ABCG1 gene variants in suicidal behavior and aggression-related traits

European Neuropsychopharmacology

Volumn 17, Issue 6-7, 2007, Pages 410-416

  Gietl, Anton ^a   Giegling, Ina ^a   Hartmann, Annette M ^a   Schneider, Barbara ^b   Schnabel, Axel ^b   Maurer, Konrad ^b   Möller, Hans Jürgen ^a   Rujescu, Dan ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

Cholesterol; ; Genetics; Polymorphism; ; Serotonin; ; Suicide;

Indexed keywords

CARRIER PROTEIN; CHOLESTEROL; PROTEIN ABCG1; STEROL; UNCLASSIFIED DRUG;

ABCG1 GENE; ADULT; AGED; AGGRESSION; ALLELE; ANGER; ARTICLE; CONTROLLED STUDY; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC TRAIT; GENETIC VARIABILITY; GENOTYPE; HOMEOSTASIS; HUMAN; IRRITABILITY; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; RATING SCALE; SCORING SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM; SUICIDAL BEHAVIOR; SUICIDE ATTEMPT; VIOLENCE;

AGGRESSION; ANGER; ATP-BINDING CASSETTE TRANSPORTERS; GENOTYPE; HUMANS; PERSONALITY INVENTORY; QUESTIONNAIRES; REFERENCE VALUES; SUICIDE; SUICIDE, ATTEMPTED; VARIATION (GENETICS);

EID: 33947723018     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2006.11.004     Document Type: Article

References (56)

