Genetics of aggressive behavior: An overview

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 171, Issue 1, 2016, Pages 3-43

  Veroude, Kim ^a   Zhang James, Yanli ^b   Fernàndez Castillo, Noèlia ^c,d   Bakker, Mireille J ^a   Cormand, Bru ^c,d   Faraone, Stephen V ^b,e  

^a RADBOUD UNIVERSITY   (Netherlands)

^b SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

^c UNIVERSITY OF BARCELONA   (Spain)

^d CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

^e UNIVERSITY OF BERGEN   (Norway)

Author keywords

Aggression; Candidate genes; Genetics; GWAS; Mutations; Twin

Indexed keywords

ADOLESCENT BEHAVIOR; AGGRESSION; ARTICLE; BIOLOGICAL MODEL; CHILD BEHAVIOR; CONCEPTUAL FRAMEWORK; CONDUCT DISORDER; DOPAMINERGIC SYSTEM; DROSOPHILA; GENE INACTIVATION; GENETIC ASSOCIATION; GENETIC DISORDER; GENETIC PREDISPOSITION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC TRAIT; GENOME ANALYSIS; GENOTYPE ENVIRONMENT INTERACTION; HERITABILITY; HUMAN; HUMAN GENETICS; MEDICAL RESEARCH; MENTAL DISEASE; MOLECULAR GENETICS; NONHUMAN; OPPOSITIONAL DEFIANT DISORDER; PHENOTYPE; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; RODENT; SEROTONINERGIC SYSTEM; SYMPTOM; TWINS; ANIMAL; BEHAVIOR; ENVIRONMENT; GENOME-WIDE ASSOCIATION STUDY; METABOLISM; PHYSIOLOGY; PROCEDURES;

SEROTONIN;

AGGRESSION; ANIMALS; BEHAVIOR; ENVIRONMENT; GENOME-WIDE ASSOCIATION STUDY; HUMANS; PHENOTYPE; SEROTONIN;

EID: 84954361857     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.32364     Document Type: Article

References (378)

