Are infants differentially sensitive to parenting? Early maternal care, DRD4 genotype and externalizing behavior during adolescence

Journal of Psychiatric Research

Volumn 59, Issue , 2014, Pages 53-59

  Nikitopoulos, Jörg ^a   Zohsel, Katrin ^a   Blomeyer, Dorothea ^a   Buchmann, Arlette F ^a   Schmid, Brigitte ^a   Jennen Steinmetz, Christine ^a   Becker, Katja ^b   Schmidt, Martin H ^a   Esser, Günter ^c   Brandeis, Daniel ^a,d   Banaschewski, Tobias ^a   Laucht, Manfred ^a,c  

^a CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c UNIVERSITY OF POTSDAM   (Germany)

^d UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Adolescence; DRD4; Early maternal care; Externalizing behavior; Gene environment interaction

Indexed keywords

DOPAMINE 4 RECEPTOR;

ADOLESCENT; ADOLESCENT BEHAVIOR; ALLELE; ANXIETY DISORDER; ARTICLE; ATTENTION DEFICIT DISORDER; BEHAVIOR DISORDER; CHILD PARENT RELATION; COHORT ANALYSIS; CONDUCT DISORDER; FEMALE; GENETIC RISK; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MATERNAL CARE; MOOD DISORDER; OPPOSITIONAL DEFIANT DISORDER; PROGENY; PROTEIN EXPRESSION; PSYCHOPATHY; QUESTIONNAIRE; SCHEDULE FOR AFFECTIVE DISORDERS AND SCHIZOPHRENIA; SOCIAL ENVIRONMENT; ANTISOCIAL PERSONALITY DISORDER; CHILD; CHILD BEHAVIOR; GENETICS; INFANT; MATERNAL BEHAVIOR; NUCLEOTIDE REPEAT; PRESCHOOL CHILD; PSYCHOLOGY; STATISTICAL MODEL;

ADOLESCENT; ANTISOCIAL PERSONALITY DISORDER; CHILD; CHILD BEHAVIOR; CHILD, PRESCHOOL; COHORT STUDIES; FEMALE; GENE-ENVIRONMENT INTERACTION; GENOTYPE; HUMANS; INFANT; LINEAR MODELS; MALE; MATERNAL BEHAVIOR; PARENTING; RECEPTORS, DOPAMINE D4; REPETITIVE SEQUENCES, NUCLEIC ACID;

EID: 84908340192     PISSN: 00223956     EISSN: 18791379     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2014.08.012     Document Type: Article

References (52)

