Association of serotonin transporter promoter gene polymorphism with violence: Relation with personality disorders, impulsivity, and childhood ADHD psychopathology

Behavioral Sciences and the Law

Volumn 22, Issue 3, 2004, Pages 415-425

  Retz, Wolfgang ^a   Retz Junginger, Petra ^a   Supprian, Tillmann ^b   Thome, Johannes ^c   Rösler, Michael ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

^c CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN; SEROTONIN TRANSPORTER;

ADOLESCENT; ADULT; ALLELE; ANXIETY DISORDER; ARTICLE; ATTENTION DEFICIT DISORDER; CAUCASIAN; DEPRESSION; DISEASE ASSOCIATION; DNA POLYMORPHISM; FORENSIC PSYCHIATRY; GENE DELETION; GENE INSERTION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; GERMANY; HUMAN; IMPULSE CONTROL DISORDER; IMPULSIVENESS; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; PERSONALITY DISORDER; PHENOTYPE; PROMOTER REGION; RECURRENT DISEASE; VIOLENCE;

ADOLESCENT; ADULT; AGED; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BASE SEQUENCE; CARRIER PROTEINS; CHILD; DNA PRIMERS; GERMANY; HUMANS; IMPULSIVE BEHAVIOR; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; NERVE TISSUE PROTEINS; PERSONALITY DISORDERS; POLYMORPHISM, GENETIC; PSYCHOPATHOLOGY; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; VIOLENCE;

EID: 3142631983     PISSN: 07353936     EISSN: None     Source Type: Journal    
DOI: 10.1002/bsl.589     Document Type: Article

References (52)

