Pepin M. et al. (2010) Rift valley fever virus (Bunyaviridae: Phlebovirus): an update on pathogenesis, molecular epidemiology, vectors, diagnostics and prevention. Veterinary Research 41, 61
32. Erwin P. C. et al. (2002) La Crosse encephalitis in Eastern Tennessee: clinical, environmental, and entomological characteristics from a blinded cohort study. American Journal of Epidemiology 155, 1060-1065
33. Appannanavar S. B. and Mishra B. (2011) An update on crimean congo hemorrhagic fever. Journal of Global Infectious Disease 3, 285-292
34. Mouraao M. P. et al. (2009) Oropouche fever outbreak, Manaus, Brazil, 2007-2008. Emerging Infectious Diseases 15, 2063-2064
35. Murray P, Rosenthal K, and Pfaller M. (2005) Medical Microbiology (4th edn), Elsevier Mosby, Philadelphia, PA
36. Shope R. (1991) Global climate change and infectious diseases. Environmental Health Perspectives 96, 171
37. Hall-Mendelin S. et al. (2010) Exploiting mosquito sugar feeding to detect mosquito-borne pathogens. Proceedings of the National Academy of Sciences 107, 11255-11259
38. Diaz Y. et al. (2015) Chikungunya virus infection: first detection of imported and autochthonous cases in panama. American Journal of Tropical Medicine and Hygiene 92, 482-485
39. Scholte F. E. et al. (2015) Stress granule components G3BP1 and G3BP2 play a proviral role early in chikungunya virus replication. Journal of Virology 89, 4457-4469
40. Gubler D. and Roehrig J. (1998) Arboviruses (Togaviridae and Flaviviridae). Topley and Wilson's Microbiology and Microbial Infections 1, 579-600
41. Guzman M. G. and Harris E. (2015) Dengue. Lancet 385, 453-465
42. WHO (2015) Dengue and severe dengue, Fact sheet no117, Updated February 2015. Available at: http://www.who.int/mediacentre/factsheets/fs117/en
43. WHO (2014) Yellow fever, Fact sheet No 100, Updated March 2014. Available at: http://www.who.int/mediacentre/factsheets/fs100/en/
44. Centers For Disease Control and Prevention (CDC) (On Line Source: http://www.cdc.gov/yellowfever/), (2011). Yellow Fever.
45. Ciota A. T. and Kramer L. D. (2013) Vector-virus interactions and transmission dynamics of West Nile virus. Viruses 5, 3021-3047
46. Centers For Disease Control and Prevention (CDC) (On Line Source: http: http://www.cdc.gov/westnile/statsmaps/preliminarymapsdata/index.html) (2015) West Nile Virus
47. Weaver S. C. and Reisen W. K. (2010) Present and future arboviral threats. Antiviral Research 85, 328-345
48. WHO (2015) Chikungunya. In Media Centre, Fact sheet No 327, Updated May 2015. Available at: http://www.who.int/mediacentre/factsheets/fs327/en/49
49. WHO (2014) Japanese encephalitis. In Media centre, Fact sheet No 386, March 2014. Available at: http://www.who.int/mediacentre/factsheets/fs386/en/
50. WHO (2010) Rift Valley fever. In Media Centre, Fact sheet No 207, Revised May 2010. Available at: http://www.who.int/mediacentre/factsheets/fs207/en/
51. European Centre for Disease Prevention and Control (ECDPC) (2010) Limit for geographic distribution of genus Hyalomma ticks (On line source: http://ecdc.europa.eu/en/healthtopics/vectors/ticks/Pages/hyalomma-marginatum-.aspx)
52. Go Y. Y., Balasuriya U. B. and Lee C. K. (2014) Zoonotic encephalitides caused by arboviruses: transmission and epidemiology of alphaviruses and flaviviruses. Clinical and Experimental Vaccine Research 3, 58-77
53. Pierson T. C. and Diamond M. S. (2013) flaviviruses. In Fields Virology (6 edn), (Knipe D. M. and Howley P. M. eds), pp. 747-794, Wolters Kluwer Health/Lippincott Williams and Wilkins, Philadelphia, PA
54. Anders K. L. et al. (2015) Households as foci for dengue transmission in highly urban Vietnam. PLoS Neglected Tropical Disease 9, e0003528
55. Mousson L. et al. (2012) The native Wolbachia symbionts limit transmission of dengue virus in Aedes albopictus. PLoS Neglected Tropical Disease 6, e1989
56. Mustafa M. S. et al. (2015) Discovery of fifth serotype of dengue virus (DENV-5): a new public health dilemma in dengue control. Medical Journal Armed Forces India 71, 67-70
57. Monath T. P. (1989) The Arboviruses: Epidemiology and Ecology, Volume V. CRC Press, Inc., United States
58. Nash D. T. (2001) Diabetes mellitus and cardiovascular disease. Diabetes Educator 27, 28-32, 34
59. Weaver S. C. and Barrett A. D. (2004) Transmission cycles, host range, evolution and emergence of arboviral disease. Nature Reviews Microbiology 2, 789-801
