The common γ-chain cytokine receptor: Tricks-and-treats for T cells

Cellular and Molecular Life Sciences

Volumn 73, Issue 2, 2016, Pages 253-269

  Waickman, Adam T ^a   Park, Joo Young ^a   Park, Jung Hyun ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Alternative splicing; Homeostasis; JAK3; Signaling; Survival

Indexed keywords

INTERLEUKIN 15; INTERLEUKIN 2 RECEPTOR BETA; INTERLEUKIN 2 RECEPTOR GAMMA; INTERLEUKIN 21; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR ALPHA; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR ALPHA; INTERLEUKIN 9; INTERLEUKIN 9 RECEPTOR; INTERLEUKIN 9 RECEPTOR ALPHA; JANUS KINASE 3; UNCLASSIFIED DRUG; CYTOKINE; CYTOKINE RECEPTOR; ISOPROTEIN;

ALTERNATIVE RNA SPLICING; CARBOXY TERMINAL SEQUENCE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; DISEASE EXACERBATION; DISEASE SEVERITY; EXON; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; HUMAN; IN VIVO STUDY; INFLAMMATORY BOWEL DISEASE; LEUKEMOGENESIS; LYMPHOCYTE DIFFERENTIATION; MULTIPLE SCLEROSIS; NONHUMAN; ORGANOGENESIS; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REMISSION; REVIEW; RHEUMATOID ARTHRITIS; SEVERE COMBINED IMMUNODEFICIENCY; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TH17 CELL; THYMOCYTE; UBIQUITINATION; UPREGULATION; X LINKED SEVERE COMBINED IMMUNODEFICIENCY; ANIMAL; CHEMISTRY; CYTOLOGY; GENETICS; IMMUNOLOGY; INFLAMMATION; LYMPHOCYTE ACTIVATION; METABOLISM; T LYMPHOCYTE;

ALTERNATIVE SPLICING; ANIMALS; CYTOKINES; HUMANS; INFLAMMATION; INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT; JANUS KINASE 3; LYMPHOCYTE ACTIVATION; PROTEIN ISOFORMS; RECEPTORS, CYTOKINE; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TH17 CELLS;

EID: 84954045053     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-015-2062-4     Document Type: Review

References (140)

1. Rochman Y, Spolski R, Leonard WJ (2009) New insights into the regulation of T cells by γc family cytokines. Nat Rev Immunol 9:480-490
2. Sugamura K, Asao H, Kondo M, Tanaka N, Ishii N, Ohbo K, Nakamura M, Takeshita T (1996) The interleukin-2 receptor γ chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID. Annu Rev Immunol 14:179-205
3. Noguchi M, Yi H, Rosenblatt HM, Filipovich AH, Adelstein S, Modi WS, McBride OW, Leonard WJ (1993) Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans. Cell 73:147-157
4. Puck JM, Nussbaum RL, Conley ME (1987) Carrier detection in X-linked severe combined immunodeficiency based on patterns of X chromosome inactivation. J Clin Invest 79:1395-1400
5. DiSanto JP, Muller W, Guy-Grand D, Fischer A, Rajewsky K (1995) Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor γ chain. Proc Natl Acad Sci USA 92:377-381
6. Schorle H, Holtschke T, Hunig T, Schimpl A, Horak I (1991) Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 352:621-624
7. von Freeden-Jeffry U, Vieira P, Lucian LA, McNeil T, Burdach SE, Murray R (1995) Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J Exp Med 181:1519-1526
8. Rodewald HR, Waskow C, Haller C (2001) Essential requirement for c-kit and common γ chain in thymocyte development cannot be overruled by enforced expression of Bcl-2. J Exp Med 193:1431-1437
9. Sudo T, Nishikawa S, Ohno N, Akiyama N, Tamakoshi M, Yoshida H, Nishikawa S (1993) Expression and function of the interleukin 7 receptor in murine lymphocytes. Proc Natl Acad Sci USA 90:9125-9129
10. Bhatia SK, Tygrett LT, Grabstein KH, Waldschmidt TJ (1995) The effect of in vivo IL-7 deprivation on T cell maturation. J Exp Med 181:1399-1409
