Behavioral phenotypes of inbred mouse strains: Implications and recommendations for molecular studies

Psychopharmacology

Volumn 132, Issue 2, 1997, Pages 107-124

  Crawley, Jacqueline N ^a   Belknap, John K ^b   Collins, Allan ^c   Crabbe, John C ^b   Frankel, Wayne ^d   Henderson, Norman ^e   Hitzemann, Robert J ^f   Maxson, Stephen C ^g   Miner, Lucinda L ^h   Silva, Alcino J ⁱ   Wehner, Jeanne M ^c   Wynshaw Boris, Anthony ^j   Paylor, Richard ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d JACKSON LABORATORY   (United States)

^e OBERLIN COLLEGE   (United States)

^f STONY BROOK UNIVERSITY   (United States)

^g UNIVERSITY OF CONNECTICUT   (United States)

^h NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

ⁱ Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^j NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

more..

Author keywords

Acoustic startle; Aggression; Alcohol; Behavior; Breeding; Cocaine; Diazepam; Embryonic stem cell lines; Genetics; Haloperidol; Inbred strains; Knockouts; Learning; Locomotion; Memory; Mouse; Nicotine; Null mutation; Open field activity; Opiates; Parental behaviors; Prepulse inhibition; Transgenic

Indexed keywords

ALCOHOL; ANXIOLYTIC AGENT; COCAINE; NEUROLEPTIC AGENT; NICOTINE; OPIATE;

AGGRESSION; ANIMAL EXPERIMENT; ANIMAL MODEL; BEHAVIOR GENETICS; BREEDING; DATA BASE; DRUG EFFECT; DRUG SENSITIVITY; INBRED STRAIN; LEARNING; LITERATURE; LOCOMOTION; MEMORY; MOUSE; MUTATION; NONHUMAN; PARENTAL BEHAVIOR; PHENOTYPE; PREPULSE INHIBITION; PRIORITY JOURNAL; REVIEW; STRAIN DIFFERENCE; TRANSGENIC MOUSE;

ANIMALS; ANTI-ANXIETY AGENTS; ANTIPSYCHOTIC AGENTS; BEHAVIOR, ANIMAL; COCAINE; ETHANOL; GENETICS, BEHAVIORAL; MICE; MICE, INBRED STRAINS; NICOTINE; PHENOTYPE;

EID: 0009703087     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050327     Document Type: Review

References (166)

