-
1
-
-
0033559793
-
Autosomal SCID caused by a point mutation in the N terminus of Jak3: Mapping of the Jak3-receptor interaction domain
-
Cacalano, N. A., T. S. Migone, F. Bazan, E. P. Hanson, M. Chen, F. Candotti, J. J. O'Shea, and J. A. Johnston. 1999. Autosomal SCID caused by a point mutation in the N terminus of Jak3: mapping of the Jak3-receptor interaction domain. EMBO J. 18:1549-1558.
-
(1999)
EMBO J.
, vol.18
, pp. 1549-1558
-
-
Cacalano, N.A.1
Migone, T.S.2
Bazan, F.3
Hanson, E.P.4
Chen, M.5
Candotti, F.6
O'Shea, J.J.7
Johnston, J.A.8
-
2
-
-
0030729823
-
Structural and functional basis for JAK3-deficient severe combined immunodeficiency
-
Candotti, F., S. A. Oakes, J. A. Johnston, S. Gillani, R. F. Schumacher, P. Mella, M. Fiorini, A. G. Ugazio, R. Badolato, L. D. Notarangelo, F. Bozzi, P. Macchi, D. Strina, P. Vezzoni, R. M. Blaese, J. J. O'Shea, and A. Villa. 1997. Structural and functional basis for JAK3-deficient severe combined immunodeficiency. Blood 90:3996-4003.
-
(1997)
Blood
, vol.90
, pp. 3996-4003
-
-
Candotti, F.1
Oakes, S.A.2
Johnston, J.A.3
Gillani, S.4
Schumacher, R.F.5
Mella, P.6
Fiorini, M.7
Ugazio, A.G.8
Badolato, R.9
Notarangelo, L.D.10
Bozzi, F.11
Macchi, P.12
Strina, D.13
Vezzoni, P.14
Blaese, R.M.15
O'Shea, J.J.16
Villa, A.17
-
3
-
-
0027227632
-
Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: Chromosomal mapping and tissue specificity of IL-2R gamma chain expression
-
Cao, X., C. A. Kozak, Y. J. Liu, M. Noguchi, E. O'Connell, and W. J. Leonard. 1993. Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma chain expression. Proc. Natl. Acad. Sci. USA 90:8464-8468.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 8464-8468
-
-
Cao, X.1
Kozak, C.A.2
Liu, Y.J.3
Noguchi, M.4
O'Connell, E.5
Leonard, W.J.6
-
4
-
-
0033965488
-
Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: Evidence for interactions between the kinase and pseudokinase domains
-
Chen, M., A. Cheng, F. Candotti, Y. J. Zhou, A. Hymel, A. Fasth, L. D. Notarangelo, and J. J. O'Shea. 2000. Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: evidence for interactions between the kinase and pseudokinase domains. Mol. Cell. Biol. 20:947-956.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 947-956
-
-
Chen, M.1
Cheng, A.2
Candotti, F.3
Zhou, Y.J.4
Hymel, A.5
Fasth, A.6
Notarangelo, L.D.7
O'Shea, J.J.8
-
5
-
-
0031009816
-
The amino terminus of JAK3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals
-
Chen, M., A. Cheng, Y. Q. Chen, A. Hymel, E. P. Hanson, L. Kimmel, Y. Minami, T. Taniguchi, P. S. Changelian, and J. J. O'Shea. 1997. The amino terminus of JAK3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals. Proc. Natl. Acad. Sci. USA 94:6910-6915.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 6910-6915
-
-
Chen, M.1
Cheng, A.2
Chen, Y.Q.3
Hymel, A.4
Hanson, E.P.5
Kimmel, L.6
Minami, Y.7
Taniguchi, T.8
Changelian, P.S.9
O'Shea, J.J.10
-
6
-
-
0035367819
-
Signaling by type I and II cytokine receptors: Ten years after
-
Gadina, M., D. Hilton, J. A. Johnston, A. Morinobu, A. Lighvani, Y. J. Zhou, R. Visconti, and J. J. O'Shea. 2001. Signaling by type I and II cytokine receptors: ten years after. Curr. Opin. Immunol. 13:363-373.
-
(2001)
Curr. Opin. Immunol.
