Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 96, Issue 2, 2000, Pages 202-216

  Greenberg, Benjamin D ^a   Qian, Li ^a   Lucas, Frank R ^a   Stella, Hu ^b   Sirota, Leo A ^b   Benjamin, Jonathan ^c   Lesch, Klaus Peter ^d   Hamer, Dean ^b   Murphy, Dennis L ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^d UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Genetics; Neuroticism; Personality traits; Promoter; Serotonin transporter

Indexed keywords

SEROTONIN TRANSPORTER;

ADULT; ALLELE; ANXIETY NEUROSIS; ARTICLE; BEHAVIOR; CORRELATION FUNCTION; DEPRESSION; DNA POLYMORPHISM; FEMALE; HOSTILITY; HUMAN; HUMAN EXPERIMENT; PERSONALITY; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM;

ADOLESCENT; ADULT; AGED; ALLELES; ANXIETY; CARRIER PROTEINS; DEMOGRAPHY; DNA REPLICATION; FEMALE; GENOTYPE; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; NERVE TISSUE PROTEINS; NEUROTIC DISORDERS; NUCLEAR FAMILY; PERSONALITY; PERSONALITY ASSESSMENT; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEX CHARACTERISTICS;

EID: 0343238139     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(20000403)96:2<202::AID-AJMG16>3.0.CO;2-J     Document Type: Article

References (65)