1. Ammassari-Teule M, Capriolo (1985) Spatial learning and memory, maze running strategies and cholinergic mechanisms in two inbred strains of mice. Behav Brain Res 17:9-16
2. Ammassari-Teule M, Hoffman H-J, Rossi-Arnaud C (1993) Learning in inbred mice: strain-specific abilities across three radial maze problems. Behav Genet 23:405-412
3. Archer J (1973) Tests for emotionality in rats and mice: a review. Anim Behav 21:205-235
4. Barlow C, Hirotsune S, Paylor R, Liyanage M, Eckhaus M, Collins F, Shiloh Y, Crawley JN, Ried T, Tagle D, Wynshaw-Boris A (1996) Atm-deficient mice: a paradigm of ataxia-telangiectasia. Cell 86:159-171
5. Batty J (1978) Plasma levels of testosterone and male sexual behaviour in strains of the house mouse (Mus inusculus). Anim Behav 26:339-348
6. Belknap JK (1980) Genetic factors in the effects of alcohol: neurosensitivity, functional tolerance and physical dependence. In: Rigter H, Crabbe JC (eds) Alcohol tolerance and dependence. Elsevier, Amsterdam, pp 157-180
7. Belknap JK, O'Toole LA (1991) In: Crabbe JC, Harris RA (eds) The genetic basis of alcohol and drug actions. Plenum Press, New York, pp 225-252
8. Belknap JK, Crabbe JC, Young ER (1993a) Voluntary consumption of ethanol in 15 inbred mouse strains. Psychopharmacology 112:352-358
9. Belknap JK, Metten P, Helms ML, O'Toole LA, Angeli-Gade S, Crabbe JC, Phillips TJ (1993b) Quantitative trait loci (QTL) applications to substances of abuse: physical dependence studies with nitrous oxide and ethanol in BXD mice. Behav Genet 23:213-222
10. Belknap JK, Mogil JS, Helms ML, Richards SP, O'Toole LA, Bergeson SE, Buck KJ (1995) Localization to chromosome 10 of a locus influencing morphine-induced analgesia in crosses derived from C57BL/6 and DBA/2 mice. Life Sci 57:PL117-PL124
11. Berrettini WH, Ferraro TN, Alexander RC, Buchberg AM, Vogel WH (1994) Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains. Nature Genet 7:54-58
12. Bindra D, Thompson WR (1953) An evaluation of defecation and urination as measures of tearfulness. J Comp Physiol Psychol 46:43-45
13. Braff DL, Stone C, Callaway E, Geyer MA, Click ID, Bali L (1978) Prestimulus effects on human startle reflex in normals and schizophrenics. Psychophysiology 15:339-343
14. Brain PF (1978) Hormones, drugs and aggression, vol. 3. Eden. Exeter
15. Broadhurst PL (1978) Drugs and the inheritance of behavior. Plenum Press, New York
16. Broida J, Svare B (1982) Postpartum aggression in C57BL/6J and DBA/2J mice: experiential and environmental influences. Behav Neural Biol 35:76-83
17. Bullock AE, Slobe BS, Collins AC (1995) Classical genetic analysis of startle and prepulse inhibition of startle in mice. Abstr Soc Neurosci 21:199
18. Buselmaier W, Vierling T, Balzereit W, Schwelger H (1981) Genetic analysis of avoidance learning by means of different psychological testing systems with inbred mice as model organisms. Psychol Res 43:317-333
19. Carlier M, Roubetoux P, Cohen-Salmon Ch (1982) Differences in patterns of pup care in Mus musculus domesticus I - comparisons between eleven inbred strains. Behav Neural Biol 35:205-210
20. Cases O, Seif I, Grimsby J, Gaspar P, Chen K, Poumin S, Muller U, Aguet M, Babinet C, Shih JC, De Maeyer E (1995) Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science 268:1763-1766
21. Cohen-Salmon Ch (1988) What role does sensory perception play in the onset and maintenance of pup care behavior in laboratory rodents? Eur Bull Cognit Psychol 8:53-94
22. Cohen-Salmon Ch, Carlier M, Roubertoux P (1982) Differences in patterns of pup care in Mus musculus domesticus II - effects of parity on eight inbred strains. Biol Behav 7:337-346