, vol.13
, pp. 363-373
-
-
Gadina, M.1
Hilton, D.2
Johnston, J.A.3
Morinobu, A.4
Lighvani, A.5
Zhou, Y.J.6
Visconti, R.7
O'Shea, J.J.8
-
7
-
-
0030665789
-
The amino-terminal region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta receptor
-
Gauzzi, M. C., G. Barbieri, M. F. Richter, G. Uze, L. Ling, M. Fellous, and S. Pellegrini. 1997. The amino-terminal region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta receptor. Proc. Natl. Acad. Sci. USA 94:11839-11844.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 11839-11844
-
-
Gauzzi, M.C.1
Barbieri, G.2
Richter, M.F.3
Uze, G.4
Ling, L.5
Fellous, M.6
Pellegrini, S.7
-
8
-
-
0035813208
-
Mapping of a region within the N terminus of Jak1 involved in cytokine receptor interaction
-
Haan, C., H. Is'harc, H. M. Hermanns, H. Schmitz-Van de Leur, I. M. Kerr, P. C. Heinrich, J. Grotzinger, and I. Behrmann. 2001. Mapping of a region within the N terminus of Jak1 involved in cytokine receptor interaction. J. Biol. Chem. 276:37451-37458.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 37451-37458
-
-
Haan, C.1
Is'harc, H.2
Hermanns, H.M.3
Schmitz-Van De Leur, H.4
Kerr, I.M.5
Heinrich, P.C.6
Grotzinger, J.7
Behrmann, I.8
-
9
-
-
0028913166
-
Endocytosis of interleukin 2 receptors in human T lymphocytes: Distinct intracellular localization and rate of the receptor alpha, beta, and gamma chains
-
Hemar, A., A. Subtil, M. Lieb, E. Morelon, R. Hellio, and A. Dautry-Varsat. 1995. Endocytosis of interleukin 2 receptors in human T lymphocytes: distinct intracellular localization and rate of the receptor alpha, beta, and gamma chains. J. Cell Biol. 129:55-64.
-
(1995)
J. Cell Biol.
, vol.129
, pp. 55-64
-
-
Hemar, A.1
Subtil, A.2
Lieb, M.3
Morelon, E.4
Hellio, R.5
Dautry-Varsat, A.6
-
10
-
-
0035694582
-
The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor
-
Huang, L. J., S. N. Constantinescu, and H. F. Lodish. 2001. The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor. Mol. Cell 8:1327-1338.
-
(2001)
Mol. Cell
, vol.8
, pp. 1327-1338
-
-
Huang, L.J.1
Constantinescu, S.N.2
Lodish, H.F.3
-
11
-
-
0034941387
-
Pathways in cytokine regulation of hematopoiesis
-
Ihle, J. 2001. Pathways in cytokine regulation of hematopoiesis. Ann. N. Y. Acad. Sci. 938:129-130.
-
(2001)
Ann. N. Y. Acad. Sci.
, vol.938
, pp. 129-130
-
-
Ihle, J.1
-
12
-
-
0033696404
-
Partial impairment of cytokine responses in Tyk2-deficient mice
-
Karaghiosoff, M., H. Neubauer, C. Lassnig, P. Kovarik, H. Schindler, H. Pircher, B. McCoy, C. Bogdan, T. Decker, G. Brem, K. Pfeffer, and M. Muller. 2000. Partial impairment of cytokine responses in Tyk2-deficient mice. Immunity 13:549-560.
-
(2000)
Immunity
, vol.13
, pp. 549-560
-
-
Karaghiosoff, M.1
Neubauer, H.2
Lassnig, C.3
Kovarik, P.4
Schindler, H.5
Pircher, H.6
McCoy, B.7
Bogdan, C.8
Decker, T.9
Brem, G.10
Pfeffer, K.11
Muller, M.12
-
13
-
-
0028301958
-
Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes
-
Kawamura, M., D. W. McVicar, J. A. Johnston, T. B. Blake, Y. Q. Chen, B. K. Lal, A. R. Lloyd, D. J. Kelvin, J. E. Staples, J. R. Ortaldo, et al. 1994. Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes. Proc. Natl. Acad. Sci. USA 91:6374-6378.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 6374-6378
-
-
Kawamura, M.1
McVicar, D.W.2
Johnston, J.A.3
Blake, T.B.4
Chen, Y.Q.5
Lal, B.K.6
Lloyd, A.R.7
Kelvin, D.J.8
Staples, J.E.9
Ortaldo, J.R.10
-
14
-
-
0038539290
-
Of JAKs, STATs, blind watchmakers, jeeps, and trains
-
Kerr, I. M., A. P. Costa-Pereira, B. F. Lillemeier, and B. Strobl. 2003. Of JAKs, STATs, blind watchmakers, jeeps, and trains. FEBS Lett. 546:1-5.
