Top-down mass spectrometry and hydrogen/deuterium exchange for comprehensive structural characterization of interferons: Implications for biosimilars

Proteomics

Volumn 14, Issue 10, 2014, Pages 1249-1258

  Pan, Jingxi ^a   Borchers, Christoph H ^a,b  

^a UNIVERSITY OF VICTORIA   (Canada)

^b UNIVERSITY OF VICTORIA   (Canada)

Author keywords

Biomedicine; Biopharmaceutical; Electron capture dissociation; Hydrogen deuterium exchange; Post translational modification; Top down

Indexed keywords

BIOSIMILAR AGENT; DEUTERIUM; DISULFIDE; HYDROGEN; INTERFERON; PROTEIN VARIANT; RECOMBINANT ALPHA2A INTERFERON; RECOMBINANT ALPHA2B INTERFERON; RECOMBINANT PROTEIN; METHIONINE;

AMINO ACID SEQUENCE; ARTICLE; DIGESTION; HUMAN; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN CONFORMATION; CHEMICAL STRUCTURE; CHEMISTRY; DEUTERIUM HYDROGEN EXCHANGE; MOLECULAR GENETICS; PROCEDURES; PROTEIN PROCESSING; CONFORMATIONAL TRANSITION; DISSOCIATION; DISULFIDE BOND; ELECTRON CAPTURE DISSOCIATION; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGEN BOND; OXIDATION; PROTEIN ANALYSIS; PROTEIN STRUCTURE; TOP DOWN MASS SPECTROMETRY;

AMINO ACID SEQUENCE; BIOSIMILAR PHARMACEUTICALS; DEUTERIUM EXCHANGE MEASUREMENT; DISULFIDES; HUMANS; INTERFERONS; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECOMBINANT PROTEINS;

EID: 84899835472     PISSN: 16159853     EISSN: 16159861     Source Type: Journal    
DOI: 10.1002/pmic.201300341     Document Type: Article

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