MAOA, childhood maltreatment, and antisocial behavior: Meta-analysis of a gene-environment interaction

Biological Psychiatry

Volumn 75, Issue 1, 2014, Pages 9-17

  Byrd, Amy L ^a   Manuck, Stephen B ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Antisocial behavior; childhood maltreatment; gene environment interaction; genetics; MAOA; meta analysis

Indexed keywords

ANTISOCIAL BEHAVIOR; CHILD ABUSE; CHILD PARENT RELATION; CROSS-SECTIONAL STUDY; ENVIRONMENTAL EXPOSURE; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; META ANALYSIS; PRIORITY JOURNAL; PROMOTER REGION; REVIEW;

ANTISOCIAL BEHAVIOR; CHILDHOOD MALTREATMENT; GENE-ENVIRONMENT INTERACTION; GENETICS; MAOA; META-ANALYSIS;

ANTISOCIAL PERSONALITY DISORDER; CHILD; CHILD ABUSE; DATABASES, FACTUAL; FEMALE; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MONOAMINE OXIDASE; SEX FACTORS;

EID: 84889570079     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2013.05.004     Document Type: Article

References (71)

1. A. Caspi, J. McClay, T.E. Moffitt, J. Mill, J. Martin, and I.W. Craig Role of genotype in the cycle of violence in maltreated children Science 297 2002 851 854
2. A. Caspi, K. Sugden, T.E. Moffitt, A. Taylor, I.W. Craig, and H. Harrington Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene Science 301 2003 386 389
3. M.R. Munafò, C. Durrant, G. Lewis, and J. Flint Gene × environment interactions at the serotonin transporter locus Biol Psychiatry 65 2009 211 219
4. N. Risch, R. Herrell, T. Lehner, K.Y. Liang, L. Eaves, and J. Hoh Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: A meta-analysis JAMA 301 2009 2462 2471
5. M. Rutter, A. Thapar, and A. Pickles Gene-environment interactions: Biologically valid pathway or artifact? Arch Gen Psychiatry 66 2009 1287 1289
6. R. Uher, and P. McGuffin The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update Mol Psychiatry 15 2010 18 22
7. K. Karg, M. Burmeister, K. Shedden, and S. Sen The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: Evidence of genetic moderation Arch Gen Psychiatry 68 2011 444 454
8. S.Z. Sabol, S. Hu, and D. Hamer A functional polymorphism in the monoamine oxidase A gene promoter Hum Genet 103 1998 273 279
9. R.M. Denney, H. Koch, and I.W. Craig Association between monoamine oxidase A activity in human male skin fibroblasts and genotype of the MAOA promoter-associated variable number tandem repeat Hum Genet 195 1999 542 551
10. J. Deakert, M. Catalano, Y.V. Syagailo, M. Bosi, O. Okladnova, and D. Di Bella Excess of high activity monoamine oxidase A gene promoter alleles in females patients with panic disorder Hum Mol Genet 8 1999 621 624
11. A. Taylor, and J. Kim-Cohen Meta-analysis of gene-environment interactions in developmental psychopathology Dev Psychopathol 19 2007 1029 1037
12. D.L. Foley, L.J. Eaves, B. Wormley, J.L. Silberg, H.H. Maes, J. Kuhn, and B. Riley Childhood adversity, monoamine oxidase a genotype, and risk for conduct disorder Arch Gen Psychiatry 61 2004 738 744
13. B.C. Haberstick, J.M. Lessem, C.J. Hopfer, A. Smolen, M.A. Ehringer, D. Timberlake, and J.K. Hewitt Monoamine oxidase A (MAOA) and antisocial behaviors in the presence of childhood and adolescent maltreatment Am J Med Genet B Neuropsychiatr Genet 135 2005 59 64
14. D. Huizinga, B.C. Haberstick, A. Smolen, S. Menard, S.E. Young, and R.P. Corley Childhood maltreatment, subsequent antisocial behavior, and the role of monoamine oxidase A genotype Biol Psychiatry 60 2006 677 683
15. J. Kim-Cohen, A. Caspi, A. Taylor, B. Williams, R. Newcombe, I.W. Craig, and T.E. Moffitt MAOA, maltreatment, and gene-environment interaction predicting children's mental health: New evidence and a meta-analysis Mol Psychiatry 11 2006 903 913
16. K.W. Nilsson, R.L. Sjoberg, M. Damberg, J. Leppert, J. Ohrvik, and P.O. Alm Role of monoamine oxidase A genotype and psychosocial factors in male adolescent criminal activity Biol Psychiatry 59 2006 121 127