-
(2003)
FEBS Lett.
, vol.546
, pp. 1-5
-
-
Kerr, I.M.1
Costa-Pereira, A.P.2
Lillemeier, B.F.3
Strobl, B.4
-
15
-
-
0035315880
-
Role of Jak kinases and STATs in cytokine signal transduction
-
Leonard, W. J. 2001. Role of Jak kinases and STATs in cytokine signal transduction. Int. J. Hematol. 73:271-277.
-
(2001)
Int. J. Hematol.
, vol.73
, pp. 271-277
-
-
Leonard, W.J.1
-
16
-
-
0025940101
-
Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic
-
Lippincott-Schwartz, J., L. Yuan, C. Tipper, M. Amherdt, L. Orci, and R. D. Klausner. 1991. Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic. Cell 67:601-616.
-
(1991)
Cell
, vol.67
, pp. 601-616
-
-
Lippincott-Schwartz, J.1
Yuan, L.2
Tipper, C.3
Amherdt, M.4
Orci, L.5
Klausner, R.D.6
-
17
-
-
0031017533
-
Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways
-
Luo, H., P. Rose, D. Barber, W. P. Hanratty, S. Lee, T. M. Roberts, A. D. D'Andrea, and C. R. Dearolf. 1997. Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways. Mol. Cell. Biol. 17:1562-1571.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 1562-1571
-
-
Luo, H.1
Rose, P.2
Barber, D.3
Hanratty, W.P.4
Lee, S.5
Roberts, T.M.6
D'Andrea, A.D.7
Dearolf, C.R.8
-
18
-
-
0029164841
-
Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)
-
Macchi, P., A. Villa, S. Giliani, M. G. Sacco, A. Frattini, F. Porta, A. G. Ugazio, J. A. Johnston, F. Candotti, J. J. O'Shea, et al. 1995. Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). Nature 377:65-68.
-
(1995)
Nature
, vol.377
, pp. 65-68
-
-
Macchi, P.1
Villa, A.2
Giliani, S.3
Sacco, M.G.4
Frattini, A.5
Porta, F.6
Ugazio, A.G.7
Johnston, J.A.8
Candotti, F.9
O'Shea, J.J.10
-
19
-
-
0037032835
-
The protein kinase complement of the human genome
-
Manning, G., D. B. Whyte, R. Martinez, T. Hunter, and S. Sudarsanam. 2002. The protein kinase complement of the human genome. Science 298: 1912-1934.
-
(2002)
Science
, vol.298
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
20
-
-
0032555576
-
Endocytosis of the common cytokine receptor gamma chain. Identification of sequences involved in internalization and degradation
-
Morelon, E., and A. Dautry-Varsat. 1998. Endocytosis of the common cytokine receptor gamma chain. Identification of sequences involved in internalization and degradation. J. Biol. Chem. 273:22044-22051.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 22044-22051
-
-
Morelon, E.1
Dautry-Varsat, A.2
-
21
-
-
0030030714
-
Blocking intracellular degradation of the erythropoietin and asialoglycoprotein receptors by calpain inhibitors does not result in the same increase in the levels of their membrane and secreted forms
-
Neumann, D., M. H. Yuk, H. F. Lodish, and G. Z. Lederkremer. 1996. Blocking intracellular degradation of the erythropoietin and asialoglycoprotein receptors by calpain inhibitors does not result in the same increase in the levels of their membrane and secreted forms. Biochem. J. 313(Pt. 2):391-399.
-
(1996)
Biochem. J.
, vol.313
, Issue.PART 2
, pp. 391-399
-
-
Neumann, D.1
Yuk, M.H.2
Lodish, H.F.3
Lederkremer, G.Z.4
-
22
-
-
0034804745
-
Mutations in severe combined immune deficiency (SCID) due to JAK3 deficiency
-
Notarangelo, L. D., P. Mella, A. Jones, G. de Saint Basile, G. Savoldi, T. Cranston, M. Vihinen, and R. F. Schumacher. 2001. Mutations in severe combined immune deficiency (SCID) due to JAK3 deficiency. Hum. Mutat. 18:255-263.