1. Adkins-Regan E. 2005. Hormones and animal social behavior. Princeton University Press.
2. Adamczyk A, Mejias R, Takamiya K, Yocum J, Krasnova IN, Calderon J, Cadet JL, Huganir RL, Pletnikov MV, Wang T. 2012. GluA3-deficiency in mice is associated with increased social and aggressive behavior and elevated dopamine in striatum. Behav Brain Res 229(1):265-272.
3. Adams AC, Domouzoglou EM, Chee MJ, Segal-Lieberman G, Pissios P, Maratos-Flier E. 2011. Ablation of the hypothalamic neuropeptide melanin concentrating hormone is associated with behavioral abnormalities that reflect impaired olfactory integration. Behav Brain Res 224(1):195-200.
4. Albaugh MD, Harder VS, Althoff RR, Rettew DC, Ehli EA, Lengyel-Nelson T, Davies GE, Ayer L, Sulman J, Stanger C, Hudziak JJ. 2010. COMT Val158Met genotype as a risk factor for problem behaviors in youth. J Am Acad Child Adolesc Psychiatry 49(8):841-849.
5. Alekseyenko OV, Lee C, Kravitz EA. 2010. Targeted manipulation of serotonergic neurotransmission affects the escalation of aggression in adult male Drosophila melanogaster. PLoS ONE 5(5): e10806.
6. Alenina N, Kikic D, et al. 2009. Growth retardation and altered autonomic control in mice lacking brain serotonin. Proc Natl Acad Sci USA 106(25):10332-10337.
7. Aluja A, Garcia LF, Blanch A, Fibla J. 2011. Association of androgen receptor gene, CAG and GGN repeat length polymorphism and impulsive-disinhibited personality traits in inmates: The role of short-long haplotype. Psychiatr Genet 21(5):229-239.
8. Anckarsäter H, Lundström S, Kollberg L, Kerekes N, Palm C, Carlström E, Långström N, Magnusson PK, Halldner L, Bölte S, Gillberg C, Gumpert C, Råstam M, Lichtenstein P. 2011. The child and adolescent twin study in Sweden (CATSS). Twin Res Hum Genet 14(06):495-508. DOI: 10.1375/twin.14.6.495
9. Angoa-Perez M, Kane MJ, Briggs DI, Sykes CE, Shah MM, Francescutti DM, Rosenberg DR, Thomas DM, Kuhn DM. 2012. Genetic depletion of brain 5HT reveals a common molecular pathway mediating compulsivity and impulsivity. J Neurochem 121(6):974-984.
10. Anney RJ, Lasky-Su J, O'Dushlaine C, Kenny E, Neale BM, Mulligan A, Franke B, Zhou K, Chen W, Christiansen H, Arias-Vasquez A, Banaschewski T, Buitelaar J, Ebstein R, Miranda A, Mulas F, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Sonuga-Barke E, Steinhausen H, Asherson P, Faraone SV, Gill M. 2008. Conduct disorder and ADHD: Evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. Am J Med Genet B Neuropsychiatr Genet 147B(8):1369-1378.
11. Antypa N, Giegling I, Calati R, Schneider B, Hartmann AM, Friedl M, Konte B, Lia L, De Ronchi D, Serretti A, Rujescu D. 2013. MAOA and MAOB polymorphisms and anger-related traits in suicidal participants and controls. Eur Arch Psychiatry Clin Neurosci 263(5):393-403.
12. Aragona BJ, Liu Y, et al. 2006. Nucleus accumbens dopamine differentially mediates the formation and maintenance of monogamous pair bonds. Nat Neurosci 9(1):133-139.
13. Armstrong TA, Boutwell BB, Flores S, Symonds M, Keller S, Gangitano DA. 2014. Monoamine oxidase A genotype, childhood adversity, and criminal behavior in an incarcerated sample. Psychiatr Genet 24(4):164-171.
14. Aslund C, Comasco E, Nordquist N, Leppert J, Oreland L, Nilsson KW. 2013. Self-reported family socioeconomic status, the 5-HTTLPR genotype, and delinquent behavior in a community-based adolescent population. Aggress Behav 39(1):52-63.
15. Azrin NH, Hutchinson RR, et al. 1966. Extinction-induced aggression. J Exp Anal Behav 9(3):191-204.
16. Banlaki Z, Elek Z, Nanasi T, Szekely A, Nemoda Z, Sasvari-Szekely M, Ronai Z. 2015. Polymorphism in the serotonin receptor 2a (HTR2A) gene as possible predisposal factor for aggressive traits. PLoS One 10(2):e0117792.
17. Barker ED, Larsson H, Viding E, Maughan B, Rijsdijk F, Fontaine N, Plomin R. 2009. Common genetic but specific environmental influences for aggressive and deceitful behaviors in preadolescent males. J Psychopathol Behav Assess 31:299-308. DOI: 10.1007/s10862-009-9132-6
18. Barros CS, Calabrese B, Chamero P, Roberts AJ, Korzus E, Lloyd K, Stowers L, Mayford M, Halpain S, Muller U. 2009. Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system. Proc Natl Acad Sci USA 106(11):4507-4512.
19. Barzman D, Eliassen J, et al. 2014. Correlations of inflammatory gene pathways, corticolimbic functional activities, and aggression in pediatric bipolar disorder: A preliminary study. Psychiatry Res 224(2):107-111.
20. Basoglu C, Oner O, Ates A, Algul A, Bez Y, Cetin M, Herken H, Erdal ME, Munir KM. 2011. Synaptosomal-associated protein 25 gene polymorphisms and antisocial personality disorder: Association with temperament and psychopathy. Can J Psychiatry 56(6):341-347.
21. Beach SR, Brody GH, Gunter TD, Packer H, Wernett P, Philibert RA. 2010. Child maltreatment moderates the association of MAOA with symptoms of depression and antisocial personality disorder. J Fam Psychol 24(1):12-20.
22. Beaver KM, Barnes JC, Boutwell BB. 2014. The 2-repeat allele of the MAOA gene confers an increased risk for shooting and stabbing behaviors. Psychiatr Q 85(3):257-265.
23. Beaver KM, DeLisi M, Vaughn MG, Barnes JC. 2010a. Monoamine oxidase A genotype is associated with gang membership and weapon use. Compr Psychiatry 51(2):130-134.
24. Beaver KM, DeLisi M, Vaughn MG, Wright JP. 2010b. The intersection of genes and neuropsychological deficits in the prediction of adolescent delinquency and low self-control. Int J Offender Ther Comp Criminol 54(1):22-42.
25. Beaver KM, Wright JP, Walsh A. 2008. A gene-based evolutionary explanation for the association between criminal involvement and number of sex partners. Biodemography Soc Biol 54(1):47-55.
26. Beitchman JH, Baldassarra L, Mik H, De Luca V, King N, Bender D, Ehtesham S, Kennedy JL. 2006. Serotonin transporter polymorphisms and persistent, pervasive childhood aggression. Am J Psychiatry 163(6):1103-1105.
27. Beitchman JH, Zai CC, Muir K, Berall L, Nowrouzi B, Choi E, Kennedy JL. 2012. Childhood aggression, callous-unemotional traits and oxytocin genes. Eur Child Adolesc Psychiatry.
28. Bergen SE, Gardner CO, Kendler KS. 2007. Age-related changes in heritability of behavioral phenotypes over adolescence and young adulthood: A meta-analysis. Twin Res Hum Genet 10(3):423-433. DOI: 10.1375/twin.10.3.423
29. Berggard C, Damberg M, Longato-Stadler E, Hallman J, Oreland L, Garpenstrand H. 2003. The serotonin 2A -1438 G/A receptor polymorphism in a group of Swedish male criminals. Neurosci Lett 347(3):196-198.
30. Bertoletti E, Michelini G, Moruzzi S, Ferrer G, Ferini-Strambi L, Stazi MA, Ogliari A, Battaglia M. 2014. A general population twin study of conduct problems and the auditory P300 waveform. J Abnorm Child Psychol 42(5):861-869. DOI: 10.1007/s10802-013-9836-7.
31. Blair RJR. 2013. The neurobiology of psychopathic traits in youth. Nat Rev Neurosci 14:786-799.
32. Boomsma D, Busjahn A, Peltonen L. 2002. Classical twin studies and beyond. Nat Rev Genet 3:872-882. DOI: 10.1038/nrg932
33. Bornovalova MA, Hicks BM, Iacono WG, Mcgue M. 2010. Familial transmission and heritability of childhood disruptive disorders. Am J Psychiatry 167(9):1066-1074.
34. Bortolato M, Godar SC, et al. 2012. NMDARs mediate the role of monoamine oxidase A in pathological aggression. J Neurosci 32(25):8574-8582.
35. Bosch OJ, Meddle SL, et al. 2005. Brain oxytocin correlates with maternal aggression: Link to anxiety. J Neurosci 25(29):6807-6815.
36. Boutwell BB, Beaver KM, Barnes JC, Vaske J. 2012. The developmental origins of externalizing behavioral problems: Parental disengagement and the role of gene-environment interplay. Psychiatry Res 197(3):337-344. DOI: 10.1016/j.psychres.2011.12.032
37. Bouwknecht JA, Hijzen TH, van der Gugten J, Maes RA, Hen R, Olivier B. 2001. Absence of 5-HT(1B) receptors is associated with impaired impulse control in male 5-HT(1B) knockout mice. Biol Psychiatry 49(7):557-568.
38. Breu J, Touma C, Holter SM, Knapman A, Wurst W, Deussing JM. 2012. Urocortin 2 modulates aspects of social behaviour in mice. Behav Brain Res 233(2):331-336.
39. Breuillaud L, Rossetti C, Meylan EM, Merinat C, Halfon O, Magistretti PJ, Cardinaux JR. 2012. Deletion of CREB-regulated transcription coactivator 1 induces pathological aggression, depression-related behaviors, and neuroplasticity genes dysregulation in mice. Biol Psychiatry 72(7):528-536.
40. Brody GH, Beach SR, Chen YF, Obasi E, Philibert RA, Kogan SM, Simons RL. 2011. Perceived discrimination, serotonin transporter linked polymorphic region status, and the development of conduct problems. Dev Psychopathol 23(2):617-627.
41. Brook M, Panizzon MS, Kosson DS, Sullivan EA, Lyons MJ, Franz CE, Eisen SA, Kremen WS. 2010. Psychopathic personality traits in middle-aged male twins: a behavior genetic investigation. J Pers Disord 24(4):473-486. DOI: 10.1521/pedi.2010.24.4.473
42. Brunner HG, Nelen M, et al. 1993. Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science 262(5133):578-580.
43. Buchmann AF, Zohsel K, Blomeyer D, Hohm E, Hohmann S, Jennen-Steinmetz C, Treutlein J, Becker K, Banaschewski T, Schmidt MH, Esser G, Brandeis D, Poustka L, Zimmermann US, Laucht M. 2014. Interaction between prenatal stress and dopamine D4 receptor genotype in predicting aggression and cortisol levels in young adults. Psychopharmacology (Berl) 231(16):3089-3097.
44. Budefeld T, Majer A, Jerin A, Majdic G. 2014. Deletion of the prion gene Prnp affects offensive aggression in mice. Behav Brain Res 266:216-221.
45. Burt SA, Mikolajewski AJ. 2008. Preliminary evidence that specific candidate genes are associated with adolescent-onset antisocial behavior. Aggress Behav 34(4):437-445.
46. Burt SA. 2009. Are there meaningful etiological differences within antisocial behavior? Results of a meta-analysis. Clin Psychol Rev 29(2):163-178. DOI: 10.1016/j.cpr.2008.12.004
47. Burt SA. 2013. Do etiological influences on aggression overlap with those on rule breaking? A meta-analysis. Psychol Med 43:1801-1812. DOI: 10.1017/S0033291712001894
48. Burt SA, Klump KL. 2009. The etiological moderation of aggressive and nonaggressive antisocial behavior by age. Twin Res Hum Genet 12(4):343-350. DOI: 10.1375/twin.12.4.343
49. Burt SA, Klump KL. 2012. Etiological distinctions between aggressive and non-aggressive antisocial behavior: Results from a nuclear twin family model. J Abnorm Child Psychol 40(7):1059-1071. DOI: 10.1007/s10802-012-9632-9
50. Burt SA, Neiderhiser JM. 2009. Aggressive versus nonaggressive antisocial behavior: Distinctive etiological moderation by age. Dev Psychol 45(4):1164-1176. DOI: 10.1037/a0016130
51. Byrd AL, Manuck SB. 2014. MAOA, childhood maltreatment, and antisocial behavior: Meta-analysis of a gene-environment interaction. Biol Psychiatry 75(1):9-17.
52. Cadoret RJ, Langbehn D, Caspers K, Troughton EP, Yucuis R, Sandhu HK, Philibert R. 2003. Associations of the serotonin transporter promoter polymorphism with aggressivity, attention deficit, and conduct disorder in an adoptee population. Compr Psychiatry 44(2):88-101.
53. Calandreau L, Marquez C, Bisaz R, Fantin M, Sandi C. 2010. Differential impact of polysialyltransferase ST8SiaII and ST8SiaIV knockout on social interaction and aggression. Genes Brain Behav 9(8):958-967.
54. Campbell A, Hausmann M. 2013. Effects of oxytocin on women's aggression depend on state anxiety. Aggress Behav 39(4):316-322.
55. Canastar A, Maxson SC. 2003. Sexual aggression in mice: Effects of male strain and of female estrous state. Behav Genet 33(5):521-528.
56. Caramaschi D, de Boer SF, et al. 2007. Differential role of the 5-HT1A receptor in aggressive and non-aggressive mice: An across-strain comparison. Physiol Behav 90(4):590-601.