1. Adkins D.E., Daw J.K., McClay J.L., van den Oord E.J. The influence of five monoamine genes on trajectories of depressive symptoms across adolescence and young adulthood. Dev Psychopathol 2012, 24:267-285.
2. Ambrosini P.J. Historical development and present status of the schedule for affective disorders and schizophrenia for school-age children (K-SADS). JAm Acad Child Adolesc Psychiatry 2000, 39:49-58.
3. Asghari V., Sanyal S., Buchwaldt S., Paterson A., Jovanovic V., Van Tol H.H. Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. JNeurochem 1995, 65:1157-1165.
4. Bakermans-Kranenburg M.J., van Ijzendoorn M.H. Gene-environment interaction of the dopamine D4 receptor (DRD4) and observed maternal insensitivity predicting externalizing behavior in preschoolers. Dev Psychobiol 2006, 48:406-409.
5. Bakermans-Kranenburg M.J., van Ijzendoorn M.H. Differential susceptibility to rearing environment depending on dopamine-related genes: new evidence and a meta-analysis. Dev Psychopathol 2011, 23:39-52.
6. Bakermans-Kranenburg M.J., van Ijzendoorn M.H., Pijlman F.T., Mesman J., Juffer F. Experimental evidence for differential susceptibility: dopamine D4 receptor polymorphism (DRD4 VNTR) moderates intervention effects on toddlers' externalizing behavior in a randomized controlled trial. Dev Psychol 2008, 44:293-300.
7. Belsky J., Pluess M. Beyond diathesis stress: differential susceptibility to environmental influences. Psychol Bull 2009, 135:885-908.
8. Berry D., Deater-Deckard K., McCartney K., Wang Z., Petrill S.A. Gene-environment interaction between dopamine receptor D4 7-repeat polymorphism and early maternal sensitivity predicts inattention trajectories across middle childhood. Dev Psychopathol 2013, 25:291-306.
9. Buchmann A.F., Zohsel K., Blomeyer D., Hohm E., Hohmann S., Jennen-Steinmetz C., et al. Interaction between prenatal stress and dopamine D4 receptor genotype in predicting aggression and cortisol levels in young adults. Psychopharmacology (Berl) 2014, 231(16):3089-3097.
10. Buckholtz J.W., Treadway M.T., Cowan R.L., Woodward N.D., Benning S.D., Li R., et al. Mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traits. Nat Neurosci 2010, 13:419-421.
11. Delmo C., Weiffenbach O., Gabriel M., Poustka F. Kiddie-SADS-Present and Lifetime version (K-SADS-PL) 3. Auflage der deutschen Forschungsversion 2000, Available at. http://www.adhs-essen.com/PDF/K-SADS_Fragebogen.pdf.
12. DiLalla L.F., Elam K.K., Smolen A. Genetic and gene-environment interaction effects on preschoolers' social behaviors. Dev Psychobiol 2009, 51:451-464.
13. Dmitrieva J., Chen C., Greenberger E., Ogunseitan O., Ding Y.C. Gender-specific expression of the DRD4 gene on adolescent delinquency, anger and thrill seeking. Soc Cogn Affect Neurosci 2011, 6:82-89.
14. Ellis B.J., Boyce W.T., Belsky J., Bakermans-Kranenburg M.J., van Ijzendoorn M.H. Differential susceptibility to the environment: an evolutionary-neurodevelopmental theory. Dev Psychopathol 2011, 23:7-28.
15. Fairchild G., van Goozen S.H., Calder A.J., Goodyer I.M. Research review: evaluating and reformulating the developmental taxonomic theory of antisocial behaviour. JChild Psychol Psychiatry 2013, 54:924-940.
16. Fearon R.P., Bakermans-Kranenburg M.J., van Ijzendoorn M.H., Lapsley A.M., Roisman G.I. The significance of insecure attachment and disorganization in the development of children's externalizing behavior: a meta-analytic study. Child Dev 2010, 81:435-456.
17. Frick P.J., Bodin S.D., Barry C.T. Psychopathic traits and conduct problems in community and clinic-referred samples of children: further development of the psychopathy screening device. Psychol Assess 2000, 12:382-393.
18. Frick P.J., Hare R.D. The psychopathy screening device 1998, Multi-Health Systems, Toronto.
19. Gizer I.R., Ficks C., Waldman I.D. Candidate gene studies of ADHD: a meta-analytic review. Hum Genet 2009, 126:51-90.
20. Graziane N.M., Yuen E.Y., Yan Z. Dopamine D4 receptors regulate GABAA receptor trafficking via an Actin/Cofilin/Myosin-dependent mechanism. JBiol Chem 2009, 284:8329-8336.
21. Grizenko N., Fortier M.E., Zadorozny C., Thakur G., Schmitz N., Duval R., et al. Maternal stress during pregnancy, ADHD symptomatology in children and genotype: gene-environment interaction. JCan Acad Child Adolesc Psychiatry 2012, 21:9-15.
22. Hare R.D. The Hare psychopathy checklist - revised 1991, Multi-Health Systems, Toronto.
23. Jaffee S.R., Strait L.B., Odgers C.L. From correlates to causes: can quasi-experimental studies and statistical innovations bring us closer to identifying the causes of antisocial behavior?. Psychol Bull 2012, 138:272-295.
24. Jörg M., Dinter R., Rose F., Villalba-Yantorno P., Esser G., Schmidt M.H., et al. Category system for microanalysis of early mother-child interaction. ZKinder Jugendpsychiatr Psychother 1994, 22:97-106.
25. Kaufman J., Birmaher B., Brent D., Rao U., Flynn C., Moreci P., et al. Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data. JAm Acad Child Adolesc Psychiatry 1997, 36:980-988.
26. Keller M.C. Gene x environment interaction studies have not properly controlled for potential confounders: the problem and the (simple) solution. Biol Psychiatry 2014, 75:18-24.
27. Kirley A., Lowe N., Mullins C., McCarron M., Daly G., Waldman I., et al. Phenotype studies of the DRD4 gene polymorphisms in ADHD: association with oppositional defiant disorder and positive family history. Am J Med Genet B Neuropsychiatr Genet 2004, 131B:38-42.