11. Fontenot JD, Rasmussen JP, Gavin MA, Rudensky AY (2005) A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol 6:1142-1151
12. + T cells. Nat Immunol 11:709-716
13. Lodolce JP, Boone DL, Chai S, Swain RE, Dassopoulos T, Trettin S, Ma A (1998) IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 9:669-676
14. + T cells. Proc Natl Acad Sci USA 101:15154-15159
15. Vogelzang A, McGuire HM, Yu D, Sprent J, Mackay CR, King C (2008) A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 29:127-137
16. Nurieva RI, Chung Y, Hwang D, Yang XO, Kang HS, Ma L, Wang YH, Watowich SS, Jetten AM, Tian Q, Dong C (2008) Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29:138-149
17. Nurieva R, Yang XO, Martinez G, Zhang Y, Panopoulos AD, Ma L, Schluns K, Tian Q, Watowich SS, Jetten AM, Dong C (2007) Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 448:480-483
18. Hong C, Luckey MA, Ligons DL, Waickman AT, Park JY, Kim GY, Keller HR, Etzensperger R, Tai X, Lazarevic V, Feigenbaum L, Catalfamo M, Walsh ST, Park JH (2014) Activated T cells secrete an alternatively spliced form of common γ-chain that inhibits cytokine signaling and exacerbates inflammation. Immunity 40:910-923
19. Walsh ST (2012) Structural insights into the common γ-chain family of cytokines and receptors from the interleukin-7 pathway. Immunol Rev 250:303-316
20. McElroy CA, Holland PJ, Zhao P, Lim JM, Wells L, Eisenstein E, Walsh ST (2012) Structural reorganization of the interleukin-7 signaling complex. Proc Natl Acad Sci USA 109:2503-2508
21. Pillet AH, Lavergne V, Pasquier V, Gesbert F, Theze J, Rose T (2010) IL-2 induces conformational changes in its preassembled receptor core, which then migrates in lipid raft and binds to the cytoskeleton meshwork. J Mol Biol 403:671-692
22. + T cells in the absence of γc cytokine receptor signaling. Eur J Immunol 43:2283-2294
23. de Saint Basile G, Arveiler B, Oberle I, Malcolm S, Levinsky RJ, Lau YL, Hofker M, Debre M, Fischer A, Griscelli C et al (1987) Close linkage of the locus for X chromosome-linked severe combined immunodeficiency to polymorphic DNA markers in Xq11-q13. Proc Natl Acad Sci USA 84:7576-7579
24. Puck JM, Nussbaum RL, Smead DL, Conley ME (1989) X-linked severe combined immunodeficiency: localization within the region Xq13.1-q21.1 by linkage and deletion analysis. Am J Hum Genet 44:724-730
25. Puck JM, Deschenes SM, Porter JC, Dutra AS, Brown CJ, Willard HF, Henthorn PS (1993) The interleukin-2 receptor γ chain maps to Xq13.1 and is mutated in X-linked severe combined immunodeficiency, SCIDX1. Hum Mol Genet 2:1099-1104
26. Cao X, Shores EW, Hu-Li J, Anver MR, Kelsall BL, Russell SM, Drago J, Noguchi M, Grinberg A, Bloom ET et al (1995) Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain. Immunity 2:223-238
27. Gougeon ML, Drean G, Le Deist F, Dousseau M, Fevrier M, Diu A, Theze J, Griscelli C, Fischer A (1990) Human severe combined immunodeficiency disease: phenotypic and functional characteristics of peripheral B lymphocytes. J Immunol 145:2873-2879
28. Matthews DJ, Clark PA, Herbert J, Morgan G, Armitage RJ, Kinnon C, Minty A, Grabstein KH, Caput D, Ferrara P et al (1995) Function of the interleukin-2 (IL-2) receptor γ-chain in biologic responses of X-linked severe combined immunodeficient B cells to IL-2, IL-4, IL-13, and IL-15. Blood 85:38-42
29. Kennedy MK, Glaccum M, Brown SN, Butz EA, Viney JL, Embers M, Matsuki N, Charrier K, Sedger L, Willis CR, Brasel K, Morrissey PJ, Stocking K, Schuh JC, Joyce S, Peschon JJ (2000) Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J Exp Med 191:771-780