57. Carlisle HJ, Luong TN, Medina-Marino A, Schenker L, Khorosheva E, Indersmitten T, Gunapala KM, Steele AD, O'Dell TJ, Patterson PH, Kennedy MB. 2011. Deletion of densin-180 results in abnormal behaviors associated with mental illness and reduces mGluR5 and DISC1 in the postsynaptic density fraction. J Neurosci 31(45):16194-16207.
58. Caspi A, Langley K, Milne B, Moffitt TE, O'Donovan M, Owen MJ, Polo Tomas M, Poulton R, Rutter M, Taylor A, Williams B, Thapar A. 2008. A replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 65(2):203-210.
59. Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, Taylor A, Poulton R. 2002. Role of genotype in the cycle of violence in maltreated children. Science 297(5582):851-854.
60. Chamero P, Katsoulidou V, Hendrix P, Bufe B, Roberts R, Matsunami H, Abramowitz J, Birnbaumer L, Zufall F, Leinders-Zufall T. 2011. G protein G(alpha)o is essential for vomeronasal function and aggressive behavior in mice. Proc Natl Acad Sci USA 108(31):12898-12903.
61. Champagne FA, Curley JP, Swaney WT, Hasen NS, Keverne EB. 2009. Paternal influence on female behavior: The role of Peg3 in exploration, olfaction, and neuroendocrine regulation of maternal behavior of female mice. Behav Neurosci 123(3):469-480.
62. Cheh MA, Millonig JH, Roselli LM, Ming X, Jacobsen E, Kamdar S, Wagner GC. 2006. En2 knockout mice display neurobehavioral and neurochemical alterations relevant to autism spectrum disorder. Brain Res 1116(1):166-176.
63. Chen B, Gu T, Ma B, Zheng G, Ke B, Zhang X, Zhang L, Wang Y, Hu L, Chen Y, Qiu J, Nie S. 2014. The CRHR1 gene contributes to genetic susceptibility of aggressive behavior towards others in Chinese southwest Han population. J Mol Neurosci 52(4):481-486.
64. Chen TJ, Blum K, Mathews D, Fisher L, Schnautz N, Braverman ER, Schoolfield J, Downs BW, Comings DE. 2005. Are dopaminergic genes involved in a predisposition to pathological aggression? Hypothesizing the importance of "super normal controls" in psychiatricgenetic research of complex behavioral disorders. Med Hypotheses 65(4):703-707.
65. Chen C, Rainnie DG, et al. 1994. Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase II. Science 266(5183):291-294.
66. Cheng D, Hong CJ, Liao DL, Tsai SJ. 2006. Association study of androgen receptor CAG repeat polymorphism and male violent criminal activity. Psychoneuroendocrinology 31(4):548-552.
67. Cherek DR, Pickens R. 1970. Schedule-induced aggression as a function of fixed-ratio Value. J Exp Anal Behav 14(3):309-311.
68. Coccara EF, Berman ME, Kavoussi RJ. 1997. Assessment of life history of aggression: Development and psychometric characteristics. Psychiatry Res 73:147-157.
69. Conner TS, Jensen KP, Tennen H, Furneaux HM, Kranzler HR, Covault J. 2010. Functional polymorphisms in the serotonin 1B receptor gene (HTR1B) predict self-reported anger and hostility among young men. Am J Med Genet B Neuropsychiatr Genet 153B(1):67-78.
70. Conway CC, Keenan-Miller D, Hammen C, Lind PA, Najman JM, Brennan PA. 2012. Coaction of stress and serotonin transporter genotype in predicting aggression at the transition to adulthood. J Clin Child Adolesc Psychol 41(1):53-63.
71. Coste SC, Heard AD, Phillips TJ, Stenzel-Poore MP. 2006. Corticotropin-releasing factor receptor type 2-deficient mice display impaired coping behaviors during stress. Genes Brain Behav 5(2):131-138.
72. Coutellier L, Beraki S, Ardestani PM, Saw NL, Shamloo M. 2012. Npas4: A neuronal transcription factor with a key role in social and cognitive functions relevant to developmental disorders. PLoS One 7(9):e46604.
73. Crawley JN, Belknap JK, et al. 1997. Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies. Psychopharmacology (Berl) 132(2):107-124.
74. Cuthbert BN, Insel TR. 2013. New directions in diagnosis research domain criteria and global mental health. In: Sorel E, editor. 21st century global mental health. Burlington, MA: Jones & Bartlett Learning. pp 55-70.
75. D'Adamo P, Welzl H, Papadimitriou S, Raffaele di Barletta M, Tiveron C, Tatangelo L, Pozzi L, Chapman PF, Knevett SG, Ramsay MF, Valtorta F, Leoni C, Menegon A, Wolfer DP, Lipp HP, Toniolo D. 2002. Deletion of the mental retardation gene Gdi1 impairs associative memory and alters social behavior in mice. Hum Mol Genet 11(21):2567-2580.
76. Dadds MR, Moul C, Cauchi A, Dobson-Stone C, Hawes DJ, Brennan J, Urwin R, Ebstein RE. 2014. Polymorphisms in the oxytocin receptor gene are associated with the development of psychopathy. Dev Psychopathol 26(1):21-31.
77. Dahanukar A, Ray A. 2011. Courtship, aggression and avoidance: Pheromones, receptors and neurons for social behaviors in Drosophila. Fly (Austin) 5(1):58-63.
78. Dankert HL, Wang L, et al. 2009. Automated monitoring and analysis of social behavior in Drosophila. Nat Methods 6(4):297-303.
79. DaVanzo JP, Chamberlain JK, et al. 1986. Regional [3H]testosterone uptake in the brain of isolated non-aggressive mice. Brain Res 369(1-2):224-230.
80. Davis JK, Mittel LB, et al. 2011. "Haplotype-based genomic sequencing of a chromosomal polymorphism in the white-throated sparrow (Zonotrichia albicollis). J Hered 102(4):380-390.
81. de Almeida RM, Miczek KA. 2002. Aggression escalated by social instigation or by discontinuation of reinforcement ("frustration") in mice: Inhibition by anpirtoline: A 5-HT1B receptor agonist. Neuropsychopharmacology 27(2):171-181.
82. Del Punta K, Leinders-Zufall T, Rodriguez I, Jukam D, Wysocki CJ, Ogawa S, Zufall F, Mombaerts P. 2002. Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes. Nature 419(6902):70-74.
83. Derringer J, Krueger RF, Irons DE, Iacono WG. 2010. Harsh discipline, childhood sexual assault, and MAOA genotype: An investigation of main and interactive effects on diverse clinical externalizing outcomes. Behav Genet 40(5):639-648.
84. DeYoung CG, Getchell M, Koposov RA, Yrigollen CM, Haeffel GJ, af Klinteberg B, Oreland L, Ruchkin VV, Pakstis AJ, Grigorenko EL. 2010. Variation in the catechol-O-methyltransferase Val 158 Met polymorphism associated with conduct disorder and ADHD symptoms, among adolescent male delinquents. Psychiatr Genet 20(1):20-24.
85. Dhakar MB, Rich ME, Reno EL, Lee HJ, Caldwell HK. 2012. Heightened aggressive behavior in mice with lifelong versus postweaning knockout of the oxytocin receptor. Horm Behav 62(1):86-92.
86. Dick DM, Aliev F, Wang JC, Grucza RA, Schuckit M, Kuperman S, Kramer J, Hinrichs A, Bertelsen S, Budde JP, Hesselbrock V, Porjesz B, Edenberg HJ, Bierut LJ, Goate A. 2008. Using dimensional models of externalizing psychopathology to aid in gene identification. Arch Gen Psychiatry 65(3):310-318.
87. Dick DM, Meyers JL, Latendresse SJ, Creemers HE, Lansford JE, Pettit GS, Bates JE, Dodge KA, Budde J, Goate A, Buitelaar JK, Ormel J, Verhulst FC, Huizink AC. 2011. CHRM2, parental monitoring, and adolescent externalizing behavior: evidence for gene-environment interaction. Psychol Sci 22(4):481-489.
88. Dijkstra JK, Lindenberg S, Zijlstra L, Bouma E, Veenstra R. 2013. The secret ingredient for social success of young males: A functional polymorphism in the 5HT2A serotonin receptor gene. PLoS One 8(2):e54821.
89. Dmitrieva J, Chen C, Greenberger E, Ogunseitan O, Ding YC. 2011. Gender-specific expression of the DRD4 gene on adolescent delinquency, anger and thrill seeking. Soc Cogn Affect Neurosci 6(1):82-89.
90. Duncan GE, Moy SS, et al. 2004. Deficits in sensorimotor gating and tests of social behavior in a genetic model of reduced NMDA receptor finction. Behav Brain Res 153(2):507-519.
91. Duysen EG, Stribley JA, Fry DL, Hinrichs SH, Lockridge O. 2002. Rescue of the acetylcholinesterase knockout mouse by feeding a liquid diet; phenotype of the adult acetylcholinesterase deficient mouse. Brain Res Dev Brain Res 137(1):43-54.
92. Edwards AC, Dodge KA, Latendresse SJ, Lansford JE, Bates JE, Pettit GS, Budde JP, Goate AM, Dick DM. 2010. MAOA-uVNTR and early physical discipline interact to influence delinquent behavior. J Child Psychol Psychiatry 51(6):679-687.
93. Edwards AC, Rollmann SM, et al. 2006. Quantitative genomics of aggressive behavior in Drosophila melanogaster. PLoS Genet 2(9):e154.
94. Edwards AC, Ayroles JF, Stone EA, Carbone MA, Lyman RF, Mackay TF. 2009. A transcriptional network associated with natural variation in Drosophila aggressive behavior. Genome Biol 10(7):R76.
95. Eisenberger NI, Way BM, Taylor SE, Welch WT, Lieberman MD. 2007. Understanding genetic risk for aggression: Clues from the brain's response to social exclusion. Biol Psychiatry 61(9):1100-1108.
96. Eley TC, Lichtenstein P, Stevenson J. 1999. Sex differences in the etiology of aggressive and nonaggressive antisocial behavior: Results from two twin studies. Child Dev 70:155-168.
97. Evans J, Reeves B, Platt H, Leibenau A, Goldman D, Jefferson K, Nutt D. 2000. Impulsiveness, serotonin genes and repetition of deliberate self-harm (DSH). Psychol Med 30(6):1327-1334.
98. Falconer DS. 1960. Introduction to quantitative genetics. Edinburgh: Oliver and Boyd.
99. Farbiash T, Berger A, Atzaba-Poria N, Auerbach JG. 2014. Prediction of preschool aggression from DRD4 risk, parental ADHD symptoms, and home chaos. J Abnorm Child Psychol 42(3):489-499.
100. Fergusson DM, Boden JM, Horwood LJ, Miller A, Kennedy MA. 2012. Moderating role of the MAOA genotype in antisocial behaviour. Br J Psychiatry 200(2):116-123.
101. Fergusson DM, Boden JM, Horwood LJ, Miller AL, Kennedy MA. 2011. MAOA, abuse exposure and antisocial behaviour: 30-year longitudinal study. Br J Psychiatry 198(6):457-463.
102. Fernandez MP, Kravitz EA. 2013. Aggression and courtship in Drosophila: Pheromonal communication and sex recognition. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 199(11):1065-1076.
103. Ficken RW, Ficken MS, et al. 1978. Differential aggression in genetically different morphs of the white-throated sparros (Zonotrichia albicollis). Z Tierpsychol 46(1):43-57.
104. Ficks CA, Dong L, Waldman ID. 2014. Sex differences in the etiology of psychopathic traits in youth. J Abnorm Psychol 123(2):406-411.
105. Ficks CA, Waldman ID. 2014. Candidate genes for aggression and antisocial behavior: A meta-analysis of association studies of the 5HTTLPR and MAOA-uVNTR. Behav Genet 44(5):427-444.
106. Fischer HS, Zernig G, Schuligoi R, Miczek KA, Hauser KF, Gerard C, Saria A. 2000. Alterations within the endogenous opioid system in mice with targeted deletion of the neutral endopeptidase ('enkephalinase') gene. Regul Pept 96(1-2):53-58.
107. Flirski M, Sieruta M, Golanska E, Kloszewska I, Liberski PP, Sobow T. 2012. PRND 3'UTR polymorphism may be associated with behavioral disturbances in Alzheimer disease. Prion 6(1):73-80.
108. Flory JD, Xu K, New AS, Finch T, Goldman D, Siever LJ. 2007. Irritable assault and variation in the COMT gene. Psychiatr Genet 17(6):344-346.
109. Foley DL, Eaves LJ, Wormley B, Silberg JL, Maes HH, Kuhn J, Riley B. 2004. Childhood adversity, monoamine oxidase a genotype, and risk for conduct disorder. Arch Gen Psychiatry 61(7):738-744.
110. Fontaine NMG, Rijsdijk FV, McCrory EJP, Viding E. 2010. Etiology of different developmental trajectories of callous-unemotional traits. J Am Acad Child Adolesc Psychiatry 49(7):656-664.
111. Fowler T, Langley K, Rice F, van den Bree MB, Ross K, Wilkinson LS, Owen MJ, O'Donovan MC, Thapar A. 2009. Psychopathy trait scores in adolescents with childhood ADHD: The contribution of genotypes affecting MAOA, 5HTT and COMT activity. Psychiatr Genet 19(6):312-319.
112. Frazzetto G, Di Lorenzo G, Carola V, Proietti L, Sokolowska E, Siracusano A, Gross C, Troisi A. 2007. Early trauma and increased risk for physical aggression during adulthood: The moderating role of MAOA genotype. PLoS One 2(5):4e486.