28. Knafo A., Israel S., Ebstein R.P. Heritability of children's prosocial behavior and differential susceptibility to parenting by variation in the dopamine receptor D4 gene. Dev Psychopathol 2011, 23:53-67.
29. Kochanska G., Kim S., Barry R.A., Philibert R.A. Children's genotypes interact with maternal responsive care in predicting children's competence: diathesis-stress or differential susceptibility?. Dev Psychopathol 2011, 23:605-616.
30. Langley K., Turic D., Rice F., Holmans P., van den Bree M.B., Craddock N., et al. Testing for gene x environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behavior. Am J Med Genet B Neuropsychiatr Genet 2008, 147B:49-53.
31. Laucht M., Esser G., Baving L., Gerhold M., Hoesch I., Ihle W., et al. Behavioral sequelae of perinatal insults and early family adversity at 8 years of age. JAm Acad Child Adolesc Psychiatry 2000, 39:1229-1237.
32. Laucht M., Esser G., Schmidt M.H. Developmental outcome of infants born with biological and psychosocial risks. JChild Psychol Psychiatry 1997, 38:843-853.
33. Lavigne J.V., Herzing L.B., Cook E.H., Lebailly S.A., Gouze K.R., Hopkins J., et al. Gene x environment effects of serotonin transporter, dopamine receptor D4, and monoamine oxidase A genes with contextual and parenting risk factors on symptoms of oppositional defiant disorder, anxiety, and depression in a community sample of 4-year-old children. Dev Psychopathol 2013, 25:555-575.
34. Lichter J.B., Barr C.L., Kennedy J.L., Van Tol H.H., Kidd K.K., Livak K.J. Ahypervariable segment in the human dopamine receptor D4 (DRD4) gene. Hum Mol Genet 1993, 2:767-773.
35. Nederhof E., Belsky J., Ormel J., Oldehinkel A.J. Effects of divorce on Dutch boys' and girls' externalizing behavior in Gene×Environment perspective: diathesis stress or differential susceptibility in the Dutch Tracking Adolescents' Individual Lives Survey study?. Dev Psychopathol 2012, 24:929-939.
36. Nobile M., Giorda R., Marino C., Carlet O., Pastore V., Vanzin L., et al. Socioeconomic status mediates the genetic contribution of the dopamine receptor D4 and serotonin transporter linked promoter region repeat polymorphisms to externalization in preadolescence. Dev Psychopathol 2007, 19:1147-1160.
37. Odgers C.L., Moffitt T.E., Broadbent J.M., Dickson N., Hancox R.J., Harrington H., et al. Female and male antisocial trajectories: from childhood origins to adult outcomes. Dev Psychopathol 2008, 20:673-716.
38. Pasco Fearon R.M., Belsky J. Infant-mother attachment and the growth of externalizing problems across the primary-school years. JChild Psychol Psychiatry 2011, 52:782-791.
39. Pauli-Pott U., Friedel S., Hinney A., Hebebrand J. Serotonin transporter gene polymorphism (5-HTTLPR), environmental conditions, and developing negative emotionality and fear in early childhood. JNeural Transm 2009, 116:503-512.
40. Pavlov K.A., Chistiakov D.A., Chekhonin V.P. Genetic determinants of aggression and impulsivity in humans. JAppl Genet 2012, 53:61-82.
41. Propper C., Willoughby M., Halpern C.T., Carbone M.A., Cox M. Parenting quality, DRD4, and the prediction of externalizing and internalizing behaviors in early childhood. Dev Psychobiol 2007, 49:619-632.
42. Rhee S.H., Waldman I.D. Genetic and environmental influences on antisocial behavior: a meta-analysis of twin and adoption studies. Psychol Bull 2002, 128:490-529.
43. Roisman G.I., Newman D.A., Fraley R.C., Haltigan J.D., Groh A.M., Haydon K.C. Distinguishing differential susceptibility from diathesis-stress: recommendations for evaluating interaction effects. Dev Psychopathol 2012, 24:389-409.
44. Rutter M., Quinton D. Psychiatric disorder - ecological factors and concepts of causation. Ecological factors in human development 1977, 173-187. North Holland, Amsterdam. M. McGurk (Ed.).
45. Seeger G., Schloss P., Schmidt M.H., Ruter-Jungfleisch A., Henn F.A. Gene-environment interaction in hyperkinetic conduct disorder (HD+ CD) as indicated by season of birth variations in dopamine receptor (DRD4) gene polymorphism. Neurosci Lett 2004, 366:282-286.
46. Shaw D.S., Hyde L.W., Brennan L.M. Early predictors of boys' antisocial trajectories. Dev Psychopathol 2012, 24:871-888.
47. Smith H.J., Sheikh H.I., Dyson M.W., Olino T.M., Laptook R.S., Durbin C.E., et al. Parenting and child DRD4 genotype interact to predict Children's early emerging effortful control. Child Dev 2012, 83:1932-1944.
48. Tuvblad C., Baker L.A. Human aggression across the lifespan: genetic propensities and environmental moderators. Adv Genet 2011, 75:171-214.
49. Uher R., Caspi A., Houts R., Sugden K., Williams B., Poulton R., et al. Serotonin transporter gene moderates childhood maltreatment's effects on persistent but not single-episode depression: replications and implications for resolving inconsistent results. JAffect Disord 2011, 135:56-65.
50. Vallone D., Picetti R., Borrelli E. Structure and function of dopamine receptors. Neurosci Biobehav Rev 2000, 24:125-132.
51. van Ijzendoorn M.H., Schuengel C., Bakermans-Kranenburg M.J. Disorganized attachment in early childhood: meta-analysis of precursors, concomitants, and sequelae. Dev Psychopathol 1999, 11:225-249.
52. Zohsel K., Buchmann A.F., Blomeyer D., Hohm E., Schmidt M.H., Esser G., et al. Mothers' prenatal stress and their children's antisocial outcomes-a moderating role for the Dopamine D4 Receptor (DRD4) gene. JChild Psychol Psychiatry 2014, 55:69-76.