30. +) thymocytes in normal and genetically modified mice. J Immunol 154:5103-5113
31. Nakajima H, Leonard WJ (1999) Role of Bcl-2 in αβ T cell development in mice deficient in the common cytokine receptor γ-chain: the requirement for Bcl-2 differs depending on the TCR/MHC affinity. J Immunol 162:782-790
32. Kondo M, Akashi K, Domen J, Sugamura K, Weissman IL (1997) Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common γ chain-deficient mice. Immunity 7:155-162
33. Nakajima H, Noguchi M, Leonard WJ (2000) Role of the common cytokine receptor γ chain (γc) in thymocyte selection. Immunol Today 21:88-94
34. DiSanto JP, Guy-Grand D, Fisher A, Tarakhovsky A (1996) Critical role for the common cytokine receptor γ chain in intrathymic and peripheral T cell selection. J Exp Med 183:1111-1118
35. McCaughtry TM, Etzensperger R, Alag A, Tai X, Kurtulus S, Park JH, Grinberg A, Love P, Feigenbaum L, Erman B, Singer A (2012) Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus. J Exp Med 209:2263-2276
36. Park JH, Adoro S, Lucas PJ, Sarafova SD, Alag AS, Doan LL, Erman B, Liu X, Ellmeier W, Bosselut R, Feigenbaum L, Singer A (2007) 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. Nat Immunol 8:1049-1059
37. Akashi K, Kondo M, von Freeden-Jeffry U, Murray R, Weissman IL (1997) Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Cell 89:1033-1041
38. von Freeden-Jeffry U, Solvason N, Howard M, Murray R (1997) The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression. Immunity 7:147-154
39. Singer A, Adoro S, Park JH (2008) Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice. Nat Rev Immunol 8:788-801
40. + T cells. Immunity 13:59-71
41. Yu Q, Park JH, Doan LL, Erman B, Feigenbaum L, Singer A (2006) Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection. J Exp Med 203:165-175
42. Park JH, Adoro S, Guinter T, Erman B, Alag AS, Catalfamo M, Kimura MY, Cui Y, Lucas PJ, Gress RE, Kubo M, Hennighausen L, Feigenbaum L, Singer A (2010) Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells. Nat Immunol 11:257-264
43. + severe combined immunodeficiency. Nat Genet 20:394-397
44. Kondo M, Takeshita T, Ishii N, Nakamura M, Watanabe S, Arai K, Sugamura K (1993) Sharing of the interleukin-2 (IL-2) receptor γ chain between receptors for IL-2 and IL-4. Science 262:1874-1877
45. Russell SM, Keegan AD, Harada N, Nakamura Y, Noguchi M, Leland P, Friedmann MC, Miyajima A, Puri RK, Paul WE et al (1993) Interleukin-2 receptor γ chain: a functional component of the interleukin-4 receptor. Science 262:1880-1883
46. Kimura Y, Takeshita T, Kondo M, Ishii N, Nakamura M, Van Snick J, Sugamura K (1995) Sharing of the IL-2 receptor γ chain with the functional IL-9 receptor complex. Int Immunol 7:115-120
47. Russell SM, Johnston JA, Noguchi M, Kawamura M, Bacon CM, Friedmann M, Berg M, McVicar DW, Witthuhn BA, Silvennoinen O et al (1994) Interaction of IL-2Rβ and γc chains with Jak1 and Jak3: implications for XSCID and XCID. Science 266:1042-1045
48. Giri JG, Ahdieh M, Eisenman J, Shanebeck K, Grabstein K, Kumaki S, Namen A, Park LS, Cosman D, Anderson D (1994) Utilization of the β and γ chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J 13(12):2822-2830
49. Asao H, Takeshita T, Ishii N, Kumaki S, Nakamura M, Sugamura K (1993) Reconstitution of functional interleukin 2 receptor complexes on fibroblastoid cells: involvement of the cytoplasmic domain of the γ chain in two distinct signaling pathways. Proc Natl Acad Sci USA 90:4127-4131
50. Noguchi M, Nakamura Y, Russell SM, Ziegler SF, Tsang M, Cao X, Leonard WJ (1993) Interleukin-2 receptor γ chain: a functional component of the interleukin-7 receptor. Science 262:1877-1880