1. Ball D, Hill L, Freeman B, Eley TC, Strelau J, Riemann R, Spinath FM, Angleitner A, Plomin R. 1997. The serotonin transporter gene and peer-rated neuroticism. NeuroReport 8:1301-1304.
2. Bellivier F, Laplanche JL, Leboyer M, Feingold J, Bottos C, Allilaire JF, Launay JM. 1997. Serotonin transporter gene and manic depressive illness: an association study. Biol Psychiatry 41:750-752.
3. Bengel D, Greenberg BD, Corá-Locatelli G, Altemus M, Heils A, Li Q, Murphy DL. 2000. Association of the serotonin transporter promoter regulatory region and obsessive-compulsive disorder. Mol Psychiatry 4:463-466.
4. Billett EA, Richter MA, King N, Heils A, Lesch KP, Kennedy JL. 1997. Obsessive compulsive disorder, response to serotonin reuptake inhibitors and the serotonin transporter gene. Mol Psychiatry 2:403-406.
5. Buss DM. 1995. Evolutionary psychology: a new paradigm for psychological science. Psychol Inquiry 6:1-30.
6. Cattell HB. 1989. The 16PF: Personality in depth. Champaign, IL: IPAT.
7. Champoux M, Bennett A, Lesch K-P, Heils A, Nielsen DA, Higley JD, Suomi SJ. 1999. Serotonin transporter gene polymorphism and neuro-behavioral development in rhesus monkey neonates. Soc Neurosci Abstr 25:32.12.
8. Cloninger CR, Przybeck TR, Svrakic DM. 1991. The Tridimensional Personality Questionnaire: U.S. normative data. Psychol Rep 69:1047-1057.
9. Cloninger CR, Svrakic DM, Przybeck TR. 1993. A psychobiological model of temperament and character. Arch Gen Psychiatry 50:975-90.
10. Cohen J. 1988. Statistical power analysis for the behavioral sciences. Hillsdale, NJ: Erlbaum.
11. Collier DA, Stöber G, Li T, Heils A, Catalano M, Di Bella D, Arranz MJ, Murray RM, Vallada HP, Bengel D, et al. 1996. A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Mol Psychiatry 1:453-460.
12. Cook EHJ, Courchesne R, Lord C, Cox NJ, Van S, Lincoln A, Haas Rea. 1997. Evidence of linkage between the serotonin transporter and autistic disorder. Mol Psychiatry 2:247-250.
13. Costa PTJ, McCrae RR. 1988. Personality in adulthood: a six-year longitudinal study of self-reports and spouse ratings on the NEO personality inventory. J Pers Soc Psychol 54:853-863.
14. Costa PTJ, McCrae RR. 1992. Revised NEO Personality Inventory (NEO PI-R) and NEO Five Inventory (NEO-FFI) professional manual. Odessa, FL: Psychological Assessment Resources.
15. Deary IJ, Battersby S, Whiteman MC. Connor JM, Fowkes FG, Harmar A. 1999. Neuroticism and polymorphisms in the serotonin transporter gene. Psychol Med 29:735-739.
16. Deckert J, Catalano M, Heils A, Di Bella D, Friess F, Politi E, Franke P, Nothen NM, Maier W, Belloni L, Lesch KP. 1997. Functional promoter polymorphism of the human serotonin transporter: lack of association with panic disorder. Psychiatr Genet 7:45-47.
17. Ebstein RP, Gritsenko I, Nemanov L, Frisch A, Osher Y, Belmaker RH. 1997. No association between the serotonin transporter gene regulatory region polymorphism and the tridimensional personality questionnaire (TPQ) temperament of harm avoidance. Mol Psychiatry 2:224-226.
18. Esterling LE, Yoshikawa T, Turner G, Bengel D, Gershon ES, Berrettini WH, Detera-Wadleigh SD. 1997. Serotonin transporter (5-HTT) gene and bipolar affective disorder. Am J Med Genet 81:37-40.
19. Fischette CT, Biegon A, McEwen BS. 1983. Sex differences in serotonin1 receptor binding in rat brain. Science 22:333-335.
20. Fischette CT, Biegon A. McEwen BS. 1984. Sex steroid modulation of the serotonin behavioral syndrome. Life Sci 35:1197-1206.
21. Flory JD, Manuck SB, Ferrell RE, Dent KM, Peters DG, Muldoon MF. 1999. Neuroticism is not associated with the serotonin transporter (5-HTTLPR) polymorphism. Mol Psychiatry 4:93-96.
22. Gelernter J, Kranzler H, Coccaro EF, Seiver LJ, New AS. 1998. Serotonin transporter protein gene polymorphism and personality measures in African American and European American subjects. Am J Psychiatry 155:1332-1338.
23. Gelernter J, Cubells JF, Kidd JR, Pakstis AJ, Kidd KK. 1999. Population studies of polymorphisms of the serotonin transporter protein gene. Am J Med Genet 88:61-66.