23. Cohen-Salmon Ch, Carlier M, Roubertoux J, Jouhaneau C, Semal C, Paillette M (1985) Differences in patterns of pup care V-pup ultrasonic emissions and pup care behavior. Physiol Behav 35:167-174
24. Crabbe JC (1986) Genetic differences in locomotor activity in mice. Pharmacol Biochem Behav 25:289-292
25. Crabbe JC, Janowsky J, Young E, Kosobud A, Stack J, Rigter H (1982) Tolerance to ethanol hypothermia in inbred mice: genotypic correlations with behavioral responses. Alcohol Clin Exp Res 6:446-458
26. Crabbe JC, Young ER, Kosobud A (1983) Genetic correlations with ethanol withdrawal severity. Pharmacol Biochem Behav 18 [Suppl 1]:541-547
27. Crabbe JC, Belknap JK, Mitchell SR, Crawshaw LI (1994a) Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice. J Pharmacol Exp Ther 269:184-192
28. Crabbe JC, Gallaher ES, Phillips TJ, Belknap JK (1994b) Genetic-determinants of sensitivity to ethanol in inbred mice. Behav Neurosci 108:186-195
29. Crabbe JC, Phillips TJ, Gallaher EJ, Crawshaw LI, Mitchell SR (1996) Common genetic determinants of ataxic and hypothermic effects of ethanol in BXD/Ty recombinant inbred mice: genetic correlations and quantitative trait loci. J Pharmacol Exp Ther 277:624-632
30. Crawley JN (1981) Neuropharmacological specificity of a simple animal model for the behavioral actions of benzodiazepines. Pharmacol Biochem Behav 15:695-699
31. Crawley JN (1996) Unusual behavioral phenotypes in inbred mouse strains. Trends Neurosci 19:181-182
32. Crawley JN, Davis LG (1982) Baseline exploratory activity predicts anxiolytic responsiveness to diazepam in five mouse strains. Brain Res Bull 8:609-612
33. Crawley JN, Goodwin FK (1980) Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines. Pharmacol Biochem Behav 13:167-170
34. Crawley JN, Marangos PJ, Paul SM, Skolnick P, Goodwin FK (1981) Purine diazepam interaction: inosine reverses diazepam-induced stimulation of mouse exploratory behavior. Science 22:725-727
35. Crawley JN, Glowa JR, Majewska MD, Paul SM (1986) Anxiolytic activity of an endogenous adrenal steroid. Brain Res 398:382-385
36. Dains K, Hitzemann B, Hitzemann R (1996) Genetics, neuroleptic-response and the organization of cholinergic neurons in the mouse striatum. J Pharmacol Exp Ther 279:1430-1438
37. deFiehre CM, Ruth JA, Collins AC (1989) Differential sensitivity of long-sleep and short-sleep mice to high doses of cocaine. Pharmacol Biochem Behav 34:887-893
38. DeFries JC, Gervais MC, Thomas EA (1978) Response to 30 generations of selection for open-field activity in laboratory mice. Behav Genet 8:3-13
39. Deitrich RA, Spuhler K (1984) Genetics of alcoholism and alcohol actions. In: Smart RG, et al. (eds) Research advances in alcohol and drug problems, 8. Plenum Press, New York, pp 47-98
40. Fanselow MS (1990) Factors governing one trial context conditioning. Anim Learn Behav 18:264-270
41. Flint J, Corley R, DeFries JC, Fulker DW, Gray JA, Miller S, Collins AC (1995) A simple genetic basis for a complex psychological trait in laboratory mice. Science 269:1432-1435
42. Franks RD, Adler LH, Waldo MC, Alpert J, Freedman R (1983) Neurophysiological studies of sensory gating in mania: comparison with schizophrenia. Biol Psychiatry 18:989-1005
43. Freedman R, Adler LL, Waldo MC, Pachtman E, Franks RD (1983) Neurophysiological evidence for a defect in inhibitory pathways in schizophrenia: comparison of medicated and drug-free patients. Biol Psychiatry 18:537-552
44. Freedman R et al. (1987) Neurobiological studies of sensory gating in schizophrenia. Schizophr Bull 13:669-677
45. Fuller JL (1964) Measurement of alcohol preference in genetic experiments. J Comp Physiol Psychol 57:85-88
46. Gallaher HJ, Jones GE, Belknap JK, Crabbe JC (1966) Identification of genetic markers for initial sensitivity and rapid tolerance to ethanol-induced ataxia using quantitative trait locus analysis in BXD recombinant inbred mice. J Pharmacol Exp Ther 277:604-612
