Serotonin receptor genes 5HT1A and 5HT2A modify the relation between childhood temperament and adulthood hostility

Genes, Brain and Behavior

Volumn 7, Issue 1, 2008, Pages 46-52

  Keltikangas Jarvinen L ^a   Puttonen, S ^a   Kivimaki M ^b   Elovainio, M ^a   Pulkki Raback L ^a   Koivu, M ^c   Rontu, R ^c   Lehtimaki T ^c  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

Gene; Hostility; Longitudinal study; Serotonin receptors; Temperament

Indexed keywords

SEROTONIN 1 RECEPTOR; SEROTONIN 2A RECEPTOR;

ADOLESCENT; ADULT; ANGER; ARTICLE; ATTITUDE; CHILD; EMOTIONALITY; FEMALE; FOLLOW UP; GENETIC VARIABILITY; GENOTYPE; HOSTILITY; HUMAN; HYPERACTIVITY; MALE; MOTHER; NORMAL HUMAN; PARANOIA; PRIORITY JOURNAL; SOCIAL BEHAVIOR; TEMPERAMENT;

ADULT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD; CHILD, PRESCHOOL; EMOTIONS; FEMALE; FINLAND; FOLLOW-UP STUDIES; GENOTYPE; HOSTILITY; HUMANS; MALE; PERSONALITY ASSESSMENT; RECEPTORS, SEROTONIN, 5-HT1; RECEPTORS, SEROTONIN, 5-HT2; RISK FACTORS; SOCIAL BEHAVIOR; SOCIAL DESIRABILITY; TEMPERAMENT; VARIATION (GENETICS);

EID: 38349022442     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2007.00324.x     Document Type: Article

References (44)