17. C.S. Widom, and L.M. Brzustowicz MAOA and the "Cycle of Violence": Childhood abuse and neglect, MAOA genotype, and risk for violent and antisocial behavior Biol Psychiatry 60 2006 684 689
18. Frazzetto G, Di Lorenzo G, Carola V, Proietti L, Sokolowska E, Siracusano A, et al. (2007): Early trauma and increased risk for physical aggression during adulthood: The moderating role of MAOA genotype. PLoS One 2:e486
19. E.J.M. van der Vegt, B.A. Oostra, A. Arias-Vásquez, J. van der Ende, F.C. Verhulst, and H. Tiemeier High activity of monoamine oxidase A is associated with externalizing behaviour in maltreated and nonmaltreated adoptees Psychiatr Genet 19 2009 209 211
20. S.R.H. Beach, G.H. Brody, T.D. Gunter, H. Packer, P. Wernett, and R.A. Philibert Child maltreatment moderates the association of MAOA with symptoms of depression and antisocial personality disorder J Fam Psychol 24 2010 12 20
21. J. Derringer, R.F. Krueger, D. Irons, and W.G. Iacono Harsh discipline, childhood sexual assault, and MAOA genotype: An investigation of main and interactive effects on diverse clinical externalizing outcomes Behav Genet 40 2010 639 648
22. A.C. Edwards, K.A. Dodge, S.J. Latendresse, J.E. Lansford, J.E. Bates, and G.S. Pettit MAOA-uVNTR and early physical discipline interact to influence delinquent behavior J Child Psychol Psychiatry 51 2010 679 687
23. C. Åslund, N. Nordquist, E. Comasco, J. Leppert, L. Oreland, and K. Nilsson Maltreatment, MAOA, and delinquency: Sex differences in gene-environment interaction in a large population-based cohort of adolescents Behav Genet 41 2011 262 272
24. D. Cicchetti, F.A. Rogosch, and E.L. Thibodeau The effects of child maltreatment on early signs of antisocial behavior: Genetic moderation by tryptophan hydroxylase, serotonin transporter, and monoamine oxidase A genes Dev Psychopathol 24 2012 907 928
25. D.M. Fergusson, J.M. Boden, L.J. Horwood, A. Miller, and M.A. Kennedy Moderating role of the MAOA genotype in antisocial behaviour Br J Psychiatry 200 2012 116 123
26. R.L. Sjöberg, K.W. Nilsson, H.L. Wargelius, J. Leppert, L. Lindström, and L. Oreland Adolescent girls and criminal activity: Role of MAOA-LPR genotype and psychosocial factors Am J Med Genet B Neuropsychiatr Genet 144B 2007 159 164
27. M.M. Vanyukov, B.S. Maher, B. Devlin, G.P. Kirillova, L. Kirisci, L.M. Yu, and R.E. Ferrell The MAOA promoter polymorphism, disruptive behavior disorders, and early onset substance use disorder: Gene-environment interaction Psychiatr Genet 17 2007 323 332
28. D. Hart, and N.R. Marmorstein Neighborhoods and genes and everything in between: Understanding adolescent aggression in social and biological contexts Dev Psychopathol 21 2009 961 973
29. K.M. Beaver, M. DeLisi, M.G. Vaughn, and J.C. Barnes Monoamine oxidase A genotype is associated with gang membership and weapon use Compr Psychiatry 51 2010 130 134
30. M.A. Enoch, C.D. Steer, T.K. Newman, N. Gibson, and D. Goldman Early life stress, MAOA, and gene-environment interactions predict behavioral disinhibition in children Genes Brain Behav 9 2010 65 74
31. L.S. Wakschlag, E.O. Kistner, D.S. Pine, G. Biesecker, K.E. Pickett, and A.D. Skol Interaction of prenatal exposure to cigarettes and MAOA genotype in pathways to youth antisocial behavior Mol Psychiatry 15 2010 928 937
32. S.S. Lee Deviant peer affiliation and antisocial behavior: Interaction with monoamine oxidase A (MAOA) genotype J Abnorm Child Psychol 39 2011 321 332
33. N. Weder, B. Yang, H. Douglas-Palumberi, J. Massey, J.H. Krystal, J. Gelernter, and J. Kaufman MAOA genotype, maltreatment, and aggressive behavior: The changing impact of genotype at varying levels of trauma Biol Psychiatry 65 2009 417 424
