Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

Nature Immunology

Volumn 11, Issue 3, 2010, Pages 257-264

  Park, Jung Hyun ^a   Adoro, Stanley ^a   Guinter, Terry ^a   Erman, Batu ^b   Alag, Amala S ^a   Catalfamo, Marta ^c   Kimura, Motoko Y ^a   Cui, Yongzhi ^d   Lucas, Philip J ^a   Gress, Ronald E ^a   Kubo, Masato ^e   Hennighausen, Lothar ^d   Feigenbaum, Lionel ^f   Singer, Alfred ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SABANCI UNIVERSITY   (Turkey)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^e RIKEN YOKOHAMA INSTITUTE   (Japan)

^f SAIC FREDERICK INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 7; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR RUNX3;

ANIMAL CELL; ARTICLE; CD8+ T LYMPHOCYTE; CELL LINEAGE; CELL MATURATION; CELL SPECIFICITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; GENETIC ENGINEERING; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THYMOCYTE;

ANIMALS; CELL COUNT; CELL DIFFERENTIATION; CELL LINEAGE; CORE BINDING FACTOR ALPHA 3 SUBUNIT; CYTOKINES; FLOW CYTOMETRY; INTERLEUKIN-7; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; T-LYMPHOCYTES, CYTOTOXIC;

EID: 76949084912     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.1840     Document Type: Article

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