113. Frisell T, Pawitan Y, Långström N, Lichtenstein P. 2012. Heritability, assortative mating and gender differences in violent crime: Results from a total population sample using twin, adoption, and sibling models. Behav Genet 42(1):3-18. DOI: 10.1007/s10519-011-9483-0
114. Frye CA, Rhodes ME, Walf A, Harney JP. 2002. Testosterone enhances aggression of wild-type mice but not those deficient in type I 5alpha-reductase. Brain Res 948(1-2):165-170.
115. Fujisawa KK, Yamagata S, Ozaki K, Ando J. 2012. Hyperactivity/inattention problems moderate environmental but not genetic mediation between negative parenting and conduct problems. J Abnorm Child Psychol 40:189-200. DOI: 10.1007/s10802-011-9559-6
116. Furnari MA, Jobes ML, Nekrasova T, Minden A, Wagner GC. 2013. Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice. PLoS One 8(4):e61321.
117. Fyffe SL, Neul JL, Samaco RC, Chao HT, Ben-Shachar S, Moretti P, McGill BE, Goulding EH, Sullivan E, Tecott LH, Zoghbi HY. 2008. Deletion of Mecp2 in Sim1-expressing neurons reveals a critical role for MeCP2 in feeding behavior, aggression, and the response to stress. Neuron 59(6):947-958.
118. Gagne JR, Saudino KJ, Asherson P. 2011. The genetic etiology of inhibitory control and behavior problems at 24 months of age. J Child Psychol Psychiatry 52:1155-1163. DOI: 10.1111/j.1469-7610.2011.02420.x
119. Gallardo-Pujol D, Andres-Pueyo A, Maydeu-Olivares A. 2013. MAOA genotype, social exclusion and aggression: An experimental test of a gene-environment interaction. Genes Brain Behav 12(1):140-145.
120. Gallitano-Mendel A, Wozniak DF, Pehek EA, Milbrandt J. 2008. Mice lacking the immediate early gene Egr3 respond to the anti-aggressive effects of clozapine yet are relatively resistant to its sedating effects. Neuropsychopharmacology 33(6):1266-1275.
121. Gammie SC, Hasen NS, Stevenson SA, Bale TL, D'Anna KL. 2005. Elevated stress sensitivity in corticotropin-releasing factor receptor 2 deficient mice decreases maternal, but not intermale aggression. Behav Brain Res 160(1):169-177.
122. Gammie SC, Bethea ED, Stevenson SA. 2007. Altered maternal profiles in corticotropin-releasing factor receptor 1 deficient mice. BMC Neurosci 8:17.
123. Gammie SC, Seasholtz AF, Stevenson SA. 2008. Deletion of corticotropin-releasing factor binding protein selectively impairs maternal, but not intermale aggression. Neuroscience 157(3):502-512.
124. Garcia LF, Aluja A, Fibla J, Cuevas L, Garcia O. 2010. Incremental effect for antisocial personality disorder genetic risk combining 5-HTTLPR and 5-HTTVNTR polymorphisms. Psychiatry Res 177(1-2):161-166.
125. Gerra G, Garofano L, Castaldini L, Rovetto F, Zaimovic A, Moi G, Bussandri M, Branchi B, Brambilla F, Friso G, Donnini C. 2005. Serotonin transporter promoter polymorphism genotype is associated with temperament, personality traits and illegal drugs use among adolescents. J Neural Transm 112(10):1397-1410.
126. Giegling I, Hartmann AM, Moller HJ, Rujescu D. 2006. Anger- and aggression-related traits are associated with polymorphisms in the 5-HT-2A gene. J Affect Disord 96(1-2):75-81.
127. Gietl A, Giegling I, Hartmann AM, Schneider B, Schnabel A, Maurer K, Moller HJ, Rujescu D. 2007. ABCG1 gene variants in suicidal behavior and aggression-related traits. Eur Neuropsychopharmacol 17(6-7):410-416.
128. Gimenez-Llort L, Fernandez-Teruel A, Escorihuela RM, Fredholm BB, Tobena A, Pekny M, Johansson B. 2002. Mice lacking the adenosine A1 receptor are anxious and aggressive, but are normal learners with reduced muscle strength and survival rate. Eur J Neurosci 16(3):547-550.
129. Gobrogge KL, Liu Y, et al. 2007. "Anterior hypothalamic neural activation and neurochemical associations with aggression in pair-bonded male prairie voles. J Comp Neurol 502(6):1109-1122.
130. Godar SC, Bortolato M, Frau R, Dousti M, Chen K, Shih JC. 2011. Maladaptive defensive behaviours in monoamine oxidase A-deficient mice. Int J Neuropsychopharmacol 14(9):1195-1207.
131. Gonda X, Fountoulakis KN, Juhasz G, Rihmer Z, Lazary J, Laszik A, Akiskal HS, Bagdy G. 2009. Association of the s allele of the 5-HTTLPR with neuroticism-related traits and temperaments in a psychiatrically healthy population. Eur Arch Psychiatry Clin Neurosci 259(2):106-113.
132. Gonzalez I, Penas-Lledo EM, Perez B, Dorado P, Alvarez M, LLerena A. 2008. Relation between CYP2D6 phenotype and genotype and personality in healthy volunteers. Pharmacogenomics 9(7):833-840.
133. Gorodetsky E, Bevilacqua L, Carli V, Sarchiapone M, Roy A, Goldman D, Enoch MA. 2014. The interactive effect of MAOA-LPR genotype and childhood physical neglect on aggressive behaviors in Italian male prisoners. Genes Brain Behav 13(6):543-549.
134. Gouin JP, Carter CS, et al. 2012. Plasma vasopressin and interpersonal functioning. Biol Psychol 91(2):270-274.
135. Grayton HM, Missler M, Collier DA, Fernandes C. 2013. Altered social behaviours in neurexin 1alpha knockout mice resemble core symptoms in neurodevelopmental disorders. PLoS One 8(6):e67114.
136. Greenberg BD, Li Q, Lucas FR, Hu S, Sirota LA, Benjamin J, Lesch KP, Hamer D, Murphy DL. 2000. Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample. Am J Med Genet 96(2):202-216.
137. Grgurevic N, Budefeld T, Rissman EF, Tobet SA, Majdic G. 2008. Aggressive behaviors in adult SF-1 knockout mice that are not exposed to gonadal steroids during development. Behav Neurosci 122(4):876-884.
138. Guo G, Ou XM, Roettger M, Shih JC. 2008. The VNTR 2 repeat in MAOA and delinquent behavior in adolescence and young adulthood: Associations and MAOA promoter activity. Eur J Hum Genet 16(5):626-634.
139. Guo G, Roettger ME, Shih JC. 2007. Contributions of the DAT1 and DRD2 genes to serious and violent delinquency among adolescents and young adults. Hum Genet 121(1):125-136.
140. Gyurak A, Haase CM, Sze J, Goodkind MS, Coppola G, Lane J, Miller BL, Levenson RW. 2013. The effect of the serotonin transporter polymorphism (5-HTTLPR) on empathic and self-conscious emotional reactivity. Emotion 13(1):25-35.
141. Haberstick BC, Lessem JM, Hewitt JK, Smolen A, Hopfer CJ, Halpern CT, Killeya-Jones LA, Boardman JD, Tabor J, Siegler IC, Williams RB, Mullan Harris K. 2014. MAOA genotype, childhood maltreatment, and their interaction in the etiology of adult antisocial behaviors. Biol Psychiatry 75(1):25-30.
142. Haberstick BC, Lessem JM, Hopfer CJ, Smolen A, Ehringer MA, Timberlake D, Hewitt JK. 2005. Monoamine oxidase A (MAOA) and antisocial behaviors in the presence of childhood and adolescent maltreatment. Am J Med Genet B Neuropsychiatr Genet 135B(1):59-64.
143. Haberstick BC, Smolen A, Hewitt JK. 2006. Family-based association test of the 5HTTLPR and aggressive behavior in a general population sample of children. Biol Psychiatry 59(9):836-843.
144. Hakulinen C, Jokela M, Hintsanen M, Merjonen P, Pulkki-Raback L, Seppala I, Lyytikainen LP, Lehtimaki T, Kahonen M, Viikari J, Raitakari OT, Keltikangas-Jarvinen L. 2013. Serotonin receptor 1B genotype and hostility, anger and aggressive behavior through the lifespan: The Young Finns study. J Behav Med 36(6):583-590.
145. Hammock EA, Lim MM, et al. 2005. Association of vasopressin 1a receptor levels with a regulatory microsatellite and behabior. Genes Brain Behav 4(5):289-301.
146. Hamshere ML, Langley K, Martin J, Agha SS, Stergiakouli E, Anney RJ, Buitelaar J, Faraone SV, Lesch KP, Neale BM, Franke B, Sonuga-Barke E, Asherson P, Merwood A, Kuntsi J, Medland SE, Ripke S, Steinhausen HC, Freitag C, Reif A, Renner TJ, Romanos M, Romanos J, Warnke A, Meyer J, Palmason H, Vasquez AA, Lambregts-Rommelse N, Roeyers H, Biederman J, Doyle AE, Hakonarson H, Rothenberger A, Banaschewski T, Oades RD, McGough JJ, Kent L, Williams N, Owen MJ, Holmans P, O'Donovan MC, Thapar A. 2013. High loading of polygenic risk for ADHD in children with comorbid aggression. Am J Psychiatry 170(8):909-916.
147. Hare RD. 1985. Comparison of procedures for the assessment of psychopathy. J Consult Clin Psychol 53:7-16.
148. Hasegawa S, Furuichi T, Yoshida T, Endoh K, Kato K, Sado M, Maeda R, Kitamoto A, Miyao T, Suzuki R, Homma S, Masushige S, Kajii Y, Kida S. 2009. Transgenic up-regulation of alpha-CaMKII in forebrain leads to increased anxiety-like behaviors and aggression. Mol Brain 2:6.
149. Heiming RS, Monning A, Jansen F, Kloke V, Lesch KP, Sachser N. 2013. To attack, or not to attack? The role of serotonin transporter genotype in the display of maternal aggression. Behav Brain Res 242:135-141.
150. Hendricks TJ, Fyodorov DV, Wegman LJ, Lelutiu NB, Pehek EA, Yamamoto B, Silver J, Weeber EJ, Sweatt JD, Deneris ES. 2003. Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior. Neuron 37(2):233-247.
151. Hennig J, Reuter M, Netter P, Burk C, Landt O. 2005. Two types of aggression are differentially related to serotonergic activity and the A779C TPH polymorphism. Behav Neurosci 119(1):16-25.
152. Hess C, Reif A, Strobel A, Boreatti-Hummer A, Heine M, Lesch KP, Jacob CP. 2009. A functional dopamine-beta-hydroxylase gene promoter polymorphism is associated with impulsive personality styles, but not with affective disorders. J Neural Transm 116(2):121-130.
153. Hicks BM, South SC, Dirago AC, Iacono WG, McGue M. 2009. Environmental adversity and increasing genetic risk for externalizing disorders. Arch Gen Psychiatry 66(6):640-648.
154. Hicks BM, Foster KT, Iacono WG, McGue M. 2013. Genetic and environmental influences on the familial transmission of externalizing disorders in adoptive and twin offspring. JAMA Psychiatry 70(10):1076-1083.
155. Hohmann S, Becker K, Fellinger J, Banaschewski T, Schmidt MH, Esser G, Laucht M. 2009. Evidence for epistasis between the 5-HTTLPR and the dopamine D4 receptor polymorphisms in externalizing behavior among 15-year-olds. J Neural Transm 116(12):1621-1629.
156. Holzinger KJ. 1929. The relative effect of nature and nurture influences on twin differences. J Educ Psychol 20:241-248.
157. Horton BM, Hudson WH, et al. 2014. Estrogen receptor alpha polymorphism in a species with alternative behavioral phenotypes. Proc Natl Acad Sci USA 111(4):1443-1448.
158. Horton BM, Hu Y, et al. 2013. Behavioral characterization of a white-throated sparrow homozygous for the ZAL2(m) chromosomal rearrangement. Behav Genet 43(1):60-70.
159. Hoyer SC, Eckart A, et al. 2008. Octopamine in male aggression of Drosophila. Curr Biol 18(3):159-167.
160. Huizinga D, Haberstick BC, Smolen A, Menard S, Young SE, Corley RP, Stallings MC, Grotpeter J, Hewitt JK. 2006. Childhood maltreatment, subsequent antisocial behavior, and the role of monoamine oxidase A genotype. Biol Psychiatry 60(7):677-683.
161. Huppke P, Maier EM, Warnke A, Brendel C, Laccone F, Gartner J. 2006. Very mild cases of Rett syndrome with skewed X inactivation. J Med Genet 43(10):814-816.
162. Huynh LY, Maney DL, et al. 2011. Chromosome-wide linkage disequilibrium caused by an inversion polymorphism in the white-throated sparrow (Zonotrichia albicollis). Heredity (Edinb) 106(4):537-546.
163. Innos J, Philips MA, Leidmaa E, Heinla I, Raud S, Reemann P, Plaas M, Nurk K, Kurrikoff K, Matto V, Visnapuu T, Mardi P, Koks S, Vasar E. 2011. Lower anxiety and a decrease in agonistic behaviour in Lsamp-deficient mice. Behav Brain Res 217(1):21-31.
164. Insel TR, Shapiro LE. 1992. Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles. Proc Natl Acad Sci USA 89(13):5981-5985.
165. Insel TR, Preston S, et al. 1995. Mating in the monogamous male: Behavioral consequences. Physiol Behav 57(4):615-627.