1. Abbar, M., Courtet, P., Bellivier, F., Leboyer, M., Boulenger, J. P., Castelhau, D., Ferreira, M., Lambercy, C., Mouthon, D., Paoloni-Giacobino, A., Vessaz, M., Malafosse, A., & Buresi, C. (2001). Suicide attempts and the tryptophan hydroxylase gene. Molecular Psychiatry, 6, 268-273.
2. Arias, B., Gasto, C., Catalan, R., Gutierrez, B., Pintor, L., & Fananas, L. (2001). The 5-HT(2A) receptor gene 102T/C polymorphism is associated with suicidal behavior in depressed patients. American Journal of Medical Genetics, 105, 801-804.
3. Barratt, E. S., Stanford, M. S., Dowdy, L., Liebman, M. J., & Kent, T. A. (1999). Impulsive and premeditated aggression: A factor analysis of self-reported acts. Psychiatry Research, 86, 163-173.
4. Belfrage, H., Lidberg, L., & Oreland, L. (1991). Platelet monoamine oxidase activity in mentally disordered violent offenders. Acta Psychiatrica Scandinavica, 85, 218-221.
5. Berman, M. E., & Coccaro, E. F. (1998). Neurobiologic correlates of violence: Relevance to criminal responsibility. Behavioural Sciences and the Law, 16, 303-318.
6. Birmaher, B., Stanley, M., Greenhill, L., Twomey, J., Gavrilescu, A., & Rabinovich, H. (1990). Platelet imipramine binding in children and adolescents with impulsive behavior. Journal of the American Academy of Child and Adolescent Psychiatry, 29, 914-918.
7. Bondy, B., Erfurth A., de Jonge, S., Kruger, M., & Meyer, H. (2000). Possible association of the short allele of the serotonin transporter promoter gene polymorphism (5-HTTLPR) with violent suicide. Molecular Psychiatry, 5, 193-195.
8. Brennan, P. A., Mednick, S. A., & Jacobsen, B. (1996). Assessing the role of genetics in crime using adoption cohorts. Ciba Foundation Symposium, 194, 115-123.
9. Brown, C. S., Kent, T. A., Bryant, S. G., Gevedon, R. M., Campbell, J. L., Felthous, A. R., Barratt, E. S., & Rose, R.M. (1989). Blood platelet uptake of serotonin in episodic aggression. Psychiatry Research, 27, 5-12.
10. Brown, G. L., Ebert, M. H., Goyer, P. F., Jimerson, D. C., Klein, W. J., Bunney, W. E., & Goodwin, F. K. (1982). Aggression suicide, and serotonin: Relationships to CSF amine metabolites. American Journal of Psychiatry, 139, 741-746.
11. Cherek, D. R., Moeller, F. G., Khan-Dawood, F., Swann, A., & Lane, S. D. (1999). Prolactin response to buspirone was reduced in violent compared to nonviolent parolees. Psychopharmacology, 142, 144-148.
12. Coccaro, E. F., Kavoussi, R. J., Lesser, J. C. (1992). Self- and other-directed human aggression: The role of the central serotonergic system. International Clinical Psychopharmacology, 6(Suppl. 6), 70-83.
13. Coccaro, E. F., Kavoussi, R. J., Sheline, Y. I., Lish, J. D., & Csemansky, J. G. (1996). Impulsive aggression in personality disorders correlates with tritiated paroxetine binding in the platelet. Archives of General Psychiatry, 53, 531-536.
14. Coccaro, E. F., Kavoussi, R. J., Trestman, R. L., Gabriel, S. M., Cooper, T. B., & Siever, L. J. (1997). Serotonin function in human subjects: Intercorrelations among central 5-HT indices and aggressiveness. Psychiatry Research, 73, 1-14.
15. Courtet, P., Baud, P., Abbar, M., Boulenger, J. P., Castelnau, D., Mouthon, D., Malafosse, A., & Buresi, C. (2001). Association between violent suicidal behavior and the low activity allele of the serotonin transporter gene. Molecular Psychiatry, 6, 338-341.
16. Dolan, M., Anderson, I. M., & Deakin, J. F. (2001). Relationship between 5-HT function and impulsivity and aggression in male offenders with personality disorders. British Journal of Psychiatry, 178, 352-359.
17. Eysenck, S. B. G., Daum, I., Schugens, M. M., & Diehl, J. M. (1990). A cross cultural study of impulsiveness, venturesomeness and empathy: Germany and England. Zeitschrift für differentielle und diagnostische Psychologie, 11, 209-213.