34. I.M. Reti, J.Z. Xu, J. Yanofski, J. McKibben, M. Uhart, and Y.J. Cheng Monoamine oxidase A regulates antisocial personality in whites with no history of physical abuse Compr Psychiatry 52 2011 188 194
35. R.L. Sjöberg, F. Ducci, C.S. Barr, T.K. Newman, L. Dell'Osso, M. Virkkunen, and D. Goldman A non-additive interaction of a functional MAO-A VNTR and testosterone predicts antisocial behavior Neuropsychopharmacology 33 2008 425 430
36. E.C. Prom-Wormley, L.J. Eaves, D.L. Foley, C.O. Gardner, K.J. Archer, and B.K. Wormley Monoamine oxidase A and childhood adversity as risk factors for conduct disorder in females Psychol Med 39 2009 579 590
37. F. Ducci, M. Enoch, C. Hodgkinson, K. Xu, M. Catena, R.W. Robin, and D. Goldman Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women Mol Psychiatry 13 2008 334 347
38. L. McGrath, B. Mustanski, A. Metzger, D. Pine, E. Kistner-Griffin, E. Cook, and L.S. Wakschlag A latent modeling approach to genotype-phenotype relationships: Maternal problem behavior clusters, prenatal smoking, and MAOA genotype Arch Womens Ment Health 15 2012 269 282
39. M.C. Whitlock Combining probability from independent tests: The weighted Z-method is superior to Fisher's approach J Evol Biol 18 2005 1368 1373
40. L.V. Hedges, and I. Olkin Statistical Methods for Meta-Analysis 1985 Academic New York
41. J.B. Richards, D. Waterworth, S. O'Rahilly, M.F. Hivert, R.J. Loos, and J.R. Perry A genome-wide association study reveals variants in ARL15 that influence adiponectin levels PLoS Genet 5 2009 e1000768
42. D. Hwang, A.G. Rust, S. Ramsey, J.J. Smith, D.M. Leslie, and A.D. Weston A data integration methodology for systems biology Proc Natl Acad Sci U S A 102 2005 17296 17301
43. S.E. Young, A. Smolen, J.K. Hewitt, B.C. Haberstick, M.C. Stallings, R.P. Corley, and T.J. Crowley Interaction between MAO-A genotype and maltreatment in the risk for conduct disorder: Failure to confirm in adolescent patients Am J Psychiatry 163 2006 1019 1025
44. A. Reif, M. Rosler, C.M. Freitag, M. Schneider, A. Eujen, and C. Kissling Nature and nurture predispose to violent behavior: Serotonergic genes and adverse childhood environment Neuropsychopharmacology 32 2007 2375 2383
45. R. Tikkanen, F. Ducci, D. Goldman, M. Holi, N. Lindberg, J. Tiihonen, and M. Virkkunen MAOA alters the effects of heavy drinking and childhood physical abuse on risk for severe impulsive acts of violence among alcoholic violent offenders Alcohol Clin Exp Res 34 2010 853 860
46. Y.Y. Huang, S.P. Cate, C. Battistuzzi, M.A. Oquendo, D. Brent, and J.J. Mann An association between a functional polymorphism in the monoamine oxidase a gene promoter, impulsive traits and early abuse experiences Neuropsychopharmacology 29 2004 1498 1505
47. E.L. Kinnally, Y. Huang, R. Haverly, A.K. Burke, H. Galfalvy, and D.P. Brent Parental care moderates the influence of MAOA-uVNTR genotype and childhood stressors on trait impulsivity and aggression in adult women Psychiatr Genet 19 2009 126 133
48. K.W. Nilsson, H.-L. Wargelius, R.L. Sjöberg, J. Leppert, and L. Oreland The MAO-A gene, platelet MAO-B activity and psychosocial environment in adolescent female alcohol-related problem behaviour Drug Alcohol Depend 93 2008 51 62
49. Z. Prichard, A. Mackinnon, A.F. Jorm, and S. Easteal No evidence for interaction between MAOA and childhood adversity for antisocial behavior Am J Med Genet B Neuropsychiatr Genet 147B 2008 228 232
50. D. Benjamin, I. Van Badel, and I. Craig A novel expression based approach for assessing the inactivation status of human X-linked genes Eur J Hum Genet 8 2000 103 108
51. L. Carrel, and H. Willard X-inactivation profile reveals extensive variability in X-linked gene expression in females Nature 434 2005 400 404
52. S.R. Jaffee, A. Caspi, T.E. Moffitt, and A. Taylor Physical maltreatment victim to antisocial child: Evidence of an environmentally mediated process J Abnorm Psychol 113 2004 44 55