47. George FR (1989) Cocaine produces low dose locomotor depressant effects in mice. Psychopharmacology 99:147-150
48. George FR, Goldberg SR (1989) Genetic approaches to the analysis of addiction processes. Trends Pharmacol Sci 10:78-83
49. George FR, Ritz MC (1991) Cocaine produces locomotor stimulation in SS/Ibg but not LS/Ibg mice. Psychopharmacology 101:18-22
50. Gerlai R (1996) Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype? Trends Neurosci 19:177-181
51. Geyer MA, Swerdlow NR, Mansbach RS, Braff DL (1990) Startle response models of sensorimotor gating and habilitation deficits in schizophrenia. Brain Res Bull 25:485-498
52. Ginsburg BE, Allee WC (1942) Some effects of conditioning on social dominance and subordination in inbred strains of mice. Physiol Zool 15:495-506
53. Giros B, Jaber M, Jones SR, Wightman RM, Caron MG (1996) Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature 379:606-612
54. Gora-Maslak G, McClearn GE, Crabbe JC, Phillips TJ, Belknap JK, Plomin R (1991) Use of recombinant inbred strains of identify quantitative trail loci in psychopharmacology. Psycho-pharmacology 104:413-424
55. Gossen M, Bujard H (1992) Tight control of gene expression in mammalian cells by tetracycline responsive promoters. Proc Nail Acad Sci USA 89:5547-5551
56. Graham FK (1975) The more or less startling effects of weak prestimulation. Psychophysiology 12:238-248
57. Grahame NJ, Phillips TJ, Burkhart-Kasch S, Cunningham CL (1995) Intravenous cocaine self-administration in the C57BL/6J mouse. Pharmacol Biochem Behav 51:827-834
58. Guillot P-V, Roubertoux PL, Crusio WE (1994) Hippocampal mossy fiber distributions and intermale aggression in seven inbred mouse strains. Brain Res 660:167-169
59. Hall CS (1934) Emotional behavior in the rat. I. Defecation and urination as measures of individual differences in emotionality. J Comp Psychol 18:385-403
60. Hall CS (1936) Emotional behavior in the rat. III. The relationship between emotionality and ambulatory activity. J Comp Psychol 22:345-352
61. Hang M, Johnson FJ, Brain PF (1992) Biological correlates of attack on lactating intruders by female mice: a topical review. In: Bjorkqvist K, Niemela P (eels) Of mice and women: aspects of female aggression. Academic Press, New York, pp 381-393
62. Hay D (1985) Essentials of behavior genetics. Blackwell, Melbourne
63. Henderson ND (1967) Prior treatment effects on open field behavior of mice: a genetic analysis. Anini Behav 15:364-376
64. Henderson ND (1986) Predicting relationships between psychological constructs and genetic characters: an analysis of changing genetic influences on activity in mice. Behav Genet 16:201-220
65. Henderson ND (1989) Genetic analysis of an avoidance-avoidance response in Mus domesticus. Behav Genet 19:387-107
66. Hewitt JK, Broadhurst PL (1983) Genetic architecture and the evolution of aggressive behavior. In: Simmel EC, Hahn ME, Walters JK (eds) Aggressive behavior: genetic and neural approaches. Erlbaum, New York, pp 37-66
67. Hitzemann RJ, Dains K, Bier-Langing CM, Zahniser NR (1991) On the selection of mice for haloperidol response and non-response. Psychopharmacology 103:244-250
68. Horowitz GP, Dudek BC (1983) Behavioral pharmacogenetics. In: Fuller JL, Simmel EC (eds) Behavior genetics: principles and applications. Erlbaum, Hillsdale, N.J., pp 117-154
69. Johansson C, Jackson DM, Zhang J, Svensson L (1995) Prepulse inhibition of acoustic startle, a measure of sensorimotor gating: effects of antipsychotics and other agents in rats. Pharmacol Biochem Behav 52:649-654
70. Johnson TE, DeFries JC, Markel PD (1992) Mapping quantitative trail loci for behavioral traits in the mouse. Behav Genet 22:635-653
