The neural background of hyper-emotional aggression induced by post-weaning social isolation

Behavioural Brain Research

Volumn 233, Issue 1, 2012, Pages 120-129

  Toth, Mate ^a   Tulogdi, Aron ^a   Biro, Laszlo ^a   Soros, Petra ^a   Mikics, Eva ^a   Haller, Jozsef ^a  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Abnormal aggression; Amygdala; Arousal; C Fos; Hypothalamus; Prefrontal cortex; Rat

Indexed keywords

GLUCOCORTICOID; PROTEIN C FOS;

AGGRESSION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTERIOR CINGULATE; AROUSAL; ARTICLE; BASOLATERAL AMYGDALA; BED NUCLEUS OF THE STRIA TERMINALIS; BEHAVIOR CHANGE; CENTRAL NUCLEUS (AMYGDALA); DORSAL PREMAMILLARY NUCLEUS; EMOTION; HYPOTHALAMIC ATTACK AREA; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; HYPOTHALAMUS; LATERAL HYPOTHALAMUS; LOCUS CERULEUS; MALE; MAMMILLARY BODY; MEDIAL AMYGDALA; NONHUMAN; ORBITAL CORTEX; PERIAQUEDUCTAL GRAY MATTER; PREDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SOCIAL ISOLATION; STRIA TERMINALIS; TASK PERFORMANCE; VENTROLATERAL PERIAQUEDUCTAL GRAY;

AGGRESSION; ANIMALS; ANIMALS, NEWBORN; BRAIN; BRAIN MAPPING; EMOTIONS; MALE; MODELS, NEUROLOGICAL; NEURONS; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, WISTAR; SOCIAL ISOLATION; STATISTICS, NONPARAMETRIC; WEANING;

EID: 84861555758     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2012.04.025     Document Type: Article

References (55)