18. Filley, C. M., Price, B. H., Nell, V., Antoinette, T., Morgan, A. S., Bresnahan, J. F., Pincus, J. H., Gelbort, M. M., Weissberg, M., & Kelly, J. P. (2001). Toward an understanding of violence: Neurobehavioral aspects of unwarranted physical aggression: Aspen Neurobehavioral Conference consensus statement. Neuropsychiatry, Neuropsychology and Behavioural Neurology, 14, 1-14.
19. Gobbi, G., Murphy, D. L., Lesch, K. P., & Blier, P. (2001). Modifications of the serotonergic system in mice lacking serotonin transporters: An in vivo electrophysiological study. The Journal of Pharmacology and Experimental Therapeutics, 296, 987-995.
20. Gould, E. (1999). Serotonin hippocampal neurogenesis. Neuropsychopharmacology, 21, 46S-51S.
21. Hallikainen, T., Saito, T., Lachman, H. M., Volavka, J., Pohjalainen, T., Ryynanen, O. P., Kauhanen, J., Syvalahti, E., Hietala, J., & Tiihonen, J. (1999). Association between low activity serotonin transporter promoter genotype and early onset alcoholism with habitual impulsive violent behavior. Molecular Psychiatry, 4, 385-388.
22. Hansson, S. R., Mezey, E., & Hoffman, B. J. (1999). Serotonin transporter messenger RNA in neural crest-derived structures and sensory pathways of the developing rat embryo. Neuroscience, 89, 243-265.
23. Heils, A., Teufel, A., Petri, S., Stöber, G., Riederer, P., Bengel, D., & Lesch, K. P. (1996). Allelic variation of human serotonin transporter gene expression. Journal of Neurochemistry, 66, 2621-2624.
24. Hiller, W., Zaudig, M., & Mombour, W. (1990). Development of diagnostic checklists for use in routine clinical care. Archives of General Psychiatry, 47, 782-784.
25. Hwu, H. G., & Chen, C. H. (2000). Association of 5HT2A receptor gene polymorphism and alcohol abuse with behavior problems. American Journal of Medical Genetics, 96, 797-800.
26. Kotler, M., Barak, P., Cohen, H., Averbuch, I. E., Grinshpoon, A., Gritsenko, I., Nemanov, L., & Ebstein, R. P. (1999). Homicidal behavior in schizophrenia associated with a genetic polymorphism determining low catechol-O-methyltransferase (COMT) activity. American Journal of Medical Genetics, 88, 628-633.
27. Kruesi, M. J., Rapoport, J. L., Hamburger, S., Hibbs, E., Potter, W. Z., Lenane, M., & Brown, G. L. (1990). Cerebrospinal fluid monoamine metabolites, aggression, and impulsivity in disruptive behavior disorders of children and adolescents. Archives of General Psychiatry, 47, 419-426.
28. Lappalainen, J., Long, J. C., Eggert, M., Ozaki, N., Robin, R. W., Brown, G. L., Naukkarinen, H., Virkkunen, M., Linnoila, M., & Goldman, D. (1998). Linkage of antisocial alcoholism to the serotonin 5-HT1B receptor gene in 2 populations. Archives of General Psychiatry, 55, 989-994.
29. Lesch, K. P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Muller, C. R., Hamer, D. H., & Murphy, D. L. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 1527-1531.
30. Lesch, K. P., & Merschdorf, U. (2000). Impulsivity, aggression, and serotonin: A molecular psychobiological perspective. Behavioural Sciences and the Law, 18, 581-604.
31. Levitan, R. D., Kaplan, A. S., Masellis, M., Basile, V. S., Walker, M. L., Lipson, N., Siegel, G. I., Woodside, D. B., Macciardi, F. M., Kennedy, S. H., & Kennedy, J. L. (2001). Polymorphism of the serotonin 5-HT1B receptor gene (HTR1B) associated with minimum lifetime body mass index in women with bulimia nervosa. Biological Psychiatry, 50, 640-643.
32. Lidberg, L., Tuck, J. R., Asberg, M., Scalia-Tomba, G. P., & Bertilsson, L. (1985). Homicide, suicide and CSF 5-HIAA. Acta Psychiatrica Scandinavica, 71, 230-236.
33. Linnoila, M., Virkkunen, M., Scheinin, M., Nuutila, A., Rimon, R., & Goodwin, F. K. (1983). Low cerebrospinal fluid 5-hydroxyindolacetic acid concentration differentiates impulsive from nonimpulsive violent behavior. Life Sciences, 33, 2609-2614.
34. Manor, I., Eisenberg, J., Tyano, S., Sever, Y., Cohen, H., Ebstein, R. P., & Kotler, M. (2001). Family-based association study of the serotonin transporter promoter region polymorphism (5-HTTLPR) in attention deficit hyperactivity disorder. American Journal of Medical Genetics, 105, 91-95.