60. Elizondo-Quiroga D. and Elizondo-Quiroga A. (2013) West Nile virus and its theories, a big puzzle in Mexico and Latin America. Journal of Global Infectious Diseases 5, 168-175
61. Wimberly M. C. et al. (2013) Spatio-temporal epidemiology of human West Nile virus disease in South Dakota. International Journal of Environmental Research and Public Health 10, 5584-5602
62. Drebot M. A. et al. (2003) West Nile virus surveillance and diagnostics: a Canadian perspective. Canadian Journal of Infectious Diseases & Medical 14, 105-114
63. Abubakr M., Mandal S. C. and Banerjee S. (2013) Natural compounds against flaviviral infections. Natural Product Communications 8, 1487-1492
64. Murray K. O. et al. (2013) West Nile virus, Texas, USA, 2012. Emerging Infectious Diseases 19, 1836-1838
65. Rosen L. (1986) The natural history of Japanese encephalitis virus. Annual Reviews in Microbiology 40, 395-414
66. Tsai T. (1997) Factors in the changing epidemiology of Japanese encephalitis and West Nile fever. Factors in the Emergence of Arboviral Diseases 179-189
67. Yun S. I. and Lee Y. M. (2014) Japanese encephalitis: the virus and vaccines. Human Vaccines & Immunotherapeutics 10, 263-279
68. Le Flohic G. et al. (2013) Review of climate, landscape, and viral genetics as drivers of the Japanese encephalitis virus ecology. PLoS Neglected Tropical Disease 7, e2208
69. Rojanasuphot S. and Tsai T. (1995) Regional Workshop on Control Strategies for Japanese Encephalitis. Presented at the Regional Workshop on Control Strategies for Japanese Encephalitis
70. Kabilan L. et al. (2004) Japanese encephalitis in India: an overview. Indian Journal of Pediatrics 71, 609-615
71. Tiwari S. et al. (2012) Japanese encephalitis: a review of the Indian perspective. Brazilian Journal of Infectious Diseases 16, 564-573
72. Hanna J. N. et al. (1996) An outbreak of Japanese encephalitis in the Torres Strait, Australia, 1995. Medical Journal of Australia 165, 256-261
73. Verma R. (2012) Japanese encephalitis vaccine: need of the hour in endemic states of India. Human Vaccines & Immunotherapeutics 8, 491-493
74. Pandey B. et al. (2003) Serodiagnosis of Japanese encephalitis among Nepalese patients by the particle agglutination assay. Epidemiology & Infection 131, 881-885
75. Rainey S. M. et al. (2014) Understanding the Wolbachiamediated inhibition of arboviruses in mosquitoes: progress and challenges. Journal of General Virology 95(Pt 3), 517-530
76. Gerdes G. (2004) Rift valley fever. Revue Scientifique et Technique-Office International des Epizooties 23, 613-624
77. Meegan J. and Bailey C. (1988) Rift Valley Fever, CRC Press, United States
78. Laughlin L. W. et al. (1979) Epidemic Rift Valley fever in Egypt: observations of the spectrum of human illness. Transactions of the Royal Society of Tropical Medicine and Hygiene 73, 630-633
79. Jupp P. et al. (2002) The 2000 epidemic of Rift Valley fever in Saudi Arabia: mosquito vector studies. Medical and Veterinary Entomology 16, 245-252
80. Shoemaker T. et al. (2002) Genetic analysis of viruses associated with emergence of Rift Valley fever in Saudi Arabia and Yemen, 2000-01. Emerging Infectious Diseases 8, 1415
81. Balkhy H. H. and Memish Z. A. (2003) Rift Valley fever: an uninvited zoonosis in the Arabian Peninsula. International Journal of Antimicrobial Agents 21, 153-157
82. Bird B. H. et al. (2008) Multiple virus lineages sharing recent common ancestry were associated with a large Rift Valley fever outbreak among livestock in Kenya during 2006-2007. Journal of Virology 82, 11152-11166
83. Mohamed M. et al. (2010) Epidemiologic and clinical aspects of a Rift Valley fever outbreak in humans in Tanzania, 2007. American Journal of Tropical Medicine and Hygiene 83, 22
84. House J. A., Turell M. J. and Mebus C. A. (1992) Rift Valley fever: present status and risk to the Western Hemisphere. Annals of the New York Academy of Sciences 653, 233-242
85. Mandell R. and Flick R. (2011) Rift Valley fever virus: a real bioterror threat. Journal of Bioterrorism & Biodefense 2, 2
86. Chevalier V. et al. (2010) Rift Valley fever - a threat for Europe? Euro Surveillance: Bulletin Europeen sur les Maladies Transmissibles= European Communicable Disease Bulletin 15, 19506-19506