51. Herrmann T, Diamantstein T (1988) The high affinity interleukin 2 receptor: evidence for three distinct polypeptide chains comprising the high affinity interleukin 2 receptor. Mol Immunol 25:1201-1207
52. Arima N, Kamio M, Imada K, Hori T, Hattori T, Tsudo M, Okuma M, Uchiyama T (1992) Pseudo-high affinity interleukin 2 (IL-2) receptor lacks the third component that is essential for functional IL-2 binding and signaling. J Exp Med 176:1265-1272
53. Nakarai T, Robertson MJ, Streuli M, Wu Z, Ciardelli TL, Smith KA, Ritz J (1994) Interleukin 2 receptor γ chain expression on resting and activated lymphoid cells. J Exp Med 180:241-251
54. Boussiotis VA, Barber DL, Nakarai T, Freeman GJ, Gribben JG, Bernstein GM, D'Andrea AD, Ritz J, Nadler LM (1994) Prevention of T cell anergy by signaling through the γc chain of the IL-2 receptor. Science 266:1039-1042
55. Miyazaki T, Kawahara A, Fujii H, Nakagawa Y, Minami Y, Liu ZJ, Oishi I, Silvennoinen O, Witthuhn BA, Ihle JN et al (1994) Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science 266:1045-1047
56. Kawamura M, McVicar DW, Johnston JA, Blake TB, Chen YQ, Lal BK, Lloyd AR, Kelvin DJ, Staples JE, Ortaldo JR et al (1994) Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes. Proc Natl Acad Sci USA 91:6374-6378
57. Johnston JA, Kawamura M, Kirken RA, Chen YQ, Blake TB, Shibuya K, Ortaldo JR, McVicar DW, O'Shea JJ (1994) Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. Nature 370:151-153
58. Witthuhn BA, Silvennoinen O, Miura O, Lai KS, Cwik C, Liu ET, Ihle JN (1994) Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature 370:153-157
59. Rodig SJ, Meraz MA, White JM, Lampe PA, Riley JK, Arthur CD, King KL, Sheehan KC, Yin L, Pennica D, Johnson EM Jr, Schreiber RD (1998) Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses. Cell 93:373-383
60. Parganas E, Wang D, Stravopodis D, Topham DJ, Marine JC, Teglund S, Vanin EF, Bodner S, Colamonici OR, van Deursen JM, Grosveld G, Ihle JN (1998) Jak2 is essential for signaling through a variety of cytokine receptors. Cell 93:385-395
61. Neubauer H, Cumano A, Muller M, Wu H, Huffstadt U, Pfeffer K (1998) Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell 93:397-409
62. Shimoda K, Kato K, Aoki K, Matsuda T, Miyamoto A, Shibamori M, Yamashita M, Numata A, Takase K, Kobayashi S, Shibata S, Asano Y, Gondo H, Sekiguchi K, Nakayama K, Nakayama T, Okamura T, Okamura S, Niho Y, Nakayama K (2000) Tyk2 plays a restricted role in IFN α signaling, although it is required for IL-12-mediated T cell function. Immunity 13:561-571
63. Karaghiosoff M, Neubauer H, Lassnig C, Kovarik P, Schindler H, Pircher H, McCoy B, Bogdan C, Decker T, Brem G, Pfeffer K, Muller M (2000) Partial impairment of cytokine responses in Tyk2-deficient mice. Immunity 13:549-560
64. Macchi P, Villa A, Giliani S, Sacco MG, Frattini A, Porta F, Ugazio AG, Johnston JA, Candotti F, O'Shea JJ et al (1995) Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). Nature 377:65-68
65. Russell SM, Tayebi N, Nakajima H, Riedy MC, Roberts JL, Aman MJ, Migone TS, Noguchi M, Markert ML, Buckley RH, O'Shea JJ, Leonard WJ (1995) Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. Science 270:797-800
66. Thomis DC, Gurniak CB, Tivol E, Sharpe AH, Berg LJ (1995) Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science 270:794-797
67. Nosaka T, van Deursen JM, Tripp RA, Thierfelder WE, Witthuhn BA, McMickle AP, Doherty PC, Grosveld GC, Ihle JN (1995) Defective lymphoid development in mice lacking Jak3. Science 270:800-802