71. Jones BC, Campbell AD, Radcliffe RA, Erwin VG (1991) Cocaine actions, brain levels and receptors in selected lines of mice. Pharmacol Biochem Behav 40:941-948
72. Jones SE, Brain PF (1987) Performance of inbred and outbred laboratory mice in putative tests of aggression. Behav Genet 17:87-96
73. 2 receptor density and neuroleptic-induced catalepsy among eight inbred strains of mice. J Pharmacol Exp Ther 267:538-547
74. Kanes SJ, Dains K, Cipp L, Gatley J, Hitzemann B, Rasmussen E, Sanderson S, Silverman M, Hitzemann R (1996) Mapping the genes for haloperidol-induced catalepsy. J Pharmacol Exp Ther 277:1016-1025
75. Kulikov A, Popova N (1996) Association between intermale aggression and genetically-defined tryptophan hydroxylase activity in the mouse brain. Aggress Behav 22:111-117
76. Lagerspetz KMJ, Lagerspetz KYH (1974) Genetic determination of aggressive behaviour. In: Van Abeelen JHK (ed) The genetics of behavior. Elsevier. New York, pp 321-346
77. Lander KS, Botstein D (1989) Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121:185-189
78. Lander ES, Kruglyak L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genet 11:241-247
79. Lander ES, Schork NJ (1994) Genetic dissection of complex traits. Science 265:2037-2048
80. Lederman B, Burki K (1991) Establishment of a germline competent C57BL/6 embryonic stem cell line. Exp Cell Res 197:254-258
81. Lipp H-P, Schwegler H, Crusio WE, Wolfer DP, Leisinger-Trigona M-C, Heimrich B, Driscoll P (1989) Using genetically-defined rodent strains for the identification of hippocampal trails relevant for two-way avoidance behavior: a non-invasive approach. Experientia 45:845-859
82. Lister RG (1987) The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology 92:180-185
83. Livy DJ, Wahisten D (1991) Tests of genetic allelism between four inbred mouse strains with absent corpus callosum. J Hered 82:459-464
84. Murks MJ, Stitzel JA, Collins AC (1989a) Genetic influences on nicotine responses. Pharmacol Biochem Behav 33:667-678
85. Marks MJ, Romm E, Campbell SM, Collins AC (1989b) Variation of nicotinic binding sites among inbred strains. Pharmacol Biochem Behav 33:679-689
86. Marks MJ, Campbell SM, Romm E, Collins AC (1991) Genotype influences the development of tolerance to nicotine in the mouse. J Pharmacol Exp Ther 259:392-402
87. Marley RJ, Witkin JM, Goldberg SR (1991) Genetic factors influence changes in sensitivity to the convulsunt properties of cocaine following chronic treatment. Brain Res 542:1-7
88. Martin GR (1981) Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci USA 78:7634-7638
89. Mathis C, Paul SM, Crawley JN (1994) Characterization of benzodiazepine-sensitive behaviors in the A/J and the C57BL/6J inbred strains of mice. Behav Genet 24:171-180
90. Mathis C, Neumann PE, Gershenfeld H, Paul SM, Crawley JN (1995) Genetic analysis of anxiety-related behaviors and responses to benzodiazepine-related drugs in AXB and BXA recombinant inbred mouse strains. Behav Genet 25:557-568
91. Maxson SC (1981) The genetics of aggression in vertebrates. In: Brain PF, Benton D (eds) The biology of aggression. Sijthoff and Noordhoff, The Netherlands, pp 69-104
92. Maxson SC (1992a) Potential genetic models of aggression and violence in males. In: Driscoll P (ed) Genetically defined animal models of neurobehavioral dysfunctions. Birkhauser, Boston, pp 174-188
93. Maxson SC (1992b) Methodological issues in genetic analyses of an agonistic behavior (offense) in male mice. In: Goldowitz D, Wahlstein D, Wimer RE (eds) Techniques for the genetic analyses of brain and behavior: focus on the mouse. Elsevier, New York, pp 349-373