1. Åkerblom, H.K., Uhari, M., Pesonen, E., Dahl, M., Kaprio, E.A., Nuutinen, E., Pietikäinen, M., Salo, M.K., Aromaa, A., Kannas, L., Keltikangas-Järvinen, L., Kuusela, V., Räsänen, L., Rönnemaa, T., Knip, M., Telama, R., Välimäki, I., Pyörälä, K. Viikari, J 1991) Cardiovascular risk in young Finns. Ann Med 23, 35 40.
2. Anderson, K.E., Lytton, H. Romney, D.M 1986) Mothers' interactions with normal and conduct-disordered boys: who affects whom? Dev Psychol 22, 604 609.
3. Auerbach, J.G., Benjamin, J., Faroy, M., Geller, V. Ebstein, R 2001) DRD4 related to infant attention and information processing: a developmental link to ADHD? Psychiatr Genet 11, 31 35.
4. Barefoot, J.C., Williams, R.B., Siegler, I.C. Schroll, M 1995) Depressive affect, hostility, and socioeconomic-status (SES) - interrelationships and joint effects on health. Psychosom Med 57, 66.
5. Bates, J.E 1986) On the relation between temperament and behavior problems. In Kohnstamm, G.A. (ed Temperament Discussed: Temperament and Development in Infancy and Childhood. Swets & Zeitlinger Publishers, Lisse, the Netherlands, pp. 181 189.
6. Berkman, L. Orth-Gomér, K 1996) Prevention of cardiovascular morbidity and mortality: role of social relations. In Orth-Gomér, K. Schneiderman, N. (eds Behavioral Medicine Approaches to Cardiovascular Disease Prevention. Lawrence Erlbaum Associates, Hillsdale, NJ, pp. 51 67.
7. Buss, A.H. Durkee, A 1957) An inventory for assessing different kinds of hostility. J Consult Psychol 21, 343 349.
8. Caspi, A., Sugden, K., Moffitt, T.E., Taylor, A., Craig, I.W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A. Poulton, R 2003) Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301, 386 389.
9. Chess, S. Thomas, A 1986) Temperament in Clinical Practice. The Guilford Press, New York.
10. Comings, D.E., Johnson, J.P., Gonzalez, N.S., Huss, M., Saucier, G., McGue, M. MacMurray, J 2000) Association between the adrenergic alpha 2A receptor gene (ADRA2A) and measures of irritability, hostility, impulsivity and memory in normal subjects. Psychiatr Genet 10, 39 42.
11. Comrey, A.L 1957) A factor analysis of items on the MMPI depression scale. Educ Psychol Meas 17, 578 585.
12. Comrey, A.L 1958) A factor analysis of items on the MMPI paranoia scale. Educ Psychol Meas 18, 99 107.
13. Degoratis, L.R 1977) SCL-90 R (Revised) Version Manual - I. Johns Hopkins University Press, Baltimore, MD.
14. Engfer, A 1986) Antecedents of perceived behaviour problems in infancy. In Kohnstamm, G.A. (ed Temperament Discussed: Temperament and Development in Infancy and Childhood. Swets & Zeitlinger Publishers, Lisse, the Netherlands, pp. 165 180.
15. Greenberg, B.D., Li, Q., Lucas, F.R., Hu, S., Sirota, L.A., Benjamin, J., Lesch, K.P., Hamer, D. Murphy, D.L 2000) Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample. Am J Med Genet 96, 202 216.
16. Heinonen, K., Räikkönen, K. Keltikangas-Järvinen, L 2005) Dispositional optimism: development over 21 years from the perspectives of perceived temperament and mothering. Pers Individ Dif 38, 425 435.
17. Houston, B.K 1994) Anger, hostility and psychophysiological reactivity. In Siegman, A.W. Smith, T.W. (eds Anger, Hostility and the Heart. Lawrence Erlbaum Associates, Hillsdale, NJ, pp. 97 115.
18. Jokela, M., Keltikangas-Järvinen, L., Kivimäki, M., Puttonen, S., Elovainio, M., Rontu, R. Lehtimäki, T 2007) Serotonin receptor 2A gene and the influence of childhood maternal nurturance on adulthood depressive symptoms. Arch Gen Psychiatry 64, 356 360.
19. Jorgensen, R.S., Frankowski, J.J., Lantinga, L.J., Phadke, K., Sprafkin, R.P. Abdul-Karim K 2001) Defensive hostility and coronary heart disease: a preliminary investigation of male veterans. Psychosom Med 63, 463 469.
20. Katainen, S., Räikkönen, K. Keltikangas-Järvinen, L 1997) Childhood temperament and mother's child-rearing attitudes: stability and interaction in a three-year follow-up study. Eur J Pers 11, 249 265.
21. Katainen, S., Räikkönen, K., Keskivaara, P. Keltikangas-Järvinen, L 1999) Maternal child-rearing attitudes and role satisfaction and children's temperament as antecedents of adolescent depressive tendencies: follow-up study of 6- to 15-year-olds. J Youth Adolesc 28, 139 163.