87. Hartley D. M. et al. (2011) Potential effects of Rift Valley fever in the United States. Emerging Infectious Diseases 17, e1
88. Walton T., Grayson M. and Monath T. (1988) The arboviruses: epidemiology and ecology. The Arboviruses: Epidemiology and Ecology 4
89. Weaver S. C. (1998) Recurrent emergence of Venezuelan equine encephalomyelitis. Emerging Infections 1, 27-42
90. Griffin D. E. (2013) Alphaviruses. In Fields Virology (Knipe D. M. and Howley P. M. eds), pp. 651-686, Wolters Kluwer Health/Lippincott Williams and Wilkins, Philadelphia, PA
91. Paessler S. and Weaver S. C. (2009) Vaccines for Venezuelan equine encephalitis. Vaccine 27(Suppl 4), D80-D85
92. Baba M. et al. (1997) Two distinct pathways for targeting proteins from the cytoplasm to the vacuole/lysosome. Journal of Cell Biology 139, 1687-1695
93. Levine B. and Kroemer G. (2008) Autophagy in the pathogenesis of disease. Cell 132, 27-42
94. Mrschtik M. and Ryan K. M. (2015) Lysosomal proteins in cell death and autophagy. FEBS Journal 282, 1858-1870
95. Fernandez A. F. and Lopez-Otin C. (2015) The functional and pathologic relevance of autophagy proteases. Journal of Clinical Investigation 125, 33-41
96. Klionsky D. J. and Emr S. D. (2000) Autophagy as a regulated pathway of cellular degradation. Science 290, 1717-1721
97. Mortimore G. E., Reeta Pösö A. and Lardeux B. R. (1989) Mechanism and regulation of protein degradation in liver. Diabetes/Metabolism Reviews 5, 49-70
98. Ghavami S. et al. (2014) Autophagy and heart disease: implications for cardiac ischemia-reperfusion damage. Current Molecular Medicine 14, 616-629
99. Papadopoulos T. and Pfeifer U. (1987) Protein turnover and cellular autophagy in growing and growth-inhibited 3T3 cells. Experimental Cell Research 171, 110-121
100. Mizushima N. (2007) Autophagy: process and function. Genes & Development 21, 2861-2873
101. Xilouri M. and Stefanis L. (2015) Chaperone mediated autophagy to the rescue: A new-fangled target for the treatment of neurodegenerative diseases. Molecular and Cellular Neuroscience 66, 29-36
102. Napolitano G. et al. (2015) Impairment of chaperone-mediated autophagy leads to selective lysosomal degradation defects in the lysosomal storage disease cystinosis. EMBO Molecular Medicine e201404223
103. Kawamura N. et al. (2012) Delivery of endosomes to lysosomes via microautophagy in the visceral endoderm of mouse embryos. Nature Communications 3, 1071
104. Cuervo A. M. and Wong E. (2014) Chaperone-mediated autophagy: roles in disease and aging. Cell Research 24, 92-104
105. Jia G. and Sowers J. R. (2015) Autophagy: a housekeeper in cardiorenal metabolic health and disease. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1852, 219-224
106. Yang Y.-p. et al. (2005) Molecular mechanism and regulation of autophagy. Acta Pharmacologica Sinica 26, 1421-1434
107. Bursch W. (2001) The autophagosomal-lysosomal compartment in programmed cell death. Cell Death and Differentiation 8, 569
108. Majeski A. E. and Fred Dice J. (2004) Mechanisms of chaperone-mediated autophagy. International Journal of Biochemistry & Cell Biology 36, 2435-2444
109. Mijaljica D., Prescott M. and Devenish R. J. (2011) Microautophagy in mammalian cells: revisiting a 40-yearold conundrum. Autophagy 7, 673-682
110. Voigt O. and Poggeler S. (2013) Self-eating to grow and kill: autophagy in filamentous ascomycetes. Applied Microbiology and Biotechnology 97, 9277-9290
111. Lemasters J. J. (2014) Variants of mitochondrial autophagy: types 1 and 2 mitophagy and micromitophagy (Type 3). Redox Biology 2, 749-754
112. Yang Z. and Klionsky D. J. (2010) Eaten alive: a history of macroautophagy. Nature Cell Biology 12, 814-822
113. Grasso D. and Vaccaro M. I. (2014) Macroautophagy and the oncogene-induced senescence. Frontiers in Endocrinology (Lausanne) 5, 157
114. Klionsky D. J. and Schulman B. A. (2014) Dynamic regulation of macroautophagy by distinctive ubiquitin-like proteins. Nature Structural & Molecular Biology 21, 336-345
115. Dice J. F. (2000) Lysosomal Pathways of Protein Degradation, Landes Bioscience, Austin, TX
116. Tooze S. A. (2013) Current views on the source of the autophagosome membrane. Essays in Biochemistry 55, 29-38
117. Pattingre S. et al. (2008) Regulation of macroautophagy by mTOR and Beclin 1 complexes. Biochimie 90, 313-323