94. Maxson SC, Shrenker P, Vigue LC (1983) Genetics, hormones and aggression. In: Svare B (ed) Hormones and aggressive behaviour. Plenum Press, New York, pp 179-196
95. May ford M, Bach ME, Huang Y-Y, Wang L, Hawkins RD, Kandel ER (1996) Controls of memory formation through regulated expression of a CaMKII transgene. Science 274:1678-1683
96. McClearn GE, Rodgers DA (1959) Differences in alcohol preference among inbred strains of mice. Q J Stud Alcohol 20:691-695
97. McGill TE (1962) Sexual behavior in three inbred strains of mice. Behaviour 19:341-350
98. McGill TE (1970) Genetic analysis of male sexual behavior. In: Lindzey G, Thiessen DD (eds) Contributions to behavior-genetic analysis: the mouse as a prototype. Appleton-Century-Crofts, New York, pp 57-88
99. McGill TE, Ransom TW (1968) Genotypic change affecting conclusions regarding the mode of inheritance of elements of behavior. Anim Behav 16:88-91
100. Metten P, Crabbe JC (1994) Common genetic determinants of severity of withdrawal from ethanol, pentoburbital and diazepam in inbred mice. Behav Pharmacol 5:533-547
101. Michard C, Carlier M (1985) Les conduites d'agression intraspecifique cez la souris domestique: differences individuelles et analyses genetique. Biol Behav 10:123-146
102. Miner LL (1997) Cocaine reward and locomotor activity in C57BL/6J and 129/SvJ inbred mice and their F1 cross. Pharmacol Biochem Behav (in press)
103. Miner LL, Collins AC (1989) Strain comparison of nicotine-induced seizure sensitivity and nicotinic receptors. Pharmacol Biochem Behav 33:469-475
104. Miner LL, Marley RJ (1995a) Chromosomal mapping of the psychomotor stimulant effects of cocaine in BXD recombinant inbred mice. Psychopharmucology 122:209-214
105. Miner LL, Marley RJ (1995b) Chromosomal mapping of loci influencing sensitivity to cocaine-induced seizures in BXD recombinant inbred strains of mice. Psychopharmacology 117:62-66
106. Mogil J, Sternberg W, Marek P, Sadowski B, Belknap J, Liebeskind J (1996) The genetics of pain and pain inhibition. Proc Natl Acad Sci USA 93:3048-3055
107. Morris RGM (1981) Spatial localisation does not depend on the presence of local cues. Learn Motiv 12:239-260
108. Mosig DW, Dewsbury DA (1976) Studies of the copulatory behavior of house mice (Mus musculus). Behav Biol 16:463-473
109. Nelson RJ, Demas GE, Huang PL, Fishman MC, Dawson VL, Dawson TM, Snyder SH (1995) Behavioral abnormalities in male mice lacking neuronal nitric oxide synthase. Nature 378:383-386
110. Ogawa S, Makino J (1981) Maternal aggression in inbred strains of mice: effects of reproductive states. Jpn J Psychol 52:78-84
111. Ogawa S, Makino J (1984) Aggressive behavior in inbred strains of mice during pregnancy. Behav Neural Biol 40:195-204
112. Ogawa S, Robbins A, Kumar N, Pfaff DW, Sundaram K, Bardin CW (1996) Effects of testosterone and 7α-O-methyl-19-nortestosterone (MENT) on sexual and aggressive behaviors in two inbred strains of male mice. Horm Behav 30:74-78
113. Ogawa S, Lubahn DB, Korach KS, Pfaff DW (1997) Behavioral effects of estrogen receptor gene disruption in male mice. Proc Natl Acad Sci USA 94:1476-1481
114. Owen EH, Logue SF, Rasmussen DL, Wehner JM (1997) Assessment of learning by the Morris water task and fear conditioning in inbred mouse strains and F1 hybrids: implications of genetic background for single gene mutations and quantitative-trait loci analyses. Neuroscience (in press)
115. Patil N, Cox DR, Bhat D, Faham M, Myers RM, Peterson AS (1995) A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation. Nature Genet 11:126-129
116. Paylor R, Crawley JN (1997) Inbred strain differences in prepulse inhibition of the mouse startle response. Psychopharmacology (in press)
117. Paylor R, Baskall L, Wehner JM (1993) Behavioral dissociations between C57BL/6 and DBA/2 mice on learning and memory tasks: a hippocampal-dysfunction hypothesis. Psychobiolosiy 21:11-26