68. Park SY, Saijo K, Takahashi T, Osawa M, Arase H, Hirayama N, Miyake K, Nakauchi H, Shirasawa T, Saito T (1995) Developmental defects of lymphoid cells in Jak3 kinase-deficient mice. Immunity 3:771-782
69. Huang LJ, Constantinescu SN, Lodish HF (2001) The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor. Mol Cell 8:1327-1338
70. Ragimbeau J, Dondi E, Alcover A, Eid P, Uze G, Pellegrini S (2003) The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression. EMBO J 22:537-547
71. Radtke S, Hermanns HM, Haan C, Schmitz-Van De Leur H, Gascan H, Heinrich PC, Behrmann I (2002) Novel role of Janus kinase 1 in the regulation of oncostatin M receptor surface expression. J Biol Chem 277:11297-11305
72. Suzuki K, Nakajima H, Saito Y, Saito T, Leonard WJ, Iwamoto I (2000) Janus kinase 3 (Jak3) is essential for common cytokine receptor γ chain (γc)-dependent signaling: comparative analysis of γc, Jak3, and γc and Jak3 double-deficient mice. Int Immunol 12:123-132
73. Hofmann SR, Lam AQ, Frank S, Zhou YJ, Ramos HL, Kanno Y, Agnello D, Youle RJ, O'Shea JJ (2004) Jak3-independent trafficking of the common γ chain receptor subunit: chaperone function of Jaks revisited. Mol Cell Biol 24:5039-5049
74. Sohn SJ, Forbush KA, Nguyen N, Witthuhn B, Nosaka T, Ihle JN, Perlmutter RM (1998) Requirement for Jak3 in mature T cells: its role in regulation of T cell homeostasis. J Immunol 160:2130-2138
75. Kondo M, Ohashi Y, Tada K, Nakamura M, Sugamura K (1994) Expression of the mouse interleukin-2 receptor γ chain in various cell populations of the thymus and spleen. Eur J Immunol 24:2026-2030
76. Bani L, David D, Moreau JL, Cayota A, Nakarai T, Ritz J, Theze J (1997) Expression of the IL-2 receptor γ subunit in resting human CD4 T lymphocytes: mRNA is constitutively transcribed and the protein stored as an intracellular component. Int Immunol 9:573-580
77. Gesbert F, Malarde V, Dautry-Varsat A (2005) Ubiquitination of the common cytokine receptor γc and regulation of expression by an ubiquitination/deubiquitination machinery. Biochem Biophys Res Commun 334:474-480
78. Markiewicz S, Bosselut R, Le Deist F, de Villartay JP, Hivroz C, Ghysdael J, Fischer A, de Saint Basile G (1996) Tissue-specific activity of the γc chain gene promoter depends upon an Ets binding site and is regulated by GA-binding protein. J Biol Chem 271:14849-14855
79. Yu S, Zhao DM, Jothi R, Xue HH (2010) Critical requirement of GABPα for normal T cell development. J Biol Chem 285:10179-10188
80. + T cells favors terminal-effector differentiation in vivo. Immunity 32:91-103
81. Amorosi S, Russo I, Amodio G, Garbi C, Vitiello L, Palamaro L, Adriani M, Vigliano I, Pignata C (2009) The cellular amount of the common γ-chain influences spontaneous or induced cell proliferation. J Immunol 182(5):3304-3309
82. Orr SJ, Roessler S, Quigley L, Chan T, Ford JW, O'Connor GM, McVicar DW (2010) Implications for gene therapy-limiting expression of IL-2R γc delineate differences in signaling thresholds required for lymphocyte development and maintenance. J Immunol 185:1393-1403
83. Smyth CM, Ginn SL, Deakin CT, Logan GJ, Alexander IE (2007) Limiting γc expression differentially affects signaling via the interleukin (IL)-7 and IL-15 receptors. Blood 110:91-98
84. + phenotype. Hum Mutat 23:522-523
85. Zhou YJ, Chen M, Cusack NA, Kimmel LH, Magnuson KS, Boyd JG, Lin W, Roberts JL, Lengi A, Buckley RH, Geahlen RL, Candotti F, Gadina M, Changelian PS, O'Shea JJ (2001) Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases. Mol Cell 8:959-969