166. Ishihama T, Ago Y, Shintani N, Hashimoto H, Baba A, Takuma K, Matsuda T. 2010. Environmental factors during early developmental period influence psychobehavioral abnormalities in adult PACAP-deficient mice. Behav Brain Res 209(2):274-280.
167. Ito W, Chehab M, Thakur S, Li J, Morozov A. 2011. BDNF-restricted knockout mice as an animal model for aggression. Genes Brain Behav 10(3):365-374.
168. Jaubert PJ, Golub MS, Lo YY, Germann SL, Dehoff MH, Worley PF, Kang SH, Schwarz MK, Seeburg PH, Berman RF. 2007. Complex, multimodal behavioral profile of the Homer1 knockout mouse. Genes Brain Behav 6(2):141-154.
169. Jensen KP, Covault J, Conner TS, Tennen H, Kranzler HR, Furneaux HM. 2009. A common polymorphism in serotonin receptor 1B mRNA moderates regulation by miR-96 and associates with aggressive human behaviors. Mol Psychiatry 14(4):381-389.
170. Johnson W, Mcgue MK, Iacono WG. 2009. School performance and genetic and environmental variance in antisocial behavior at the transition from adolescence to adulthood. Dev Psychol 45(4):973-987. DOI: 10.1037/a0016225
171. Jonsson EG, von Gertten C, Gustavsson JP, Yuan QP, Lindblad-Toh K, Forslund K, Rylander G, Mattila-Evenden M, Asberg M, Schalling M. 2001. Androgen receptor trinucleotide repeat polymorphism and personality traits. Psychiatr Genet 11(1):19-23.
172. Juarez P, Valdovinos MG, May ME, Lloyd BP, Couppis MH, Kennedy CH. 2013. Serotonin(2)A/C receptors mediate the aggressive phenotype of TLX gene knockout mice. Behav Brain Res 256:354-361.
173. Kaidanovich-Beilin O, Lipina TV, Takao K, van Eede M, Hattori S, Laliberte C, Khan M, Okamoto K, Chambers JW, Fletcher PJ, MacAulay K, Doble BW, Henkelman M, Miyakawa T, Roder J, Woodgett JR. 2009. Abnormalities in brain structure and behavior in GSK-3alpha mutant mice. Mol Brain 2:35.
174. Kang JI, Namkoong K, Kim SJ. 2008. Association of DRD4 and COMT polymorphisms with anger and forgiveness traits in healthy volunteers. Neurosci Lett 430(3):252-257.
175. Karl T, Lin S, Schwarzer C, Sainsbury A, Couzens M, Wittmann W, Boey D, von Horsten S, Herzog H. 2004. Y1 receptors regulate aggressive behavior by modulating serotonin pathways. Proc Natl Acad Sci USA 101(34):12742-12747.
176. Kayasuga Y, Chiba S, Suzuki M, Kikusui T, Matsuwaki T, Yamanouchi K, Kotaki H, Horai R, Iwakura Y, Nishihara M. 2007. Alteration of behavioural phenotype in mice by targeted disruption of the progranulin gene. Behav Brain Res 185(2):110-118.
177. Keltikangas-Jarvinen L, Puttonen S, Kivimaki M, Elovainio M, Pulkki-Raback L, Koivu M, Rontu R, Lehtimaki T. 2008. Serotonin receptor genes 5HT1A and 5HT2A modify the relation between childhood temperament and adulthood hostility. Genes Brain Behav 7(1):46-52.
178. Kendler KS, Patrick CJ, Larsson H, Gardner CO, Lichtenstein P. 2013. Genetic and environmental risk factors in males for self-report externalizing traits in mid-adolescence and criminal behavior through young adulthood. Psychol Med 43:2161-2168.
179. Kieling C, Hutz MH, Genro JP, Polanczyk GV, Anselmi L, Camey S, Hallal PC, Barros FC, Victora CG, Menezes AM, Rohde LA. 2013. Gene-environment interaction in externalizing problems among adolescents: Evidence from the Pelotas 1993 Birth Cohort Study. J Child Psychol Psychiatry 54(3):298-304.
180. Kim-Cohen J, Caspi A, Taylor A, Williams B, Newcombe R, Craig IW, Moffitt TE. 2006. MAOA, maltreatment, and gene-environment interaction predicting children's mental health: New evidence and a meta-analysis. Mol Psychiatry 11(10):903-913.
181. Kim C, Jeon D, Kim YH, Lee CJ, Kim H, Shin HS. 2009. Deletion of N-type Ca(2+) channel Ca(v)2.2 results in hyperaggressive behaviors in mice. J Biol Chem 284(5):2738-2745.
182. Kim S, Ma L, Jensen KL, Kim MM, Bond CT, Adelman JP, Yu CR. 2012. Paradoxical contribution of SK3 and GIRK channels to the activation of mouse vomeronasal organ. Nat Neurosci 15(9):1236-1244.
183. Kirley A, Lowe N, Mullins C, McCarron M, Daly G, Waldman I, Fitzgerald M, Gill M, Hawi Z. 2004. Phenotype studies of the DRD4 gene polymorphisms in ADHD: Association with oppositional defiant disorder and positive family history. Am J Med Genet B Neuropsychiatr Genet 131B(1):38-42.
184. Kohl C, Riccio O, Grosse J, Zanoletti O, Fournier C, Klampfl SM, Schmidt MV, Sandi C. 2013. The interplay of conditional NCAM-knockout and chronic unpredictable stress leads to increased aggression in mice. Stress 16(6):647-654.
185. Konig M, Zimmer AM, Steiner H, Holmes PV, Crawley JN, Brownstein MJ, Zimmer A. 1996. Pain responses, anxiety and aggression in mice deficient in pre-proenkephalin. Nature 383(6600):535-538.
186. Kourmouli N, Samakouri M, Mamatsiou A, Trypsianis G, Livaditis M, Veletza S. 2013. Effect of BDNF Val66Met and serotonin transporter 5-HTTLPR polymorphisms on psychopathological characteristics in a sample of university students. Psychiatr Genet 23(5):188-197.
187. Kretschmer T, Vitaro F, Barker ED. 2014. The association between peer and own aggression is moderated by the val-met polymorphism. J Res Adolesc 24(1):177-185.
188. Krsiak M. 1975. Timid singly-housed mice: Their value in prediction of psychotropic activity of drugs. Br J Pharmacol 55(1):141-150.
189. Kuepper Y, Grant P, Wielpuetz C, Hennig J. 2013. MAOA-uVNTR genotype predicts interindividual differences in experimental aggressiveness as a function of the degree of provocation. Behav Brain Res 247:73-78.
190. Kulikova MA, Maluchenko NV, Timofeeva MA, Shlepzova VA, Schegolkova JV, Sysoeva OV, Ivanitsky AM, Tonevitsky AG. 2008. Effect of functional catechol-O-methyltransferase Val158Met polymorphism on physical aggression. Bull Exp Biol Med 145(1):62-64.
191. Kumar RA, McGhee KA, Leach S, Bonaguro R, Maclean A, Aguirre-Hernandez R, Abrahams BS, Coccaro EF, Hodgins S, Turecki G, Condon A, Muir WJ, Brooks-Wilson AR, Blackwood DH, Simpson EM. 2008. Initial association of NR2E1 with bipolar disorder and identification of candidate mutations in bipolar disorder, schizophrenia, and aggression through resequencing. Am J Med Genet B Neuropsychiatr Genet 147B(6):880-889.
192. Lahey BB, Van Hulle Ca, Singh AL, Waldman ID, Rathouz PJ. 2011. Higher-order genetic and environmental structure of prevalent forms of child and adolescent psychopathology. Arch Gen Psychiatry 68(2):181-189. DOI: 10.1001/archgenpsychiatry.2010.192
193. Lamb DJ, Middeldorp CM, Van Beijsterveldt CEM, Boomsma DI. 2012. Gene-environment interaction in teacher-rated internalizing and externalizing problem behavior in 7- to 12-year-old twins. J Child Psychol Psychiatry 53:818-825. DOI: 10.1111/j.1469-7610.2011.02497.x
194. Latendresse SJ, Bates JE, Goodnight JA, Lansford JE, Budde JP, Goate A, Dodge KA, Pettit GS, Dick DM. 2011. Differential susceptibility to adolescent externalizing trajectories: Examining the interplay between CHRM2 and peer group antisocial behavior. Child Dev 82(6):1797-1814.
195. Lazzari VM, Becker RO, de Azevedo MS, Morris M, Rigatto K, Almeida S, Lucion AB, Giovenardi M. 2013. Oxytocin modulates social interaction but is not essential for sexual behavior in male mice. Behav Brain Res 244:130-136.
196. Ledent C, Vaugeois JM, Schiffmann SN, Pedrazzini T, El Yacoubi M, Vanderhaeghen JJ, Costentin J, Heath JK, Vassart G, Parmentier M. 1997. Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor. Nature 388(6643):674-678.
197. Lee SS, Lahey BB, Waldman I, Van Hulle CA, Rathouz P, Pelham WE, Loney J, Cook EH. 2007. Association of dopamine transporter genotype with disruptive behavior disorders in an eight-year longitudinal study of children and adolescents. Am J Med Genet B Neuropsychiatr Genet 144B(3):310-317.
198. Ligthart L, Bartels M, Hoekstra RA, Hudziak JJ, Boomsma DI. 2005. Genetic contributions to subtypes of aggression. Twin Res Hum Genet 8(5):483-491.
199. Liao DL, Hong CJ, Shih HL, Tsai SJ. 2004. Possible association between serotonin transporter promoter region polymorphism and extremely violent crime in Chinese males. Neuropsychobiology 50(4):284-287.
200. Lim MM, Wang Z, et al. 2004. Enhanced partner preference in a promiscuous species by manipulating the expression of a single gene. Nature 429(6993):754-757.
201. Lindzey G, Winston H, et al. 1961. Social dominance in inbred mouse strains. Nature 191:474-476.
202. Liu GX, Liu S, Cai GQ, Sheng ZJ, Cai YQ, Jiang J, Sun X, Ma SK, Wang L, Wang ZG, Fei J. 2007. Reduced aggression in mice lacking GABA transporter subtype 1. J Neurosci Res 85(3):649-655.
203. Liu Y, Slotine J, Barabasi A. 2011. Controllability of complex networks. Nature 473:167-173.
204. Loconto J, Papes F, Chang E, Stowers L, Jones EP, Takada T, Kumanovics A, Fischer Lindahl K, Dulac C. 2003. Functional expression of murine V2R pheromone receptors involves selective association with the M10 and M1 families of MHC class Ib molecules. Cell 112(5):607-618.
205. Logue MW, Solovieff N, Leussis MP, Wolf EJ, Melista E, Baldwin C, Koenen KC, Petryshen TL, Miller MW. 2013. The ankyrin-3 gene is associated with posttraumatic stress disorder and externalizing comorbidity. Psychoneuroendocrinology 38(10):2249-2257.
206. Lonstein JS, Gammie SC. 2002. Sensory, hormonal, and neural control of maternal aggression in laboratory rodents. Neurosci Biobehav Rev 26(8):869-888.
207. Lopez-Castroman J, Jaussent I, Beziat S, Guillaume S, Baca-Garcia E, Genty C, Olie E, Courtet P. 2014. Increased severity of suicidal behavior in impulsive aggressive patients exposed to familial adversities. Psychol Med 44(14):3059-3068.
208. Lu RB, Lin WW, Lee JF, Ko HC, Shih JC. 2003. Neither antisocial personality disorder nor antisocial alcoholism is associated with the MAO-A gene in Han Chinese males. Alcohol Clin Exp Res 27(6):889-893.
209. Luppino D, Moul C, Hawes DJ, Brennan J, Dadds MR. 2014. Association between a polymorphism of the vasopressin 1B receptor gene and aggression in children. Psychiatr Genet 24(5):185-190.
210. Mackay TF, Richards S, Stone EA, Barbadilla A, Ayroles JF, Zhu D, Casillas S, Han Y, Magwire MM, Cridland JM, Richardson MF, Anholt RR, Barron M, Bess C, Blankenburg KP, Carbone MA, Castellano D, Chaboub L, Duncan L, Harris Z, Javaid M, Jayaseelan JC, Jhangiani SN, Jordan KW, Lara F, Lawrence F, Lee SL, Librado P, Linheiro RS, Lyman RF, Mackey AJ, Munidasa M, Muzny DM, Nazareth L, Newsham I, Perales L, Pu LL, Qu C, Ramia M, Reid JG, Rollmann SM, Rozas J, Saada N, Turlapati L, Worley KC, Wu YQ, Yamamoto A, Zhu Y, Bergman CM, Thornton KR, Mittelman D, Gibbs RA. 2012. The drosophila melanogaster genetic reference panel. Nature 482:173-178.
211. Malik AI, Zai CC, Abu Z, Nowrouzi B, Beitchman JH. 2012. The role of oxytocin and oxytocin receptor gene variants in childhood-onset aggression. Genes Brain Behav 11(5):545-551.
212. Malik AI, Zai CC, Berall L, Abu Z, Din F, Nowrouzi B, Chen S, Beitchman JH. 2014. The role of genetic variants in genes regulating the oxytocin-vasopressin neurohumoral system in childhood-onset aggression. Psychiatr Genet 24(5):201-210.
213. Malki K, Pain O, et al. 2014. Genes and gene networks implicated in aggression Related behaviour. Neurogenetics 15(4): 255-266.
214. Mandiyan VS, Coats JK, Shah NM. 2005. Deficits in sexual and aggressive behaviors in Cnga2 mutant mice. Nat Neurosci 8(12):1660-1662.
215. Maney DL, Goodson JL. 2011. Neurogenomic mechanisms of aggression in songbirds. Adv Genet 75:83-119.
216. Mann JJ, Currier D, Murphy L, Huang YY, Galfalvy H, Brent D, Greenhill L, Oquendo M. 2008. No association between a TPH2 promoter polymorphism and mood disorders or monoamine turnover. J Affect Disord 106(1-2):117-121.
217. Manuck SB, Flory JD, Ferrell RE, Dent KM, Mann JJ, Muldoon MF. 1999. Aggression and anger-related traits associated with a polymorphism of the tryptophan hydroxylase gene. Biol Psychiatry 45(5):603-614.