118. Paylor R, Tracy R, Wehner JM, Rudy JW (1994) DBA/2 and C57BL/6 mice differ in contexual fear but not auditory fear conditioning. Behav Neurosci 108:810-817
119. Pellow S, File SE (1986) Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat. Pharmacol Biochem Behav 24:525-529
120. Pellow S, Chopin P, File SE, Briley M (1985) Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 14:149-167
121. Phillips RG, LeDoux JE (1992) Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav Neurosci 106:274-285
122. Phillips TJ, Crabbe JC (1991) Behavioral studies of genetic differences in alcohol action. In: Crabbe JC, Harris RA (eds) The genetic basis of alcohol and drug action. Plenum Press, New York, pp 25-104
123. Phillips TJ, Lessov CN, Harland RD, Mitchell SR (1996) Evaluation of potential genetic associations between ethanol tolerance and sensitization in BXD/Ty recombinant inbred mice. J Pharmacol Exp Ther 277:613-623
124. Plomin R, McClearn GE, Gora-Maslak G, Neiderhiser JM (1991) Use of recombinant inbred strains to detect quantitative trait loci associated with behaviour. Behav Genet 21:99-116
125. Reinstein DK, DeBoissier T, Robinson N, Wurtman RJ (1983) Radial maze performance in three strains of mice: role of the fimbria/fornix. Brain Res 263:172-176
126. Robinson SF, Marks MJ, Collins AC (1996) Inbred mouse strains vary in oral self-selection of nicotine. Psychopharmacology 124:332-339
127. Roullet P, Lassalle JM (1990) Genetic variation, hippocampal mossy fibres distribution, novelty reactions and spatial representation in mice. Behav Brain Res 41:61-69
128. Roullet P, Lassale JM (1995) Radial maze learning using exclusively distant visual cues reveals learners and nonlearners among inbred mouse strains. Physiol Behav 58:1189-1195
129. Ruth JA, Ullman EA, Collins AC (1988) An analysis of cocaine effects on locomotor activities and heart rate in four inbred mouse strains. Pharmacol Biochem Behav 29:157-162
130. Saudou FD, Amara A, Dierich A, LeMeur M, Ramboz S, Segu L, Buhot M-C, Hen R (1994) Enhanced aggressive behavior in mice lacking 5HT1B receptor. Science 265:1875-1878
131. Sauer B (1993) Manipulation of transgenes by site-specific recombination: use of Cre-recombinase. Methods Enzymol 225:890-900
132. Schneider CW, Evans SK, Chenoweth MB, Beman FL (1973) Ethanol preference and behavioral tolerance in mice: biochemical and neurophysiological mechanisms. J Comp Physiol Psychol 82:466-474
133. Scott JP (1942) Genetic differences in the social behavior of inbred strains in mice. J Hered 33:11-15
134. Scott JP (1966) Agonistic behavior of mice and rats: a review. Am Zool 6:683-701
135. Seule TW (1991) Genetic differences in response to cocaine and stimulant drugs. In: Crabbe JC, Harris RA (eds) The genetic basis of alcohol and drug actions. Plenum Press, New York, pp 279-321
136. Seale TW, Carney JM (1991) Genetic determinants of susceptibility to the rewarding and other behavioral actions of cocaine. J Addict Dis 10:141-162
137. Selmanoff MK, Maxson SC, Ginsburg BE (1976) Chromosomal determinants of intermale aggressive behavior in inbred mice. Behav Genet 6:53-69
138. Selmanoff MK, Abreu E, Goldman BD, Ginsburg BE (1977) Manipulation of aggressive behaviors in adult DBA/2Bg and C57BL/10Bg male mice implanted with testosterone in silastic tubing. Horm Behav 8:377-390
139. Shuster L, Yu G, Bates A (1977) Sensitization to cocaine stimulation in mice. Psychopharmacology 52:185-190
140. Shuster L, Garhart CA, Powers J, Grumfeld Y, Kanel G (1988) Hepatotoxicity of cocaine. NIDA Res Monogr 88:250-275
141. Silver LM (1995) Mouse genetics: concepts and applications. Oxford University Press, New York