-
(2001)
Hum. Mutat.
, vol.18
, pp. 255-263
-
-
Notarangelo, L.D.1
Mella, P.2
Jones, A.3
De Saint Basile, G.4
Savoldi, G.5
Cranston, T.6
Vihinen, M.7
Schumacher, R.F.8
-
23
-
-
0036233585
-
Cytokine signaling in 2002: New surprises in the Jak/Stat pathway
-
O'Shea, J. J., M. Gadina, and R. D. Schreiber. 2002. Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell 109(Suppl.): S121-S131.
-
(2002)
Cell
, vol.109
, Issue.SUPPL.
-
-
O'Shea, J.J.1
Gadina, M.2
Schreiber, R.D.3
-
24
-
-
0037192833
-
Novel role for Janus kinase 1 in the regulation of oncostatin M receptor surface expression
-
Radtke, S., H. M. Hermanns, C. Haan, H. Schmitz-Van De Leur, H. Gascan, P. C. Heinrich, and I. Behrmann. 2002. Novel role for Janus kinase 1 in the regulation of oncostatin M receptor surface expression. J. Biol. Chem. 277: 11237-11305.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 11237-11305
-
-
Radtke, S.1
Hermanns, H.M.2
Haan, C.3
Schmitz-Van De Leur, H.4
Gascan, H.5
Heinrich, P.C.6
Behrmann, I.7
-
25
-
-
0037415720
-
The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression
-
Ragimbeau, J., E. Dondi, A. Alcover, P. Eid, G. Uze, and S. Pellegrini. 2003. The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression. EMBO J. 22:537-547.
-
(2003)
EMBO J.
, vol.22
, pp. 537-547
-
-
Ragimbeau, J.1
Dondi, E.2
Alcover, A.3
Eid, P.4
Uze, G.5
Pellegrini, S.6
-
26
-
-
0032544656
-
Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1
-
Richter, M. F., G. Dumenil, G. Uze, M. Fellous, and S. Pellegrini. 1998. Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1. J. Biol. Chem. 273: 24723-24729.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 24723-24729
-
-
Richter, M.F.1
Dumenil, G.2
Uze, G.3
Fellous, M.4
Pellegrini, S.5
-
27
-
-
0028171065
-
Interaction of IL-2Rβ and γc chains with Jak1 and Jak3: Implications for XSCID and XCID
-
Russell, S. M., J. A. Johnston, M. Noguchi, M. Kawamura, C. M. Bacon, M. Friedmann, M. Berg, D. W. McVicar, B. A. Witthuhn, O. Silvennoinen, et al. 1994. Interaction of IL-2Rβ and γc chains with Jak1 and Jak3: implications for XSCID and XCID. Science 266:1042-1045.
-
(1994)
Science
, vol.266
, pp. 1042-1045
-
-
Russell, S.M.1
Johnston, J.A.2
Noguchi, M.3
Kawamura, M.4
Bacon, C.M.5
Friedmann, M.6
Berg, M.7
McVicar, D.W.8
Witthuhn, B.A.9
Silvennoinen, O.10
-
28
-
-
0028857954
-
Mutation of Jak3 in a patient with SCID: Essential role of Jak3 in lymphoid development
-
Russell, S. M., N. Tayebi, H. Nakajima, M. C. Riedy, J. L. Roberts, M. J. Aman, T. S. Migone, M. Noguchi, M. L. Markert, R. H. Buckley, et al. 1995. Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. Science 270:797-800.
-
(1995)
Science
, vol.270
, pp. 797-800
-
-
Russell, S.M.1
Tayebi, N.2
Nakajima, H.3
Riedy, M.C.4
Roberts, J.L.5
Aman, M.J.6
Migone, T.S.7
Noguchi, M.8
Markert, M.L.9
Buckley, R.H.10
-
29
-
-
0034012330
-
Regulation of the Jak2 tyrosine kinase by its pseudokinase domain
-
Saharinen, P., K. Takaluoma, and O. Silvennoinen. 2000. Regulation of the Jak2 tyrosine kinase by its pseudokinase domain. Mol. Cell. Biol. 20:3387-3395.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 3387-3395
-
-
Saharinen, P.1
Takaluoma, K.2
Silvennoinen, O.3
-
30
-
-
1842291572
-
Crucial role of Jak3 in negative selection of self-reactive T cells
-
Saijo, K., S. Y. Park, Y. Ishida, H. Arase, and T. Saito. 1997. Crucial role of Jak3 in negative selection of self-reactive T cells. J. Exp. Med. 185:351-356.