218. Manuck SB, Flory JD, Ferrell RE, Mann JJ, Muldoon MF. 2000. A regulatory polymorphism of the monoamine oxidase-A gene may be associated with variability in aggression, impulsivity, and central nervous system serotonergic responsivity. Psychiatry Res 95(1):9-23.
219. Manuck SB, Flory JD, Muldoon MF, Ferrell RE. 2002. Central nervous system serotonergic responsivity and aggressive disposition in men. Physiol Behav 77(4-5):705-709.
220. Marino MD, Bourdelat-Parks BN, Cameron Liles L, Weinshenker D. 2005. Genetic reduction of noradrenergic function alters social memory and reduces aggression in mice. Behav Brain Res 161(2):197-203.
221. Matsuoka Y, Furuyashiki T, Yamada K, Nagai T, Bito H, Tanaka Y, Kitaoka S, Ushikubi F, Nabeshima T, Narumiya S. 2005. Prostaglandin E receptor EP1 controls impulsive behavior under stress. Proc Natl Acad Sci USA 102(44):16066-16071.
222. McGrath LM, Mustanski B, Metzger A, Pine DS, Kistner-Griffin E, Cook E, Wakschlag LS. 2012. A latent modeling approach to genotype-phenotype relationships: maternal problem behavior clusters, prenatal smoking, and MAOA genotype. Arch Womens Ment Health 15(4):269-282.
223. Meier MH, Slutske WS, Heath AC, Martin NG. 2011. Sex differences in the genetic and environmental influences on childhood conduct disorder and adult antisocial behavior. J Abnorm Psychol 120(2):377-388. DOI: 10.1016/j.biotechadv.2011.08.021
224. Melotti L, Thomsen LR, et al. 2013. Delay discounting task in pigs reveals response strategies related to dopamine metabolite. Physiol Behav 120:182-192.
225. Merjonen P, Keltikangas-Jarvinen L, Jokela M, Seppala I, Lyytikainen LP, Pulkki-Raback L, Kivimaki M, Elovainio M, Kettunen J, Ripatti S, Kahonen M, Viikari J, Palotie A, Peltonen L, Raitakari OT, Lehtimaki T. 2011. Hostility in adolescents and adults: A genome-wide association study of the Young Finns. Transl Psychiatry 1:e11.
226. Mick E, McGough J, Deutsch CK, Frazier JA, Kennedy D, Goldberg RJ. 2014. Genome-wide association study of proneness to anger. PLoS One 9(1):e87257.
227. Mick E, McGough J, Loo S, Doyle AE, Wozniak J, Wilens TE, Smalley S, McCracken J, Biederman J, Faraone SV. 2011. Genome-wide association study of the child behavior checklist dysregulation profile. J Am Acad Child Adolesc Psychiatry 50(8):807-817 e808.
228. Miczek KA, Fish EW, et al. 2003. Neurosteroids, GABAA receptors, and escalated aggressive behavior. Horm Behav 44(3):242-257.
229. Miczek KA, Maxson SC, et al. 2001. Aggressive behavioral phenotypes in mice. Behav Brain Res 125(1-2):167-181.
230. Miles DR, Carey G. 1997. Genetic and environmental architecture of human aggression. Journal of Personality and Social Psychology 72(I):207-217. DOI: 10.1037/0022-3514.72.1.207
231. Miller BA. 2014. Trpc2. Handb Exp Pharmacol 222:53-65.
232. Mineur YS, Crusio WE. 2002. Behavioral and neuroanatomical characterization of FVB/N inbred mice. Brain Res Bull 57(1):41-47.
233. Miodovnik A, Diplas AI, Chen J, Zhu C, Engel SM, Wolff MS. 2012. Polymorphisms in the maternal sex steroid pathway are associated with behavior problems in male offspring. Psychiatr Genet 22(3):115-122.
234. Mohn AR, Gainetdinov RR, et al. 1999. Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. Cell 98(4):427-436.
235. Montani G, Tonelli S, Sanghez V, Ferrari PF, Palanza P, Zimmer A, Tirindelli R. 2013. Aggressive behaviour and physiological responses to pheromones are strongly impaired in mice deficient for the olfactory G-protein -subunit G8. J Physiol 591(Pt 16):3949-3962.
236. Morgan C, Thomas RE, Cone RD. 2004. Melanocortin-5 receptor deficiency promotes defensive behavior in male mice. Horm Behav 45(1):58-63.
237. Mosienko V, Bert B, et al. 2012. Exaggerated aggression and decreased anxiety in mice deficient in brain serotonin. Transl Psychiatry 2:e122.
238. Moul C, Dobson-Stone C, Brennan J, Hawes D, Dadds M. 2013. An exploration of the serotonin system in antisocial boys with high levels of callous-unemotional traits. PLoS One 8(2):e56619.
239. Mouri A, Hoshino Y, Narusawa S, Ikegami K, Mizoguchi H, Murata Y, Yoshimura T, Nabeshima T. 2014. Thyrotoropin receptor knockout changes monoaminergic neuronal system and produces methylphenidate-sensitive emotional and cognitive dysfunction. Psychoneuroendocrinology 48:147-161.
240. Murakami M, Nakagawasai O, Yanai K, Nunoki K, Tan-No K, Tadano T, Iijima T. 2007. Modified behavioral characteristics following ablation of the voltage-dependent calcium channel beta3 subunit. Brain Res 1160:102-112.
241. Musci RJ, Bradshaw CP, Maher B, Uhl GR, Kellam SG, Ialongo NS. 2014. Reducing aggression and impulsivity through school-based prevention programs: a gene by intervention interaction. Prev Sci 15(6):831-840.
242. Neale MC, Cardon LR. 1992. Methodology for genetic studies of twins and families. Dordrecht, The Netherlands: Kluwer Academic Publishers.
243. Nicot A, Otto T, Brabet P, Dicicco-Bloom EM. 2004. Altered social behavior in pituitary adenylate cyclase-activating polypeptide type I receptor-deficient mice. J Neurosci 24(40):8786-8795.
244. Nikitopoulos J, Zohsel K, Blomeyer D, Buchmann AF, Schmid B, Jennen-Steinmetz C, Becker K, Schmidt MH, Esser G, Brandeis D, Banaschewski T, Laucht M. 2014. Are infants differentially sensitive to parenting? Early maternal care, DRD4 genotype and externalizing behavior during adolescence. J Psychiatr Res 59:53-59.
245. Nikolas M, Klump KL, Burt SA. 2013. Etiological contributions to the covariance between children's perceptions of inter-parental conflict and child behavior problems. J Abnorm Child Psychol 41(2):239-251. DOI: 10.1016/j.biotechadv.2011.08.021
246. Niv S, Ashrafulla S, Tuvblad C, Joshi A, Raine A, Leahy R, Baker LA. 2015. Childhood EEG frontal alpha power as a predictor of adolescent antisocial behavior: A twin heritability study. Biol Psychol 105:72-76. DOI: 10.1016/j.biopsycho.2014.11.010
247. Niv S, Tuvblad C, Raine A, Baker LA. 2013. Aggression and rule-breaking: Heritability and stability of antisocial behavior problems in childhood and adolescence. J Crime Justice 41(5): DOI: 10.1016/j.jcrimjus.2013.06.014
248. Nobile M, Giorda R, Marino C, Carlet O, Pastore V, Vanzin L, Bellina M, Molteni M, Battaglia M. 2007. Socioeconomic status mediates the genetic contribution of the dopamine receptor D4 and serotonin transporter linked promoter region repeat polymorphisms to externalization in preadolescence. Dev Psychopathol 19(4):1147-1160.
249. Nomura M, Andersson S, Korach KS, Gustafsson JA, Pfaff DW, Ogawa S. 2006. Estrogen receptor-beta gene disruption potentiates estrogen-inducible aggression but not sexual behaviour in male mice. Eur J Neurosci 23(7):1860-1868.
250. Ophir AG, Wolff JO, et al. 2008. Variation in neural V1aR predicts sexual fidelity and space use among male prairie voles in semi-natural settings. Proc Natl Acad Sci USA 105(4):1249-1254.
251. O'Tuathaigh CM, O'Connor AM, O'Sullivan GJ, Lai D, Harvey R, Croke DT, Waddington JL. 2008. Disruption to social dyadic interactions but not emotional/anxiety-related behaviour in mice with heterozygous 'knockout' of the schizophrenia risk gene neuregulin-1. Prog Neuropsychopharmacol Biol Psychiatry 32(2):462-466.
252. Ouagazzal AM, Moreau JL, Pauly-Evers M, Jenck F. 2003. Impact of environmental housing conditions on the emotional responses of mice deficient for nociceptin/orphanin FQ peptide precursor gene. Behav Brain Res 144(1-2):111-117.
253. Patel A, Siegel A, Zalcman SS. 2010. Lack of aggression and anxiolytic-like behavior in TNF receptor (TNF-R1 and TNF-R2) deficient mice. Brain Behav Immun 24(8):1276-1280.
254. Perroud N, Jaussent I, Guillaume S, Bellivier F, Baud P, Jollant F, Leboyer M, Lewis CM, Malafosse A, Courtet P. 2010. COMT but not serotonin-related genes modulates the influence of childhood abuse on anger traits. Genes Brain Behav 9(2):193-202.
255. Persson ML, Wasserman D, Jonsson EG, Bergman H, Terenius L, Gyllander A, Neiman J, Geijer T. 2000. Search for the influence of the tyrosine hydroxylase (TCAT)(n) repeat polymorphism on personality traits. Psychiatry Res 95(1):1-8.
256. Philibert RA, Wernett P, Plume J, Packer H, Brody GH, Beach SR. 2011. Gene environment interactions with a novel variable Monoamine Oxidase A transcriptional enhancer are associated with antisocial personality disorder. Biol Psychol 87(3):366-371.
257. Pickles A, Hill J, Breen G, Quinn J, Abbott K, Jones H, Sharp H. 2013. Evidence for interplay between genes and parenting on infant temperament in the first year of life: Monoamine oxidase A polymorphism moderates effects of maternal sensitivity on infant anger proneness. J Child Psychol Psychiatry 54(12):1308-1317.
258. Pingault JB, Cote SM, Booij L, Ouellet-Morin I, Castellanos-Ryan N, Vitaro F, Turecki G, Tremblay RE. 2013. Age-dependent effect of the MAOA gene on childhood physical aggression. Mol Psychiatry 18(11):1151-1152.
259. Plomin R, Chipuer HM, Neiderhiser JM. 1994. Behavioral genetic evidence for the importance of non-shared environment. In: Hetherington EM, Reiss D, Plomin R, editors. Separate social worlds of siblings: The impact of non-shared environment on development. Hillsdale, New Jersey: Lawrence Erlbaum Associates, Inc. Publishers. pp 1-32.
260. Posthuma D, Beem AL, de Geus EJC, van Baal GCM, von Hjelmborg JB, Iachine I, Boomsma DI. 2003. Theory and practice in quantitative genetics. Twin Res 6(5):361-376. DOI: 10.1375/twin.6.5.361
261. Prichard ZM, Jorm AF, Mackinnon A, Easteal S. 2007. Association analysis of 15 polymorphisms within 10 candidate genes for antisocial behavioural traits. Psychiatr Genet 17(5):299-303.
262. Prince JE, Brignall AC, Cutforth T, Shen K, Cloutier JF. 2013. Kirrel3 is required for the coalescence of vomeronasal sensory neuron axons into glomeruli and for male-male aggression. Development 140(11):2398-2408.
263. Prom-Wormley EC, Eaves LJ, Foley DL, Gardner CO, Archer KJ, Wormley BK, Maes HH, Riley BP, Silberg JL. 2009. Monoamine oxidase A and childhood adversity as risk factors for conduct disorder in females. Psychol Med 39(4):579-590.
264. Qian QJ, Liu J, Wang YF, Yang L, Guan LL, Faraone SV. 2009. Attention deficit hyperactivity disorder comorbid oppositional defiant disorder and its predominately inattentive type: Evidence for an association with COMT but not MAOA in a chinese sample. Behav Brain Funct 5:8.
265. Ragnauth AK, Devidze N, Moy V, Finley K, Goodwillie A, Kow LM, Muglia LJ, Pfaff DW. 2005. Female oxytocin gene-knockout mice, in a semi-natural environment, display exaggerated aggressive behavior. Genes Brain Behav 4(4):229-239.
266. Rainero I, Rubino E, Negro E, Gallone S, Galimberti D, Gentile S, Scarpini E, Pinessi L. 2011. Heterosexual pedophilia in a frontotemporal dementia patient with a mutation in the progranulin gene. Biol Psychiatry 70(9):e43-44.
267. Rajender S, Pandu G, Sharma JD, Gandhi KP, Singh L, Thangaraj K. 2008. Reduced CAG repeats length in androgen receptor gene is associated with violent criminal behavior. Int J Legal Med 122(5):367-372.
268. Reif A, Jacob CP, Rujescu D, Herterich S, Lang S, Gutknecht L, Baehne CG, Strobel A, Freitag CM, Giegling I, Romanos M, Hartmann A, Rosler M, Renner TJ, Fallgatter AJ, Retz W, Ehlis AC, Lesch KP. 2009. Influence of functional variant of neuronal nitric oxide synthase on impulsive behaviors in humans. Arch Gen Psychiatry 66(1):41-50.
269. Reif A, Rosler M, Freitag CM, Schneider M, Eujen A, Kissling C, Wenzler D, Jacob CP, Retz-Junginger P, Thome J, Lesch KP, Retz W. 2007. Nature and nurture predispose to violent behavior: Serotonergic genes and adverse childhood environment. Neuropsychopharmacology 32(11):2375-2383.