86. Wang X, Lupardus P, Laporte SL, Garcia KC (2009) Structural biology of shared cytokine receptors. Annu Rev Immunol 27:29-60
87. Izuhara K, Miyajima A, Harada N (1993) The chimeric receptor between interleukin-2 receptor β chain and interleukin-4 receptor transduces interleukin-2 signal. Biochem Biophys Res Commun 190:992-1000
88. Katz G, Pobezinsky LA, Jeurling S, Shinzawa M, Van Laethem F, Singer A (2014) T cell receptor stimulation impairs IL-7 receptor signaling by inducing expression of the microRNA miR-17 to target Janus kinase 1. Sci Signal 7:ra83
89. Lee IH, Li WP, Hisert KB, Ivashkiv LB (1999) Inhibition of interleukin 2 signaling and signal transducer and activator of transcription (STAT)5 activation during T cell receptor-mediated feedback inhibition of T cell expansion. J Exp Med 190:1263-1274
90. Zhu J, Huang H, Guo L, Stonehouse T, Watson CJ, Hu-Li J, Paul WE (2000) Transient inhibition of interleukin 4 signaling by T cell receptor ligation. J Exp Med 192:1125-1134
91. + T cell homeostasis to promote cell survival instead of cell death. Nat Immunol 14:143-151
92. Noguchi M, Sarin A, Aman MJ, Nakajima H, Shores EW, Henkart PA, Leonard WJ (1997) Functional cleavage of the common cytokine receptor γ chain (γc) by calpain. Proc Natl Acad Sci USA 94:11534-11539
93. Haan C, Rolvering C, Raulf F, Kapp M, Druckes P, Thoma G, Behrmann I, Zerwes HG (2011) Jak1 has a dominant role over Jak3 in signal transduction through γc-containing cytokine receptors. Chem Biol 18:314-323
94. Gaffen SL (2001) Signaling domains of the interleukin 2 receptor. Cytokine 14:63-77
95. Nelson BH, McIntosh BC, Rosencrans LL, Greenberg PD (1997) Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor γc chain for Janus kinase activation leading to T cell proliferation. Proc Natl Acad Sci USA 94:1878-1883
96. Nelson BH, Lord JD, Greenberg PD (1996) A membrane-proximal region of the interleukin-2 receptor γc chain sufficient for Jak kinase activation and induction of proliferation in T cells. Mol Cell Biol 16:309-317
97. Nakamura Y, Russell SM, Mess SA, Friedmann M, Erdos M, Francois C, Jacques Y, Adelstein S, Leonard WJ (1994) Heterodimerization of the IL-2 receptor β- and γ-chain cytoplasmic domains is required for signalling. Nature 369:330-333
98. Durum SK (2014) IL-7 and TSLP receptors: twisted sisters. Blood 124:4-5
99. Zenatti PP, Ribeiro D, Li W, Zuurbier L, Silva MC, Paganin M, Tritapoe J, Hixon JA, Silveira AB, Cardoso BA, Sarmento LM, Correia N, Toribio ML, Kobarg J, Horstmann M, Pieters R, Brandalise SR, Ferrando AA, Meijerink JP, Durum SK, Yunes JA, Barata JT (2011) Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia. Nat Genet 43:932-939
100. Shochat C, Tal N, Gryshkova V, Birger Y, Bandapalli OR, Cazzaniga G, Gershman N, Kulozik AE, Biondi A, Mansour MR, Twizere JC, Muckenthaler MU, Ben-Tal N, Constantinescu SN, Bercovich D, Izraeli S (2014) Novel activating mutations lacking cysteine in type I cytokine receptors in acute lymphoblastic leukemia. Blood 124:106-110
101. Tsujino S, Di Santo JP, Takaoka A, McKernan TL, Noguchi S, Taya C, Yonekawa H, Saito T, Taniguchi T, Fujii H (2000) Differential requirement of the cytoplasmic subregions of γc chain in T cell development and function. Proc Natl Acad Sci USA 97:10514-10519
102. Goldsmith MA, Lai SY, Xu W, Amaral MC, Kuczek ES, Parent LJ, Mills GB, Tarr KL, Longmore GD, Greene WC (1995) Growth signal transduction by the human interleukin-2 receptor requires cytoplasmic tyrosines of the β chain and non-tyrosine residues of the γc chain. J Biol Chem 270:21729-21737