1. Abildayeva K., Jansen P.J., Hirsch-Reinshagen V., Bloks V.W., Bakker A.H., Ramaekers F.C., de Vente J., Groen A.K., Wellington C.L., Kuipers F., and Mulder M. 24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux. J. Biol. Chem. 281 18 (2006) 12799-12808
2. Atmaca M., Kuloglu M., Tezcan E., and Ustundag B. Serum leptin and cholesterol levels in schizophrenic patients with and without suicide attempts. Acta Psychiatr. Scand. 108 3 (2003) 208-214
3. Barrett J.C., Fry B., Maller J., and Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21 (2005) 263-265
4. Brent D.A., and Mann J.J. Family genetic studies, suicide, and suicidal behavior. Am. J. Med. Genet., C, Semin. Med. Genet. 133 1 (2005) 13-24
5. Buss A.H., and Durkee A. An inventory for assessing different kinds of hostility. J. Consult. Psychiatry 21 (1957) 343-348
6. Buydens-Branchey L., Branchey M., Hudson J., and Fergeson P. Low HDL cholesterol, aggression and altered central serotonergic activity. Psychiatry Res. 93 2 (2000) 93-102
7. Dean M., and Allikmets R. Evolution of ATP-binding cassette transporter genes. Curr. Opin. Genet. Dev. 5 6 (1995) 779-785
8. Dietschy J.M., and Turley S.D. Cholesterol metabolism in the brain. Curr. Opin. Lipidol. 12 2 (2001) 105-112
9. Dumais A., Lesage A.D., Lalovic A., Seguin M., Tousignant M., Chawky N., and Turecki G. Is violent method of suicide a behavioral marker of lifetime aggression?. Am. J. Psychiatry 162 7 (2005) 1375-1378
10. Egeland J.A., and Sussex J.N. Suicide and family loading for affective disorders. JAMA 254 (1985) 915-918
11. First M.B., Spitzer R.L., Gibbon M., and Williams T.W. Structured Clinical Interview for DSM-IV Axis I and II Disorders (1997), American Psychiatric Press, Washington, DC
12. Fritze J., Schneider B., and Lanczik M. Autoaggressive behaviour and cholesterol. Neuropsychobiology 26 4 (1992) 180-181
13. Garland M., Hickey D., Corvin A., Golden J., Fitzpatrick P., Cunningham S., and Walsh N. Total serum cholesterol in relation to psychological correlates in parasuicide. Br. J. Psychiatry 177 (2000) 77-83
14. Golomb B.A., Stattin H., and Mednick S. Low cholesterol and violent crime. J. Psychiatr. Res. 34 4-5 (2000) 301-309
15. Guillem E., Pelissolo A., Notides C., and Lepine J.P. Relationship between attempted suicide, serum cholesterol level and novelty seeking in psychiatric in-patients. Psychiatry Res. 112 1 (2002) 83-88
16. Hampel R., and Selg H. FAF-Fragebogen zur Erfassung von Aggressivitätsfaktoren (1975), Hofgrefe Verlag für Psychologie, Gottingen
17. Hayashi H., Campenot R.B., Vance D.E., and Vance J.E. Glial lipoproteins stimulate axon growth of central nervous system neurons in compartmented cultures. J. Biol. Chem. 279 14 (2004) 14009-14015
18. Hayden E.P., and Nurnberger Jr. J.I. Molecular genetics of bipolar disorder. Genes Brain Behav. 5 1 (2006) 85-95
19. Higgins C.F. ABC transporters: from microorganisms to man. Annu. Rev. Cell Biol. 8 (1992) 67-113
20. Hillbrand M., Spitz R.T., and Foster H.G. Serum cholesterol and aggression in hospitalized male forensic patients. J. Behav. Med. 18 1 (1995) 33-43
21. Hillbrand M., Waite B.M., Rosenstein M., Harackiewicz D., Lingswiler V.M., and Stehney M. Serum cholesterol concentrations and non-physical aggression in healthy adults. J. Behav. Med. 28 3 (2005) 295-299
22. Joseph S.B., and Tontonoz P. LXRs: new therapeutic targets in atherosclerosis?. Curr. Opin. Pharmacol. 3 2 (2003) 192-197
23. Joseph S.B., Laffitte B.A., Patel P.H., Watson M.A., Matsukuma K.E., Walczak R., Collins J.L., Osborne T.F., and Tontonoz P. Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors. J. Biol. Chem. 277 13 (2002) 11019-11025
24. Kamali M., Oquendo M.A., and Mann J.J. Understanding the neurobiology of suicidal behavior. Depress. Anxiety 14 3 (2001) 164-176
25. Kaplan J.R., Shively C.A., Fontenot M.B., Morgan T.M., Howell S.M., Manuck S.B., Muldoon M.F., and Mann J.J. Demonstration of an association among dietary cholesterol, central serotonergic activity, and social behavior in monkeys. Psychosom. Med. 56 6 (1994) 479-484
26. Karten B., Campenot R.B., Vance D.E., and Vance J.E. Expression of ABCG1, but not ABCA1, correlates with cholesterol release by cerebellar astroglia. J. Biol. Chem. 281 7 (2006) 4049-4057
27. Kim Y.K., and Myint A.M. Clinical application of low serum cholesterol as an indicator for suicide risk in major depression. J. Affect. Disord. 81 2 (2004) 161-166
28. Lalovic A., Merkens L., Russell L., Arsenault-Lapierre G., Nowaczyk M.J., Porter F.D., Steiner R.D., and Turecki G. Cholesterol metabolism and suicidality in Smith-Lemli-Opitz syndrome carriers. Am. J. Psychiatry 161 11 (2004) 2123-2126