24. Goldberg LR. 1993. The structure of phenotypic personality traits. Am Psychol 48:26-34.
25. Greenberg BD, Tolliver TJ, Huang SJ, Li Q, Bengel D. Murphy DL. 1999. Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Am J Med Genet 88:83-87.
26. Hanna GL, Himle JA, Curtis GC, Koram DQ, Weele JV-V, Leventhal BL, Cook EH. 1998. Serotonin transporter and seasonal variation in blood serotonin in families with obsessive-compulsive disorder. Neuropsychopharmacology 18:102-111.
27. Hansson SR, Mezey E, Hoffman BJ. 1998. Serotonin transporter messenger RNA in the developing rat brain: early expression in serotonergic neurons and transient expression in non-serotonergic neurons. Neuroscience 83:1185-1201.
28. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D, Lesch KP. 1996. Allelic variation of human serotonin transporter gene expression. J Neurochem 66:2621-2624.
29. Heils A, Mössner R, Lesch KP. 1997. The human serotonin transporter gene polymorphism-basic research and clinical implications. J Neural Transm 104:1005-1014.
30. Hensler JG, Ferry RC, Labow DM, Kovachich GB, Frazer A. 1994. Quantitative autoradiography of the serotonin transporter to assess the distribution of serotonergic projections from the dorsal raphe nucleus. Synapse 17:1-15.
31. Jang KL, Livesley WJ, Vernon PA. 1996. Heritability of the big five personality dimensions and their facets: a twin study. J Pers 64:577-591.
32. Jorm AF, Henderson AS, Jacomb PA, Christensen H, Korten AE, Rodgers B, Tan X, Easteal S. 1998. An association study of a functional polymorphism of the serotonin transporter gene with personality and psychiatric symptoms. Mol Psychiatry 3:449-451.
33. Katsuragi S, Kunugi H, Sano A, Tsutsumi T, Isogawa K, Nanko S, Akiyoshi J. 1999. Association between serotonin transporter gene polymorphism and anxiety-related traits. Biol Psychiatry 45:368-370.
34. Knutson B, Wolkowitz OM, Cole SW, Chan T, Moore EA, Johnson RC, Terpstra J. 1998. Selective alteration of personality and social behavior by serotonergic intervention. Am J Psychiatry 155:373-379.
35. Kumakiri C, Kodama K, Shimizu E, Yamanouchi N, Okada S, Noda S, Okamoto H, Sato T, Shirasawa H. 1999. Study of the association between the serotonin transporter gene regulatory region polymorphism and personality traits in a Japanese population. Neurosci Lett 263: 205-207.
36. Lesch K-P, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL. 1996. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-1531.
37. Lesch KP, Meyer J, Glatz K, Flugge G, Hinney A, Hebebrand J, Klauck SM, Poustka A, Poustka F, Bengel D, et al. 1997. The 5-HT transporter gene-linked polymorphic region (5-HTTLPR) in evolutionary perspective: alternative biallelic variation in rhesus monkeys. Rapid communication. J Neural Transm 104:1259-1266.
38. Li T, Holmes C, Sham PC, Vallada H, Birkett J, Kirov G, Lesch K-P, Powell J, Lovestone S, Collier D. 1997. Allelic functional variation of serotonin transporter expression is a susceptibility factor for late onset Alzheimer's disease. NeuroReport 8:683-686.
39. Little KY, McLaughlin DP, Zhang L, Livermore CS, Dalack GW, Patrick M, DelProposto ZS, Hill E, Cassin BJ, Watson SJ, et al. 1998. Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels. Am J Psychiatry 155:207-213.
40. Loehlin JC. 1992. Genes and environment in personality development. Newburg Park, CA: Sage Publications.
41. Malhotra AK, Goldman D, Mazzanti C, Clifton A, Breier A, Pickar D. 1998. A functional serotonin transporter (5-HTT) polymorphism is associated with psychosis in neuroleptic-free schizophrenics. Mol Psychiatry 3: 328-332.
42. Matsushita S, Muramatsu T, Kimura M, Shirakawa O, Mita T, Nakai T, Higuchi S. 1997. Serotonin transporter gene regulatory region polymorphism and panic disorder [letter]. Mol Psychiatry 2:390-392.
43. Mazzanti CM, Lappalainen J, Long JC, Naukkarinen H, Eggert M, Virkkunen M, Linnoila M, Goldman D. 1998. Role of the serotonin transporter promoter polymorphism in anxiety related traits. Arch Gen Psychiatry 55:936-940.