53. D.M. Fergusson, and J.L. Horwood Exposure to interparental violence in childhood and psychosocial adjustment in young adulthood Child Abuse Negl 22 1998 339 357
54. S.R. Jaffee, T.E. Moffitt, A. Caspi, A. Taylor, and L. Arseneault Influence of adult domestic violence on children's internalizing and externalizing problems: An environmentally informative twin study J Am Acad Child Adolesc Psychiatry 41 2002 1095 1103
55. A. Caspi, T.E. Moffitt, J. Morgan, M. Rutter, A. Taylor, and L. Arseneault Maternal expressed emotion predicts children's antisocial behavior problems: Using monozygotic-twin differences to identify environmental effects on behavioral development Dev Psychol 40 2004 149 161
56. D.P. Farrington, and J.D. Hawkins Predicting participation, early onset and later persistence in officially recorded offending Crim Behav Mental Health 1 1991 1 33
57. B.K. Luntz, and C.S. Widom Antisocial personality disorder in abused and neglected children grown up Am J Psychiatry 151 1994 670 674
58. K.A. Dodge, and M.R. Sherrill The interaction of nature and nurture in antisocial behavior D.J. Flannery, A.T. Vazsonyi, I.D. Waldman, The Cambridge Handbook of Violent Behavior and Aggression 2007 Cambridge University Press New York 215 242
59. J.E. Lansford, K.A. Dodge, G.S. Pettit, J.E. Bates, J. Crozier, and J. Kaplow A 12-year prospective study of the long-term effects of early child physical maltreatment on psychological, behavioral, and academic problems in adolescence Arch Pediatr Adolesc Med 156 2002 824 830
60. J. McCord Questioning the value of punishment Social Problems 38 1992 167 176
61. S.R. Jaffee, A. Caspi, T.E. Moffitt, K.A. Dodge, M. Rutter, A. Taylor, and L.A. Tully Nature x nurture: Genetic vulnerabilities interact with physical maltreatment to promote conduct problems Dev Psychopathol 17 2005 67 84
62. J. Fan, J. Fossella, T. Sommer, Y. Wu, and M.I. Posner Mapping the genetic variation of executive attention onto brain activity Proc Natl Acad Sci U S A 100 2003 7406 7411
63. A. Meyer-Lindenberg, J.W. Buckholtz, B. Kolachana, A. R Hariri, L. Pezawas, and G. Blasi Neural mechanisms of genetic risk for impulsivity and violence in humans Proc Natl Acad Sci U S A 103 2006 6269 6274
64. A. Cerasa, M.C. Gioia, F.P. Fera, L, M. Kiguori, P. Lanza, and M. Muglia Ventro-lateral prefrontal activity during working memory is modulated by MAO A genetic variation Brain Res 1201 2008 114 121
65. L. Passamonti, F. Fera, A. Magariello, A. Cerasa, M.C. Gioia, and M. Muglia Monoamine oxidase-A genetic variations influence brain activity associated with inhibitory control: New insight into the neural correlates of impulsivity Biol Psychiatry 59 2006 334 340
66. S. Enge, M. Fleischhauer, K.-P. Lesch, A. Reif, and A. Strobel Serotonergic modulation in executive functioning: Linking genetic variations to working memory performance Neuropsychologia 49 2011 3776 3785
67. J.W. Buckholtz, and A. Meyer-Lindenberg MAOA and the neurogenetic architecture of human aggression Trends Neurosci 31 2008 120 129
68. J.W. Buckholtz, J.H. Callicott, B. Kolachana, A.R. Hariri, T.E. Goldberg, and M. Genderson Genetic variation in MAOA modulates ventromedial prefrontal circuitry mediating individual differences in human personality Mol Psychiatry 13 2008 313 324
69. B.-T. Lee, and B.J. Ham Monoamine oxidase A-uVNTR genotype affects limbic brain activity in response to affective facial stimuli Neuroreport 19 2008 515 519
70. V. Nikulina, C.S. Widom, and L.M. Brzustowicz Child abuse and neglect, MAOA, and mental health outcomes: A prospective examination Biol Psychiatry 71 2012 350 357
71. R.A. Philibert, T.D. Gunter, S.R.H. Beach, G.H. Brody, and A. Madan MAOA methylation is associated with nicotine and alcohol dependence in women Am J Med Genet B Neuropsychiatr Genet 147B 2008 565 570