22. Keltikangas-Järvinen, L 2002) Psychology and the risk for cardiovascular disorder: a developmental perspective. In Bäckman, L. von Hofsten, C eds Psychology at the Turn of the Millennium. Vol. 1. Psychology Press, Hove, pp. 335 353.
23. Keltikangas-Järvinen, L. Ravaja, N 2002) Relationships between hostility and physiological coronary heart disease risk factors in young adults: moderating influence of perceived social support and sociability. Psychol Health 17, 173 190.
24. Keltikangas-Järvinen, L., Pulkki-Råback, L., Puttonen, S., Viikari, J. Raitakari, O.T 2006) Childhood hyperactivity as a predictor of carotid artery intima media thickness over a period of 21 years: the cardiovascular risk in young Finns study. Psychosom Med 68, 509 516.
25. Knox, S.S., Wilk, J.B., Zhang, Y., Weidner, G. Ellison, R.C 2004) A genome scan for hostility: the national heart, lung, and blood institute family heart study. Mol Psychiatry 9, 124 126.
26. Knutson, B., Wolkowitz, O.M., Cole, S.W., Chan, T., Moore, E.A., Johnson, R.C., Terpstra, J., Turner, R.A. Reus, V.I 1998) Selective alteration of personality and social behavior by serotonergic intervention. Am J Psychiatry 155, 373 379.
27. Kraemer, H.C., Stice, E., Kazdin, A., Offord, D. Kupfer, D 2001) How do risk factors work together? Mediators, moderators, and independent, overlapping, and proxy risk factors. Am J Psychiatry 158, 848 856.
28. Kusumi, I. Koyama, T 1998) Serotonin-2A receptor function in affective disorders. In Ozawa, H., Saito, T. Takahata, N. (eds Signal Transduction in Affective Disorders. Springer, Tokyo, pp. 21 34.
29. Lee, C.L. Bates, J.E 1985) Mother-child interaction at age two years and perceived difficult temperament. Child Dev 56, 1314 1325.
30. Livak, K.J 1999) Allelic discrimination using fluorogenic probes and the 5′ nuclease assay. Genet Anal 14, 143 149.
31. Manuck, S.B., Flory, J.D., McCaffery, J.M., Matthews, K.A., Mann, J.J. Muldon, M.F 1998) Aggression, impulsivity, and central nervous system serotonergic responsivity in a nonpatient sample. Neuropsychopharmacology 19, 287 299.
32. Matthews, K.A., Woodall, K.L., Kenyon, K. Jacob, T 1996) Negative family environment as a predictor of boys' future status on measures of hostile attitudes, interview behavior and anger expression. Health Psychol 15, 30 37.
33. McGonigle, M.M., Smith, T.W., Benjamin, L.S. Turner, C.W 1993) Hostility and nonshared family environment: a study of monozygotic twins. J Res Pers 27, 23 34.
34. Miller, T.Q., Smith, T.W., Turner, C.W., Guijarro, M.L. Hallet, A.J 1996) A meta-analytic review of research on hostility and physical health. Psychol Bull 119, 322 348.
35. Pesonen, A., Räikkönen, K., Keskivaara, P. Keltikangas- Järvinen, L 2003) Difficult temperament in childhood and adulthood: continuity from maternal perceptions to self-ratings over 17 years. Pers Individ Dif 34, 19 31.
36. Reif, A. Lesch, K.P 2003) Toward a molecular architecture of personality. Behav Brain Res 139, 1 20.
37. Rose, R.J 1988) Genetic and environmental variance in content dimensions of the MMPI. J Pers Soc Psychol 55, 302 311.
38. Siegler, J.C 1994) Hostility and risk: lifestyle variables. In Siegman, A.W. Smith, T.W. (eds Anger, Hostility and the Heart. Lawrence Erlbaum Associates, Hillsdale, NJ, pp. 199 215.
39. Smith, T.W 1994) Concepts and methods in the study of anger, hostility and health. In Siegman, A.W. Smith, T.W. (eds Anger, Hostility and the Heart. Lawrence Erlbaum Associates, Hillsdale, NJ, pp. 23 42.
40. Smith, T.W., McGonigle, M., Turner, C.W., Ford, M.H. Slattery, M.L 1991) Cynical hostility in adult male twins. Psychosom Med 53, 684 692.
41. Staner, L. Mendlewicz, J 1998) Heredity and role of serotonin in aggressive impulsive behavior. Encephale 24, 355 364.
42. Weissman, M., Fox, K. Klerman, G.L 1973) Hostility and depression associated with suicide attempts. Am J Psychiatry 130, 450 455.
43. Wells, E 1980) Behavioral Patterns of Children in School. Vitality Health Statistics, No. 113.
44. Woodall, K.L. Matthews, K.A 1993) Changes in and stability of hostile characteristics: results from a 4-year longitudinal-study of children. J Pers Soc Psychol 64, 491 499.