118. Hurley J. H. and Schulman B. A. (2014) Atomistic autophagy: the structures of cellular self-digestion. Cell 157, 300-311
119. Levine B. and Yuan J. (2005) Autophagy in cell death: an innocent convict? Journal of Clinical Investigation 115, 2679-2688
120. Shibutani S. T. and Yoshimori T. (2014) A current perspective of autophagosome biogenesis. Cell research 24, 58-68
121. Klionsky D. J. et al. (2003) A unified nomenclature for yeast autophagy-related genes. Developmental Cell 5, 539-545
122. Xie Y. et al. (2015) Posttranslational modification of autophagy-related proteins in macroautophagy. Autophagy 11, 28-45
123. Mizushima N. (2010) The role of the Atg1/ULK1 complex in autophagy regulation. Current Opinion in Cell Biology 22, 132-139
124. Hall M. (2008) mTOR-what does it do? In Transplantation Proceedings 40, Elsevier
125. Mercer C. A., Kaliappan A. and Dennis P. B. (2009) A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. Autophagy 5, 649-662
126. Chiarini F. et al. (2015) Current treatment strategies for inhibiting mTOR in cancer. Trends in Pharmacological Sciences 36, 124-135
127. Jung C. H. et al. (2010) mTOR regulation of autophagy. FEBS letters 584, 1287-1295
128. Czarny P. et al. (2015) Autophagy in DNA damage response. International Journal of Molecular Sciences 16, 2641-2662
129. Simonsen A. and Tooze S. A. (2009) Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes. Journal of Cell Biology 186, 773-782
130. Morel E., Dupont N. and Codogno P. (2014) Autophagy regulation: RNF2 targets AMBRA1. Cell Research 24, 1029-1030
131. Jordan T. X. and Randall G. (2012) Manipulation or capitulation: virus interactions with autophagy. Microbes and Infection 14, 126-139
132. Kabeya Y. et al. (2000) LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO Journal 19, 5720-5728
133. Slobodkin M. R. and Elazar Z. (2013) The Atg8 family: multifunctional ubiquitin-like key regulators of autophagy. Essays in Biochemistry 55, 51-64
134. Matsunaga K. et al. (2009) Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nature Cell Biology 11, 385-396
135. Zhong Y. et al. (2009) Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nature Cell Biology 11, 468-476
136. Mizushima N. et al. (2008) Autophagy fights disease through cellular self-digestion. Nature 451, 1069-1075
137. Call J. A., Eckhardt S. G. and Camidge D. R. (2008) Targeted manipulation of apoptosis in cancer treatment. Lancet Oncology 9, 1002-1011
138. Yeganeh B. et al. (2013) Asthma and influenza virus infection: focusing on cell death and stress pathways in influenza virus replication. Iranian Journal of Allergy, Asthma and Immunology 12, 1-17
139. Rashedi I. et al. (2007) Autoimmunity and apoptosis-therapeutic implications. Current Medicinal Chemistry 14, 3139-3151
140. Fulda S. and Debatin K. (2006) Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene 25, 4798-4811
141. Ghavami S. et al. (2009) Apoptosis and cancer: mutations within caspase genes. Journal of Medical Genetics 46, 497-510
142. Ghavami S. et al. (2005) Apoptosis in liver diseases-detection and therapeutic applications. Medical Science Monitor 11, RA337-RRA45
143. Hassan M. et al. (2014) Apoptosis and molecular targeting therapy in cancer. BioMed Research International, 150845
144. Ghavami S. et al. (2014) Autophagy and apoptosis dysfunction in neurodegenerative disorders. Progress in Neurobiology 112, 24-49
145. Shalini S. et al. (2015) Old, new and emerging functions of caspases. Cell Death & Differentiation 22, 526-539
146. Fuchs Y. and Steller H. (2011) Programmed cell death in animal development and disease. Cell 147, 742-758
147. Kubli D. A. and Gustafsson A. B. (2012) Mitochondria and mitophagy: the yin and yang of cell death control. Circulation Research 111, 1208-1221
148. Er E. et al. (2006) Mitochondria as the target of the pro-apoptotic protein Bax. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1757, 1301-1311
149. Crow M. T. et al. (2004) The mitochondrial death pathway and cardiac myocyte apoptosis. Circulation Research 95, 957-970
150. Ghavami S. et al. (2010) Statin-triggered cell death in primary human lung mesenchymal cells involves p53-PUMA and release of Smac and Omi but not cytochrome c. Biochim Biophys Acta 1803, 452-467
151. Ghavami S. et al. (2008) S100A8/9 induces cell death via a novel, RAGE-independent pathway that involves selective release of Smac/DIABLO and Omi/HtrA2. Biochim Biophys Acta 1783, 297-311
