Deletion of densin-180 results in abnormal behaviors associated with mental illness and reduces mGlur5 and DISC1 in the postsynaptic density fraction

Journal of Neuroscience

Volumn 31, Issue 45, 2011, Pages 16194-16207

  Carlisle, Holly J ^a,c   Luong, Tinh N ^a   Medina Marino, Andrew ^a,d   Schenker, Leslie ^a   Khorosheva, Eugenia ^a   Indersmitten, Tim ^b   Gunapala, Keith M ^a   Steele, Andrew D ^a   O'Dell, Thomas J ^b   Patterson, Paul H ^a   Kennedy, Mary B ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c AMGEN INC   (United States)

^d CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTININ; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; DENSIN 180; DISRUPTED IN SCHIZOPHRENIA 1 PROTEIN; METABOTROPIC RECEPTOR 5; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BRAIN HOMOGENATE; BRAIN LEVEL; BRAIN NERVE CELL; CONTROLLED STUDY; DYNAMICS; ENDOPHENOTYPE; ENZYME REGULATION; EXCITATORY POSTSYNAPTIC POTENTIAL; FEMALE; GENE; GENE DELETION; HIPPOCAMPUS; HOMOZYGOTE; KNOCKOUT MOUSE; LONG TERM DEPRESSION; LRRC7 GENE; MALE; MENTAL DISEASE; MOUSE; NEUROPATHOLOGY; NONHUMAN; POSTSYNAPTIC DENSITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SYNAPTIC TRANSMISSION;

ACTINS; AGGRESSION; ANIMALS; BEHAVIOR, ANIMAL; BICUCULLINE; BODY WEIGHT; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CELLS, CULTURED; DENDRITIC SPINES; DISEASE MODELS, ANIMAL; EMBRYO, MAMMALIAN; ENDOPHENOTYPES; EXPLORATORY BEHAVIOR; FEMALE; GABA ANTAGONISTS; GABA-A RECEPTOR ANTAGONISTS; GENE EXPRESSION REGULATION; GENOTYPE; GLIAL FIBRILLARY ACIDIC PROTEIN; GLYCINE; GREEN FLUORESCENT PROTEINS; HIPPOCAMPUS; INHIBITION (PSYCHOLOGY); LONG-TERM POTENTIATION; LONG-TERM SYNAPTIC DEPRESSION; MALE; MEMBRANE POTENTIALS; MEMORY, SHORT-TERM; MENTAL DISORDERS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; MUSCLE STRENGTH; MUTATION; NERVE TISSUE PROTEINS; NEURONS; PATCH-CLAMP TECHNIQUES; PICROTOXIN; POST-SYNAPTIC DENSITY; PSYCHOMOTOR PERFORMANCE; RECEPTORS, AMPA; RECEPTORS, KAINIC ACID; RECOGNITION (PSYCHOLOGY); ROTAROD PERFORMANCE TEST; SIALOGLYCOPROTEINS; STATISTICS, NONPARAMETRIC; TIME FACTORS;

EID: 80755181273     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5877-10.2011     Document Type: Article

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