270. Reti IM, Xu JZ, Yanofski J, McKibben J, Uhart M, Cheng YJ, Zandi P, Bienvenu OJ, Samuels J, Willour V, Kasch-Semenza L, Costa P, Bandeen-Roche K, Eaton WW, Nestadt G. 2011. Monoamine oxidase A regulates antisocial personality in whites with no history of physical abuse. Compr Psychiatry 52(2):188-194.
271. Retz W, Reif A, Freitag CM, Retz-Junginger P, Rosler M. 2010. Association of a functional variant of neuronal nitric oxide synthase gene with self-reported impulsiveness, venturesomeness and empathy in male offenders. J Neural Transm 117(3):321-324.
272. Retz W, Retz-Junginger P, Supprian T, Thome J, Rosler M. 2004. Association of serotonin transporter promoter gene polymorphism with violence: relation with personality disorders, impulsivity, and childhood ADHD psychopathology. Behav Sci Law 22(3):415-425.
273. Reuter M, Hennig J. 2005. Pleiotropic effect of the TPH A779C polymorphism on nicotine dependence and personality. Am J Med Genet B Neuropsychiatr Genet 134B(1):20-24.
274. Reuter M, Weber B, Fiebach CJ, Elger C, Montag C. 2009. The biological basis of anger: Associations with the gene coding for DARPP-32 (PPP1R1B) and with amygdala volume. Behav Brain Res 202(2):179-183.
275. Rhee SH, Waldman ID. 2002. Genetic and environmental influences on antisocial behavior: A meta-analysis of twin and adoption studies. Psychol Bull 128(3):490-529. DOI: 10.1037//0033-2909.128.3.490
276. Rhee SH, Waldman ID. 2011. Genetic and environmental influences on aggression. In: Shaver PR, Mikulincer M, editors. Human aggression and violence: Causes, manifestations and consequences. Washington, DC: American Psychological Association. pp 143-163.
277. Ribeiro AC, Musatov S, Shteyler A, Simanduyev S, Arrieta-Cruz I, Ogawa S, Pfaff DW. 2012. siRNA silencing of estrogen receptor-alpha expression specifically in medial preoptic area neurons abolishes maternal care in female mice. Proc Natl Acad Sci USA 109(40):16324-16329.
278. Richter S, Gorny X, Marco-Pallares J, Kramer UM, Machts J, Barman A, Bernstein HG, Schule R, Schols L, Rodriguez-Fornells A, Reissner C, Wustenberg T, Heinze HJ, Gundelfinger ED, Duzel E, Munte TF, Seidenbecher CI, Schott BH. 2011. A potential role for a genetic variation of AKAP5 in human aggression and anger control. Front Hum Neurosci 5:175.
279. Robbers S, Van Oort F, Huizink A, Verhulst F, Van Beijsterveldt C, Boomsma D, Bartels M. 2012. Childhood problem behavior and parental divorce: Evidence for gene-environment interaction. Soc Psychiatry Psychiatr Epidemiol 47:1539-1548. DOI: 10.1007/s00127-011-0470-9
280. Rodriguez-Arias M, Navarrete F, Daza-Losada M, Navarro D, Aguilar MA, Berbel P, Minarro J, Manzanares J. 2013. CB1 cannabinoid receptor-mediated aggressive behavior. Neuropharmacology 75:172-180.
281. Rodriguiz RM, Chu R, Caron MG, Wetsel WC. 2004. Aberrant responses in social interaction of dopamine transporter knockout mice. Behav Brain Res 148(1-2):185-198.
282. Rotondo A, Schuebel K, Bergen A, Aragon R, Virkkunen M, Linnoila M, Goldman D, Nielsen D. 1999. Identification of four variants in the tryptophan hydroxylase promoter and association to behavior. Mol Psychiatry 4(4):360-368.
283. Roubertoux PL, Guillot PV, et al. 2005. Attack behaviors in mice: From factorial structure to quantitative trait loci mapping. Eur J Pharmacol 526(1-3):172-185.
284. Rujescu D, Giegling I, Bondy B, Gietl A, Zill P, Moller HJ. 2002. Association of anger-related traits with SNPs in the TPH gene. Mol Psychiatry 7(9):1023-1029.
285. Rujescu D, Giegling I, Mandelli L, Schneider B, Hartmann AM, Schnabel A, Maurer K, Moller HJ, Serretti A. 2008. NOS-I and -III gene variants are differentially associated with facets of suicidal behavior and aggression-related traits. Am J Med Genet B Neuropsychiatr Genet 147B(1):42-48.
286. Sadeh N, Javdani S, Verona E. 2013. Analysis of monoaminergic genes, childhood abuse, and dimensions of psychopathy. J Abnorm Psychol 122(1):167-179.
287. Sagazio A, Shohreh R, Salvatori R. 2011. Effects of GH deficiency and GH replacement on inter-male aggressiveness in mice. Growth Horm IGF Res 21(2):76-80.
288. Sakai JT, Boardman JD, Gelhorn HL, Smolen A, Corley RP, Huizinga D, Menard S, Hewitt JK, Stallings MC. 2010. Using trajectory analyses to refine phenotype for genetic association: Conduct problems and the serotonin transporter (5HTTLPR). Psychiatr Genet 20(5):199-206.
289. Sakai JT, Crowley TJ, Stallings MC, McQueen M, Hewitt JK, Hopfer C, Hoft NR, Ehringer MA. 2012. Test of association between 10 single nucleotide polymorphisms in the oxytocin receptor gene and conduct disorder. Psychiatr Genet 22(2):99-102.
290. Sakai JT, Lessem JM, Haberstick BC, Hopfer CJ, Smolen A, Ehringer MA, Timberlake D, Hewitt JK. 2007. Case-control and within-family tests for association between 5HTTLPR and conduct problems in a longitudinal adolescent sample. Psychiatr Genet 17(4):207-214.
291. Sakai JT, Young SE, Stallings MC, Timberlake D, Smolen A, Stetler GL, Crowley TJ. 2006. Case-control and within-family tests for an association between conduct disorder and 5HTTLPR. Am J Med Genet B Neuropsychiatr Genet 141B(8):825-832.
292. Sandnabba NK. 1996. Selective breeding for isolation-induced intermale aggression in mice: associated responses and environmental influences. Behav Genet 26(5):477-488.
293. Sanislow CA, Pine DS, Quinn KJ, Kozak MJ, Garvey MA, Heinssen RK, Wang PS, Cuthbert BN. 2010. Developing constructs for psychopathology research: Research domain criteria. J Abnorm Psychol 119(November):631-639. DOI: 10.1037/a0020909
294. Scheinin M, Sallinen J, Haapalinna A. 2001. Evaluation of the alpha2C-adrenoceptor as a neuropsychiatric drug target studies in transgenic mouse models. Life Sci 68(19-20):2277-2285.
295. Schlomer GL, Cleveland HH, Vandenbergh DJ, Feinberg ME, Neiderhiser JM, Greenberg MT, Spoth R, Redmond C. 2015. Developmental differences in early adolescent aggression: A gene x environment x intervention analysis. J Youth Adolesc 44(3):581-597.
296. Schulz-Heik RJ, Rhee, SH, Silvern LE, Haberstick BC, Hopfer C, Lessem JM, Hewitt JK. 2010. The association between conduct problems and maltreatment: Testing genetic and environmental mediation. Behav Genet 40(3):338-348. DOI: 10.1016/j.biotechadv.2011.08.021
297. Scott AL, Bortolato M, Chen K, Shih JC. 2008. Novel monoamine oxidase A knock out mice with human-like spontaneous mutation. Neuroreport 19(7):739-743.
298. Scotti MA, Carlton ED, Demas GE, Grippo AJ. 2015. Social isolation disrupts innate immune responses in both male and female prairie voles and enhances agonistic behavior in female prairie voles (Microtus ochrogaster). Horm Behav 70:7-13.
299. Serretti A, Mandelli L, Giegling I, Schneider B, Hartmann AM, Schnabel A, Maurer K, Moller HJ, Rujescu D. 2007. HTR2C and HTR1A gene variants in German and Italian suicide attempters and completers. Am J Med Genet B Neuropsychiatr Genet 144B(3):291-299.
300. Shehzad Z, DeYoung CG, Kang Y, Grigorenko EL, Gray JR. 2012. Interaction of COMT val158met and externalizing behavior: Relation to prefrontal brain activity and behavioral performance. Neuroimage 60(4):2158-2168.
301. Shorter J, Couch C, Huang W, Carbone MA, Peiffer J, Anholt RR, Mackay TF. 2015. Genetic architecture of natural variation in Drosophila melanogaster aggressive behavior. Proc Natl Acad Sci USA.
302. Singh AL, Waldman ID. 2010. The etiology of associations between negative emotionality and childhood externalizing disorders. J Abnorm Psychol 119(2)):376-388. DOI: 10.1037/a0019342
303. Sluyter F, Bult A, et al. 1997. No evidence for a Y chromosomal effect on alternative behavioral strategies in mice. Behav Genet 27(5):477-482.
304. Sluyter F, Bohus B, et al. 1995. Autosomal and Y chromosomal effects on the stereotyped response to apomorphine in wild house mice. Pharmacol Biochem Behav 52(1):17-22.
305. Smearman EL, Winiarski DA, Brennan PA, Najman J, Johnson KC. 2015. Social stress and the oxytocin receptor gene interact to predict antisocial behavior in an at-risk cohort. Dev Psychopathol 27(1):309-318.
306. Sokolowski M, Wasserman J, Wasserman D. 2010. Association of polymorphisms in the SLIT2 axonal guidance gene with anger in suicide attempters. Mol Psychiatry 15(1):10-11.
307. Sonuga-Barke EJ, Lasky-Su J, Neale BM, Oades R, Chen W, Franke B, Buitelaar J, Banaschewski T, Ebstein R, Gill M, Anney R, Miranda A, Mulas F, Roeyers H, Rothenberger A, Sergeant J, Steinhausen HC, Thompson M, Asherson P, Faraone SV. 2008. Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan. Am J Med Genet B Neuropsychiatr Genet 147B(8):1359-1368.
308. Sorensen DB, Dahl K, Ersboll AK, Kirkeby S, d'Apice AJ, Hansen AK. 2008. Aggression in cataract-bearing alpha-1, 3-galactosyltransferase knockout mice. Lab Anim 42(1):34-44.
309. Spatola CA, Rende R, Battaglia M. 2010. Genetic and environmental influences upon the CBCL/6-18 DSM-oriented scales: Similarities and differences across three different computational approaches and two age ranges. Euro Child Adolesc Psychiatry 19:647-658. DOI: 10.1007/s00787-010-0102-z
310. Stanford SC, Salmon P. 1989. Neurochemical correlates of behavioural responses to frustrative nonreward in the rat: Implications for the role of central noradrenergic neurones in behavioural adaptation to stress. Exp Brain Res 75(1):133-138.
311. Stork O, Ji FY, Kaneko K, Stork S, Yoshinobu Y, Moriya T, Shibata S, Obata K. 2000. Postnatal development of a GABA deficit and disturbance of neural functions in mice lacking GAD65. Brain Res 865(1):45-58.
312. Sturtevant AH. 1915. Experiments on sex recognition and the problem of sexual selection in Drosoophilia. J Animal Behav 5(5):351-366.
313. Sysoeva OV, Maluchenko NV, Timofeeva MA, Portnova GV, Kulikova MA, Tonevitsky AG, Ivanitsky AM. 2009. Aggression and 5HTT polymorphism in females: Study of synchronized swimming and control groups. Int J Psychophysiol 72(2):173-178.
314. Takahashi A, Miczek KA. 2014. Neurogenetics of aggressive behavior: Studies in rodents. Curr Top Behav Neurosci 17:3-44.
315. Tanabe Y, Fujita E, Hayashi YK, Zhu X, Lubbert H, Mezaki Y, Senoo H, Momoi T. 2013. Synaptic adhesion molecules in Cadm family at the neuromuscular junction. Cell Biol Int 37(7):731-736.
316. Tellegen A. 1982. Brief manual for the multidimensional personality questionnaire. Minneapolis.
317. Thorneycroft HB. 1966. Chromosomal polymorphism in the white-throated sparrow, Zonotrichia albicollis (Gmelin). Science 154(3756):1571-1572.
318. Tielbeek JJ, Medland SE, Benyamin B, Byrne EM, Heath AC, Madden PA, Martin NG, Wray NR, Verweij KJ. 2012. Unraveling the genetic etiology of adult antisocial behavior: A genome-wide association study. PLoS One 7(10):e45086.
319. Tiihonen J, Rautiainen MR, Ollila HM, Repo-Tiihonen E, Virkkunen M, Palotie A, Pietilainen O, Kristiansson K, Joukamaa M, Lauerma H, Saarela J, Tyni S, Vartiainen H, Paananen J, Goldman D, Paunio T. 2014. Genetic background of extreme violent behavior. Mol Psychiatry 20:786-792.
320. Toda K, Saibara T, Okada T, Onishi S, Shizuta Y. 2001. A loss of aggressive behaviour and its reinstatement by oestrogen in mice lacking the aromatase gene (Cyp19). J Endocrinol 168(2):217-220.
321. Toth M, Tulogdi A, Biro L, Soros P, Mikics E, Haller J. 2012. The neural background of hyper-emotional aggression induced by post-weaning social isolation. Behav Brain Res 233(1):120-129.
322. Trainor BC, Workman JL, Jessen R, Nelson RJ. 2007. Impaired nitric oxide synthase signaling dissociates social investigation and aggression. Behav Neurosci 121(2):362-369.
323. Trzaskowski M, Dale PS, Plomin R. 2013. No genetic influence for childhood behavior problems from DNA analysis. J Am Acad Child Adolesc Psychiatry 52(10):1048-1056.e3. DOI: 10.1016/j.jaac.2013.07.016