152. Petros A. M., Olejniczak E. T. and Fesik S. W. (2004) Structural biology of the Bcl-2 family of proteins. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1644, 83-94
153. Kim E. et al. (2014) Nuclear and cytoplasmic p53 suppress cell invasion by inhibiting respiratory Complex-I activity via Bcl-2 family proteins. Oncotarget 5, 8452-8465
154. Ghavami S. et al. (2009) Role of BNIP3 in TNF-induced cell death-TNF upregulates BNIP3 expression. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1793, 546-560
155. Saelens X. et al. (2004) Toxic proteins released from mitochondria in cell death. Oncogene 23, 2861-2874
156. Wang K. (2014) Molecular mechanisms of liver injury: apoptosis or necrosis. Experimental and Toxicologic Pathology 66, 351-356
157. Ghavami S. et al. (2004) Mechanism of apoptosis induced by S100A8/A9 in colon cancer cell lines: the role of ROS and the effect of metal ions. Journal of Leukocyte Biology 76, 169-175
158. Wu C. C. and Bratton S. B. (2013) Regulation of the intrinsic apoptosis pathway by reactive oxygen species. Antioxidants & Redox Signaling 19, 546-558
159. Moll U. M. and Zaika A. (2001) Nuclear and mitochondrial apoptotic pathways of p53. FEBS letters 493, 65-69
160. Ghavami S. et al. (2011) Mevalonate cascade regulation of airway mesenchymal cell autophagy and apoptosis: a dual role for p53. PloS ONE 6, e16523
161. Reed S. M. and Quelle D. E. (2014) p53 acetylation: regulation and consequences. Cancers (Basel) 7, 30-69
162. Michalak E. et al. (2008) In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute. Cell Death & Differentiation 15, 1019-1029
163. Zhang L. N., Li J. Y. and Xu W. (2013) A review of the role of Puma, Noxa and Bim in the tumorigenesis, therapy and drug resistance of chronic lymphocytic leukemia. Cancer Gene Therapy 20, 1-7
164. Peng Y. et al. (2015) Baicalein induces apoptosis of human cervical cancer HeLa cells in vitro. Molecular Medicine Reports 11, 2129-2134
165. Tilly J. L. (2001) Commuting the death sentence: how oocytes strive to survive. Nature Reviews Molecular Cell Biology 2, 838-848
166. Li P. et al. (1997) Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91, 479-489
167. Pour-Jafari H., Ghavami S. and Maddika S. (2005) Mitochondrial physiology and toxicity (Mitotoxicity); importance for the immune system, programmed cell death and cancer. Current Medicinal Chemistry-Anti-Inflammatory & Anti-Allergy Agents 4, 439-448
168. Saveljeva S. et al. (2015) Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells. Cell Death & Disease 6, e1587
169. Sovolyova N. et al. (2014) Stressed to death - mechanisms of ER stress-induced cell death. Biological Chemistry 395, 1-13
170. Hetz C., Chevet E. and Harding H. P. (2013) Targeting the unfolded protein response in disease. Nature Reviews Drug Discovery 12, 703-719
171. Logue S. E. et al. (2013) New directions in ER stress-induced cell death. Apoptosis 18, 537-546
172. Guan B. J. et al. (2014) Translational control during endoplasmic reticulum stress beyond phosphorylation of the translation initiation factor eIF2alpha. Journal of Biological Chemistry 289, 12593-12611
173. Kozutsumi Y. et al. (1988) The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucoseregulated proteins. Nature 332, 462-464
174. Hetz C. (2012) The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nature Reviews Molecular Cell Biology 13, 89-102
175. Lin J. H. et al. (2007) IRE1 signaling affects cell fate during the unfolded protein response. Science 318, 944-949
176. Coelho D. S., Gaspar C. J. and Domingos P. M. (2014) Ire1 mediated mRNA splicing in a C-terminus deletion mutant of Drosophila Xbp1. PloS ONE 9, e105588
177. Yu B. et al. (2014) Single prolonged stress induces ATF6 alpha-dependent endoplasmic reticulum stress and the apoptotic process in medial frontal cortex neurons. BMC Neuroscience 15, 115
178. Yoshida H. et al. (2001) XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107, 881-891
179. Guo F. J. et al. (2014) ATF6 upregulates XBP1S and inhibits ER stress-mediated apoptosis in osteoarthritis cartilage. Cellular Signalling 26, 332-342
180. Doyle K. M. et al. (2011) Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders. Journal of Cellular and Molecular Medicine 15, 2025-2039