142. Simon NG (1979) The genetics of intermale aggression in mice: recent research and alternative strategies. Neurosci Biobehav Rev 3:97-106
143. Smithies O, Maeda N (1995) Gene targeting approaches to complex genetic diseases: atherosclerosis and essential hypertension. Proc Natl Acad Sci USA 92:5266-5272
144. Suda Y, Suzuki M, Ikawa Y, Aizawa S (1987) Mouse embryonic stem cells exhibit indefinite proliferative potential. J Cell Physiol 133:197-201
145. Svare B (1988) Genotype modulates the aggression-promoting quality of progesterone in pregnant mice. Horm Behav 22:90-99
146. Swerdlow NR, Geyer MA (1993) Clozapine and haloperidol in an animal model of sensorimotor gating deficits in schizophrenia. Pharmacol Biochem Behav 44:741-744
147. Swerdlow NR, Keith VA, Braff DL, Geyer MA (1991) Effects of spiperone, raclopride, SCH 23390 and clozapine on apomorphine inhibition of sensorimotor gataing of the startle response in the rat. J Pharmacol Exp Ther 256:530-536
148. Swerdlow RN, Braff DL, Taaid N, Geyer MA (1994a) Assessing the validity of an animal model of deficient sensorimotor gat-ing in schizopfirenic patients. Arch Gen Psychiatry 51:139-154
149. Swerdlow NR, Zisook D, Taaid N (1994h) Seroquel (ICI 204,636) restores propulse inhibition of acoustic startle in apomorphine-treated rats: similarities to clozapine. Psychopharmacology 114:675-678
150. Taylor BA (1972) Genetic relationships between inbred strains of mice. J Hered 63:83-86
151. Thompson ML, Sinister L, Casey H, Kanel GC (1984) Sex and strain differences in response to cocaine. Biochem Pharmacol 33:1299-1307
152. Tolliver BK, Carney JM (1994) Sensitization to stereotypy in DBA/2J but not C57BL/6J mice with repeated cocaine. Pharmacol Biochem Behav 48:169-173
153. Tolliver BK, Belknap JK, Woods WE, Carney JM (1994) Genetic analysis of sensitization and tolerance to cocaine. J Pharmacol Exp Ther 270:1230-1238
154. Trullas R, Skolnick P (1993) Differences in fear motivated behaviors among inbred mouse strains. Psychopharmacology 111:323-331
155. Tsien JZ, Chen DF, Gerber D, Tom C, Mercer HH, Anderson DJ, Mayford M, Kandel ER, Tonegawa S (1996) Subregion- and cell type-restricted gene knockout in mouse brain. Cell 87:1317-1326
156. Upchurch M, Wehner JM (1989) Inheritance of spatial learning ability in inbred mice: a classical izenetic analysis. Behav Neurosci 103:1251-1258
157. Vale JR, Ray D (1972) A diallel analysis of male sex behavior. Behav Genet 2:199-209
158. Van Abeelen JH (1977) Rearing responses and locomotor activity in mice: single locus control. Behav Neural Biol 19:401-404
159. Wahlslen D (1972) Genetic experiments with animal learning: a critical review. Behav Biol 7:143-182
160. Walsh RN, Cummins RA (1976) The open field test: a critical review. Psychol Bull 83:482-504
161. Weinberger SB, Koob GF, Marlinez JL Jr (1992) Differences in one-way active avoidance learning by means of different psychological testing systems with inbred mice as model organisms. Behav Genet 22:177-188
162. Wiener HL, Reith MEA (1990) Correlation between cocaine-induced locomotion and cocaine disposition in the brain among four inbred strains of mice. Pharmacol Biochem Behav 36:699-701
163. Wiles M, Keller G (1991) Multiple hematopoetic lineages develop from embryonic stem (ES) cell lines in culture. Development 111:259-267
164. Willot J, Carlson S, Chen H (1994) Prepulse inhibition of the startle response in mice: relationship to hearing loss and auditory system plasticity. Behav Neurosci 108:703-713
165. Womer DE, Jones BC, Erwin VG (1994) Characterization of dopamine transporter and locomotor effects of cocaine, GBR 12909. epidepride and SCH 23390 in C57BL and DBA mice. Pharmacol Biochem Behav 48:327-3335
166. th, 1996