35. Miles, D. R., & Carey, G. (1997). Genetic and environmental architecture of human aggression. Journal of Personality and Social Psychology, 72, 207-217.
36. Nakamura, T., Matsushita, S., Nishiguchi, N., Kimura, M., Yoshino, A., & Higuchi, S. (1999). Association of a polymorphism of the 5HT2A receptor gene promoter region with alcohol dependence. Molecular Psychiatry, 4, 85-88.
37. New, A. S., Gelemter, J., Goodman, M., Mitropoulou, V., Koenigsberg, H., Silverman, J., & Siever, L. J. (2001). Suicide, impulsive aggression, and HTR1B genotype. Biological Psychiatry, 50, 62-65.
38. O'Keane, V., Moloney, E., O'Neill, H., O'Connor, A., Smith, C., & Dinan, T. G. (1992). Blunted prolactin responses to d-fenfluramine in sociopathy: Evidence for subsensitivity of central serotonergic function. British Journal of Psychiatry, 160, 643-646.
39. Preuss, U. W., Koller, G., Soyka, M., & Bondy, B. (2001). Association between suicide attempts and 5-HTTLPR-S-allele in alcohol-dependent and control subjects: Further evidence from a German alcohol-dependent inpatient sample. Biological Psychiatry, 50, 636-639.
40. Raap, D. K., & van de Kar, L. D. (1999). Selective serotonin reuptake inhibitors and neuroendocrine function. Life Sciences, 65, 1217-1235.
41. Reist, C., Mazzanti, C., Vu, R., Tran, D., & Goldman, D. (2001). Serotonin transporter promoter polymorphism is associated with attenuated prolactin response to fenfluramine. American Journal of Medical Genetics, 105, 363-368.
42. Retz, W., Thome, J., Blocher, D., Baader, M., & Rösler, M. (2002). Association of attention deficit hyperactivity disorder-related psychopathology and personality traits with the serotonin transporter promoter region polymorphism. Neuroscience Letters, 319, 133-136.
43. Retz-Junginger, P., Retz, W., Blocher, D., Stieglitz, R. D., Georg, T., Supprian, T., Wender, P. H., & Rösler, M. (2003). [Diagnostic validity and reliability of the WURS-k for retrospective diagnosis of ADHD]. Nervenarzt, 74, 987-993.
44. Retz-Junginger, P., Retz, W., Blocher, D., Weijers, H. G., Trott, G. E., Wender, P. H., & Rösler, M. (2002). [The German short-form of the Wender Utah Rating Scale (WURS-k) for the retrospective assessment of the hyperkinetic syndrome in adults]. Nervenarzt, 73, 830-838.
45. Sander, T., Harms, H., Dufeu, P., Kuhn, S., Hoehe, M., Lesch, K. P., Rommelspacher, H., & Schmidt, L. G. (1998). Serotonin transporter gene variants in alcohol-dependent subjects with dissocial personality disorder. Biological Psychiatry, 43, 908-912.
46. Schalling, D., Asberg, M., Edman, G., & Oreland, L. (1987). Markers for vulnerability to psychopathology: Temperament traits associated with platelet MAO activity. Acta Psychiatrica Scandinavica, 76, 172-182.
47. Seeger, G., Schloss, P., & Schmidt, M. H. (2001). Functional polymorphism within the promoter of the serotonin transporter gene is associated with severe hyperkinetic disorders. Molecular Psychiatry, 6, 235-238.
48. Virkkunen, M., Rawlings, R., Tokola, R., Poland, R. E., Guidotti, A., Nemeroff, C., Bissette, G., Kalogeras, K., Karonen, S. L., & Linnoila, M. (1994). CSF biochemistries, glucose metabolism, and diurnal activity rhythms in alcoholic, violent offenders, fire setters, and healthy volunteers. Archives of General Psychiatry, 51, 20-27.
49. Vitiello, B., & Stoff, D. M. (1997). Subtypes of aggression and their relevance to child psychiatry. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 307-315.
50. Volavka, J. (1999). The neurobiology of violence: An update. Journal of Neuropsychiatry and Clinical Neurosciences, 11, 307-314.
51. Wender, P. H. (1995). Attention deficit hyperactivivy disorder in adults. New York: Oxford University Press.
52. Zalsman, G., Frisch, A., Bromberg, M., Gelemter, J., Michaelovsky, E., Campino, A., Erlich, Z., Tyano, S., Apter, A., & Weizman, A. (2001). Family-based association study of serotonin transporter promoter in suicidal adolescents: No association with suicidality but possible role in violence traits. American Journal of Medical Genetics, 105, 239-245.