Mapping Protein-Ligand Interactions with Proteolytic Fragmentation, Hydrogen/Deuterium Exchange-Mass Spectrometry

Methods in Enzymology

Volumn 566, Issue , 2016, Pages 357-404

  Gallagher, Elyssia S ^a   Hudgens, Jeffrey W ^a,b  

^a NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY   (United States)

^b UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE   (United States)

Author keywords

Epitope; Higher order structure; Hydrogen deuterium exchange; Mass spectrometry; Molecular dynamics; Protein structure; Protein ligand interaction; Proteomics; Protocol

Indexed keywords

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; BETA SHEET; BINDING AFFINITY; COLLISIONALLY ACTIVATED DISSOCIATION; COVALENT BOND; CRYSTAL STRUCTURE; DEUTERIUM HYDROGEN EXCHANGE; DISSOCIATION CONSTANT; DISULFIDE BOND; EQUILIBRIUM CONSTANT; FRAGMENTATION REACTION; HYDROGEN BOND; LIGAND BINDING; MASS SPECTROMETRY; MOLECULAR DYNAMICS; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN LIGAND INTERACTION; PROTEIN PROTEIN INTERACTION; PROTEIN QUATERNARY STRUCTURE; PROTEIN SECONDARY STRUCTURE; PROTEOMICS; TEMPERATURE DEPENDENCE; X RAY CRYSTALLOGRAPHY; CHEMISTRY; METABOLISM; PROCEDURES;

DEUTERIUM; EPITOPE; HYDROGEN; LIGAND; PEPTIDE; PROTEIN;

DEUTERIUM; EPITOPES; HYDROGEN; LIGANDS; MASS SPECTROMETRY; MOLECULAR DYNAMICS SIMULATION; PEPTIDES; PROTEIN CONFORMATION; PROTEINS; PROTEOLYSIS; PROTEOMICS;

EID: 84954374477     PISSN: 00766879     EISSN: 15577988     Source Type: Book Series    
DOI: 10.1016/bs.mie.2015.08.010     Document Type: Chapter

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