103. Asao H, Kumaki S, Takeshita T, Nakamura M, Sugamura K (1992) IL-2-dependent in vivo and in vitro tyrosine phosphorylation of IL-2 receptor γ chain. FEBS Lett 304:141-145
104. Lindemann MJ, Benczik M, Gaffen SL (2003) Anti-apoptotic signaling by the interleukin-2 receptor reveals a function for cytoplasmic tyrosine residues within the common γ (γc) receptor subunit. J Biol Chem 278:10239-10249
105. Kobayashi N, Nakagawa S, Minami Y, Taniguchi T, Kono T (1993) Cloning and sequencing of the cDNA encoding a mouse IL-2 receptor γ. Gene 130:303-304
106. Jameson SC, Renkema KR (2014) An uncommon tail about the common γ-chain. Immunity 40:859-860
107. Levine SJ (2004) Mechanisms of soluble cytokine receptor generation. J Immunol 173:5343-5348
108. Rubin LA, Kurman CC, Fritz ME, Biddison WE, Boutin B, Yarchoan R, Nelson DL (1985) Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro. J Immunol 135:3172-3177
109. Holter W, Goldman CK, Casabo L, Nelson DL, Greene WC, Waldmann TA (1987) Expression of functional IL 2 receptors by lipopolysaccharide and interferon-γ stimulated human monocytes. J Immunol 138:2917-2922
110. Honda M, Kitamura K, Takeshita T, Sugamura K, Tokunaga T (1990) Identification of a soluble IL-2 receptor β-chain from human lymphoid cell line cells. J Immunol 145:4131-4135
111. Idzerda RL, March CJ, Mosley B, Lyman SD, Vanden Bos T, Gimpel SD, Din WS, Grabstein KH, Widmer MB, Park LS et al (1990) Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily. J Exp Med 171:861-873
112. Goodwin RG, Friend D, Ziegler SF, Jerzy R, Falk BA, Gimpel S, Cosman D, Dower SK, March CJ, Namen AE et al (1990) Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Cell 60:941-951
113. Renauld JC, Druez C, Kermouni A, Houssiau F, Uyttenhove C, Van Roost E, Van Snick J (1992) Expression cloning of the murine and human interleukin 9 receptor cDNAs. Proc Natl Acad Sci USA 89:5690-5694
114. Mortier E, Bernard J, Plet A, Jacques Y (2004) Natural, proteolytic release of a soluble form of human IL-15 receptor α-chain that behaves as a specific, high affinity IL-15 antagonist. J Immunol 173:1681-1688
115. Bergamaschi C, Bear J, Rosati M, Beach RK, Alicea C, Sowder R, Chertova E, Rosenberg SA, Felber BK, Pavlakis GN (2012) Circulating IL-15 exists as heterodimeric complex with soluble IL-15Rα in human and mouse serum. Blood 120:e1-e8
116. Spangler JB, Moraga I, Mendoza JL, Garcia KC (2015) Insights into cytokine-receptor interactions from cytokine engineering. Annu Rev Immunol 33:139-167
117. Wang X, Rickert M, Garcia KC (2005) Structure of the quaternary complex of interleukin-2 with its α, β, and γc receptors. Science 310:1159-1163
118. Stauber DJ, Debler EW, Horton PA, Smith KA, Wilson IA (2006) Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor. Proc Natl Acad Sci USA 103:2788-2793
119. Olosz F, Malek TR (2000) Three loops of the common γ chain ectodomain required for the binding of interleukin-2 and interleukin-7. J Biol Chem 275:30100-30105
120. Rickert M, Boulanger MJ, Goriatcheva N, Garcia KC (2004) Compensatory energetic mechanisms mediating the assembly of signaling complexes between interleukin-2 and its α, β, and γc receptors. J Mol Biol 339:1115-1128
121. Shimizu A, Kondo S, Sabe H, Ishida N, Honjo T (1986) Structure and function of the interleukin 2 receptor: affinity conversion model. Immunol Rev 92:103-120
122. Liparoto SF, Myszka DG, Wu Z, Goldstein B, Laue TM, Ciardelli TL (2002) Analysis of the role of the interleukin-2 receptor γ chain in ligand binding. Biochemistry 41:2543-2551