1. Chapple C.L., Tyler K.A., Bersani B.E. Child neglect and adolescent violence: examining the effects of self-control and peer rejection. Violence and Victims 2005, 20:39-53.
2. Green A.E., Gesten E.L., Greenwald M.A., Salcedo O. Predicting delinquency in adolescence and young adulthood: a longitudinal analysis of early risk factors. Youth Violence and Juvenile Justice 2008, 6:323-342.
3. Kim J., Cicchetti D. Longitudinal pathways linking child maltreatment, emotion regulation, peer relations, and psychopathology. Journal of Child Psychology and Psychiatry and Allied Disciplines 2010, 51:706-716.
4. Kotch J.B., Lewis T., Hussey J.M., English D., Thompson R., Litrownik A.J., et al. Importance of early neglect for childhood aggression. Pediatrics 2008, 121:725-731.
5. Lévesque M., Bigras M., Pauzé R. Externalizing problems and problematic sexual behaviors: same etiology. Aggressive Behaviour 2010, 36:358-370.
6. Woodruff K., Lee B. Identifying and predicting problem behavior trajectories among pre-school children investigated for child abuse and neglect. Child Abuse and Neglect 2011, 35:491-503.
7. Day H.D., Seay B.M., Hale P., Hendricks D. Early social deprivation and the ontogeny of unrestricted social behavior in the laboratory rat. Developmental Psychobiology 1982, 15:47-59.
8. Harlow H.F., Dodsworth R.O., Harlow M.K. Total social isolation in monkeys. Proceedings of the National Academy of Sciences of the United States of America 1965, 54:90-97.
9. Kempes M.M., Gulickx M.M., van Daalen H.J., Louwerse A.L., Sterck E.H. Social competence is reduced in socially deprived rhesus monkeys (Macaca mulatta). Journal of Comparative Psychology 2008, 122:62-67.
10. Potegal M., Einon D. Aggressive behaviors in adult rats deprived of playfighting experience as juveniles. Developmental Psychobiology 1989, 22:159-172.
11. Sachser N., Lick C., Stanzel K. The environment, hormones, and aggressive behaviour: a 5-year-study in guinea pigs. Psychoneuroendocrinology 1994, 19:697-707.
12. de Almeida R.M., Miczek K.A. Aggression escalated by social instigation or by discontinuation of reinforcement (frustration) in mice: inhibition by anpirtoline: a 5-HT1B receptor agonist. Neuropsychopharmacology 2002, 27:171-181.
13. de Boer S.F., van der Vegt B.J., Koolhaas J.M. Individual variation in aggression of feral rodent strains: a standard for the genetics of aggression and violence. Behavior Genetics 2003, 33:485-501.
14. Haller J., Kruk M.R. Normal and abnormal aggression: human disorders and novel laboratory models. Neuroscience and Biobehavioral Reviews 2006, 30:292-303.
15. Haller J., van de Schraaf J., Kruk M.R. Deviant forms of aggression in glucocorticoid hyporeactive rats: a model for 'pathological' aggression. Journal of Neuroendocrinology 2001, 13:102-107.
16. Miczek K.A., Fish E.W., De Bold J.F., De Almeida R.M. Social and neural determinants of aggressive behavior: pharmacotherapeutic targets at serotonin, dopamine and gamma-aminobutyric acid systems. Psychopharmacology 2002, 163:434-458.
17. Natarajan D., de Vries H., Saaltink D.J., de Boer S.F., Koolhaas J.M. Delineation of violence from functional aggression in mice: an ethological approach. Behavior Genetics 2009, 39:73-90.
18. Tóth M., Halász J., Mikics E., Barsy B., Haller J. Early social deprivation induces disturbed social communication and violent aggression in adulthood. Behavioral Neuroscience 2008, 122:849-854.
19. Toth M., Mikics E., Tulogdi A., Aliczki M., Haller J. Post-weaning social isolation induces abnormal forms of aggression in conjunction with increased glucocorticoid and autonomic stress responses. Hormones and Behavior 2011, 60:28-36.
20. Kollack-Walker S., Newman S.W. Mating and agonistic behavior produce different patterns of Fos immunolabeling in the male Syrian hamster brain. Neuroscience 1995, 66:721-736.
21. Halász J., Liposits Z., Kruk M.R., Haller J. Neural background of glucocorticoid dysfunction-induced abnormal aggression in rats: involvement of fear- and stress-related structures. European Journal of Neuroscience 2002, 15:561-569.
22. Lin D., Boyle M.P., Dollar P., Lee H., Lein E.S., Perona P., et al. Functional identification of an aggression locus in the mouse hypothalamus. Nature 2011, 470:221-226.
23. Haller J., Tóth M., Halasz J., De Boer S.F. Patterns of violent aggression-induced brain c-fos expression in male mice selected for aggressiveness. Physiology and Behavior 2006, 88:173-182.
24. Tulogdi A., Toth M., Halasz J., Mikics E., Fuzesi T., Haller J. Brain mechanisms involved in predatory aggression are activated in a laboratory model of violent intra-specific aggression. European Journal of Neuroscience 2010, 32:1744-1753.
25. Woodworth C.H. Attack elicited in rats by electrical stimulation of the lateral hypothalamus. Physiology and Behavior 1971, 6:345-353.
26. Siegel A., Roeling T.A., Gregg T.R., Kruk M.R. Neuropharmacology of brain-stimulation-evoked aggression. Neuroscience and Biobehavioral Reviews 1999, 23:359-389.
27. Canteras N.S. The medial hypothalamic defensive system: hodological organization and functional implications. Pharmacology Biochemistry and Behavior 2002, 71:481-491.