324. Tucker-Drob E, Harden P. 2013. Gene-by-prescholl interaction on development of early externalizing problems. J Child Psychol Psychiatry 54(1):77-85. DOI: 10.1111/j.1469-7610.2012.02578
325. Tuvblad C, Baker LA. 2011. Human aggression across the lifespan: Genetic propensities and environmental moderators. Adv Genet 171-214. DOI: 10.1016/B978-0-12-380858-5.00007-1
326. Tuvblad C, Narusyte J, Grann M, Sarnecki J, Lichtenstein P. 2011. The genetic and environmental etiology of antisocial behavior from childhood to emerging adulthood. Behav Genet 41:629-640. DOI: 10.1007/s10519-011-9463-4
327. Tuvblad C, Raine A, Zheng M, Baker LA. 2009a. Genetic and environmental stability differs in reactive and proactive aggression. Aggress Behav 35(August):437-452. DOI: 10.1002/ab.20319
328. Tuvblad C, Zheng M, Raine A, Baker LA. 2009b. A common genetic factor explains the covariation among ODD and CD symptoms in 9-10 year old boys and girls. J Abnorm Child Psychol 37(2):153-167. DOI: 10.1007/s10802-008-9278-9.A
329. Uchida S, Hara K, Kobayashi A, Fujimoto M, Otsuki K, Yamagata H, Hobara T, Abe N, Higuchi F, Shibata T, Hasegawa S, Kida S, Nakai A, Watanabe Y. 2011. Impaired hippocampal spinogenesis and neurogenesis and altered affective behavior in mice lacking heat shock factor 1. Proc Natl Acad Sci USA 108(4):1681-1686.
330. van der Vegt EJ, Oostra BA, Arias-Vasquez A, van der Ende J, Verhulst FC, Tiemeier H. 2009. High activity of monoamine oxidase A is associated with externalizing behaviour in maltreated and nonmaltreated adoptees. Psychiatr Genet 19(4):209-211.
331. van Oortmerssen GA, Bakker TC. 1981. Artificial selection for short and long attack latencies in wild Mus musculus domesticus. Behav Genet 11(2):115-126.
332. Vaske J, Boisvert D, Wright JP. 2012. Genetic and environmental contributions to the relationship between violent victimization and criminal behavior. J Interpers Violence 27:3213-3235. DOI: 10.1177/0886260512441254
333. Vassos E, Collier DA, Fazel S. 2014. Systematic meta-analyses and field synopsis of genetic association studies of violence and aggression. Mol Psychiatry 19(4):471-477.
334. Verhoeven FE, Booij L, Kruijt AW, Cerit H, Antypa N, Does W. 2012. The effects of MAOA genotype, childhood trauma, and sex on trait and state-dependent aggression. Brain Behav 2(6):806-813.
335. Vermeersch H, T'Sjoen G, Kaufman JM, Van Houtte M. 2013. ESR1 polymorphisms, daily hassles, anger expression, and depressive symptoms in adolescent boys and girls. Horm Behav 63(3):447-453.
336. Verona E, Joiner TE, Johnson F, Bender TW. 2006. Gender specific gene-environment interactions on laboratory-assessed aggression. Biol Psychol 71(1):33-41.
337. Veselka L, Schermer JA, Vernon PA. 2011. Beyond the big five: The dark triad and the supernumerary personality inventory. Twin Res Hum Genet 14(2):158-168. DOI: 10.1375/twin.14.2.150
338. Viding E, Hanscombe KB, Curtis CJ, Davis OS, Meaburn EL, Plomin R. 2010. In search of genes associated with risk for psychopathic tendencies in children: A two-stage genome-wide association study of pooled DNA. J Child Psychol Psychiatry 51(7):780-788.
339. Viding E, Larsson H, Jones AP. 2008. Quantitative genetic studies of antisocial behaviour. Philos Trans R Soc Lond B Biol Sci 363(1503):2519-2527. DOI: 10.1098/rstb.2008.0037
340. Viding E, McCrory EJ. 2012. Genetic and neurocognitive contributions to the development of psychopathy. Dev Psychopathol 24:969-983.
341. Viding E, Price TS, Jaffee SR, Trzaskowski M, Davis OSP, Meaburn EL, Haworth CMA, Plomin R. 2013. Genetics of callous-unemotional behavior in children. PLoS One 8(7):e65789.
342. Vindas MA, Johansen IB, et al. 2014. Frustrative reward omission increases aggressive behaviour of inferior fighters. Proc Biol Sci 281(1784):20140300.
343. Vindas MA, Folkedal O, et al. 2012. Omission of expected reward agitates Atlantic salmon (Salmo salar). Anim Cogn 15(5):903-911.
344. Vukhac KL, Sankoorikal EB, Wang Y. 2001. Dopamine D2L receptor- and age-related reduction in offensive aggression. Neuroreport 12(5):1035-1038.
345. Wakschlag LS, Kistner EO, Pine DS, Biesecker G, Pickett KE, Skol AD, Dukic V, Blair RJ, Leventhal BL, Cox NJ, Burns JL, Kasza KE, Wright RJ, Cook EH Jr. 2010. Interaction of prenatal exposure to cigarettes and MAOA genotype in pathways to youth antisocial behavior. Mol Psychiatry 15(9):928-937.
346. Waldman ID, Tackett JL, Van Hulle CA, Applegate B, Pardini D, Frick PJ, Lahey BB. 2011. Child and adolescent conduct disorder substantially shares genetic influences with three socioemotional dispositions. J Abnorm Psychol 120:57-70. DOI: 10.1037/a0021351
347. Walum H, Westberg L, et al. 2008. Genetic variation in the vasopressin receptor 1a gene (AVPR1A) associates with pair-bonding behavior in humans. Proc Natl Acad Sci USA 105(37):14153-14156.
348. Wang L, Anderson DJ. 2010. Identification of an aggression-promoting pheromone and its receptor neurons in Drosophila. Nature 463(7278):227-231.
349. Wang Z, Storm DR. 2011. Maternal behavior is impaired in female mice lacking type 3 adenylyl cyclase. Neuropsychopharmacology 36(4):772-781.
350. Wasserman D, Geijer T, Sokolowski M, Rozanov V, Wasserman J. 2007. Genetic variation in the hypothalamic-pituitary-adrenocortical axis regulatory factor, T-box 19, and the angry/hostility personality trait. Genes Brain Behav 6(4):321-328.
351. Weder N, Yang BZ, Douglas-Palumberi H, Massey J, Krystal JH, Gelernter J, Kaufman J. 2009. MAOA genotype, maltreatment, and aggressive behavior: The changing impact of genotype at varying levels of trauma. Biol Psychiatry 65(5):417-424.
352. Wersinger SR, Caldwell HK, Martinez L, Gold P, Hu SB, Young WS, 3rd. 2007. Vasopressin 1a receptor knockout mice have a subtle olfactory deficit but normal aggression. Genes Brain Behav 6(6):540-551.
353. Westberg L, Henningsson S, Landen M, Annerbrink K, Melke J, Nilsson S, Rosmond R, Holm G, Anckarsater H, Eriksson E. 2009. Influence of androgen receptor repeat polymorphisms on personality traits in men. J Psychiatry Neurosci 34(3):205-213.
354. Westberg L, Melke J, Landen M, Nilsson S, Baghaei F, Rosmond R, Jansson M, Holm G, Bjorntorp P, Eriksson E. 2003. Association between a dinucleotide repeat polymorphism of the estrogen receptor alpha gene and personality traits in women. Mol Psychiatry 8(1):118-122.
355. Wichers M, Gardner C, Maes HH, Lichtenstein P, Larsson H, Kendler KS. 2013. Genetic innovation and stability in externalizing problem behavior across development: A multi-informant twin study. Behav Genet 43:191-201. DOI: 10.1007/s10519-013-9586-x
356. Widom CS, Brzustowicz LM. 2006. MAOA and the "cycle of violence:" Childhood abuse and neglect, MAOA genotype, and risk for violent and antisocial behavior. Biol Psychiatry 60(7):684-689.
357. Williams LM, Gatt JM, Kuan SA, Dobson-Stone C, Palmer DM, Paul RH, Song L, Costa PT, Schofield PR, Gordon E. 2009. A polymorphism of the MAOA gene is associated with emotional brain markers and personality traits on an antisocial index. Neuropsychopharmacology 34(7):1797-1809.
358. Willoughby MT, Mills-Koonce R, Propper CB, Waschbusch DA. 2013. Observed parenting behaviors interact with a polymorphism of the brain-derived neurotrophic factor gene to predict the emergence of oppositional defiant and callous-unemotional behaviors at age 3 years. Dev Psychopathol 25(4 Pt 1):903-917.
359. Wu WL, Lin YW, Min MY, Chen CC. 2010. Mice lacking Asic3 show reduced anxiety-like behavior on the elevated plus maze and reduced aggression. Genes Brain Behav 9(6):603-614.
360. Yadav R, Gupta SC, Hillman BG, Bhatt JM, Stairs DJ, Dravid SM. 2012. Deletion of glutamate delta-1 receptor in mouse leads to aberrant emotional and social behaviors. PLoS One 7(3):e32969.
361. Yang J, Lee MS, Lee SH, Lee BC, Kim SH, Joe SH, Jung IK, Choi IG, Ham BJ. 2010. Association between tryptophan hydroxylase 2 polymorphism and anger-related personality traits among young Korean women. Neuropsychobiology 62(3):158-163.
362. Yang JW, Lee SH, Ryu SH, Lee BC, Kim SH, Joe SH, Jung IK, Choi IG, Ham BJ. 2007. Association between monoamine oxidase A polymorphisms and anger-related personality traits in Korean women. Neuropsychobiology 56(1):19-23.
363. Yangngam S, Plong-On O, Sripo T, Roongpraiwan R, Hansakunachai T, Wirojanan J, Sombuntham T, Ruangdaraganon N, Limprasert P. 2014. Mutation screening of the neurexin 1 gene in thai patients with intellectual disability and autism spectrum disorder. Genet Test Mol Biomarkers 18(7):510-515.
364. Yeh MT, Coccaro EF, Jacobson KC. 2010. Multivariate behavior genetic analyses of aggressive behavior subtypes. Behav Genet 40(5):603-617. DOI: 10.1007/s10519-010-9363-z
365. Yoon HK, Lee HJ, Kim L, Lee MS, Ham BJ. 2012. Impact of tryptophan hydroxylase 2 G-703T polymorphism on anger-related personality traits and orbitofrontal cortex. Behav Brain Res 231(1):105-110.
366. Young SE, Smolen A, Corley RP, Krauter KS, DeFries JC, Crowley TJ, Hewitt JK. 2002. Dopamine transporter polymorphism associated with externalizing behavior problems in children. Am J Med Genet 114(2):144-149.
367. Young SE, Smolen A, Hewitt JK, Haberstick BC, Stallings MC, Corley RP, Crowley TJ. 2006. Interaction between MAO-A genotype and maltreatment in the risk for conduct disorder: Failure to confirm in adolescent patients. Am J Psychiatry 163(6):1019-1025.
368. Young LJ, Wang Z. 2004. The neurobiology of pair bonding. Nat Neurosci 7(10):1048-1054.
369. Young SE, Friedman NP, Willcutt EG, Corley RP, Hewitt JK. 2009. Behavioral disinhibition: Liability for externalizing spectrum disorders and its genetic and environmental relation to response inhibition across adolescence. J Abnorm Psychol 118(1):117-130. DOI: 10.1037/a0014657
370. Zai CC, Ehtesham S, Choi E, Nowrouzi B, de Luca V, Stankovich L, Davidge K, Freeman N, King N, Kennedy JL, Beitchman JH. 2012a. Dopaminergic system genes in childhood aggression: Possible role for DRD2. World J Biol Psychiatry 13(1):65-74.
371. Zai CC, Muir KE, Nowrouzi B, Shaikh SA, Choi E, Berall L, Trepanier MO, Beitchman JH, Kennedy JL. 2012b. Possible genetic association between vasopressin receptor 1B and child aggression. Psychiatry Res 200(2-3):784-788.
372. Zalsman G, Frisch A, Bromberg M, Gelernter J, Michaelovsky E, Campino A, Erlich Z, Tyano S, Apter A, Weizman A. 2001. Family-based association study of serotonin transporter promoter in suicidal adolescents: No association with suicidality but possible role in violence traits. Am J Med Genet 105(3):239-245.
373. Zimmermann P, Mohr C, Spangler G. 2009. Genetic and attachment influences on adolescents' regulation of autonomy and aggressiveness. J Child Psychol Psychiatry 50(11):1339-1347.
374. Zohsel K, Buchmann AF, Blomeyer D, Hohm E, Schmidt MH, Esser G, Brandeis D, Banaschewski T, Laucht M. 2014. Mothers' prenatal stress and their children's antisocial outcomes-a moderating role for the dopamine D4 receptor (DRD4) gene. J Child Psychol Psychiatry 55(1):69-76.
375. Zou J, Storm DR, Xia Z. 2013. Conditional deletion of ERK5 MAP kinase in the nervous system impairs pheromone information processing and pheromone-evoked behaviors. PLoS One 8(10):e76901.
376. Zouk H, McGirr A, Lebel V, Benkelfat C, Rouleau G, Turecki G. 2007. The effect of genetic variation of the serotonin 1B receptor gene on impulsive aggressive behavior and suicide. Am J Med Genet B Neuropsychiatr Genet 144B(8):996-1002.
377. Achenbach TM, Rescorla LA. 2001. Manual for the ASEBA school-age forms & profiles. Burlington, University of Vermont, Research: ASEBA.
378. Zwarts L, Versteven M, et al. 2012. Genetics and neurobiology of aggression in Drosophila. Fly (Austin) 6(1):35-48.