123. Damjanovich S, Bene L, Matko J, Alileche A, Goldman CK, Sharrow S, Waldmann TA (1997) Preassembly of interleukin 2 (IL-2) receptor subunits on resting Kit 225 K6 T cells and their modulation by IL-2, IL-7, and IL-15: a fluorescence resonance energy transfer study. Proc Natl Acad Sci USA 94:13134-13139
124. Malka Y, Hornakova T, Royer Y, Knoops L, Renauld JC, Constantinescu SN, Henis YI (2008) Ligand-independent homomeric and heteromeric complexes between interleukin-2 or -9 receptor subunits and the γ chain. J Biol Chem 283:33569-33577
125. Pillet AH, Juffroy O, Mazard-Pasquier V, Moreau JL, Gesbert F, Chastagner P, Colle JH, Theze J, Rose T (2008) Human IL-2Rβ chains form IL-2 binding homodimers. Eur Cytokine Netw 19:49-59
126. Rose T, Pillet AH, Lavergne V, Tamarit B, Lenormand P, Rousselle JC, Namane A, Theze J (2010) Interleukin-7 compartmentalizes its receptor signaling complex to initiate CD4 T lymphocyte response. J Biol Chem 285:14898-14908
127. Basu R, Hatton RD, Weaver CT (2013) The Th17 family: flexibility follows function. Immunol Rev 252:89-103
128. Laurence A, Tato CM, Davidson TS, Kanno Y, Chen Z, Yao Z, Blank RB, Meylan F, Siegel R, Hennighausen L, Shevach EM, O'Shea JJ (2007) Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 26:371-381
129. Rangachari M, Kuchroo VK (2013) Using EAE to better understand principles of immune function and autoimmune pathology. J Autoimmun 45:31-39
130. Nielsen OH, Kirman I, Johnson K, Giedlin M, Ciardelli T (1998) The circulating common γ chain (CD132) in inflammatory bowel disease. Am J Gastroenterol 93:323-328
131. Nishio J, Kohsaka H, Shimamura T, Hamuro J, Miyasaka N (2001) Abundant expression of common cytokine receptor γ chain (CD132) in rheumatoid joints. J Rheumatol 28:240-244
132. Meissner U, Blum H, Schnare M, Rollinghoff M, Gessner A (2001) A soluble form of the murine common γ chain is present at high concentrations in vivo and suppresses cytokine signaling. Blood 97:183-191
133. Hoyer KK, Dooms H, Barron L, Abbas AK (2008) Interleukin-2 in the development and control of inflammatory disease. Immunol Rev 226:19-28
134. Ouyang W, Kolls JK, Zheng Y (2008) The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 28:454-467
135. Voss SD, Leary TP, Sondel PM, Robb RJ (1993) Identification of a direct interaction between interleukin 2 and the p64 interleukin 2 receptor γ chain. Proc Natl Acad Sci USA 90:2428-2432
136. Schnyder B, Lugli S, Feng N, Etter H, Lutz RA, Ryffel B, Sugamura K, Wunderli-Allenspach H, Moser R (1996) Interleukin-4 (IL-4) and IL-13 bind to a shared heterodimeric complex on endothelial cells mediating vascular cell adhesion molecule-1 induction in the absence of the common γ chain. Blood 87:4286-4295
137. Chomarat P, Banchereau J (1998) Interleukin-4 and interleukin-13: their similarities and discrepancies. Int Rev Immunol 17:1-52
138. Park LS, Martin U, Garka K, Gliniak B, Di Santo JP, Muller W, Largaespada DA, Copeland NG, Jenkins NA, Farr AG, Ziegler SF, Morrissey PJ, Paxton R, Sims JE (2000) Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: formation of a functional heteromeric complex requires interleukin 7 receptor. J Exp Med 192:659-670
139. + T cell development. J Exp Med 200:159-168
140. Hechinger AK, Smith BA, Flynn R, Hanke K, McDonald-Hyman C, Taylor PA, Pfeifer D, Hackanson B, Leonhardt F, Prinz G, Dierbach H, Schmitt-Graeff A, Kovarik J, Blazar BR, Zeiser R (2015) Therapeutic activity of multiple common γ-chain cytokine inhibition in acute and chronic GVHD. Blood 125:570-580