181. Donnelly N. et al. (2013) The eIF2alpha kinases: their structures and functions. Cellular and Molecular Life Sciences 70, 3493-3511
182. Novoa I. et al. (2001) Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha. Journal of Cell Biology 153, 1011-1022
183. Cullinan S. B. et al. (2003) Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Molecular and Cellular Biology 23, 7198-7209
184. Shelly S. et al. (2009) Autophagy is an essential component of Drosophila immunity against vesicular stomatitis virus. Immunity 30, 588-598
185. Orvedahl A. et al. (2010) Autophagy protects against Sindbis virus infection of the central nervous system. Cell Host & Microbe 7, 115-127
186. Lee Y.-R. et al. (2008) Autophagic machinery activated by dengue virus enhances virus replication. Virology 374, 240-248
187. Li J.-K. et al. (2012) Autophagy is involved in the early step of Japanese encephalitis virus infection. Microbes and Infection 14, 159-168
188. Krejbich-Trotot P. et al. (2011) Chikungunya triggers an autophagic process which promotes viral replication. Virology Journal 8, 432
189. Meng S. et al. (2012) Avian reovirus triggers autophagy in primary chicken fibroblast cells and Vero cells to promote virus production. Archives of Virology 157, 661-668
190. Shai B. et al. (2013) Epizootic hemorrhagic disease virus induces and benefits from cell stress, autophagy, and apoptosis. Journal of Virology 87, 13397-13408
191. Arnoldi F. et al. (2014) Rotavirus increases levels of lipidated LC3 supporting accumulation of infectious progeny virus without inducing autophagosome formation. PloS ONE 9, e95197
192. Heaton N. S. and Randall G. (2011) Dengue virus and autophagy. Viruses 3, 1332-1341
193. Panyasrivanit M. et al. (2011) Induced autophagy reduces virus output in dengue infected monocytic cells. Virology 418, 74-84
194. Vandergaast R. and Fredericksen B. L. (2012) West Nile virus (WNV) replication is independent of autophagy in mammalian cells. PloS ONE 7, e45800
195. Lee Y.-R. et al. (2013) Dengue virus infection induces autophagy: an in vivo study. Journal of Biomedical Science 20, 65
196. Shi J. and Luo H. (2012) Interplay between the cellular autophagy machinery and positive-stranded RNA viruses. Acta Biochimica et Biophysica Sinica 44, 375-384
197. Chi P. I. et al. (2013) The p17 nonstructural protein of avian reovirus triggers autophagy enhancing virus replication via activation of phosphatase and tensin deleted on chromosome 10 (PTEN) and AMP-activated protein kinase (AMPK), as well as dsRNA-dependent protein kinase (PKR)/eIF2a signaling pathways. Journal of Biological Chemistry 288, 3571-3584
198. den Boon J. A. and Ahlquist P. (2010) Organelle-like membrane compartmentalization of positive-strand RNA virus replication factories. Annual Review of Microbiology 64, 241-256
199. Panyasrivanit M. et al. (2009) Co-localization of constituents of the dengue virus translation and replication machinery with amphisomes. Journal of General Virology 90, 448-456
200. Jackson W. T. et al. (2005) Subversion of cellular autophagosomal machinery by RNA viruses. PLoS Biology 3, e156
201. Panyasrivanit M. et al. (2009) Linking dengue virus entry and translation/replication through amphisomes. Autophagy 5, 434-435
202. Singh R. and Cuervo A. M. (2012) Lipophagy: connecting autophagy and lipid metabolism. International Journal of Cell Biology, 282041
203. Heaton N. S. and Randall G. (2010) Dengue virus-induced autophagy regulates lipid metabolism. Cell Host & Microbe 8, 422-432
204. Jensen S. and Thomsen A. R. (2012) Sensing of RNA viruses: a review of innate immune receptors involved in recognizing RNA virus invasion. Journal of Virology 86, 2900-2910
205. Loo Y.-M. et al. (2008) Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. Journal of Virology 82, 335-345
206. Hou F. et al. (2011) MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response. Cell 146, 448-461
207. Jounai N. et al. (2007) The Atg5-Atg12 conjugate associates with innate antiviral immune responses. Proceedings of the National Academy of Sciences 104, 14050-14055
208. Jin R. et al. (2013) Japanese encephalitis virus activates autophagy as a viral immune evasion strategy. PloS ONE 8, e52909
209. McLean J. E. et al. (2011) Flavivirus NS4A-induced autophagy protects cells against death and enhances virus replication. Journal of Biological Chemistry 286, 22147-22159