-
(1997)
J. Exp. Med.
, vol.185
, pp. 351-356
-
-
Saijo, K.1
Park, S.Y.2
Ishida, Y.3
Arase, H.4
Saito, T.5
-
31
-
-
0032030618
-
Requirement for Jak3 in mature T cells: Its role in regulation of T-cell homeostasis
-
Sohn, S. J., K. A. Forbush, N. Nguyen, B. Witthuhn, T. Nosaka, J. N. Ihle, and R. M. Perlmutter. 1998. Requirement for Jak3 in mature T cells: its role in regulation of T-cell homeostasis. J. Immunol. 160:2130-2138.
-
(1998)
J. Immunol.
, vol.160
, pp. 2130-2138
-
-
Sohn, S.J.1
Forbush, K.A.2
Nguyen, N.3
Witthuhn, B.4
Nosaka, T.5
Ihle, J.N.6
Perlmutter, R.M.7
-
32
-
-
0000311479
-
A cytosolic domain of the erythropoietin receptor contributes to endoplasmic reticulum-associated degradation
-
Supino-Rosin, L., A. Yoshimura, H. Altaratz, and D. Neumann. 1999. A cytosolic domain of the erythropoietin receptor contributes to endoplasmic reticulum-associated degradation. Eur. J. Biochem. 263:410-419.
-
(1999)
Eur. J. Biochem.
, vol.263
, pp. 410-419
-
-
Supino-Rosin, L.1
Yoshimura, A.2
Altaratz, H.3
Neumann, D.4
-
34
-
-
0031054442
-
Peripheral expression of Jak3 is required to maintain T lymphocyte function
-
Thomis, D. C., and L. J. Berg. 1997. Peripheral expression of Jak3 is required to maintain T lymphocyte function. J. Exp. Med. 185:197-206.
-
(1997)
J. Exp. Med.
, vol.185
, pp. 197-206
-
-
Thomis, D.C.1
Berg, L.J.2
-
35
-
-
0028835347
-
Distinct domains of the protein tyrosine kinase tyk2 required for binding of interferon-alpha/beta and for signal transduction
-
Velazquez, L., K. E. Mogensen, G. Barbieri, M. Fellous, G. Uze, and S. Pellegrini. 1995. Distinct domains of the protein tyrosine kinase tyk2 required for binding of interferon-alpha/beta and for signal transduction. J. Biol. Chem. 270:3327-3334.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 3327-3334
-
-
Velazquez, L.1
Mogensen, K.E.2
Barbieri, G.3
Fellous, M.4
Uze, G.5
Pellegrini, S.6
-
36
-
-
18244393495
-
Unexpected effects of FERM domain mutations on catalytic activity of Jak3: Structural implication for Janus kinases
-
Zhou, Y. J., M. Chen, N. A. Cusack, L. H. Kimmel, K. S. Magnuson, J. G. Boyd, W. Lin, J. L. Roberts, A. Lengi, R. H. Buckley, R. L. Geahlen, F. Candotti, M. Gadina, P. S. Changelian, and J. J. O'Shea. 2001. Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases. Mol. Cell 8:959-969.
-
(2001)
Mol. Cell
, vol.8
, pp. 959-969
-
-
Zhou, Y.J.1
Chen, M.2
Cusack, N.A.3
Kimmel, L.H.4
Magnuson, K.S.5
Boyd, J.G.6
Lin, W.7
Roberts, J.L.8
Lengi, A.9
Buckley, R.H.10
Geahlen, R.L.11
Candotti, F.12
Gadina, M.13
Changelian, P.S.14
O'Shea, J.J.15
-
37
-
-
0031444188
-
Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity
-
Zhou, Y. J., E. P. Hanson, Y. Q. Chen, K. Magnuson, M. Chen, P. G. Swann, R. L. Wange, P. S. Changelian, and J. J. O'Shea. 1997. Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity. Proc. Natl. Acad. Sci. USA 94:13850-13855.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 13850-13855
-
-
Zhou, Y.J.1
Hanson, E.P.2
Chen, Y.Q.3
Magnuson, K.4
Chen, M.5
Swann, P.G.6
Wange, R.L.7
Changelian, P.S.8
O'Shea, J.J.9
|