29. Lalovic A., Levy E., Luheshi G., Canetti L., Grenier E., Sequeira A., and Turecki G. Cholesterol content in brains of suicide completers. Int. J. Neuropsychopharmacol. 17 (2006) 1-8 (Electronic publication ahead of print)
30. Lee H.J., and Kim Y.K. Serum lipid levels and suicide attempts. Acta Psychiatr. Scand. 108 3 (2003) 215-221
31. Mann J.J., Waternaux C., Haas G.L., and Malone K.M. Toward a clinical model of suicidal behavior in psychiatric patients. Am. J. Psychiatry 156 (1999) 181-189
32. Mann J.J., Brent D.A., and Arango V. The neurobiology and genetics of suicide and attempted suicide: a focus on the serotonergic system. Neuropsychopharmacology 24 (2001) 467-477
33. Mauch D.H., Nagler K., Schumacher S., Goritz C., Muller E.C., Otto A., and Pfrieger F.W. CNS synaptogenesis promoted by glia-derived cholesterol. Science 294 5545 (2001) 1354-1357
34. Nakamura M., Ueno S., Sano A., and Tanabe H. Polymorphisms of the human homologue of the Drosophila white gene are associated with mood and panic disorders. Mol. Psychiatry 4 2 (1999) 155-162
35. Pfrieger F.W. Cholesterol homeostasis and function in neurons of the central nervous system. Cell. Mol. Life Sci. 60 6 (2003) 1158-1171
36. Pierce D.W. The predictive validation of a suicide intent scale: a five year follow-up. Br. J. Psychiatry 139 (1981) 391-396
37. Plutchik R., van Praag H.M., and Conte H.R. Correlates of suicide and violence risk: III. A two-stage model of countervailing forces. Psychiatry Res. 28 2 (1989) 215-225
38. Pucadyil T.J., and Chattopadhyay A. Cholesterol modulates the antagonist-binding function of hippocampal serotonin1A receptors. Biochim. Biophys. Acta 1714 1 (2005) 35-42
39. Rice J.P., Reich T., Bucholz K.K., Neuman R.J., Fishman R., and Rochberg N. Comparison of direct interview and family history diagnoses of alcohol dependence. Alcohol. Clin. Exp. Res. 19 (1995) 1018-1023
40. Roy A. Genetics of suicide. Ann. N.Y. Acad. Sci. 487 (1986) 97-105
41. Roy A., Segal N.L., Centerwall B.S., and Robinette C.D. Suicide in twins. Arch. Gen. Psychiatry 48 (1991) 29-32
42. Rujescu D., Giegling I., Dahmen N., Szegedi A., Anghelescu I., Gietl A., Schafer M., Muller-Siecheneder F., Bondy B., and Moller H.J. Association study of suicidal behavior and affective disorders with a genetic polymorphism in ABCG1, a positional candidate on chromosome 21q22.3. Neuropsychobiology 42 Suppl 1 (2000) 22-25
43. Rujescu D., Giegling I., Bondy B., Gietl A., Zill P., and Möller H.J. Association of anger-related traits with SNPs in the TPH gene. Mol. Psychiatry 7 (2002) 1023-1029
44. Rujescu D., Giegling I., Sato T., Hartmann A.M., and Möller H.J. Genetic variations in tryptophan hydroxylase in suicidal behavior; analysis and meta analysis. Biol. Psychiatry 15, 54 4 (2003) 465-473
45. Rujescu D., Giegling I., Gietl A., Hartmann A.M., and Moller H.J. A functional single nucleotide polymorphism (V158M) in the COMT gene is associated with aggressive personality traits. Biol. Psychiatry 54 1 (2003) 34-39
46. Rujescu, D., Thalmeier, A., Moller, H.J., Bronisch, T., Giegling, I., in press. Molecular genetic findings in suicidal behavior; What is beyond the serotonergic system? Arch. Suicide Res.
47. Schmitz G., Langmann T., and Heimerl S. Role of ABCG1 and other ABCG family members in lipid metabolism. J. Lipid Res. 42 10 (2001) 1513-1520
48. Schulsinger F. A family study of suicide. In: Schou M., and Stromgren E. (Eds). Origin, Prevention, and Treatment of Affective Disorders (1979), Academic Press, New York 277-287
49. Spielberger C.D. State-Trait Anger Expression Inventory (1991), Psychological Assessment Resources, Odessa, FL
50. Statham D.J., Heath A.C., Madden P.A.F., Bucholz K.K., Biesrut L., Dinwiddie S.H., et al. Suicidal behaviour: an epidemiological and genetic study. Psychol. Med. 28 (1998) 839-855
51. Troisi A., and D'Argenio A. Apolipoprotein A-I/apolipoprotein B ratio and aggression in violent and nonviolent young adult males. J. Psychiatr. Res. (2006) (Jan 30, Electronic publication ahead of print)
52. Vance J.E., Hayashi H., and Karten B. Cholesterol homeostasis in neurons and glial cells. Semin. Cell Dev. Biol. 16 2 (2005) 193-212
53. Vaughan A.M., and Oram J.F. ABCG1 redistributes cell cholesterol to domains removable by high density lipoprotein but not by lipid-depleted apolipoproteins. J. Biol. Chem. 280 34 (2005) 30150-30157
54. Vevera J., Zukov I., Morcinek T., and Papezova H. Cholesterol concentrations in violent and non-violent women suicide attempters. Eur. Psychiatr. 18 1 (2003) 23-27
55. Vevera J., Fisar Z., Kvasnicka T., Zdenek H., Starkova L., Ceska R., and Papezova H. Cholesterol-lowering therapy evokes time-limited changes in serotonergic transmission. Psychiatry Res. 133 2-3 (2005) 197-203
56. Virkkunen M. Serum cholesterol in antisocial personality. Neuropsychobiology 5 1 (1979) 27-30