44. McBride PA, Tierney H, DeMeo M, Chen JS, Mann JJ. 1990. Effects of age and gender on CNS serotonergic responsivity in normal adults. Biol Psychiatry 27:1143-1155.
45. McCrae RR, Costa PT. 1985. Comparison of EPI and psychoticism scales with measures of the five-factor model of personality. Personality Individual Differences 6:587-597.
46. McCrae RR, Costa PTJ. 1990. Personality in adulthood. New York: Guilford Press.
47. McDougle CJ, Epperson CN, Price LH, Gelernter J. 1998. Evidence for linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and obsessive compulsive disorder. Mol Psychiatry 3:270-273.
48. McQueen JK, Wilson H, Fink G. 1997. Estradiol-17 beta increases serotonin transporter (SERT) mRNA levels and the density of SERT-binding sites in female rat brain. Brain Res Mol Brain Res 45:13-23.
49. Nishizawa S, Benkelfat C, Young SN, Leyton M, Mzengeza S, De Montigny C, Blier P, Diksic M. 1997. Differences between males and females in rates of serotonin synthesis in human brain. Proc Natl Acad Sci 94: 5308-5313.
50. Oliveira JR, Gallindo RM, Maia LG, Brito-Marques PR, Otto PA, Passos-Bueno MR, Morais MA, Jr., Zatz M. 1998. The short variant of the polymorphism within the promoter region of the serotonin transporter gene is a risk factor for late onset Alzheimer's disease. Mol Psychiatry 3:438-441.
51. Plomin R, Owen MJ, McGuffin P. 1994. The genetic basis of complex human behaviors. Science 264:1733-1739.
52. Rees M, Norton N, Jones I, McCandless F, Scourfield J, Holmans P, Moorhead S, Feldman E, Sadler S, Cole T, et al. 1997. Association studies of bipolar disorder at the human serotonin transporter gene (hSERT; 5HTT). Mol Psychiatry 2:398-402.
53. Regier DA, Farmer ME, Rae DS, Myers JK, Kramer M, Robins LN, George LK, Karno M, Locke BZ. 1993. One-month prevalence of mental disorders in the United States and sociodemographic characteristics: the Epidemiologic Catchment Area study. Acta Psychiatr Scand 88:35-47.
54. Ricketts MH, Hamer RM, Sage JI, Manowitz P, Feng F, Menza MA. 1998. Association of a serotonin transporter gene promoter polymorphism with harm avoidance behaviour in an elderly population. Psychiatr Genet 8:41-44.
55. Sabol SZ, Nelson ML, Fisher C, Gunzerath L, Brody CL, Hu S, Sirota LA, Marcus SE, Greenberg BD, Lucas FRI, et al. 1999. A genetic association for cigarette smoking behavior. Health Psychol 18:1-7.
56. Sander T, Harms H, Lesch K-P, Dufeu P, Kuhn S, Hoehe M, Rommelspacher H, Schmidt LG. 1997. Association analysis of a regulatory variation of the serotonin transporter gene with severe alcohol dependence. Alcohol Clin Exp Res 21:1356-1359.
57. Sirota LA, Greenberg BD, Murphy DL, Hamer DH. 1999. Non-linear association between the serotonin transporter promoter polymorphism and neuroticism: a caution against using extreme samples to identify quantitative trait loci. Psychiatr Genet 9:35-38.
58. Suarez BK, Hampe CL, O'Rourke D, Van Eerdewegh P, Reich T. 1995. Sib-based detection of QTLs. Genet Epidemiol 12:675-680.
59. Suarez EC. 1999. Relations of trait depression and anxiety to low lipid and lipoprotein concentrations in healthy young adult women. Psychosom Med 61:273-279.
60. Suarez EC, Bares MP, Harralson TL. 1998. The relation of hostility to lipids and lipoproteins in women: evidence for the role of antagonistic hostility. Ann Behav Med 20:59-63.
61. Westenberg HG, Murphy DL, Den Boer JA. 1996. Advances in the neurobiology of anxiety disorders. New York: Wiley.
62. Whitaker-Azmitia PM, Peroutka SJ. 1990. The neuropharmacology of serotonin. Ann N Y Acad Sci 600:1-718.
63. Wichems C, Sora I, Andrews AM, Bengel D, Uhl G, Murphy DL. 1998. Altered responses to psychoactive drugs and spontaneous behavior differences in mice lacking the serotonin transporter (Abs). Fourth IUPHAR Satellite Meeting on Serotonin.
64. Zar JH. 1996. Biostatistical analysis. Upper Saddler River. NJ: Prentice Hall.
65. Zhang L, Barker JL, Xing G, Giorgi O, Ma W, Chang YH, Hu Q, Choi N, Rubinow DR. 1997. 5-HT1A receptor mRNA expressions differ in the embryonic spinal cord of male and female rats. Neurosci Lett 237:41-44.