28. Motta S.C., Goto M., Gouveia F.V., Baldo M.V., Canteras N.S., Swanson L.W. Dissecting the brain's fear system reveals the hypothalamus is critical for responding in subordinate conspecific intruders. Proceedings of the National Academy of Sciences of the United States of America 2009, 106:4870-4875.
29. Halasz J., Toth M., Mikics E., Hrabovszky E., Barsy B., Barsvari B., et al. The effect of neurokinin1 receptor blockade on territorial aggression and in a model of violent aggression. Biological Psychiatry 2008, 63:271-278.
30. Lammers J.H., Kruk M.R., Meelis W., van der Poel A.M. Hypothalamic substrates for brain stimulation-induced attack, teeth-chattering and social grooming in the rat. Brain Research 1988, 449:311-327.
31. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 1998, Academic Press, San Diego. 4th ed.
32. Holm S. A simple sequentially rejective multiple test procedure. Scandinavian Journal of Statistics 1979, 6:65-70.
33. Comoli E., Ribeiro-Barbosa E.R., Negrão N., Goto M., Canteras N.S. Functional mapping of the prosencephalic systems involved in organizing predatory behavior in rats. Neuroscience 2005, 130:1055-1067.
34. Vitiello B., Behar D., Hunt J., Stoff D., Ricciuti A. Subtyping aggression in children and adolescents. Journal of Neuropsychiatry and Clinical Neurosciences 1990, 2:189-192.
35. Blair R.J. Neurocognitive models of aggression, the antisocial personality disorders, and psychopathy. Journal of Neurology, Neurosurgery and Psychiatry 2001, 71:727-731.
36. Meloy J.R. Empirical basis and forensic application of affective and predatory violence. Australian and New Zealand Journal of Psychiatry 2006, 40:539-547.
37. Ramírez J.M., Andreu J.M. Aggression, and some related psychological constructs (anger, hostility, and impulsivity); some comments from a research project. Neuroscience and Biobehavioral Reviews 2006, 30:276-291.
38. Muñoz L.C., Frick P.J., Kimonis E.R., Aucoin K.J. Types of aggression, responsiveness to provocation, and callous-unemotional traits in detained adolescents. Journal of Abnormal Child Psychology 2008, 36:15-28.
39. Blanchard R.J., Wall P.M., Blanchard D.C. Problems in the study of rodent aggression. Hormones and Behavior 2003, 44:161-170.
40. Jacobs C., Van Den Broeck W., Simoens P. Increased volume and neuronal number of the basolateral nuclear group of the amygdaloid body in aggressive dogs. Behavioural Brain Research 2006, 170:119-125.
41. Levinson D.M., Reeves D.L., Buchanan D.R. Reductions in aggression and dominance status in guinea pigs following bilateral lesions in the basolateral amygdala or lateral septum. Physiology and Behavior 1980, 25:963-971.
42. McGregor A., Herbert J. Differential effects of excitotoxic basolateral and corticomedial lesions of the amygdala on the behavioural and endocrine responses to either sexual or aggression-promoting stimuli in the male rat. Brain Research 1992, 574:9-20.
43. Shaikh M.B., Brutus M., Siegel H.E., Siegel A. Regulation of feline aggression by the bed nucleus of stria terminalis. Brain Research Bulletin 1986, 16:179-182.
44. Dalley J.W., Cardinal R.N., Robbins T.W. Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates. Neuroscience and Biobehavioral Reviews 2004, 28:771-784.
45. Halász J., Tóth M., Kalló I., Liposits Z., Haller J. The activation of prefrontal cortical neurons in aggression - a double labeling study. Behavioural Brain Research 2006, 175:166-175.
46. Ferris C.F., Stolberg T., Kulkarni P., Murugavel M., Blanchard R., Blanchard D.C., et al. Imaging the neural circuitry and chemical control of aggressive motivation. BMC Neuroscience 2008, 9:111.
47. Harmon-Jones E., Sigelman J. State anger and prefrontal brain activity: evidence that insult-related relative left-prefrontal activation is associated with experienced anger and aggression. Journal of Personality and Social Psychology 2001, 80:797-803.
48. Sander D., Grandjean D., Pourtois G., Schwartz S., Seghier M.L., Scherer K.R., et al. Emotion and attention interactions in social cognition: brain regions involved in processing anger prosody. Neuroimage 2005, 28:848-858.
49. Fone K.C., Porkess M.V. Behavioural and neurochemical effects of post-weaning social isolation in rodents-relevance to developmental neuropsychiatric disorders. Neuroscience and Biobehavioral Reviews 2008, 32:1087-1102.
50. Haller J., Makara G.B., Kruk M.R. Catecholaminergic involvement in the control of aggression: hormones, the peripheral sympathetic, and central noradrenergic systems. Neuroscience and Biobehavioral Reviews 1998, 22:85-97.
51. Kruk M.R., Westphal K.G., Van Erp A.M., van Asperen J., Cave B.J., Slater E., et al. The hypothalamus: cross-roads of endocrine and behavioural regulation in grooming and aggression. Neuroscience and Biobehavioral Reviews 1998, 23:163-177.
52. Mikics E., Kruk M.R., Haller J. Genomic and non-genomic effects of glucocorticoids on aggressive behavior in male rats. Psychoneuroendocrinology 2004, 29:618-635.
53. Nelson R.J., Chiavegatto S. Molecular basis of aggression. Trends in Neurosciences 2001, 24:713-719.
54. Haller J., Tóth M., Halász J. The activation of raphe serotonergic neurons in normal and hypoarousal-driven aggression: a double labeling study in rats. Behavioural Brain Research 2005, 161:88-94.
55. Couppis M.H., Kennedy C.H. The rewarding effect of aggression is reduced by nucleus accumbens dopamine receptor antagonism in mice. Psychopharmacology 2008, 197:449-456.