Enhanced partner preference in a promiscuous species by manipulating the expression of a single gene

Nature

Volumn 429, Issue 6993, 2004, Pages 754-757

  Lim, Miranda M ^a   Wang, Zuoxin ^b   Olazábal, Daniel E ^a   Ren, Xianghul ^c   Terwilliger, Ernest F ^c   Young, Larry J ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b FLORIDA STATE UNIVERSITY   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; GENES; NEUROLOGY; SOCIAL ASPECTS;

MOLECULAR MECHANISMS; SOCIAL STRUCTURES;

BIODIVERSITY;

DOPAMINE; RECEPTOR SUBTYPE; SATELLITE DNA; VASOPRESSIN; VASOPRESSIN V1 RECEPTOR;

BIOLOGY;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; FOREBRAIN; GENE EXPRESSION; GENE TRANSFER; GLOBUS PALLIDUS; NONHUMAN; PRIORITY JOURNAL; RECEPTOR GENE; SOCIAL BEHAVIOR; SOCIAL STRUCTURE; VOLE;

ANIMALS; ARVICOLINAE; CHOICE BEHAVIOR; FEMALE; MALE; PAIR BOND; PROSENCEPHALON; RECEPTORS, DOPAMINE; RECEPTORS, VASOPRESSIN; SEXUAL BEHAVIOR, ANIMAL;

ANIMALIA; MAMMALIA; MICROTUS; MICROTUS OCHROGASTER; MICROTUS PENNSYLVANICUS; MURIDAE;

EID: 3042634232     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02539     Document Type: Article

References (28)

1. Gruder-Adams, S. & Getz, L. L. Comparison of the mating system and paternal behavior in Microtus ochragaster and M. pennsylvanicus. J. Mamm. 66, 165-167 (1985).
2. Aragona, B. J., Liu, Y., Curtis, J. T., Stephan, F. K. & Wang, Z. A critical role for nucleus accumbens dopamine in partner-preference formation in male prairie voles. J. Neurosci. 23, 3483-3490 (2003).
3. Gingrich, B., Liu, Y., Cascio, C., Wang, Z. & Insel, T. R. Dopamine D2 receptors in the nucleus accumbens are important for social attachment in female prairie voles (Microtus ochrogaster). Behav. Neurosci. 114, 173-183 (2000).
4. Lim, M. M. & Young, L. J. Vasopressin-dependent neural circuits underlying pair bonding in the monogamous prairie vole. Neuroscience 125, 35-45 (2004).
5. Insel, T. R., Wang, Z. X. & Ferris, C. F. Patterns of brain vasopressin receptor distribution associated with social organization in microtine rodents. J. Neurosci. 14, 5381-5392 (1994).
6. Kleiman, D. G. Monogamy in mammals. Q. Rev. Biol. 52, 39-69 (1977).
7. Winslow, J. T., Hastings, N., Carter, C. S., Harbaugh, C. R. & Insel, T. R. A role for central vasopressin in pair bonding in monogamous prairie voles. Nature 365, 545-548 (1993).
8. Wang, Z., Ferris, C. F. & De Vries, G. J. Role of septal vasopressin innervation in paternal behavior in prairie voles (Microtus ochrogaster). Proc. Natl Acad. Sci. USA 91, 400-404 (1994).
9. Young, L. J., Nilsen, R., Waymire, K. G., MacGregor, G. R. & Insel, T. R. Increased affiliative response to vasopressin in mice expressing the V1a receptor from a monogamous vote. Nature 400, 766-768 (1999).
10. Lim, M. M., Murphy, A. Z. & Young, L. J. Ventral striatopallidal oxytocin and vasopressin V1a receptors in the monogamous prairie vole (Microtus ochrogaster). J. Comp. Neurol. 468, 555-570 (2004).
11. Young, L. J., Toloczko, D. & Insel, T. R. Localization of vasopressin (V1a) receptor binding and mRNA in the rhesus monkey brain. J. Neuroendocrinol. 11, 291-297 (1999).
12. Young, L. J. Frank A. Beach Award. Oxytocin and vasopressin receptors and species-typical social behaviors. Horm. Behav. 36, 212-221 (1999).
13. Wang, Z. et al. Vasopressin in the forebrain of common marmosets (Callithrix jacchus): studies with in situ hybridization, immunocytochemistry and receptor autoradiography. Brain Res. 768, 147-156 (1997).
14. Bester-Meredith, J. K., Young, L. J. & Marler, C. A. Species differences in paternal behavior and aggression in peromyscus and their associations with vasopressin immunoreactivity and receptors. Horm. Behav. 36, 25-38 (1999).
15. Parker, K. J. & Lee, T. M. Development of selective partner preferences in captive male and female meadow voles, Microtus pennsylvanicus. Anim. Behav. 61, 1217-1226 (2001).
16. Wang, Z. et al. Dopamine D2 receptor-mediated regulation of partner preferences in female prairie voles (Microtus ochrogaster): a mechanism for pair bonding? Behav. Neurosci. 113, 602-611 (1999).
17. Roberts, R. L., Williams, J. R., Wang, A. K. & Carter, C. S. Cooperative breeding and monogamy in prairie voles: influence of the sire and geographical variation. Anim. Behav. 55, 1131-1140 (1998).
18. Bielsky, I. E., Bao-Hu, S., Szegda, K. L., Westphal, H. & Young, L. J. Profound impairment in social recognition and reduction in anxiety-like behavior in vasopressin V1a receptor knockout mice. Neuropsychopharmacology 29, 483-493 (2004).
19. Landgraf, R. et al. Viral vector-mediated gene transfer of the vole V1a vasopressin receptor in the rat septum: improved social discrimination and active social behaviour. Eur. J. Neurosci. 18, 403-411 (2003).
20. Aragona, B. J. et al. Opposite modulation of social attachment by D1- and D2-type dopamine receptor activation in nucleus accumbens shell. Horm. Behav. 44, 37 (2003).
21. Robinson, G. E. & Ben-Shahar, Y. Social behavior and comparative genomics: new genes or new gene regulation? Genes Brain Behav. 1, 197-203 (2002).
22. Hammock, E. A. D. & Young, L. J. Functional microsatelite polymorphism associated with divergent social structure in vole species. Mol. Biol. Evol. (in the press).
23. Phelps, S. M. & Young, L. J. Extraordinary diversity in vasopressin (V1a) receptor distributions among wild prairie voles (Microtus ochrogaster): patterns of variation and covariation. J. Comp. Neurol. 466, 564-576 (2003).
24. Hammock, E. A. D. & Young, L. J. Variation in the vasopressin V1a receptor promoter and expression: implications for inter- and intraspecific variation in social behaviour. Eur J. Neurosci. 16, 399-402 (2002).
25. Barberis, C. & Tribollet, E. Vasopressin and oxytocin receptors in the central nervous system. Crit. Rev. Neurobiol. 10, 119-154 (1996).
26. Kim, S. J. et al. Transmission disequilibrium testing of arginine vasopressin receptor 1A (AVPRIA) polymorphisms in autism. Mol. Psychiatry 7, 503-507 (2002).
27. Pitkow, L. J. et al. Facilitation of affiliation and pair-bond formation by vasopressin receptor gene transfer into the ventral forebrain of a monogamous vole. J. Neurosci. 21, 7392-7396 (2001).
28. Young, L. J., Winslow, J. T., Nilsen, R. & Insel, T. R. Species differences in V1a receptor gene expression in monogamous and nonmonogamous voles: behavioral consequences. Behav. Neurosci. 111, 599-605 (1997).