210. Miller S. et al. (2007) The non-structural protein 4A of dengue virus is an integral membrane protein inducing membrane alterations in a 2 K-regulated manner. Journal of Biological Chemistry 282, 8873-8882
211. Joubert P.-E. et al. (2012) Chikungunya virus-induced autophagy delays caspase-dependent cell death. Journal of Experimental Medicine 209, 1029-1047
212. Collins M. (1995) Potential roles of apoptosis in viral pathogenesis. American Journal of Respiratory and Critical Care Medicine 152, S20
213. Clarke P. et al. (2014) Death receptor-mediated apoptotic signaling is activated in the brain following infection with West Nile virus in the absence of a peripheral immune response. Journal of Virology 88, 1080-1089
214. Turpin E. et al. (2005) Influenza virus infection increases p53 activity: role of p53 in cell death and viral replication. Journal of Virology 79, 8802-8811
215. Lewis J. et al. (1996) Alphavirus-induced apoptosis in mouse brains correlates with neurovirulence. Journal of Virology 70, 1828-1835
216. Samuel M. A., Morrey J. D. and Diamond M. S. (2007) Caspase 3-dependent cell death of neurons contributes to the pathogenesis of West Nile virus encephalitis. Journal of Virology 81, 2614-2623
217. Sun J., Yu Y. and Deubel V. (2012) Japanese encephalitis virus NS1' protein depends on pseudoknot secondary structure and is cleaved by caspase during virus infection and cell apoptosis. Microbes and Infection 14, 930-940
218. Stollar V., Shenk T. E. and Stollar B. D. (1972) Doublestranded RNA in hamster, chick, and mosquito cells infected with Sindbis virus. Virology 47, 122-132
219. Stollar B. D. and Stollar V. (1970) Immunofluorescent demonstration of double-stranded RNA in the cytoplasm of Sindbis virus-infected cells. Virology 42, 276-280
220. Domingo-Gil E. et al. (2011) Diversity in viral anti-PKR mechanisms: a remarkable case of evolutionary convergence. PloS ONE 6, e16711
221. Akgul C. (2009) Mcl-1 is a potential therapeutic target in multiple types of cancer. Cellular and Molecular Life Sciences 66, 1326-1336
222. Venticinque L. and Meruelo D. (2010) Sindbis viral vector induced apoptosis requires translational inhibition and signaling through Mcl-1 and Bak. Molecular Cancer 9, 37
223. Krejbich-Trotot P. et al. (2011) Chikungunya virus mobilizes the apoptotic machinery to invade host cell defenses. FASEB Journal 25, 314-325
224. Rodrigues R. et al. (2012) Crimean-Congo hemorrhagic fever virus-infected hepatocytes induce ER-stress and apoptosis crosstalk. PloS ONE 7, e29712
225. Medin C. L. and Rothman A. L. (2006) Cell type-specific mechanisms of interleukin-8 induction by dengue virus and differential response to drug treatment. Journal of Infectious Diseases 193, 1070-1077
226. Li A. et al. (2003) IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis. Journal of Immunology 170, 3369-3376
227. Lee C.-J., Liao C.-L. and Lin Y.-L. (2005) Flavivirus activates phosphatidylinositol 3-kinase signaling to block caspasedependent apoptotic cell death at the early stage of virus infection. Journal of Virology 79, 8388-8399
228. van Marle G. et al. (2007) West Nile virus-induced neuroinflammation: glial infection and capsid protein-mediated neurovirulence. Journal of Virology 81, 10933-10949
229. Jan J.-T. and Griffin D. E. (1999) Induction of apoptosis by Sindbis virus occurs at cell entry and does not require virus replication. Journal of Virology 73, 10296-10302
230. Urbanowski M. D. and Hobman T. C. (2013) The West Nile virus capsid protein blocks apoptosis through a phosphatidylinositol 3-Kinase-dependent mechanism. Journal of Virology 87, 872-881
231. del Carmen Parquet M. et al. (2001) West Nile virus-induced bax-dependent apoptosis. FEBS Letters 500, 17-24
232. Fujikura D. et al. (2012) CLIPR-59 regulates TNF-a-induced apoptosis by controlling ubiquitination of RIP1. Cell Death & Disease 3, e264
233. Medigeshi G. R. et al. (2007) West Nile virus infection activates the unfolded protein response, leading to CHOP induction and apoptosis. Journal of Virology 81, 10849-10860
234. Chu J. and Ng M. (2003) The mechanism of cell death during West Nile virus infection is dependent on initial infectious dose. Journal of General Virology 84, 3305-3314
235. Yang M. R. et al. (2008) West Nile virus capsid protein induces p53-mediated apoptosis via the sequestration of HDM2 to the nucleolus. Cellular Microbiology 10, 165-176
236. Smith J. L. et al. (2012) Induction of the cellular microRNA, Hs-154, by West Nile virus contributes to virus-mediated apoptosis through repression of antiapoptotic factors. Journal of Virology 86, 5278-5287
237. Yang T.-C. et al. (2010) Japanese encephalitis virus down-regulates thioredoxin and induces ROS-mediated ASK1-ERK/p38 MAPK activation in human promonocyte cells. Microbes and Infection 12, 643-651
238. Lin R.-J., Liao C.-L. and Lin Y.-L. (2004) Replication-incompetent virions of Japanese encephalitis virus trigger neuronal cell death by oxidative stress in a culture system. Journal of General Virology 85, 521-533
239. Melian E. B. et al. (2010) NS1' of flaviviruses in the Japanese encephalitis virus serogroup is a product of ribosomal frameshifting and plays a role in viral neuroinvasiveness. Journal of Virology 84, 1641-1647
240. Liao C.-L. et al. (1998) Antiapoptotic but not antiviral function of humanbcl-2 assists establishment of Japanese encephalitis virus persistence in cultured cells. Journal of Virology 72, 9844-9854
241. Silveira G. F. et al. (2011) Dengue virus type 3 isolated from a fatal case with visceral complications induces enhanced proinflammatory responses and apoptosis of human dendritic cells. Journal of Virology 85, 5374-5383
242. Palmer D. R. et al. (2005) Differential effects of dengue virus on infected and bystander dendritic cells. Journal of Virology 79, 2432-2439
243. Li J. et al. (2012) Dengue virus utilizes calcium modulating cyclophilin-binding ligand to subvert apoptosis. Biochemical and Biophysical Research Communications 418, 622-627
244. Nasirudeen A. and Liu D. X. (2009) Gene expression profiling by microarray analysis reveals an important role for caspase-1 in dengue virus-induced p53-mediated apoptosis. Journal of Medical Virology 81, 1069-1081
245. Austin D. et al. (2012) p53 Activation following Rift Valley fever virus infection contributes to cell death and viral production. PloS ONE 7, e36327
246. Won S. et al. (2007) NSm protein of Rift Valley fever virus suppresses virus-induced apoptosis. Journal of Virology 81, 13335-13345
247. Ikegami T. et al. (2009) Rift Valley fever virus NSs protein promotes post-transcriptional downregulation of protein kinase PKR and inhibits eIF2a phosphorylation. PLoS Pathogens 5, e1000287
248. Kohl A. et al. (2003) Bunyamwera virus nonstructural protein NSs counteracts interferon regulatory factor 3-mediated induction of early cell death. Journal of Virology 77, 7999-8008
249. Mortola E., Noad R. and Roy P. (2004) Bluetongue virus outer capsid proteins are sufficient to trigger apoptosis in mammalian cells. Journal of Virology 78, 2875-2883
250. Nagaleekar V. K. et al. (2007) Bluetongue virus induces apoptosis in cultured mammalian cells by both caspase-dependent extrinsic and intrinsic apoptotic pathways. Archives of Virology 152, 1751-1756
251. Stassen L., Huismans H. and Theron J. (2012) African horse sickness virus induces apoptosis in cultured mammalian cells. Virus Research 163, 385-389
252. Ambrose R. L. and Mackenzie J. M. (2011) West Nile virus differentially modulates the unfolded protein response to facilitate replication and immune evasion. Journal of Virology 85, 2723-2732
253. Ambrose R. L. and Mackenzie J. M. (2013) ATF6 signaling is required for efficient West Nile virus replication by promoting cell survival and inhibition of innate immune responses. Journal of Virology 87, 2206-2214
254. Rathore A. P., Ng M. L. and Vasudevan S. G. (2013) Differential unfolded protein response during Chikungunya and Sindbis virus infection: CHIKV nsP4 suppresses eIF2alpha phosphorylation. Virology Journal 10, 36
255. Yu C. Y. et al. (2006) Flavivirus infection activates the XBP1 pathway of the unfolded protein response to cope with endoplasmic reticulum stress. Journal of Virology 80, 11868-11880
256. Umareddy I. et al. (2007) Dengue virus serotype infection specifies the activation of the unfolded protein response. Virology Journal 4, 91
257. Fraser J. E. et al. (2014). A nuclear transport inhibitor that modulates the unfolded protein response and provides in vivo protection against lethal Dengue virus infection. Journal of Infectious Diseases 210, 1780-1791, doi: 10.1093/infdis/jiu319